STANDARD_NAME GSE25123_CTRL_VS_IL4_AND_ROSIGLITAZONE_STIM_MACROPHAGE_DN SYSTEMATIC_NAME M7909 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE25123_CTRL_VS_IL4_AND_ROSIGLITAZONE_STIM_MACROPHAGE_DN NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes down-regulated in wildtype bone marrow-derived macrophages: control versus IL4 [GeneID=3565] and rosiglitazone [PubChem=77999]. DESCRIPTION_FULL Conditional macrophage-specific PPARg knockout mice were generated on C57Bl/6 background by breeding PPARg fl/- (one allele is floxed, the other is null) and lysozyme Cre transgenic mice. PPARg and IL-4 signaling was analyzed on bone marrow-derived macrophages. Bone marrow of 3 mice per group was isolated and differentiated to macrophages with M-CSF (20 ng/ml). 20 ng/ml IL-4 was used to induce alternative macrophage activation and 1 uM Rosiglitazone (RSG) was used to activate PPARg. From each mouse 4 samples were generated: 1. M-CSF, 2. M-CSF+RSG, 3. IL-4 and 4. IL-4+RSG. All compounds were added throughout the whole differentiation process, and fresh media was added every other day. Control cells were treated with vehicle (DMSO:ethanol). After 10 days, RNA was isolated and gene expression profiles were analyzed using Mouse Genome 430 2.0 microarrays from Affymetrix. PMID 21093321 GEOID GSE25123 AUTHORS Szanto A,Balint BL,Nagy ZS,Barta E,Dezso B,Pap A,Szeles L,Poliska S,Oros M,Evans RM,Barak Y,Schwabe J,Nagy L CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE25123_2326_200_DN FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS AGFG2,AIF1L,AIRN,AMMECR1L,ASPRV1,ASTN2,ATP2B3,ATXN7L3B,BDAG1,C10orf10,C10orf35,C11orf41,C12orf73,C19orf2,C1orf151,C2orf3,C3orf18,C3orf24,C4orf44,C6orf26,C7orf72,C9orf102,C9orf11,C9orf140,CA7,CAPN6,CCAR1,CCDC157,CCDC79,CCNE1,CD28,CD302,CDKL3,CHODL,CHRAC1,CIR1,CLCA1,CLCN3,CLDN12,CLDN18,CLMP,CNOT6,COMMD2,COX7A2,CR1L,CREB1,CRYGS,CSDC2,CSNK2A2,CTNND2,CWC22,CXCL13,CXorf56,CYP11B1,CYP2S1,DDX3X,DHTKD1,DNAI2,DNAJB14,DUOXA2,DZIP3,EIF2D,EMILIN2,EPHA6,EPHA7,ESD,ESF1,EXOC6,F8A1,FAM196B,FAM198B,FEN1,FHIT,FIBIN,FOXP1,FRZB,FXYD6,GABRA4,GABRB3,GAPVD1,GM2A,GREM2,GRIA2,GSX2,HBXIP,HECTD2,IRX5,KALRN,KCNK7,KCNN2,KHDC1L,KIAA0430,KIAA0528,KIAA1033,KLHL13,LAGE3,LARGE,LMO3,LPAR4,LPPR4,LRRC3B,MAP1A,MAP2K4,MAP3K2,MBD5,MBNL2,MBOAT4,MBTD1,MCCC1,MED30,METTL11A,METTL2B,MFAP3,MGA,MMP16,MPZ,MRPL11,MRPL20,MRPL33,MRPL55,MRPS36,MS4A18,MTF1,MUT,MYCBP2,MYO1H,N6AMT2,NAA16,NAB1,NAV1,NDUFA12,NDUFA13,NDUFA2,NDUFB11,NDUFB2,NDUFB3,NFIA,NIPBL,NOVA1,NUDT7,PAN3,PCDHB12,PDE1C,PITPNB,PITPNC1,PLOD2,PNMT,POLR1D,POU5F2,PPP1R3A,PRELID1,PRKACA,PRKACB,PROCA1,PSMA5,PSMB4,PTAFR,RAD54B,RALY,RIC3,RIMS3,RPF2,RPL26,RPL31,RPS14,RPS7,RRM2,SAMM50,SCRN3,SHH,SLC1A2,SLC22A17,SLC35D2,SNRNP25,SNW1,SOCS2,SOHLH2,SON,SPATA7,SRP19,ST18,SYNJ2BP,TAOK3,TBX15,TCEAL1,TMEM110,TMEM74,TMPRSS2,TTC32,UBN2,URGCP,USP53,VAMP3,VIPAR,WT1,XRCC4,ZCCHC5,ZNF292,ZNF536,ZNF679 GENE_SYMBOLS AGFG2,AIF1L,AIRN,AMMECR1L,ASPRV1,ASTN2,ATP2B3,ATXN7L3B,CCDC180,DEPP1,FAM241B,KIAA1549L,UQCC6,URI1,MICOS10,GCFC2,C3orf18,FANCD2OS,MSANTD1,SAPCD1,SPATA48,ERCC6L2,EQTN,SAPCD2,CA7,CAPN6,CCAR1,CCDC157,TERB1,CCNE1,CD28,CD302,CDKL3,CHODL,CHRAC1,CIR1,CLCA1,CLCN3,CLDN12,CLDN18,CLMP,CNOT6,COMMD2,COX7A2,CR1L,CREB1,CRYGS,CSDC2,CSNK2A2,CTNND2,CWC22,CXCL13,STEEP1,CYP11B1,CYP2S1,DDX3X,DHTKD1,DNAI2,DNAJB14,DUOXA2,DZIP3,EIF2D,EMILIN2,EPHA6,EPHA7,ESD,ESF1,EXOC6,F8A1,INSYN2B,GASK1B,FEN1,FHIT,FIBIN,FOXP1,FRZB,FXYD6,GABRA4,GABRB3,GAPVD1,GM2A,GREM2,GRIA2,GSX2,LAMTOR5,HECTD2,IRX5,KALRN,KCNK7,KCNN2,KHDC1L,MARF1,C2CD5,WASHC4,KLHL13,LAGE3,LARGE1,LMO3,LPAR4,PLPPR4,LRRC3B,MAP1A,MAP2K4,MAP3K2,MBD5,MBNL2,MBOAT4,MBTD1,MCCC1,MED30,NTMT1,METTL2B,MFAP3,MGA,MMP16,MPZ,MRPL11,MRPL20,MRPL33,MRPL55,MRPS36,MS4A18,MTF1,MMUT,MYCBP2,MYO1H,EEF1AKMT1,NAA16,NAB1,NAV1,NDUFA12,NDUFA13,NDUFA2,NDUFB11,NDUFB2,NDUFB3,NFIA,NIPBL,NOVA1,NUDT7,PAN3,PCDHB12,PDE1C,PITPNB,PITPNC1,PLOD2,PNMT,POLR1D,POU5F2,PPP1R3A,PRELID1,PRKACA,PRKACB,PROCA1,PSMA5,PSMB4,PTAFR,RAD54B,RALY,RIC3,RIMS3,RPF2,RPL26,RPL31,RPS14,RPS7,RRM2,SAMM50,SCRN3,SHH,SLC1A2,SLC22A17,SLC35D2,SNRNP25,SNW1,SOCS2,SOHLH2,SON,SPATA7,SRP19,ST18,SYNJ2BP,TAOK3,TBX15,TCEAL1,STIMATE,TMEM74,TMPRSS2,TTC32,UBN2,URGCP,USP53,VAMP3,VIPAS39,WT1,XRCC4,RTL3,ZNF292,ZNF536,ZNF679 FOUNDER_NAMES