STANDARD_NAME GSE23114_WT_VS_SLE2C1_MOUSE_SPLEEN_B1A_BCELL_DN SYSTEMATIC_NAME M8289 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE23114_WT_VS_SLE2C1_MOUSE_SPLEEN_B1A_BCELL_DN NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes down-regulated in spleen B lymphocytes: wildtype versus lupus susceptibility locus Sle2c1. DESCRIPTION_FULL Sle2c1 is an NZM2410-derived lupus susceptibility locus that induces an expansion of the B1a cell compartment. B1a cells have a repertoire enriched for autoreactivity, and an expansion of this B cell subset occurs in several mouse models of lupus. Here we showed that expression of Sle2c1 enhances NZB cellular phenotypes that have been associated with autoimmune pathogenesis. A combination of genetic mapping and candidate gene analysis presents Cdkn2c, a gene encoding for cyclin kinase inhibitor p18INK4c (p18), as the top candidate gene for inducing the Slec2c1 associated expansion of B1a cells. A novel SNP in the Cdkn2c promoter is associated with a significantly reduced Cdkn2c expression in the splenic B cells and B1a cells from Sle2c1-carrying mice, which leads to defective G1 cell cycle arrest in splenic B cells and increased proliferation of Pc B1a cells. As cell cycle is differentially regulated in B1a and B2 cells, these results suggest that Cdkn2c play a critical role in B1a cell self renewal, and that its impaired expression leads to an accumulation of these cells with high autoreactive potential. PMID 21543644 GEOID GSE23114 AUTHORS Xu Z,Potula HH,Vallurupalli A,Perry D,Baker H,Croker BP,Dozmorov I,Morel L CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE23114_3029_200_DN FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS ABCC10,ABR,ACAA1,ACCN2,ACR,ACVR2B,ADA,AIF1,ALDH6A1,ALOX5,AREG,ARSA,B3GALT4,BIN1,C1orf38,CCNE1,CD300C,CD37,CDC25B,CDH2,CDH22,CDH3,CDIPT,CDK19,CDON,CDX2,CENPB,CHD2,CHRNA4,CIT,CIZ1,CLCN7,CNP,CPZ,CRP,CTSA,CTSK,CTSW,CXCR4,CXCR6,CYP3A5,DDIT3,DGCR2,DGKA,DGKZ,DNAJB1,DNASE1L1,ECI1,EDN2,EN2,ERC1,ERICH1,ETV1,EXTL3,FAM38A,FAM3A,FAM50A,FCER2,FCHO1,FGFR4,FLOT2,FOXO4,GADD45A,GATA4,GDPD5,GGA2,GLYAT,GNB2,GPI,GRIK3,HDGF,HGFAC,HIST1H1E,HIST1H2AM,HIST1H2BE,HIST1H2BI,HIST1H3H,HIST1H4B,HPGD,HSD3B2,ID1,IDH3G,IGLV3-25,IMPDH1,IRF2BP1,ITGB2,ITIH4,JAK3,JUNB,KAT2A,KCNJ12,KCTD2,KIAA1024,KLF5,KRTAP5-9,LFNG,LHX2,LILRA2,LOC728767,LPAR2,MAN2B1,MAP3K3,MAP3K9,MAP4K2,MAPK11,MAPK3,MDK,MEGF6,MICA,MICAL3,MT2A,MVD,MYO1A,MYO6,MYST2,NAAA,NAGLU,NCAPD2,NME3,NNMT,NRTN,NUCB1,P2RX5,PCBP3,PCDH7,PCOLCE,PFKL,PHKG2,PHLDA2,PIK3IP1,PIM1,PIM2,PLA2G1B,PLA2G4C,PLCD1,PLXNA3,POLE2,PPARD,PPEF2,PPIF,PPP2R5D,PPT2,PSD,PTPN18,PYGM,R3HDM1,RAPSN,RASGRP2,RBM38,RELN,RGP1,RGS9,RHBDL1,RPGRIP1L,RPL14,RPS14,S100A1,SC5DL,SEC14L2,SERPINF1,SIRPA,SIT1,SIX1,SLC25A42,SLC29A2,SMAGP,SNTA1,SPEG,SPTA1,SRCAP,STMN2,STX11,SUN2,TBC1D9B,TBXA2R,TCAP,TFAP4,TFDP2,TLR1,TMSB10,TRAF3IP2,TRAFD1,TRAM2,TREX1,TRIB2,TSC22D3,TSC22D4,TSN,TTLL3,TXNIP,UBE2C,UPK3A,USP19,VAMP5,VIPR1,WNT8B,WWOX,ZBTB25,ZNF101,ZNF8 GENE_SYMBOLS ABCC10,ABR,ACAA1,ASIC1,ACR,ACVR2B,ADA,AIF1,ALDH6A1,ALOX5,AREG,ARSA,B3GALT4,BIN1,THEMIS2,CCNE1,CD300C,CD37,CDC25B,CDH2,CDH22,CDH3,CDIPT,CDK19,CDON,CDX2,CENPB,CHD2,CHRNA4,CIT,CIZ1,CLCN7,CNP,CPZ,CRP,CTSA,CTSK,CTSW,CXCR4,CXCR6,CYP3A5,DDIT3,DGCR2,DGKA,DGKZ,DNAJB1,DNASE1L1,ECI1,EDN2,EN2,ERC1,ERICH1,ETV1,EXTL3,PIEZO1,FAM3A,FAM50A,FCER2,FCHO1,FGFR4,FLOT2,FOXO4,GADD45A,GATA4,GDPD5,GGA2,GLYAT,GNB2,GPI,GRIK3,HDGF,HGFAC,H1-4,H2AC17,H2BC6,H2BC10,H3C10,H4C2,HPGD,HSD3B2,ID1,IDH3G,IGLV3-25,IMPDH1,IRF2BP1,ITGB2,ITIH4,JAK3,JUNB,KAT2A,KCNJ12,KCTD2,MINAR1,KLF5,KRTAP5-9,LFNG,LHX2,LILRA2,,LPAR2,MAN2B1,MAP3K3,MAP3K9,MAP4K2,MAPK11,MAPK3,MDK,MEGF6,MICA,MICAL3,MT2A,MVD,MYO1A,MYO6,KAT7,NAAA,NAGLU,NCAPD2,NME3,NNMT,NRTN,NUCB1,P2RX5,PCBP3,PCDH7,PCOLCE,PFKL,PHKG2,PHLDA2,PIK3IP1,PIM1,PIM2,PLA2G1B,PLA2G4C,PLCD1,PLXNA3,POLE2,PPARD,PPEF2,PPIF,PPP2R5D,PPT2,PSD,PTPN18,PYGM,R3HDM1,RAPSN,RASGRP2,RBM38,RELN,RGP1,RGS9,RHBDL1,RPGRIP1L,RPL14,RPS14,S100A1,SC5D,SEC14L2,SERPINF1,SIRPA,SIT1,SIX1,SLC25A42,SLC29A2,SMAGP,SNTA1,SPEG,SPTA1,SRCAP,STMN2,STX11,SUN2,TBC1D9B,TBXA2R,TCAP,TFAP4,TFDP2,TLR1,TMSB10,TRAF3IP2,TRAFD1,TRAM2,TREX1,TRIB2,TSC22D3,TSC22D4,TSN,TTLL3,TXNIP,UBE2C,UPK3A,USP19,VAMP5,VIPR1,WNT8B,WWOX,ZBTB25,ZNF101,ZNF8 FOUNDER_NAMES