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<MSIGDB BUILD_DATE="Jan 29, 2026" VERSION="2026.1.Hs" NAME="export">
    <GENESET STANDARD_NAME="GSE22589_HEALTHY_VS_HIV_INFECTED_DC_UP" SYSTEMATIC_NAME="M7805" HISTORICAL_NAMES="" PMID="20829794" AUTHORS="Manel N,Hogstad B,Wang Y,Levy DE,Unutmaz D,Littman DR" GEOID="GSE22589" EXACT_SOURCE="GSE22589_3650_200_UP" GENESET_LISTING_URL="" EXTERNAL_DETAILS_URL="" CHIP="HUMAN_GENE_SYMBOL" CONTRIBUTOR="Jernej Godec" CONTRIBUTOR_ORG="Dana-Farber Cancer Institute" DESCRIPTION_BRIEF="Genes up-regulated in monocyte-derived dendritic cells: control versus HIV infection." DESCRIPTION_FULL="Dendritic cells (DC) serve a key function in host defense, linking innate detection of microbes to the activation of pathogen-specific adaptive immune responses. Whether there is cell-intrinsic recognition of HIV-1 by host innate pattern-recognition receptors and subsequent coupling to antiviral T cell responses is not yet known. DC are largely resistant to infection with HIV-1, but facilitate infection of co-cultured T-helper cells through a process of trans-enhancement. We show here that, when DC resistance to infection is circumvented, HIV-1 induces DC maturation, an antiviral type I interferon response and activation of T cells. This innate response is dependent on the interaction of newly-synthesized HIV-1 capsid (CA) with cellular cyclophilin A (CypA) and the subsequent activation of the transcription factor IRF3. Because the peptidyl-prolyl isomerase CypA also interacts with CA to promote HIV-1 infectivity, our results suggest that CA conformation has evolved under opposing selective pressures for infectivity versus furtiveness. Thus, a cell intrinsic sensor for HIV-1 exists in DC and mediates an antiviral immune response, but it is not typically engaged due to absence of DC infection. The virulence of HIV-1 may be related to evasion of this response, whose manipulation may be necessary to generate an effective HIV-1 vaccine." TAGS="" MEMBERS="ACOT11,ADAM8,ANUBL1,ARMC1,ATMIN,ATP6V0E2,BAG2,BAG4,BAHD1,BDH1,C11orf51,C13orf27,C14orf147,C18orf55,C19orf42,C19orf48,C5orf43,C6orf186,CAMK1D,CAMSAP1L1,CCDC101,CCDC117,CCT4,CDC14B,CDC42SE1,CELSR3,CES3,CHST11,CIRH1A,CLUAP1,COBRA1,COG5,COIL,COX10,CSRP2BP,CSTF1,CTPS,DEPTOR,DIMT1L,DLGAP2,DNAJC2,DPP3,DUS1L,DYNC1LI2,ECHDC1,ECSIT,EIF3G,ENTPD5,ERRFI1,ESF1,ETV5,FAM109B,FAM63A,FAM98A,FASTKD5,FUCA2,FXR2,G3BP1,GAR1,GLRX5,GPR97,GTPBP4,HAS3,HAUS3,HEATR3,HIPK1,HNRNPA1,HNRNPH2,HNRNPR,ING5,INSR,IPO11,IPO4,ISG20L2,ITFG1,ITPR3,KCNAB2,KCTD20,KDM2B,KIAA0528,KIAA0664,LARS2,MAK16,MAPRE1,MARCH6,MAST3,MAT2A,MDC1,MEGF9,MEPCE,METTL1,METTL3,MRPS2,MTAP,MTMR10,MUM1,NAP1L1,NARFL,NDUFB8,NFIC,NGLY1,NOP56,ORC6,P4HB,PA2G4,PAFAH2,PAK1IP1,PDCD6IP,PDP1,PELP1,PIGN,PIGX,PIGY,PINX1,PITPNB,POLR2D,POLR2H,PPIL4,PPRC1,PPWD1,PRKAB1,PRKCB,PRMT3,PRMT7,PRPF19,PSMD6,PSPC1,PTCD3,PTPLA,RAB14,RAD17,RIOK1,RMND5B,RNF150,ROBO2,RPL10,RPL13,RRP15,RRP9,RRS1,SCYL1,SERBP1,SETD1A,SETD6,SH3BP5L,SIKE1,SLC11A1,SLC16A1,SLC25A13,SLC25A30,SLC25A36,SLC36A4,SMC1A,SMYD4,SNRPD2,SPRED2,STT3B,SVIP,SYS1,TAF3,TAF5L,TARDBP,TASP1,TCF12,TCP1,TCTA,TFDP2,THBS1,TIMM9,TM6SF1,TMEM126A,TMEM62,TNFRSF9,TRMT61A,TRUB1,TTL,TTLL4,TUBGCP2,TXNRD2,TYSND1,UBA2,UBP1,UCHL5,USP37,USPL1,VSTM2A,WDR12,WTAP,YARS,YRDC,ZDHHC13,ZNF14,ZNF229,ZNF266,ZNF454,ZNF569,ZNF655,ZRANB3,ZXDC,ZYG11B" MEMBERS_SYMBOLIZED="ACOT11,ADAM8,ADGRG3,ANAPC15,ARMC1,ATMIN,ATP6V0E2,BAG2,BAG4,BAHD1,BDH1,C19orf48P,C2CD5,CAMK1D,CAMSAP2,CCDC117,CCT4,CDC14B,CDC42SE1,CELSR3,CES3,CHST11,CIAO3,CLUAP1,CLUH,COG5,COIL,COX10,CSTF1,CTPS1,DEPTOR,DIMT1,DLGAP2,DNAJC2,DPP3,DUS1L,DYNC1LI2,ECHDC1,ECSIT,EIF3G,ENTPD5,ERRFI1,ESF1,ETV5,FAM98A,FASTKD5,FUCA2,FXR2,G3BP1,GAR1,GLRX5,GTPBP4,HACD1,HAS3,HAUS3,HEATR3,HIPK1,HNRNPA1,HNRNPH2,HNRNPR,ING5,INSR,IPO11,IPO4,IRF4,ISG20L2,ITFG1,ITPR3,KAT14,KCNAB2,KCTD20,KDM2B,LARS2,MAK16,MAPRE1,MARCHF6,MAST3,MAT2A,MDC1,MEGF9,MEPCE,METTL1,METTL24,METTL3,MINDY1,MRPS2,MTAP,MTMR10,NAP1L1,NDUFB8,NELFB,NFIC,NGLY1,NOP56,ORC6,P4HB,PA2G4,PAFAH2,PAK1IP1,PDCD6IP,PDP1,PELP1,PHETA2,PIGN,PIGX,PIGY,PINX1,PITPNB,POLR2D,POLR2H,PPIL4,PPRC1,PPWD1,PRKAB1,PRKCB,PRMT3,PRMT7,PRPF19,PSMD6,PSPC1,PTCD3,RAB14,RAD17,RIOK1,RMND5B,RNF150,ROBO2,RPL10,RPL13,RRP15,RRP9,RRS1,SCYL1,SERBP1,SETD1A,SETD6,SGF29,SH3BP5L,SIKE1,SLC11A1,SLC16A1,SLC25A13,SLC25A30,SLC25A36,SLC36A4,SMC1A,SMIM15,SMIM7,SMYD4,SNRPD2,SPRED2,SPTSSA,STT3B,SVIP,SYS1,TAF3,TAF5L,TARDBP,TASP1,TCF12,TCP1,TCTA,TEX30,TFDP2,THBS1,TIMM21,TIMM9,TM6SF1,TMEM126A,TMEM62,TNFRSF9,TRMT61A,TRUB1,TTL,TTLL4,TUBGCP2,TXNRD2,TYSND1,UBA2,UBP1,UCHL5,USP37,USPL1,UTP4,VSTM2A,WDR12,WTAP,YARS1,YRDC,ZDHHC13,ZFAND4,ZNF14,ZNF229,ZNF266,ZNF454,ZNF569,ZNF655,ZRANB3,ZXDC,ZYG11B" MEMBERS_EZID="10015,10054,10072,101,10146,10165,10196,10208,10236,10299,10466,10528,10575,10587,10781,10844,112869,114826,115708,120103,1352,142940,1477,148266,150275,1503,150368,150465,155066,171546,1783,1951,1955,200734,201595,204851,2119,219743