STANDARD_NAME GSE24210_CTRL_VS_IL35_TREATED_TCONV_CD4_TCELL_UP SYSTEMATIC_NAME M7841 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE24210_CTRL_VS_IL35_TREATED_TCONV_CD4_TCELL_UP NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes up-regulated in T conv cells: control versus treated with IL35. DESCRIPTION_FULL Regulatory T cells (Tregs) play a critical role in the maintenance of immunological self-tolerance. Naïve human or murine T cell treatment with the inhibitory cytokine IL35 induces a regulatory population, termed iTR35, that mediates suppression via IL35, but not IL10 or TGFβ, neither express nor require Foxp3, are strongly suppressive in five in vivo models, and exhibit in vivo stability. Treg-mediated suppression induces iTR35 generation in an IL35- and IL10-dependent manner in vitro, and in inflammatory conditions in vivo in Trichuris-infected intestines and within the tumor microenvironment, where they appear to contribute to the regulatory milieu. iTR35 may constitute a key mediator of infectious tolerance and may contribute to Treg-mediated tumor progression, and ex vivo-generated iTR35 may possess therapeutic utility. PMID 20953201 GEOID GSE24210 AUTHORS Collison LW,Chaturvedi V,Henderson AL,Giacomin PR,Guy C,Bankoti J,Finkelstein D,Forbes K,Workman CJ,Brown SA,Rehg JE,Jones ML,Ni HT,Artis D,Turk MJ,Vignali DA CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE24210_2705_200_UP FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS ABCB1,ACVR1B,AES,ALDH3A2,ALPK2,AP2A2,AP4B1,APOBEC1,ARAP1,ARHGAP26,ARHGDIB,ARMC3,BBS2,BBX,BCL7A,BLNK,BRAF,BTG1,C16orf54,C19orf12,C6orf70,C9orf46,CAMK1D,CAMKMT,CBFA2T3,CCBP2,CCDC111,CCDC82,CCNL2,CD1D,CD40,CD47,CD74,CDC25B,CDC42EP3,CDC42SE2,CDKN1B,CELF2,CEP192,CEP350,CEP68,CKLF,CLIC1,CLK1,CMTM7,CNOT6L,CR2,CREB3L2,CREBL2,CRIM1,CRIP1,CRLF3,CXCR5,CYTH1,DENND1C,DFFA,DTX3L,DUSP11,DUSP6,EHD3,ELL3,EMID1,FAM102A,FAM123B,FAM63B,FANCA,FBXL4,FGD2,FRY,FTSJD2,GABPB2,GCOM1,GMFG,GPD1L,HEPACAM2,HERC2,HIST3H2A,HIVEP2,HSH2D,IFT140,IGKC,IL9R,ING1,INVS,IRF2,IRF2BPL,ITGA6,ITM2B,ITPR1,ITPR3,JAK1,JAK3,KCTD12,KDM3A,KIDINS220,KLF3,KLHL24,KLRAQ1,LACE1,LCOR,LIMK2,LPP,LTA,LY6D,LY86,MAP3K3,MCL1,MCTP2,MED13L,METTL7A,MORC3,MOSC2,MS4A1,MTSS1,MYL4,MZB1,NAB1,NCK2,NCKAP1L,NOD1,NOTCH2,NUAK2,NUFIP2,OXR1,PADI2,PAK1,PDE1B,PDE2A,PHC3,PHF20L1,PHF21A,PIK3R4,PKIB,PLEKHO1,PLK1S1,POLG2,POLI,PRKACB,PRR13,PSD3,PSD4,PSMB9,PTEN,PTPRC,PXK,RAB19,RAB3IP,RAC2,RAPGEF4,RAPGEF5,RASGRP1,RASSF4,RCSD1,RDM1,RERE,REV3L,RNF139,ROCK1,RSRC1,SEC11C,SF3B1,SFN,SFT2D2,SGPP1,SHISA5,SLAMF1,SLC26A11,SLC35B3,SLC40A1,SLC44A2,SLC50A1,SNX2,SNX29,SPATA13,SPG11,STRADB,SYS1,TAPBP,TBC1D10C,TEC,TECPR1,TLR1,TLR4,TMEM123,TOP2B,TPST1,TRAF3,TRAF5,TRIB2,TRIM11,TRIOBP,TXNIP,UROS,USP6NL,VIM,VPS41,WDR44,ZMYND8,ZNF592,ZNF622 GENE_SYMBOLS ABCB1,ACVR1B,TLE5,ALDH3A2,ALPK2,AP2A2,AP4B1,APOBEC1,ARAP1,ARHGAP26,ARHGDIB,ARMC3,BBS2,BBX,BCL7A,BLNK,BRAF,BTG1,C16orf54,C19orf12,ERMARD,PLGRKT,CAMK1D,CAMKMT,CBFA2T3,ACKR2,PRIMPOL,CCDC82,CCNL2,CD1D,CD40,CD47,CD74,CDC25B,CDC42EP3,CDC42SE2,CDKN1B,CELF2,CEP192,CEP350,CEP68,CKLF,CLIC1,CLK1,CMTM7,CNOT6L,CR2,CREB3L2,CREBL2,CRIM1,CRIP1,CRLF3,CXCR5,CYTH1,DENND1C,DFFA,DTX3L,DUSP11,DUSP6,EHD3,ELL3,EMID1,EEIG1,AMER1,MINDY2,FANCA,FBXL4,FGD2,FRY,CMTR1,GABPB2,GCOM1,GMFG,GPD1L,HEPACAM2,HERC2,H2AC25,HIVEP2,HSH2D,IFT140,IGKC,IL9R,ING1,INVS,IRF2,IRF2BPL,ITGA6,ITM2B,ITPR1,ITPR3,JAK1,JAK3,KCTD12,KDM3A,KIDINS220,KLF3,KLHL24,PPP1R21,AFG1L,LCOR,LIMK2,LPP,LTA,LY6D,LY86,MAP3K3,MCL1,MCTP2,MED13L,METTL7A,MORC3,MTARC2,MS4A1,MTSS1,MYL4,MZB1,NAB1,NCK2,NCKAP1L,NOD1,NOTCH2,NUAK2,NUFIP2,OXR1,PADI2,PAK1,PDE1B,PDE2A,PHC3,PHF20L1,PHF21A,PIK3R4,PKIB,PLEKHO1,KIZ,POLG2,POLI,PRKACB,PRR13,PSD3,PSD4,PSMB9,PTEN,PTPRC,PXK,RAB19,RAB3IP,RAC2,RAPGEF4,RAPGEF5,RASGRP1,RASSF4,RCSD1,RDM1,RERE,REV3L,RNF139,ROCK1,RSRC1,SEC11C,SF3B1,SFN,SFT2D2,SGPP1,SHISA5,SLAMF1,SLC26A11,SLC35B3,SLC40A1,SLC44A2,SLC50A1,SNX2,SNX29,SPATA13,SPG11,STRADB,SYS1,TAPBP,TBC1D10C,TEC,TECPR1,TLR1,TLR4,TMEM123,TOP2B,TPST1,TRAF3,TRAF5,TRIB2,TRIM11,TRIOBP,TXNIP,UROS,USP6NL,VIM,VPS41,WDR44,ZMYND8,ZNF592,ZNF622 FOUNDER_NAMES