STANDARD_NAME GSE24726_WT_VS_E2_2_KO_PDC_DN SYSTEMATIC_NAME M8061 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE24726_WT_VS_E2_2_KO_PDC_DN NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes down-regulated in plasmacytoid dendritic cells: wildtype versus TCF4 [GeneID=6925] knockout. DESCRIPTION_FULL The interferon-producing plasmacytoid dendritic cells (PDC) share common progenitors with antigen-presenting classical dendritic cells (cDC), yet they possess distinct morphology and molecular features resembling those of lymphocytes. It is unclear whether the unique cell fate of PDC is actively maintained in the steady state. We report that the deletion of transcription factor E2-2 from mature peripheral PDC caused their spontaneous differentiation into cells with cDC properties. This included the loss of PDC markers, increase in MHC class II expression and T cell priming capacity, acquisition of dendritic morphology and induction of cDC signature genes. Genome-wide chromatin immunoprecipitation revealed direct binding of E2-2 to key PDC-specific and lymphoid genes, as well as to certain genes enriched in cDC. Thus, E2-2 actively maintains the cell fate of mature PDC and opposes the “default” cDC fate, in part through direct regulation of lineage-specific gene expression programs. PMID 21145760 GEOID GSE24726 AUTHORS Ghosh HS,Cisse B,Bunin A,Lewis KL,Reizis B CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE24726_2452_200_DN FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS AACS,AARS,ABCA1,ABCA3,ABCF2,ABHD16A,ACP5,ACPP,ACSL5,ADAM17,ADCK5,AFP,AHR,AKAP7,AOAH,AP2S1,AP3M1,ARHGEF37,ARRDC2,ATOX1,ATP5G1,ATP5G3,ATXN7L1,BCAT2,BCL3,BNIP2,BSCL2,C12orf42,C19orf59,C7orf43,C9orf46,C9orf89,CCDC125,CCL17,CCL7,CDV3,CEBPB,CEBPD,CFLAR,CIAPIN1,CLEC6A,CLN5,CMKLR1,CNNM2,COMTD1,CRELD2,CS,CTSK,CYB5A,CYBA,CYBB,DNAJB1,DNAJB2,DNAJB6,DNAJC21,DNAJC3,DNER,DOCK1,DRAM1,EGLN3,EGR1,EGR2,EIF3B,EMILIN2,FAM108C1,FAM177A1,FAM98B,FASN,FKBP15,FTSJD2,FXC1,GBGT1,GBP2,GNL3,GPR132,GTF2E2,HCAR2,HEXIM1,HLA-DQA1,HRAS,HVCN1,IL13RA1,ING1,IRF7,ISCU,ISG15,ISOC1,ITGAM,JAK1,KLF7,KLHDC10,KLRAQ1,LITAF,LMAN2,LPCAT3,LSS,LYPD6,MANF,MARCH1,ME2,MET,METAP1,MGAT4A,MKKS,MLF2,MMP19,MPHOSPH10,MRPL52,MRPL54,MTHFD2L,NCBP1,NFE2L2,NFKB2,NFYC,NME6,NPEPPS,NRP2,NUDT19,NUFIP1,P2RX4,P4HA2,PAG1,PARP3,PARP9,PDCD11,PDE4DIP,PDPN,PECAM1,PIK3R5,PIP5K1A,PKM2,PKNOX1,PLEK,PLEKHA8,PPP1R3B,PRELID2,PRKCD,PRSS8,PSMB10,PSMD1,PTK2,PYGL,RAP1GDS1,RLF,RNF128,RNF149,RNF181,RNF19A,RPS6KA4,SAMSN1,SART3,SCAMP5,SDF2L1,SDHD,SIGLEC7,SLC11A1,SLC13A3,SLC25A6,SLC31A2,SLC37A4,SLC44A1,SMOX,SNX20,SPINT2,SQLE,SQRDL,ST6GALNAC6,STAT3,STK40,SUN1,SYN1,TAGLN2,TANC2,TESK2,TKT,TM7SF2,TOR1AIP1,TPST2,TRAF1,TRAF2,TRAPPC10,TRAPPC6A,TWF1,TXNDC11,UAP1,UBASH3B,UBE2F,UGCG,USP18,VEGFA,VPRBP,VPS36,VPS37A,VRK3,WNT9B,WSB2,ZDHHC18,ZDHHC21,ZNF292,ZNF821 GENE_SYMBOLS AACS,AARS1,ABCA1,ABCA3,ABCF2,ABHD16A,ACP5,ACP3,ACSL5,ADAM17,ADCK5,AFP,AHR,AKAP7,AOAH,AP2S1,AP3M1,ARHGEF37,ARRDC2,ATOX1,ATP5MC1,ATP5MC3,ATXN7L1,BCAT2,BCL3,BNIP2,BSCL2,C12orf42,MCEMP1,TRAPPC14,PLGRKT,CARD19,CCDC125,CCL17,CCL7,CDV3,CEBPB,CEBPD,CFLAR,CIAPIN1,CLEC6A,CLN5,CMKLR1,CNNM2,COMTD1,CRELD2,CS,CTSK,CYB5A,CYBA,CYBB,DNAJB1,DNAJB2,DNAJB6,DNAJC21,DNAJC3,DNER,DOCK1,DRAM1,EGLN3,EGR1,EGR2,EIF3B,EMILIN2,ABHD17C,FAM177A1,FAM98B,FASN,FKBP15,CMTR1,TIMM10B,GBGT1,GBP2,GNL3,GPR132,GTF2E2,HCAR2,HEXIM1,HLA-DQA1,HRAS,HVCN1,IL13RA1,ING1,IRF7,ISCU,ISG15,ISOC1,ITGAM,JAK1,KLF7,KLHDC10,PPP1R21,LITAF,LMAN2,LPCAT3,LSS,LYPD6,MANF,MARCHF1,ME2,MET,METAP1,MGAT4A,MKKS,MLF2,MMP19,MPHOSPH10,MRPL52,MRPL54,MTHFD2L,NCBP1,NFE2L2,NFKB2,NFYC,NME6,NPEPPS,NRP2,NUDT19,NUFIP1,P2RX4,P4HA2,PAG1,PARP3,PARP9,PDCD11,PDE4DIP,PDPN,PECAM1,PIK3R5,PIP5K1A,PKM,PKNOX1,PLEK,PLEKHA8,PPP1R3B,PRELID2,PRKCD,PRSS8,PSMB10,PSMD1,PTK2,PYGL,RAP1GDS1,RLF,RNF128,RNF149,RNF181,RNF19A,RPS6KA4,SAMSN1,SART3,SCAMP5,SDF2L1,SDHD,SIGLEC7,SLC11A1,SLC13A3,SLC25A6,SLC31A2,SLC37A4,SLC44A1,SMOX,SNX20,SPINT2,SQLE,SQOR,ST6GALNAC6,STAT3,STK40,SUN1,SYN1,TAGLN2,TANC2,TESK2,TKT,TM7SF2,TOR1AIP1,TPST2,TRAF1,TRAF2,TRAPPC10,TRAPPC6A,TWF1,TXNDC11,UAP1,UBASH3B,UBE2F,UGCG,USP18,VEGFA,DCAF1,VPS36,VPS37A,VRK3,WNT9B,WSB2,ZDHHC18,ZDHHC21,ZNF292,ZNF821 FOUNDER_NAMES