STANDARD_NAME GSE25123_ROSIGLITAZONE_VS_IL4_AND_ROSIGLITAZONE_STIM_PPARG_KO_MACROPHAGE_DAY10_DN SYSTEMATIC_NAME M7992 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE25123_ROSIGLITAZONE_VS_IL4_AND_ROSIGLITAZONE_STIM_PPARG_KO_MACROPHAGE_DAY10_DN NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes down-regulated in bone marrow-derived macrophages with PPARG [GeneID=5468] knockout treated with rosiglitazone [PubChem=77999]: control versus IL4 [GeneID=3565]. DESCRIPTION_FULL Conditional macrophage-specific PPARg knockout mice were generated on C57Bl/6 background by breeding PPARg fl/- (one allele is floxed, the other is null) and lysozyme Cre transgenic mice. PPARg and IL-4 signaling was analyzed on bone marrow-derived macrophages. Bone marrow of 3 mice per group was isolated and differentiated to macrophages with M-CSF (20 ng/ml). 20 ng/ml IL-4 was used to induce alternative macrophage activation and 1 uM Rosiglitazone (RSG) was used to activate PPARg. From each mouse 4 samples were generated: 1. M-CSF, 2. M-CSF+RSG, 3. IL-4 and 4. IL-4+RSG. All compounds were added throughout the whole differentiation process, and fresh media was added every other day. Control cells were treated with vehicle (DMSO:ethanol). After 10 days, RNA was isolated and gene expression profiles were analyzed using Mouse Genome 430 2.0 microarrays from Affymetrix. PMID 21093321 GEOID GSE25123 AUTHORS Szanto A,Balint BL,Nagy ZS,Barta E,Dezso B,Pap A,Szeles L,Poliska S,Oros M,Evans RM,Barak Y,Schwabe J,Nagy L CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE25123_2336_200_DN FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS ABCB4,ADIPOR2,ADORA3,AIM2,ALS2,AMBRA1,ANKIB1,ARAP1,ARHGEF4,ATP13A2,ATP6V0B,BASP1,BCL2L2,BCL7C,BSCL2,BSDC1,C11orf10,C17orf59,C1orf198,C20orf94,C9orf68,CADPS,CAPN5,CCDC17,CHMP1A,CIITA,CLCN4,CNN2,CNOT8,CRISP1,CUL9,CYB5R3,DDI2,DNAJC4,DOCK8,DYNC1H1,EME2,EMID2,EML3,EPHB2,ERBB2IP,ERCC5,ERO1LB,FAM120C,FAM134C,FAM171B,FAM193B,FAM40A,FAM69A,FAM76B,FBXL17,FOXO3,FZD10,GALK1,GIT2,GM2A,GOLGA1,GPR114,GPR35,GRINA,GRRP1,HAAO,HIVEP3,HLA-E,HMHA1,HPS5,HSD11B2,IL2RA,INPP5K,ITGB2,KBTBD7,KCTD12,KIAA0528,KIAA0913,KIAA1033,KLHDC5,KRT31,LDLRAD3,LEFTY1,LGALS4,LMAN2L,LMF1,LRP10,LRRC1,LRRC56,LYST,MAN2A1,MAP4K3,MAP7D1,MARK2,MATN2,MBNL1,MRGPRG,MYO9B,MYOG,NBR1,NDST2,NECAP2,NEUROD6,NFKBIE,NFRKB,NIPBL,NR2C2AP,NR3C1,ORC4,OSTM1,P2RY12,P2RY13,PADI2,PCMTD2,PIK3CD,PLEKHA2,PLEKHB2,PPAPDC2,PPCS,PQLC2,PRKAG2,PTK2,PTMS,PTPN20B,PTPRC,RAB3IP,RAC2,RAI1,RAI2,RAP1A,RASA4,RBM5,RCOR3,RECQL5,REP15,RGAG4,RGP1,RGS7BP,RLF,RNF122,SASH3,SBK1,SCAMP2,SCAP,SDCCAG8,SENP6,SEPSECS,SERPINA4,SIGLEC10,SIGMAR1,SIKE1,SIRPA,SIRT7,SLAMF9,SLC12A3,SLC24A6,SLC35C2,SLC6A6,SLCO4A1,SMEK2,SNX17,SPIN1,ST8SIA6,STARD3,STOML3,STX16,SYK,TBC1D10C,TCF12,THY1,TLR7,TMEM181,TMEM231,TMEM86A,TMEM8B,TNFAIP3,TNFAIP8,TPPP,TRAPPC10,TRAPPC5,TRIM14,TRIM44,TRIT1,TRMT2B,TUBGCP5,UBL3,UNC93B1,USP49,VAMP1,VANGL2,WDR13,WNK1,WRN,ZC3H11A,ZDHHC9,ZMIZ2,ZNF18,ZNF217,ZNF280D,ZNF383,ZNF467,ZNF608,ZNHIT2,ZXDB GENE_SYMBOLS ABCB4,ADIPOR2,ADORA3,AIM2,ALS2,AMBRA1,ANKIB1,ARAP1,ARHGEF4,ATP13A2,ATP6V0B,BASP1,BCL2L2,BCL7C,BSCL2,BSDC1,TMEM258,BORCS6,C1orf198,SLX4IP,SPATA6L,CADPS,CAPN5,CCDC17,CHMP1A,CIITA,CLCN4,CNN2,CNOT8,CRISP1,CUL9,CYB5R3,DDI2,DNAJC4,DOCK8,DYNC1H1,EME2,COL26A1,EML3,EPHB2,ERBIN,ERCC5,ERO1B,FAM120C,RETREG3,FAM171B,FAM193B,STRIP1,DIPK1A,FAM76B,FBXL17,FOXO3,FZD10,GALK1,GIT2,GM2A,GOLGA1,ADGRG5,GPR35,GRINA,FAM110D,HAAO,HIVEP3,HLA-E,ARHGAP45,HPS5,HSD11B2,IL2RA,INPP5K,ITGB2,KBTBD7,KCTD12,C2CD5,ZSWIM8,WASHC4,KLHL42,KRT31,LDLRAD3,LEFTY1,LGALS4,LMAN2L,LMF1,LRP10,LRRC1,LRRC56,LYST,MAN2A1,MAP4K3,MAP7D1,MARK2,MATN2,MBNL1,MRGPRG,MYO9B,MYOG,NBR1,NDST2,NECAP2,NEUROD6,NFKBIE,NFRKB,NIPBL,NR2C2AP,NR3C1,ORC4,OSTM1,P2RY12,P2RY13,PADI2,PCMTD2,PIK3CD,PLEKHA2,PLEKHB2,PLPP6,PPCS,SLC66A1,PRKAG2,PTK2,PTMS,PTPN20,PTPRC,RAB3IP,RAC2,RAI1,RAI2,RAP1A,RASA4,RBM5,RCOR3,RECQL5,REP15,RTL5,RGP1,RGS7BP,RLF,RNF122,SASH3,SBK1,SCAMP2,SCAP,SDCCAG8,SENP6,SEPSECS,SERPINA4,SIGLEC10,SIGMAR1,SIKE1,SIRPA,SIRT7,SLAMF9,SLC12A3,SLC8B1,SLC35C2,SLC6A6,SLCO4A1,PPP4R3B,SNX17,SPIN1,ST8SIA6,STARD3,STOML3,STX16,SYK,TBC1D10C,TCF12,THY1,TLR7,TMEM181,TMEM231,TMEM86A,TMEM8B,TNFAIP3,TNFAIP8,TPPP,TRAPPC10,TRAPPC5,TRIM14,TRIM44,TRIT1,TRMT2B,TUBGCP5,UBL3,UNC93B1,USP49,VAMP1,VANGL2,WDR13,WNK1,WRN,ZC3H11A,ZDHHC9,ZMIZ2,ZNF18,ZNF217,ZNF280D,ZNF383,ZNF467,ZNF608,ZNHIT2,ZXDB FOUNDER_NAMES