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<MSIGDB BUILD_DATE="Jan 29, 2026" VERSION="2026.1.Hs" NAME="export">
    <GENESET STANDARD_NAME="GSE24142_EARLY_THYMIC_PROGENITOR_VS_DN3_THYMOCYTE_ADULT_DN" SYSTEMATIC_NAME="M4564" HISTORICAL_NAMES="" PMID="22581009" AUTHORS="Belyaev NN,Biró J,Athanasakis D,Fernandez-Reyes D,Potocnik AJ" GEOID="GSE24142" EXACT_SOURCE="GSE24142_2152_200_DN" GENESET_LISTING_URL="" EXTERNAL_DETAILS_URL="" CHIP="HUMAN_GENE_SYMBOL" CONTRIBUTOR="Jernej Godec" CONTRIBUTOR_ORG="Dana-Farber Cancer Institute" DESCRIPTION_BRIEF="Genes down-regulated in comparison of adult thymic progenitors versus adult DN3 thymocytes." DESCRIPTION_FULL="Development of T-cells provides a unique opportunity to study cell-fate determination due to the accessability and the well defined stages of developmental stages. In order to understand the genetic programs underlying fetal and adult T‑cell fate specification we subjected highly purified fetal and adult T-cell progenitor populations to a genome‑wide transcriptional analysis. The aim was to identify molecular elements that govern T-cell fate specification as a whole but ultimately to isolate elements that were specific for a given population in a specific developmental window." TAGS="" MEMBERS="ACAA2,ACTN1,ADA,AGFG1,AHI1,AHR,ANXA2,AP3S1,ARNTL,ARPP21,ATP1B1,ATP8A1,AXL,BCL11B,BHLHE40,BLVRA,BRP44L,BST1,C12orf10,C15orf24,C18orf32,C19orf60,C19orf70,C1QTNF1,C3orf37,C6orf26,C9orf64,CAMKV,CAPZA3,CBL,CCDC109B,CCT7,CD247,CD28,CD3D,CD3G,CDC34,CDC42SE2,CDK6,CHCHD3,CHD1L,CHUK,CHURC1,CIRH1A,CKAP2,CLTB,CNTNAP2,CPSF4L,CRCP,D4S234E,DDC,DDX47,DGKA,DGKE,DHX40,EIF5A,ENDOU,ENTPD5,EPCAM,ERCC8,ERP44,EXOSC2,FBLN2,FKBP5,GALNT10,GBP6,GCOM1,GDPD1,GFRA1,GPHN,GPR133,GRAP2,GSR,GTF2H2,GZMA,H19,HCCS,HIBADH,HMGA1,HMGCS2,HSD11B1,HSDL2,ID3,IKZF4,IL2RA,INO80C,INSL5,ITGA6,ITK,ITM2C,KHDC1L,LCK,LEF1,LIPG,MAPKAPK5,MBD2,MLLT3,MPZL2,MRPL12,MRPL49,MRPL55,MRPS26,MRPS33,MS4A6A,MST1R,MVK,NAF1,NCK2,NCKAP1,NDUFAF3,NDUFS1,NEFH,NFKBIE,NGLY1,NME3,NOC2L,NR3C1,OSTC,PDLIM5,PFN2,PGAM2,PHF2,PHTF1,PITHD1,PLA2G12A,PLD3,PLD4,PLIN3,PLXDC2,PMM1,PNO1,POLM,POLR2F,PPIC,PPPDE2,PQLC3,PRAF2,PRKCA,PRKCB,PRKCQ,PSMB10,PSMB5,PTCRA,PTPRF,RAB8A,RAG1,RAG2,RFXAP,RGS14,RHOA,RHOH,RPL11,RPL24,RPL36A,RRAS2,RRP1,SEC24D,SEMA4A,SEPT6,SF3B5,SH2D1A,SH3KBP1,SIT1,SLAIN1,SLAMF1,SLAMF6,SLC35B1,SLC35B3,SLC35D1,SMO,SOCS1,SPATS2,STIP1,SUN2,SVIL,SYAP1,SYF2,SYNJ2,SYTL3,TCF12,TCOF1,TIMM13,TM7SF2,TM9SF1,TMEM111,TMEM131,TMEM134,TMEM165,TMEM50B,TNFAIP8L1,TNFRSF18,TPP2,TRDMT1,TUBB2B,TUBB3,TUBG2,UBE2D3,UBL4A,XBP1,ZW10" MEMBERS_SYMBOLIZED="ACAA2,ACTN1,ADA,ADGRD1,AGFG1,AHI1,AHR,ANXA2,AP3S1,ARPP21,ATP1B1,ATP8A1,AXL,BCL11B,BHLHE40,BLVRA,BMAL1,BST1,C18orf32,C1QTNF1,CAMKV,CAPZA3,CBL,CCT7,CD247,CD28,CD3D,CD3G,CDC34,CDC42SE2,CDK6,CHCHD3,CHD1L,CHUK,CHURC1,CKAP2,CLTB,CNTNAP2,CPSF4L,CRCP,DDC,DDX47,DESI1,DGKA,DGKE,DHX40,EIF5A,EMC3,EMC7,ENDOU,ENTPD5,EPCAM,ERCC8,ERP44,EXOSC2,FBLN2,FKBP5,GALNT10,GBP6,GCOM1,GDPD1,GFRA1,GPHN,GRAP2,GSR,GTF2H2,GZMA,H19,HCCS,HIBADH,HMCES,HMGA1,HMGCS2,HSD11B1,HSDL2,ID3,IKZF4,IL2RA,INO80C,INSL5,ITGA6,ITK,ITM2C,KHDC1L,LCK,LEF1,LIPG,MAPKAPK5,MBD2,MCUB,MICOS13,MLLT3,MPC1,MPZL2,MRPL12,MRPL49,MRPL55,MRPS26,MRPS33,MS4A6A,MST1R,MVK,MYG1,NAF1,NCK2,NCKAP1,NDUFAF3,NDUFS1,NEFH,NFKBIE,NGLY1,NME3,NOC2L,NR3C1,NSG1,OSTC,PDLIM5,PFN2,PGAM2,PHF2,PHTF1,PITHD1,PLA2G12A,PLD3,PLD4,PLIN3,PLXDC2,PMM1,PNO1,POLM,POLR2F,PPIC,PRAF2,PRKCA,PRKCB,PRKCQ,PSMB10,PSMB5,PTCRA,PTPRF,QNG1,RAB8A,RAG1,RAG2,REX1BD,RFXAP,RGS14,RHOA,RHOH,RPL11,RPL24,RPL36A,RRAS2,RRP1,SAPCD1,SEC24D,SEMA4A,SEPTIN6,SF3B5,SH2D1A,SH3KBP1,SIT1,SLAIN1,SLAMF1,SLAMF6,SLC35B1,SLC35B3,SLC35D1,SLC66A3,SMO,SOCS1,SPATS2,STIP1,SUN2,SVIL,SYAP1,SYF2,SYNJ2,SYTL3,TCF12,TCOF1,TIMM13,TM7SF2,TM9SF1,TMEM131,TMEM134,TMEM165,TMEM50B,TNFAIP8L1,TNFRSF18,TPP2,TRDMT1,TUBB2B,TUBB3,TUBG2,UBE2D3,UBL4A,UTP4,XBP1,ZW10" MEMBERS_EZID="100,100129128,10022,10205,1021,10226,10237,10243,10381,10396,10449,10548,10574,10611,10636,10745,10777,10787,10963,11112,11230,1147,114836,114897,1161,1176,1212,122060,122618,125476,125988,126282,128308,130814,145781,1606,163351,1644,171558,1787,196,1984,2199,22800,2289,23071,23157,23169,23404,23505,23646,25777,25915,25949,26047,26155,26517,26586,2674,27065,27175,27240,27297,27351,27434,283120,283383,284161,2908,2936,2966,3001,30011,302,3052,3158,3159,3267,3290,3399,347733,3559,3655,3702,387,3932,399,401251,406,4068,4072,4218,4300,4486,4598