STANDARD_NAME	GSE22589_HEALTHY_VS_HIV_INFECTED_DC_UP
SYSTEMATIC_NAME	M7805
COLLECTION	C7:IMMUNESIGDB
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE22589_HEALTHY_VS_HIV_INFECTED_DC_UP
NAMESPACE	HUMAN_GENE_SYMBOL
DESCRIPTION_BRIEF	Genes up-regulated in monocyte-derived dendritic cells: control versus HIV infection.
DESCRIPTION_FULL	Dendritic cells (DC) serve a key function in host defense, linking innate detection of microbes to the activation of pathogen-specific adaptive immune responses. Whether there is cell-intrinsic recognition of HIV-1 by host innate pattern-recognition receptors and subsequent coupling to antiviral T cell responses is not yet known. DC are largely resistant to infection with HIV-1, but facilitate infection of co-cultured T-helper cells through a process of trans-enhancement. We show here that, when DC resistance to infection is circumvented, HIV-1 induces DC maturation, an antiviral type I interferon response and activation of T cells. This innate response is dependent on the interaction of newly-synthesized HIV-1 capsid (CA) with cellular cyclophilin A (CypA) and the subsequent activation of the transcription factor IRF3. Because the peptidyl-prolyl isomerase CypA also interacts with CA to promote HIV-1 infectivity, our results suggest that CA conformation has evolved under opposing selective pressures for infectivity versus furtiveness. Thus, a cell intrinsic sensor for HIV-1 exists in DC and mediates an antiviral immune response, but it is not typically engaged due to absence of DC infection. The virulence of HIV-1 may be related to evasion of this response, whose manipulation may be necessary to generate an effective HIV-1 vaccine.
PMID	20829794
GEOID	GSE22589
AUTHORS	Manel N,Hogstad B,Wang Y,Levy DE,Unutmaz D,Littman DR
CONTRIBUTOR	Jernej Godec
CONTRIBUTOR_ORG	Dana-Farber Cancer Institute
EXACT_SOURCE	GSE22589_3650_200_UP
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	