STANDARD_NAME GSE22601_CD4_SINGLE_POSITIVE_VS_CD8_SINGLE_POSITIVE_THYMOCYTE_DN SYSTEMATIC_NAME M6251 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE22601_CD4_SINGLE_POSITIVE_VS_CD8_SINGLE_POSITIVE_THYMOCYTE_DN NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes down-regulated in single positive thymocytes: CD4 [GeneID=920] versus CD8. DESCRIPTION_FULL T cells develop from progenitors that migrate from the bone marrow into the thymus. Thymocytes are subdivided roughly as being double negative (DN), double positive (DP), or single positive (SP), based on the expression of the CD4 and CD8 coreceptors. The DN stage is heterogeneous and can be subdivided into four distinct subsets in mice based on the expression of CD44 and CD25. In human, three distinct DN stages can be recognized: a CD34+CD38−CD1a− stage that represents the most immature thymic subset and the consecutive CD34+CD38+CD1a− and CD34+CD38+CD1a+ stages. Human DN thymocytes mature via an immature single positive (ISP CD4+) and a DP stage into CD4+ or CD8+ SP T cells that express functional T cell receptors (TCR) and that exit the thymus. In this study, gene expression was measured in each of these nine stages. PMID 15928199 GEOID GSE22601 AUTHORS Dik WA,Pike-Overzet K,Weerkamp F,de Ridder D,de Haas EF,Baert MR,van der Spek P,Koster EE,Reinders MJ,van Dongen JJ,Langerak AW,Staal FJ CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE22601_3418_200_DN FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS ABCF2,ACADL,ACP5,AGER,AKAP8,AKIRIN1,ALKBH1,ANKIB1,ANKRD11,ARHGAP1,ATF7IP,ATP10A,ATP6V0A2,BACH1,BAZ2A,BCCIP,C12orf4,C14orf119,C16orf70,C18orf32,C1orf189,C20orf24,C21orf33,C5orf34,C5orf51,C9orf16,CALCRL,CD164,CIB1,CISD1,CLK4,CMAS,CNP,CREB3,CXXC1,CYB5A,DBNL,DCAF11,DCAF8,DGKA,DIEXF,DMTF1,DOCK2,DPH5,DPP4,DUSP11,EGR1,EHD3,EIF2AK1,EMG1,ENSA,ESYT1,EVI2B,FAM100B,FAM102A,FAM32A,FAM53A,FEZ2,GBP7,GDAP2,GDI1,GIMAP4,GIMAP8,GMFB,GMFG,GPR125,GRAMD3,GRB2,HBP1,HECTD3,HSD17B4,IFT57,IL18RAP,INPP1,IRAK3,IRF2,ITGA6,ITGB1BP1,ITGB3,ITPKB,JAK3,KCTD12,KLHDC3,L1CAM,LAMTOR3,LBH,LIPA,LMBRD1,MARCH2,MCTP2,METRNL,MFNG,MTERFD1,MYO6,NARF,NCLN,NCRNA00116,NDUFA6,NDUFAF4,NEMF,NFKBIE,NFRKB,OSTM1,PAPD5,PAPOLG,PATZ1,PCMTD2,PFN1,PHLPP1,PKP3,PLCG2,PLCXD2,PLOD1,PNN,PON2,POU2AF1,PREB,PRIC285,PRKAR2A,PRKD3,PRR14,PRR14L,PTPRE,RAB19,RBFA,RBM33,RBX1,RC3H1,RCN1,RER1,RFK,RHOBTB2,RNASET2,RPS6KA1,RPS6KB2,RSRC2,RUNDC1,S1PR4,SAMHD1,SCAMP3,SCML4,SEC16A,SEC23B,SEC63,SELL,SELO,SENP7,SEPT9,SH2D1A,SIDT2,SIRT2,SLA,SLA2,SLAMF6,SLC15A4,SLC25A33,SLC2A4RG,SLC36A1,SLC9A9,SLCO4A1,SMAD7,SNAP23,SNRK,SNX10,SNX14,SNX33,SQRDL,SRSF6,SSBP4,STIM2,STX16,SYS1,TAB2,TAF8,TASP1,TMEM126A,TMEM173,TMEM20,TMOD3,TRAM1,TRAPPC8,TRPM4,TSR1,TWF2,TYROBP,UBAC2,UBE2F,UBE2H,UNC5A,UPF2,UQCRHL,USP12,VPS54,WDR43,YTHDC1,YWHAZ,ZDHHC3,ZFC3H1,ZNF260,ZYG11B GENE_SYMBOLS ABCF2,ACADL,ACP5,AGER,AKAP8,AKIRIN1,ALKBH1,ANKIB1,ANKRD11,ARHGAP1,ATF7IP,ATP10A,ATP6V0A2,BACH1,BAZ2A,BCCIP,C12orf4,C14orf119,PHAF1,C18orf32,CFAP141,RAB5IF,GATD3,C5orf34,RIMOC1,BBLN,CALCRL,CD164,CIB1,CISD1,CLK4,CMAS,CNP,CREB3,CXXC1,CYB5A,DBNL,DCAF11,DCAF8,DGKA,UTP25,DMTF1,DOCK2,DPH5,DPP4,DUSP11,EGR1,EHD3,EIF2AK1,EMG1,ENSA,ESYT1,EVI2B,UBALD2,EEIG1,FAM32A,FAM53A,FEZ2,GBP7,GDAP2,GDI1,GIMAP4,GIMAP8,GMFB,GMFG,ADGRA3,GRAMD2B,GRB2,HBP1,HECTD3,HSD17B4,IFT57,IL18RAP,INPP1,IRAK3,IRF2,ITGA6,ITGB1BP1,ITGB3,ITPKB,JAK3,KCTD12,KLHDC3,L1CAM,LAMTOR3,LBH,LIPA,LMBRD1,MARCHF2,MCTP2,METRNL,MFNG,MTERF3,MYO6,NARF,NCLN,MTLN,NDUFA6,NDUFAF4,NEMF,NFKBIE,NFRKB,OSTM1,TENT4B,PAPOLG,PATZ1,PCMTD2,PFN1,PHLPP1,PKP3,PLCG2,PLCXD2,PLOD1,PNN,PON2,POU2AF1,PREB,HELZ2,PRKAR2A,PRKD3,PRR14,PRR14L,PTPRE,RAB19,RBFA,RBM33,RBX1,RC3H1,RCN1,RER1,RFK,RHOBTB2,RNASET2,RPS6KA1,RPS6KB2,RSRC2,RUNDC1,S1PR4,SAMHD1,SCAMP3,SCML4,SEC16A,SEC23B,SEC63,SELL,SELENOO,SENP7,SEPTIN9,SH2D1A,SIDT2,SIRT2,SLA,SLA2,SLAMF6,SLC15A4,SLC25A33,SLC2A4RG,SLC36A1,SLC9A9,SLCO4A1,SMAD7,SNAP23,SNRK,SNX10,SNX14,SNX33,SQOR,SRSF6,SSBP4,STIM2,STX16,SYS1,TAB2,TAF8,TASP1,TMEM126A,STING1,SLC35G1,TMOD3,TRAM1,TRAPPC8,TRPM4,TSR1,TWF2,TYROBP,UBAC2,UBE2F,UBE2H,UNC5A,UPF2,UQCRHL,USP12,VPS54,WDR43,YTHDC1,YWHAZ,ZDHHC3,ZFC3H1,ZNF260,ZYG11B FOUNDER_NAMES