,4719,4744,4794,481,4832,497661,51000,51176,51202,51650,51660,5217,5224,5253,5372,5435,5480,54806,54927,55013,55049,55568,55768,5578,5579,558,55831,55858,5588,56851,56902,5693,56941,5699,56990,57095,5792,58505,5896,5897,5994,60314,6135,6152,6173,6182,64218,64231,642843,64375,644,64919,64949,6504,65244,6608,683,6840,6938,6949,7108,7174,7323,740,7494,757,79012,79665,80194,81579,81618,8266,83443,84263,84267,8440,84898,84916,8526,8550,8553,8568,8651,867,87,8784,8871,8909,8932,915,91612,917,9183,919,92345,93661,9388,940,9402,94056,94120,9557,957,9871,997" MEMBERS_MAPPING="ACAA2,ACAA2,10449|ACTN1,ACTN1,87|ADA,ADA,100|AGFG1,AGFG1,3267|AHI1,AHI1,54806|AHR,AHR,196|ANXA2,ANXA2,302|AP3S1,AP3S1,1176|ARNTL,BMAL1,406|ARPP21,ARPP21,10777|ATP1B1,ATP1B1,481|ATP8A1,ATP8A1,10396|AXL,AXL,558|BCL11B,BCL11B,64919|BHLHE40,BHLHE40,8553|BLVRA,BLVRA,644|BRP44L,MPC1,51660|BST1,BST1,683|C12orf10,MYG1,60314|C15orf24,EMC7,56851|C18orf32,C18orf32,497661|C19orf60,REX1BD,55049|C19orf70,MICOS13,125988|C1QTNF1,C1QTNF1,114897|C3orf37,HMCES,56941|C6orf26,SAPCD1,401251|C9orf64,QNG1,84267|CAMKV,CAMKV,79012|CAPZA3,CAPZA3,93661|CBL,CBL,867|CCDC109B,MCUB,55013|CCT7,CCT7,10574|CD247,CD247,919|CD28,CD28,940|CD3D,CD3D,915|CD3G,CD3G,917|CDC34,CDC34,997|CDC42SE2,CDC42SE2,56990|CDK6,CDK6,1021|CHCHD3,CHCHD3,54927|CHD1L,CHD1L,9557|CHUK,CHUK,1147|CHURC1,CHURC1,91612|CIRH1A,UTP4,84916|CKAP2,CKAP2,26586|CLTB,CLTB,1212|CNTNAP2,CNTNAP2,26047|CPSF4L,CPSF4L,642843|CRCP,CRCP,27297|D4S234E,NSG1,27065|DDC,DDC,1644|DDX47,DDX47,51202|DGKA,DGKA,1606|DGKE,DGKE,8526|DHX40,DHX40,79665|EIF5A,EIF5A,1984|ENDOU,ENDOU,8909|ENTPD5,ENTPD5,957|EPCAM,EPCAM,4072|ERCC8,ERCC8,1161|ERP44,ERP44,23071|EXOSC2,EXOSC2,23404|FBLN2,FBLN2,2199|FKBP5,FKBP5,2289|GALNT10,GALNT10,55568|GBP6,GBP6,163351|GCOM1,GCOM1,145781|GDPD1,GDPD1,284161|GFRA1,GFRA1,2674|GPHN,GPHN,10243|GPR133,ADGRD1,283383|GRAP2,GRAP2,9402|GSR,GSR,2936|GTF2H2,GTF2H2,2966|GZMA,GZMA,3001|H19,H19,283120|HCCS,HCCS,3052|HIBADH,HIBADH,11112|HMGA1,HMGA1,3159|HMGCS2,HMGCS2,3158|HSD11B1,HSD11B1,3290|HSDL2,HSDL2,84263|ID3,ID3,3399|IKZF4,IKZF4,64375|IL2RA,IL2RA,3559|INO80C,INO80C,125476|INSL5,INSL5,10022|ITGA6,ITGA6,3655|ITK,ITK,3702|ITM2C,ITM2C,81618|KHDC