ACOT11,ADAM8,ANUBL1,ARMC1,ATMIN,ATP6V0E2,BAG2,BAG4,BAHD1,BDH1,C11orf51,C13orf27,C14orf147,C18orf55,C19orf42,C19orf48,C5orf43,C6orf186,CAMK1D,CAMSAP1L1,CCDC101,CCDC117,CCT4,CDC14B,CDC42SE1,CELSR3,CES3,CHST11,CIRH1A,CLUAP1,COBRA1,COG5,COIL,COX10,CSRP2BP,CSTF1,CTPS,DEPTOR,DIMT1L,DLGAP2,DNAJC2,DPP3,DUS1L,DYNC1LI2,ECHDC1,ECSIT,EIF3G,ENTPD5,ERRFI1,ESF1,ETV5,FAM109B,FAM63A,FAM98A,FASTKD5,FUCA2,FXR2,G3BP1,GAR1,GLRX5,GPR97,GTPBP4,HAS3,HAUS3,HEATR3,HIPK1,HNRNPA1,HNRNPH2,HNRNPR,ING5,INSR,IPO11,IPO4,ISG20L2,ITFG1,ITPR3,KCNAB2,KCTD20,KDM2B,KIAA0528,KIAA0664,LARS2,MAK16,MAPRE1,MARCH6,MAST3,MAT2A,MDC1,MEGF9,MEPCE,METTL1,METTL3,MRPS2,MTAP,MTMR10,MUM1,NAP1L1,NARFL,NDUFB8,NFIC,NGLY1,NOP56,ORC6,P4HB,PA2G4,PAFAH2,PAK1IP1,PDCD6IP,PDP1,PELP1,PIGN,PIGX,PIGY,PINX1,PITPNB,POLR2D,POLR2H,PPIL4,PPRC1,PPWD1,PRKAB1,PRKCB,PRMT3,PRMT7,PRPF19,PSMD6,PSPC1,PTCD3,PTPLA,RAB14,RAD17,RIOK1,RMND5B,RNF150,ROBO2,RPL10,RPL13,RRP15,RRP9,RRS1,SCYL1,SERBP1,SETD1A,SETD6,SH3BP5L,SIKE1,SLC11A1,SLC16A1,SLC25A13,SLC25A30,SLC25A36,SLC36A4,SMC1A,SMYD4,SNRPD2,SPRED2,STT3B,SVIP,SYS1,TAF3,TAF5L,TARDBP,TASP1,TCF12,TCP1,TCTA,TFDP2,THBS1,TIMM9,TM6SF1,TMEM126A,TMEM62,TNFRSF9,TRMT61A,TRUB1,TTL,TTLL4,TUBGCP2,TXNRD2,TYSND1,UBA2,UBP1,UCHL5,USP37,USPL1,VSTM2A,WDR12,WTAP,YARS,YRDC,ZDHHC13,ZNF14,ZNF229,ZNF266,ZNF454,ZNF569,ZNF655,ZRANB3,ZXDC,ZYG11B
GENE_SYMBOLS	ACOT11,ADAM8,ZFAND4,ARMC1,ATMIN,ATP6V0E2,BAG2,BAG4,BAHD1,BDH1,ANAPC15,TEX30,SPTSSA,TIMM21,SMIM7,C19orf48P,SMIM15,METTL24,CAMK1D,CAMSAP2,SGF29,CCDC117,CCT4,CDC14B,CDC42SE1,CELSR3,CES3,CHST11,UTP4,CLUAP1,NELFB,COG5,COIL,COX10,KAT14,CSTF1,CTPS1,DEPTOR,DIMT1,DLGAP2,DNAJC2,DPP3,DUS1L,DYNC1LI2,ECHDC1,ECSIT,EIF3G,ENTPD5,ERRFI1,ESF1,ETV5,PHETA2,MINDY1,FAM98A,FASTKD5,FUCA2,FXR2,G3BP1,GAR1,GLRX5,ADGRG3,GTPBP4,HAS3,HAUS3,HEATR3,HIPK1,HNRNPA1,HNRNPH2,HNRNPR,ING5,INSR,IPO11,IPO4,ISG20L2,ITFG1,ITPR3,KCNAB2,KCTD20,KDM2B,C2CD5,CLUH,LARS2,MAK16,MAPRE1,MARCHF6,MAST3,MAT2A,MDC1,MEGF9,MEPCE,METTL1,METTL3,MRPS2,MTAP,MTMR10,IRF4,NAP1L1,CIAO3,NDUFB8,NFIC,NGLY1,NOP56,ORC6,P4HB,PA2G4,PAFAH2,PAK1IP1,PDCD6IP,PDP1,PELP1,PIGN,PIGX,PIGY,PINX1,PITPNB,POLR2D,POLR2H,PPIL4,PPRC1,PPWD1,PRKAB1,PRKCB,PRMT3,PRMT7,PRPF19,PSMD6,PSPC1,PTCD3,HACD1,RAB14,RAD17,RIOK1,RMND5B,RNF150,ROBO2,RPL10,RPL13,RRP15,RRP9,RRS1,SCYL1,SERBP1,SETD1A,SETD6,SH3BP5L,SIKE1,SLC11A1,SLC16A1,SLC25A13,SLC25A30,SLC25A36,SLC36A4,SMC1A,SMYD4,SNRPD2,SPRED2,STT3B,SVIP,SYS1,TAF3,TAF5L,TARDBP,TASP1,TCF12,TCP1,TCTA,TFDP2,THBS1,TIMM9,TM6SF1,TMEM126A,TMEM62,TNFRSF9,TRMT61A,TRUB1,TTL,TTLL4,TUBGCP2,TXNRD2,TYSND1,UBA2,UBP1,UCHL5,USP37,USPL1,VSTM2A,WDR12,WTAP,YARS1,YRDC,ZDHHC13,ZNF14,ZNF229,ZNF266,ZNF454,ZNF569,ZNF655,ZRANB3,ZXDC,ZYG11B
FOUNDER_NAMES