STANDARD_NAME	GSE24142_EARLY_THYMIC_PROGENITOR_VS_DN3_THYMOCYTE_ADULT_DN
SYSTEMATIC_NAME	M4564
COLLECTION	C7:IMMUNESIGDB
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE24142_EARLY_THYMIC_PROGENITOR_VS_DN3_THYMOCYTE_ADULT_DN
NAMESPACE	HUMAN_GENE_SYMBOL
DESCRIPTION_BRIEF	Genes down-regulated in comparison of adult thymic progenitors versus adult DN3 thymocytes.
DESCRIPTION_FULL	Development of T-cells provides a unique opportunity to study cell-fate determination due to the accessability and the well defined stages of developmental stages. In order to understand the genetic programs underlying fetal and adult T‑cell fate specification we subjected highly purified fetal and adult T-cell progenitor populations to a genome‑wide transcriptional analysis. The aim was to identify molecular elements that govern T-cell fate specification as a whole but ultimately to isolate elements that were specific for a given population in a specific developmental window.
PMID	22581009
GEOID	GSE24142
AUTHORS	Belyaev NN,Biró J,Athanasakis D,Fernandez-Reyes D,Potocnik AJ
CONTRIBUTOR	Jernej Godec
CONTRIBUTOR_ORG	Dana-Farber Cancer Institute
EXACT_SOURCE	GSE24142_2152_200_DN
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	ACAA2,ACTN1,ADA,AGFG1,AHI1,AHR,ANXA2,AP3S1,ARNTL,ARPP21,ATP1B1,ATP8A1,AXL,BCL11B,BHLHE40,BLVRA,BRP44L,BST1,C12orf10,C15orf24,C18orf32,C19orf60,C19orf70,C1QTNF1,C3orf37,C6orf26,C9orf64,CAMKV,CAPZA3,CBL,CCDC109B,CCT7,CD247,CD28,CD3D,CD3G,CDC34,CDC42SE2,CDK6,CHCHD3,CHD1L,CHUK,CHURC1,CIRH1A,CKAP2,CLTB,CNTNAP2,CPSF4L,CRCP,D4S234E,DDC,DDX47,DGKA,DGKE,DHX40,EIF5A,ENDOU,ENTPD5,EPCAM,ERCC8,ERP44,EXOSC2,FBLN2,FKBP5,GALNT10,GBP6,GCOM1,GDPD1,GFRA1,GPHN,GPR133,GRAP2,GSR,GTF2H2,GZMA,H19,HCCS,HIBADH,HMGA1,HMGCS2,HSD11B1,HSDL2,ID3,IKZF4,IL2RA,INO80C,INSL5,ITGA6,ITK,ITM2C,KHDC1L,LCK,LEF1,LIPG,MAPKAPK5,MBD2,MLLT3,MPZL2,MRPL12,MRPL49,MRPL55,MRPS26,MRPS33,MS4A6A,MST1R,MVK,NAF1,NCK2,NCKAP1,NDUFAF3,NDUFS1,NEFH,NFKBIE,NGLY1,NME3,NOC2L,NR3C1,OSTC,PDLIM5,PFN2,PGAM2,PHF2,PHTF1,PITHD1,PLA2G12A,PLD3,PLD4,PLIN3,PLXDC2,PMM1,PNO1,POLM,POLR2F,PPIC,PPPDE2,PQLC3,PRAF2,PRKCA,PRKCB,PRKCQ,PSMB10,PSMB5,PTCRA,PTPRF,RAB8A,RAG1,RAG2,RFXAP,RGS14,RHOA,RHOH,RPL11,RPL24,RPL36A,RRAS2,RRP1,SEC24D,SEMA4A,SEPT6,SF3B5,SH2D1A,SH3KBP1,SIT1,SLAIN1,SLAMF1,SLAMF6,SLC35B1,SLC35B3,SLC35D1,SMO,SOCS1,SPATS2,STIP1,SUN2,SVIL,SYAP1,SYF2,SYNJ2,SYTL3,TCF12,TCOF1,TIMM13,TM7SF2,TM9SF1,TMEM111,TMEM131,TMEM134,TMEM165,TMEM50B,TNFAIP8L1,TNFRSF18,TPP2,TRDMT1,TUBB2B,TUBB3,TUBG2,UBE2D3,UBL4A,XBP1,ZW10
GENE_SYMBOLS	ACAA2,ACTN1,ADA,AGFG1,AHI1,AHR,ANXA2,AP3S1,BMAL1,ARPP21,ATP1B1,ATP8A1,AXL,BCL11B,BHLHE40,BLVRA,MPC1,BST1,MYG1,EMC7,C18orf32,REX1BD,MICOS13,C1QTNF1,HMCES,SAPCD1,QNG1,CAMKV,CAPZA3,CBL,MCUB,CCT7,CD247,CD28,CD3D,CD3G,CDC34,CDC42SE2,CDK6,CHCHD3,CHD1L,CHUK,CHURC1,UTP4,CKAP2,CLTB,CNTNAP2,CPSF4L,CRCP,NSG1,DDC,DDX47,DGKA,DGKE,DHX40,EIF5A,ENDOU,ENTPD5,EPCAM,ERCC8,ERP44,EXOSC2,FBLN2,FKBP5,GALNT10,GBP6,GCOM1,GDPD1,GFRA1,GPHN,ADGRD1,GRAP2,GSR,GTF2H2,GZMA,H19,HCCS,HIBADH,HMGA1,HMGCS2,HSD11B1,HSDL2,ID3,IKZF4,IL2RA,INO80C,INSL5,ITGA6,ITK,ITM2C,KHDC1L,LCK,LEF1,LIPG,MAPKAPK5,MBD2,MLLT3,MPZL2,MRPL12,MRPL49,MRPL55,MRPS26,MRPS33,MS4A6A,MST1R,MVK,NAF1,NCK2,NCKAP1,NDUFAF3,NDUFS1,NEFH,NFKBIE,NGLY1,NME3,NOC2L,NR3C1,OSTC,PDLIM5,PFN2,PGAM2,PHF2,PHTF1,PITHD1,PLA2G12A,PLD3,PLD4,PLIN3,PLXDC2,PMM1,PNO1,POLM,POLR2F,PPIC,DESI1,SLC66A3,PRAF2,PRKCA,PRKCB,PRKCQ,PSMB10,PSMB5,PTCRA,PTPRF,RAB8A,RAG1,RAG2,RFXAP,RGS14,RHOA,RHOH,RPL11,RPL24,RPL36A,RRAS2,RRP1,SEC24D,SEMA4A,SEPTIN6,SF3B5,SH2D1A,SH3KBP1,SIT1,SLAIN1,SLAMF1,SLAMF6,SLC35B1,SLC35B3,SLC35D1,SMO,SOCS1,SPATS2,STIP1,SUN2,SVIL,SYAP1,SYF2,SYNJ2,SYTL3,TCF12,TCOF1,TIMM13,TM7SF2,TM9SF1,EMC3,TMEM131,TMEM134,TMEM165,TMEM50B,TNFAIP8L1,TNFRSF18,TPP2,TRDMT1,TUBB2B,TUBB3,TUBG2,UBE2D3,UBL4A,XBP1,ZW10
FOUNDER_NAMES