1L,KHDC1L,100129128|LCK,LCK,3932|LEF1,LEF1,51176|LIPG,LIPG,9388|MAPKAPK5,MAPKAPK5,8550|MBD2,MBD2,8932|MLLT3,MLLT3,4300|MPZL2,MPZL2,10205|MRPL12,MRPL12,6182|MRPL49,MRPL49,740|MRPL55,MRPL55,128308|MRPS26,MRPS26,64949|MRPS33,MRPS33,51650|MS4A6A,MS4A6A,64231|MST1R,MST1R,4486|MVK,MVK,4598|NAF1,NAF1,92345|NCK2,NCK2,8440|NCKAP1,NCKAP1,10787|NDUFAF3,NDUFAF3,25915|NDUFS1,NDUFS1,4719|NEFH,NEFH,4744|NFKBIE,NFKBIE,4794|NGLY1,NGLY1,55768|NME3,NME3,4832|NOC2L,NOC2L,26155|NR3C1,NR3C1,2908|OSTC,OSTC,58505|PDLIM5,PDLIM5,10611|PFN2,PFN2,5217|PGAM2,PGAM2,5224|PHF2,PHF2,5253|PHTF1,PHTF1,10745|PITHD1,PITHD1,57095|PLA2G12A,PLA2G12A,81579|PLD3,PLD3,23646|PLD4,PLD4,122618|PLIN3,PLIN3,10226|PLXDC2,PLXDC2,84898|PMM1,PMM1,5372|PNO1,PNO1,56902|POLM,POLM,27434|POLR2F,POLR2F,5435|PPIC,PPIC,5480|PPPDE2,DESI1,27351|PQLC3,SLC66A3,130814|PRAF2,PRAF2,11230|PRKCA,PRKCA,5578|PRKCB,PRKCB,5579|PRKCQ,PRKCQ,5588|PSMB10,PSMB10,5699|PSMB5,PSMB5,5693|PTCRA,PTCRA,171558|PTPRF,PTPRF,5792|RAB8A,RAB8A,4218|RAG1,RAG1,5896|RAG2,RAG2,5897|RFXAP,RFXAP,5994|RGS14,RGS14,10636|RHOA,RHOA,387|RHOH,RHOH,399|RPL11,RPL11,6135|RPL24,RPL24,6152|RPL36A,RPL36A,6173|RRAS2,RRAS2,22800|RRP1,RRP1,8568|SEC24D,SEC24D,9871|SEMA4A,SEMA4A,64218|SEPT6,SEPTIN6,23157|SF3B5,SF3B5,83443|SH2D1A,SH2D1A,4068|SH3KBP1,SH3KBP1,30011|SIT1,SIT1,27240|SLAIN1,SLAIN1,122060|SLAMF1,SLAMF1,6504|SLAMF6,SLAMF6,114836|SLC35B1,SLC35B1,10237|SLC35B3,SLC35B3,51000|SLC35D1,SLC35D1,23169|SMO,SMO,6608|SOCS1,SOCS1,8651|SPATS2,SPATS2,65244|STIP1,STIP1,10963|SUN2,SUN2,25777|SVIL,SVIL,6840|SYAP1,SYAP1,94056|SYF2,SYF2,25949|SYNJ2,SYNJ2,8871|SYTL3,SYTL3,94120|TCF12,TCF12,6938|TCOF1,TCOF1,6949|TIMM13,TIMM13,26517|TM7SF2,TM7SF2,7108|TM9SF1,TM9SF1,10548|TMEM111,EMC3,55831|TMEM131,TMEM131,23505|TMEM134,TMEM134,80194|TMEM165,TMEM165,55858|TMEM50B,TMEM50B,757|TNFAIP8L1,TNFAIP8L1,126282|TNFRSF18,TNFRSF18,8784|TPP2,TPP2,7174|TRDMT1,TRDMT1,1787|TUBB2B,TUBB2B,347733|TUBB3,TUBB3,10381|TUBG2,TUBG2,27175|UBE2D3,UBE2D3,7323|UBL4A,UBL4A,8266|XBP1,XBP1,7494|ZW10,ZW10,9183" FILTERED_BY_SIMILARITY="" FOUNDER_NAMES="" REFINEMENT_DATASETS="" VALIDATION_DATASETS="" CATEGORY_CODE="C7" ORGANISM="Mus musculus" SUB_CATEGORY_CODE="IMMUNESIGDB"/>
</MSIGDB>
