STANDARD_NAME GSE23984_CTRL_VS_HYPOCALEMIC_VITAMIND_ANALOG_TCELL_UP SYSTEMATIC_NAME M8051 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE23984_CTRL_VS_HYPOCALEMIC_VITAMIND_ANALOG_TCELL_UP NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes up-regulated in T cells: control versus TX527 (hypocalemic analog of 25-hydroxyvitamin D3 [PubChem=1593]). DESCRIPTION_FULL Hypocalcemic vitamin D analogs are appealing molecules to exploit the immunomodulatory actions of active vitamin D in vivo. The functional modulation of dendritic cells is regarded as the key mechanism underlying their ability to regulate T cell responses. In contrast, the direct actions of vitamin D and structural analogs on T lymphocytes remain less well characterized. Microarray analysis was performed to gain insight into the direct immunomodulatory actions of TX527, a hypocalcemic vitamin D analog, on human T lymphocytes. Gene expression analysis revealed that TX527 regulated a wide variety of genes involved in different aspects of T cell function, including cellular growth and proliferation, cell death, cellular development, cellular movement and cell-to-cell signalling and interaction. PMID 21131424 GEOID GSE23984 AUTHORS Baeke F,Korf H,Overbergh L,Verstuyf A,Thorrez L,Van Lommel L,Waer M,Schuit F,Gysemans C,Mathieu C CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE23984_3463_200_UP FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS AACS,AARS,ABHD11,ADCK3,ADRA2C,AFP,AGPAT5,AIFM2,AIMP2,ALDH3B1,AP1G2,AP2S1,AP3M1,APP,ARHGEF37,ARL5A,ATP5D,ATP5G1,ATP6V0C,ATP6V1E1,BAZ1A,BLCAP,BTG1,C13orf15,C17orf64,C17orf85,C19orf25,C19orf38,C19orf59,C1orf93,C1QBP,C1R,C6orf115,CAPNS1,CBX5,CCDC125,CCT2,CD33,CD38,CEACAM21,CHSY1,CLMP,CLYBL,CNIH4,CNPY4,COX6A1,CP,CPD,CRELD1,CRTC3,CS,CSE1L,CTSC,CYB5B,CYP51A1,DDIT4,DDT,DMPK,DMXL2,DNER,EFNA2,EGR2,EMILIN2,ENO3,ETHE1,FADS2,FAM109A,FAM176B,FASN,FGR,FKBP15,FOXL2,FXC1,GAB1,GBE1,GLB1,GLYCTK,GNG12,GPD2,GPR132,HNRNPA1,HSD17B7,HYAL2,IDI1,IGF2R,IL13RA1,IMPDH2,IPO13,JAK2,JDP2,KIAA0146,KLF7,KLRAQ1,LANCL2,LANCL3,LCMT1,LCN2,LPCAT3,LPHN2,MAP2,MAPRE1,MDH2,MED14,MEGF9,METAP1,MGAT4A,MIF,MINA,MRPL45,MRPS11,MSR1,MTHFD2,MYD88,NDUFS6,NLRX1,NPL,NUDT19,NUS1,ODC1,OGDH,PAFAH1B2,PARK7,PARL,PARP3,PCDH7,PDPN,PDZD11,PECAM1,PGP,PIK3R5,PKM2,PMVK,PPBP,PRELID2,PROCR,PSEN1,PSMA7,PSMD10,PSTPIP1,PTGES,PTGES2,PTGIR,PVRL2,RAB10,RASIP1,RC3H1,RFX5,RPS6KA4,SCAMP1,SDHD,SESN2,SH2B2,SIGLEC7,SLC13A3,SLC25A1,SLC25A10,SLC25A12,SLC37A4,SLC4A7,SLC6A13,SLITRK3,SLMO2,SMAD6,SNF8,SPINT2,SRA1,STARD7,STX12,SUN1,SYN1,TANK,TCP10L,TM7SF2,TMEM123,TMEM170B,TMEM173,TPMT,TRAF3,TRAPPC2,TREM1,TRPS1,TTC35,TUBA4A,TUBB,TXN,TYMS,UBAC2,UBXN8,UFSP2,UQCR10,VEGFA,VHL,VMP1,VPRBP,VPS29,WDYHV1,XPNPEP1,ZDHHC5,ZNF238,ZNHIT1 GENE_SYMBOLS AACS,AARS1,ABHD11,COQ8A,ADRA2C,AFP,AGPAT5,AIFM2,AIMP2,ALDH3B1,AP1G2,AP2S1,AP3M1,APP,ARHGEF37,ARL5A,ATP5F1D,ATP5MC1,ATP6V0C,ATP6V1E1,BAZ1A,BLCAP,BTG1,RGCC,CHCT1,NCBP3,C19orf25,C19orf38,MCEMP1,C1QBP,C1R,PRXL2B,ABRACL,CAPNS1,CBX5,CCDC125,CCT2,CD33,CD38,CEACAM21,CHSY1,CLMP,CLYBL,CNIH4,CNPY4,COX6A1,CP,CPD,CRELD1,CRTC3,CS,CSE1L,CTSC,CYB5B,CYP51A1,DDIT4,DDT,DMPK,DMXL2,DNER,EFNA2,EGR2,EMILIN2,ENO3,ETHE1,FADS2,PHETA1,EVA1B,FASN,FGR,FKBP15,FOXL2,TIMM10B,GAB1,GBE1,GLB1,GLYCTK,GNG12,GPD2,GPR132,HNRNPA1,HSD17B7,HYAL2,IDI1,IGF2R,IL13RA1,IMPDH2,IPO13,JAK2,JDP2,SPIDR,KLF7,PPP1R21,LANCL2,LANCL3,LCMT1,LCN2,LPCAT3,ADGRL2,MAP2,MAPRE1,MDH2,MED14,MEGF9,METAP1,MGAT4A,MIF,RIOX2,MRPL45,MRPS11,MSR1,MTHFD2,MYD88,NDUFS6,NLRX1,NPL,NUDT19,NUS1,ODC1,OGDH,PAFAH1B2,PARK7,PARL,PARP3,PCDH7,PDPN,PDZD11,PECAM1,PGP,PIK3R5,PKM,PMVK,PPBP,PRELID2,PROCR,PSEN1,PSMA7,PSMD10,PSTPIP1,PTGES,PTGES2,PTGIR,NECTIN2,RAB10,RASIP1,RC3H1,RFX5,RPS6KA4,SCAMP1,SDHD,SESN2,SH2B2,SIGLEC7,SLC13A3,SLC25A1,SLC25A10,SLC25A12,SLC37A4,SLC4A7,SLC6A13,SLITRK3,PRELID3B,SMAD6,SNF8,SPINT2,SRA1,STARD7,STX12,SUN1,SYN1,TANK,TCP10L,TM7SF2,TMEM123,TMEM170B,STING1,TPMT,TRAF3,TRAPPC2,TREM1,TRPS1,EMC2,TUBA4A,TUBB,TXN,TYMS,UBAC2,UBXN8,UFSP2,UQCR10,VEGFA,VHL,VMP1,DCAF1,VPS29,NTAQ1,XPNPEP1,ZDHHC5,ZBTB18,ZNHIT1 FOUNDER_NAMES