STANDARD_NAME	GSE23505_UNTREATED_VS_4DAY_IL6_IL1_TGFB_TREATED_CD4_TCELL_DN
SYSTEMATIC_NAME	M7868
COLLECTION	C7:IMMUNESIGDB
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE23505_UNTREATED_VS_4DAY_IL6_IL1_TGFB_TREATED_CD4_TCELL_DN
NAMESPACE	HUMAN_GENE_SYMBOL
DESCRIPTION_BRIEF	Genes down-regulated in CD4 [GeneID=920] T cells: untreated versus IL6 and TGFB1 [GeneID=3569;7040].
DESCRIPTION_FULL	CD4+ T cells that selectively produce interleukin (IL)-17, are critical for host defense and autoimmunity1-4. Crucial for T helper17 (Th17) cells in vivo5,6, IL-23 has been thought to be incapable of driving initial differentiation. Rather, IL-6 and transforming growth factor (TGF)-β1 have been argued to be the factors responsible for initiating specification7-10. Herein, we show that Th17 differentiation occurs in the absence of TGF-β signaling. Neither IL-6 nor IL-23 alone efficiently generated Th17 cells; however, these cytokines in combination with IL-1β effectively induced IL-17 production in naïve precursors, independently of TGF-β. Epigenetic modification of the Il17a/Il17f and Rorc promoters proceeded without TGF-β1, allowing the generation of cells that co-expressed Rorγt and T-bet. T-bet+Rorγt+ Th17 cells are generated in vivo during experimental allergic encephalomyelitis (EAE), and adoptively transferred Th17 cells generated with IL-23 in the absence of TGF-β1 were more pathogenic in this experimental disease. These data suggest a new model for Th17 differentiation. Consistent with genetic data linking the IL23R with autoimmunity, our findings re-emphasize the role of IL-23 and therefore have important implications for the development of new therapies.
PMID	20962846
GEOID	GSE23505
AUTHORS	Ghoreschi K,Laurence A,Yang XP,Tato CM,McGeachy MJ,Konkel JE,Ramos HL,Wei L,Davidson TS,Bouladoux N,Grainger JR,Chen Q,Kanno Y,Watford WT,Sun HW,Eberl G,Shevach EM,Belkaid Y,Cua DJ,Chen W,O'Shea JJ
CONTRIBUTOR	Jernej Godec
CONTRIBUTOR_ORG	Dana-Farber Cancer Institute
EXACT_SOURCE	GSE23505_2886_200_DN