,222008,222487,222658,22893,22919,23031,23059,23082,23212,23271,23277,23300,23395,23398,23435,23491,23556,23560,23594,23760,2519,253512,258010,25906,25920,25940,26027,26135,26520,27000,27043,27097,27292,27339,285676,29090,3038,3178,3188,3604,3643,3662,3710,4144,4234,4507,4673,4714,4782,5034,5036,5051,50515,51018,51116,51194,51218,51295,51377,51552,51575,53346,54206,5433,5437,54433,54496,54503,54704,54893,54965,54984,55003,55027,55037,55156,55186,55269,55617,5564,55759,55768,5579,55793,55862,56257,56339,56882,57118,57325,57410,57484,57695,5884,60493,6092,6134,6137,622,64118,643155,64428,64777,64798,6556,6566,6633,6938,6950,6988,7029,7057,728464,7342,7561,7772,79027,79086,79364,79441,79693,79699,79711,79918,80021,80143,80851,81533,8161,81875,8243,83732,83860,84083,84233,84289,84549,84678,84798,84916,84992,8514,85313,8555,8565,8666,90196,9136,9200,9228,93081,93550,9513,9530,9532,957,9589,9654,9656,9739,9847,9861" MEMBERS_MAPPING="ACOT11,ACOT11,26027|ADAM8,ADAM8,101|ANUBL1,ZFAND4,93550|ARMC1,ARMC1,55156|ATMIN,ATMIN,23300|ATP6V0E2,ATP6V0E2,155066|BAG2,BAG2,9532|BAG4,BAG4,9530|BAHD1,BAHD1,22893|BDH1,BDH1,622|C11orf51,ANAPC15,25906|C13orf27,TEX30,93081|C14orf147,SPTSSA,171546|C18orf55,TIMM21,29090|C19orf42,SMIM7,79086|C19orf48,C19orf48P,84798|C5orf43,SMIM15,643155|C6orf186,METTL24,728464|CAMK1D,CAMK1D,57118|CAMSAP1L1,CAMSAP2,23271|CCDC101,SGF29,112869|CCDC117,CCDC117,150275|CCT4,CCT4,10575|CDC14B,CDC14B,8555|CDC42SE1,CDC42SE1,56882|CELSR3,CELSR3,1951|CES3,CES3,23491|CHST11,CHST11,50515|CIRH1A,UTP4,84916|CLUAP1,CLUAP1,23059|COBRA1,NELFB,25920|COG5,COG5,10466|COIL,COIL,8161|COX10,COX10,1352|CSRP2BP,KAT14,57325|CSTF1,CSTF1,1477|CTPS,CTPS1,1503|DEPTOR,DEPTOR,64798|DIMT1L,DIMT1,27292|DLGAP2,DLGAP2,9228|DNAJC2,DNAJC2,27000|DPP3,DPP3,10072|DUS1L,DUS1L,64118|DYNC1LI2,DYNC1LI2,1783|ECHDC1,ECHDC1,55862|ECSIT,ECSIT,51295|EIF3G,EIF3G,8666|ENTPD5,ENTPD5,957|ERRFI1,ERRFI1,54206|ESF1,ESF1,51575|ETV5,ETV5,2119|FAM109B,PHETA2,150368|FAM63A,MINDY1,55793|FAM98A,FAM98A,25940|FASTKD5,FASTKD5,60493|FUCA2,FUCA2,2519|FXR2,FXR2,9513|G3BP1,G3BP1,10146|GAR1,GAR1,54433|GLRX5,GLRX5,51218|GPR97,ADGRG3,222487|GTPBP4,GTPBP4,23560|HAS3,HAS3,3038|HAUS3,HAUS3,79441|HEATR3,HEATR3,55027|HIPK1,HIPK1,204851|HNRNPA1,HNRNPA1,3178|HNRNPH2,HNRNPH2,3188|HNRNPR,HNRNPR,10236|ING5,ING5,84289|INSR,INSR,3643|IPO11,IPO11,51194|IPO4,IPO4,79711|ISG20L2,ISG20L2,81875|ITFG1,ITFG1,81533|ITPR3,ITPR3,3710|KCNAB2,KCNAB2,8514|KCTD20,KCTD20,222658|KDM2B,KDM2B,84678|KIAA0528,C2CD5,9847|KIAA0664,CLUH,23277|LARS2,LARS2,23395|MAK16,MAK16,84549|MAPRE1,MAPRE1,22919|MARCH6,MARCHF6,10299|MAST3,MAST3,23031|MAT2A,MAT2A,4144|MDC1,MDC1,9656|MEGF9,MEGF9,1955|MEPCE,MEPCE,56257|METTL1,METTL1,4234|METTL3,METTL3,56339|MRPS2,MRPS2,51116|MTAP,MTAP,4507|MTMR10,MTMR10,54893|MUM1,IRF4,3662|NAP1L1,NAP1L1,4673|NARFL,CIAO3,64428|NDUFB8,NDUFB8,4714|NFIC,NFIC,4782|NGLY1,NGLY1,55768|NOP56,NOP56,10528|ORC6,ORC6,23594|P4HB,P4HB,5034|PA2G4,PA2G4,5036|PAFAH2,PAFAH2,5051|PAK1IP1,PAK1IP1,55003|PDCD6IP,PDCD6IP,10015|PDP1,PDP1,54704|PELP1,PELP1,27043|PIGN,PIGN,23556|PIGX,PIGX,54965|PIGY,PIGY,84992|PINX1,PINX1,54984|PITPNB,PITPNB,23760|POLR2D,POLR2D,5433|POLR2H,POLR2H,5437|PPIL4,PPIL4,85313|PPRC1,PPRC1,23082|PPWD1,PPWD1,23398|PRKAB1,PRKAB1,5564|PRKCB,PRKCB,5579|PRMT3,PRMT3,10196|PRMT7,PRMT7,54496|PRPF19,PRPF19,27339|PSMD6,PSMD6,9861|PSPC1,PSPC1,55269|PTCD3,PTCD3,55037|PTPLA,HACD1,9200|RAB14,RAB14,51552|RAD17,RAD17,5884|RIOK1,RIOK1,83732|RMND5B,RMND5B,64777|RNF150,RNF150,57484|ROBO2,ROBO2,6092|RPL10,RPL10,6134|RPL13,RPL13,6137|RRP15,RRP15,51018|RRP9,RRP9,9136|RRS1,RRS1,23212|SCYL1,SCYL1,57410|SERBP1,SERBP1,26135|SETD1A,SETD1A,9739|SETD6,SETD6,79918|SH3BP5L,SH3BP5L,80851|SIKE1,SIKE1,80143|SLC11A1,SLC11A1,6556|SLC16A1,SLC16A1,6566|SLC25A13,SLC25A13,10165|SLC25A30,SLC25A30,253512|SLC25A36,SLC25A36,55186|SLC36A4,SLC36A4,120103|SMC1A,SMC1A,8243|SMYD4,SMYD4,114826|SNRPD2,SNRPD2,6633|SPRED2,SPRED2,200734|STT3B,STT3B,201595|SVIP,SVIP,258010|SYS1,SYS1,90196|TAF3,TAF3,83860|TAF5L,TAF5L,27097|TARDBP,TARDBP,23435|TASP1,TASP1,55617|TCF12,TCF12,6938|TCP1,TCP1,6950|TCTA,TCTA,6988|TFDP2,TFDP2,7029|THBS1,THBS1,7057|TIMM9,TIMM9,26520|TM6SF1,TM6SF1,53346|TMEM126A,TMEM126A,84233|TMEM62,TMEM62,80021|TNFRSF9,TNFRSF9,3604|TRMT61A,TRMT61A,115708|TRUB1,TRUB1,142940|TTL,TTL,150465|TTLL4,TTLL4,9654|TUBGCP2,TUBGCP2,10844|TXNRD2,TXNRD2,10587|TYSND1,TYSND1,219743|UBA2,UBA2,10054|UBP1,UBP1,7342|UCHL5,UCHL5,51377|USP37,USP37,57695|USPL1,USPL1,10208|VSTM2A,VSTM2A,222008|WDR12,WDR12,55759|WTAP,WTAP,9589|YARS,YARS1,8565|YRDC,YRDC,79693|ZDHHC13,ZDHHC13,54503|ZNF14,ZNF14,7561|ZNF229,ZNF229,7772|ZNF266,ZNF266,10781|ZNF454,ZNF454,285676|ZNF569,ZNF569,148266|ZNF655,ZNF655,79027|ZRANB3,ZRANB3,84083|ZXDC,ZXDC,79364|ZYG11B,ZYG11B,79699" FILTERED_BY_SIMILARITY="" FOUNDER_NAMES="" REFINEMENT_DATASETS="" VALIDATION_DATASETS="" CATEGORY_CODE="C7" ORGANISM="Homo sapiens" SUB_CATEGORY_CODE="IMMUNESIGDB"/>
</MSIGDB>