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	ABCC4,ABCC5,ACAT1,ACBD4,ACOX1,ACP2,ACSL3,ACTG2,ADAMTS6,ADAMTS8,ADCK4,ADIPOR2,AGBL5,AGPAT5,AKR7A2,ALKBH4,ANKRD54,ANKZF1,ARID4A,ASH1L,B3GNT2,BAG3,BAG4,BCKDHA,BMI1,BPHL,BTRC,C11orf68,C11orf71,C1orf182,C1orf93,C20orf30,C21orf2,C6orf170,C8orf37,CAMK2D,CASP6,CBR1,CCDC117,CCDC62,CCPG1,CDK5R1,CDKAL1,CEP19,CHMP1A,CNOT6L,CNP,CSTB,CUL4A,CXCL10,CYB5A,CYB5D2,DAG1,DBP,DDX42,DHX34,DMWD,DNAJA3,DPP4,DYNLT3,EARS2,ECI2,EGR3,EIF4B,EME2,ESAM,EXOSC5,EZH1,FAM120B,FAM160A1,FAM73A,FAM98C,FGF13,FIBP,GLG1,GNL1,GPATCH4,GTF2H3,HAGHL,HIF1A,HMG20A,HMHA1,IKBIP,IL27RA,INPP5K,IPO8,ISCU,JARID2,KDSR,KIF5C,LACTB,LASS6,LDHB,LOC55908,LRP6,LSM14B,MAML1,MANBA,MAP1B,MAP2K5,MBOAT7,MFSD4,MIB1,MMP11,MOV10,MSI2,MST4,MTFMT,MYCBP2,NDST2,NFKBIE,NINJ1,NISCH,NLK,NLRP6,NOXO1,NUDT12,NUMA1,OAS1,OPA1,PACRGL,PAM,PCDHB12,PDE6D,PER1,PGPEP1,PHF23,PIGX,PIGY,PLEKHA8,POLR1C,QSOX2,QTRT1,RAB11B,RABL3,RASGRP1,RCL1,RFESD,RMND1,RNF128,RNF139,RNF149,RNF19A,RNF41,ROMO1,RPL13,RPS25,RSAD2,RYK,SDHAF1,SERINC5,SESTD1,SH3RF1,SLC14A1,SMAD4,SNHG8,SOX4,SREK1,ST3GAL1,STK4,STK40,SUFU,SYT11,TARS2,TCF12,TEF,TGIF1,TGIF2,TIRAP,TLCD1,TMEM191C,TMEM200A,TMEM63B,TMEM87B,TNC,TNF,TNS1,TPP1,TRAF1,TRIM21,TTC33,UBAC2,USP19,USP6NL,UTRN,VPS41,WBSCR27,WDR11,WDR12,WDR77,YPEL3,ZCCHC12,ZFAND1,ZNF217,ZNF24,ZNF329,ZNF518A,ZNF623,ZNF799,ZXDC
GENE_SYMBOLS	ABCC4,ABCC5,ACAT1,ACBD4,ACOX1,ACP2,ACSL3,ACTG2,ADAMTS6,ADAMTS8,COQ8B,ADIPOR2,AGBL5,AGPAT5,AKR7A2,ALKBH4,ANKRD54,ANKZF1,ARID4A,ASH1L,B3GNT2,BAG3,BAG4,BCKDHA,BMI1,BPHL,BTRC,C11orf68,C11orf71,TSACC,PRXL2B,TMEM230,CFAP410,TBC1D32,CFAP418,CAMK2D,CASP6,CBR1,CCDC117,CCDC62,CCPG1,CDK5R1,CDKAL1,CEP19,CHMP1A,CNOT6L,CNP,CSTB,CUL4A,CXCL10,CYB5A,CYB5D2,DAG1,DBP,DDX42,DHX34,DMWD,DNAJA3,DPP4,DYNLT3,EARS2,ECI2,EGR3,EIF4B,EME2,ESAM,EXOSC5,EZH1,FAM120B,FHIP1A,MIGA1,FAM98C,FGF13,FIBP,GLG1,GNL1,GPATCH4,GTF2H3,HAGHL,HIF1A,HMG20A,ARHGAP45,IKBIP,IL27RA,INPP5K,IPO8,ISCU,JARID2,KDSR,KIF5C,LACTB,CERS6,LDHB,ANGPTL8,LRP6,LSM14B,MAML1,MANBA,MAP1B,MAP2K5,MBOAT7,MFSD4A,MIB1,MMP11,MOV10,MSI2,STK26,MTFMT,MYCBP2,NDST2,NFKBIE,NINJ1,NISCH,NLK,NLRP6,NOXO1,NUDT12,NUMA1,OAS1,OPA1,PACRGL,PAM,PCDHB12,PDE6D,PER1,PGPEP1,PHF23,PIGX,PIGY,PLEKHA8,POLR1C,QSOX2,QTRT1,RAB11B,RABL3,RASGRP1,RCL1,RFESD,RMND1,RNF128,RNF139,RNF149,RNF19A,RNF41,ROMO1,RPL13,RPS25,RSAD2,RYK,SDHAF1,SERINC5,SESTD1,SH3RF1,SLC14A1,SMAD4,SNHG8,SOX4,SREK1,ST3GAL1,STK4,STK40,SUFU,SYT11,TARS2,TCF12,TEF,TGIF1,TGIF2,TIRAP,TLCD1,TMEM191C,TMEM200A,TMEM63B,TMEM87B,TNC,TNF,TNS1,TPP1,TRAF1,TRIM21,TTC33,UBAC2,USP19,USP6NL,UTRN,VPS41,METTL27,WDR11,WDR12,WDR77,YPEL3,ZCCHC12,ZFAND1,ZNF217,ZNF24,ZNF329,ZNF518A,ZNF623,ZNF799,ZXDC
FOUNDER_NAMES