STANDARD_NAME	GSE26351_WNT_VS_BMP_PATHWAY_STIM_HEMATOPOIETIC_PROGENITORS_DN
SYSTEMATIC_NAME	M8480
COLLECTION	C7:IMMUNESIGDB
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE26351_WNT_VS_BMP_PATHWAY_STIM_HEMATOPOIETIC_PROGENITORS_DN
NAMESPACE	HUMAN_GENE_SYMBOL
DESCRIPTION_BRIEF	Genes down-regulated in CD34+ [GeneID=947] cells treated with GSK-3 Inhibitor IX (BIO) [PubChem=5287844] versus those stimulated by BMP4 [GeneID=652].
DESCRIPTION_FULL	Analysis of mobilized peripheral blood CD34+ cells from a healthy volunteer under erythroid differentiation conditions with and without stimulation to the BMP or Wnt signaling pathways. For erythroid differentiation, expanded CD34+ cells were placed in Stemspan SFEM medium supplemented with 2% pen/strep, 20ng/ml SCF, 1U/ml Epo, 5ng/ml IL3, 2uM dexamethasone, and 1uM beta-estradiol. Arrays were performed 2 hours after addition of cytokines. For signaling pathway stimulation, cells were exposed to 0.5uM BIO (a GSK3 inhibitor) for Wnt pathway activation, 25ng/ml rhBMP4 for BMP pathway activation, or vehicle control for 2 hours. Three biological replicates were performed per treatment group. We used microarrays to detail the global program of gene expression changes after Wnt or BMP pathway stimulation in human CD34+ hematopoietic progenitors under erythroid differentiation conditions.
PMID	22036566
GEOID	GSE26351
AUTHORS	Trompouki E,Bowman TV,Lawton LN,Fan ZP,Wu DC,DiBiase A,Martin CS,Cech JN,Sessa AK,Leblanc JL,Li P,Durand EM,Mosimann C,Heffner GC,Daley GQ,Paulson RF,Young RA,Zon LI
CONTRIBUTOR	Jernej Godec
CONTRIBUTOR_ORG	Dana-Farber Cancer Institute
EXACT_SOURCE	GSE26351_2247_200_DN
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	AAGAB,ACCS,ACVR2A,AGPS,AKAP13,ALDH7A1,ALG14,ALKBH5,ANKRD50,ANKS3,ARMC7,ARVCF,ASPH,ATP6V1D,B4GALT6,BAZ1B,BCKDHB,C10orf118,C11orf30,C11orf67,C11orf74,C14orf119,C16orf52,C17orf101,C18orf55,C19orf12,C1orf27,C20orf24,C5orf28,C6orf145,C6orf203,C7orf23,CBX7,CDC42EP4,CDK10,CDK5R1,CLUAP1,CMYA5,COMMD9,CR1L,CST7,CTNND1,CXorf56,CYP2R1,DDIT4,DFNA5,DGAT1,DMAP1,DNAJC7,DOLK,DYNLT3,E4F1,EDEM3,EED,ELP2,ELP3,ENDOG,ENG,EXOC6B,FAM108C1,FAM3C,FAM40A,FARP1,FGF13,FUT11,FZD8,GAN,GAS2L1,GGNBP2,GHDC,GKAP1,GNA13,GSDMD,HGSNAT,HIVEP3,HK3,IKBKG,IL6ST,IRS2,ITGB3BP,ITPKB,KCTD18,KCTD3,KIAA0240,KIAA1279,KIF1B,KLHL24,LAP3,LMF1,LOC100009676,LRRC33,LTF,LUC7L2,LUZP1,MADD,MAEA,MAP2K3,MAP3K4,MAP3K5,MAPRE2,MARCH5,MBTD1,MCART6,MEIR5,MESDC2,METTL23,MMP9,MMS19,MON1B,MTF1,MYO1E,NAT8L,NKRF,NMD3,PCM1,PCMT1,PCMTD1,PCP4,PDZD8,PER3,PHF20,PHIP,PIGP,PIGX,PIK3R4,PLBD2,PORCN,POU2F2,PPM1E,PPP2CA,PRKCE,PRRC1,PRUNE2,PSMA8,PUM2,QSER1,RAB27A,RAB35,RABEP2,REPS1,RGL2,RMND5B,RNF115,RNF121,RNF216,RRAGC,RRP1B,RSRC2,RWDD3,SEC22A,SHISA5,SLC22A17,SLC38A9,SLFN13,SMCR8,SNRNP48,SNX14,SOCS6,SPAST,STX2,TATDN1,TBL2,TEF,TFB2M,TIAL1,TMED5,TMEM65,TMEM68,TMEM8C,TMF1,TMOD1,TNNT1,TOE1,TRIAP1,TRIM8,TRUB1,TSSC4,TTC27,TTC39B,TUBGCP6,TWF1,UBA5,UBLCP1,UBR1,USP19,WLS,XPNPEP3,XPO7,XYLB,YPEL2,YTHDF1,YTHDF2,ZBTB48,ZDHHC18,ZNF32,ZNF513,ZNF622,ZNF862,ZRSR2,ZSWIM3
GENE_SYMBOLS	AAGAB,ACCS,ACVR2A,AGPS,AKAP13,ALDH7A1,ALG14,ALKBH5,ANKRD50,ANKS3,ARMC7,ARVCF,ASPH,ATP6V1D,B4GALT6,BAZ1B,BCKDHB,CCDC186,EMSY,AAMDC,IFTAP,C14orf119,MOSMO,OGFOD3,TIMM21,C19orf12,ODR4,RAB5IF,TMEM267,PXDC1,MTRES1,TMEM243,CBX7,CDC42EP4,CDK10,CDK5R1,CLUAP1,CMYA5,COMMD9,CR1L,CST7,CTNND1,STEEP1,CYP2R1,DDIT4,GSDME,DGAT1,DMAP1,DNAJC7,DOLK,DYNLT3,E4F1,EDEM3,EED,ELP2,ELP3,ENDOG,ENG,EXOC6B,ABHD17C,FAM3C,STRIP1,FARP1,FGF13,FUT11,FZD8,GAN,GAS2L1,GGNBP2,GHDC,GKAP1,GNA13,GSDMD,HGSNAT,HIVEP3,HK3,IKBKG,IL6ST,IRS2,ITGB3BP,ITPKB,KCTD18,KCTD3,BICRAL,KIFBP,KIF1B,KLHL24,LAP3,LMF1,ZBTB11-AS1,NRROS,LTF,LUC7L2,LUZP1,MADD,MAEA,MAP2K3,MAP3K4,MAP3K5,MAPRE2,MARCHF5,MBTD1,SLC25A53,SFR1,MESD,METTL23,MMP9,MMS19,MON1B,MTF1,MYO1E,NAT8L,NKRF,NMD3,PCM1,PCMT1,PCMTD1,PCP4,PDZD8,PER3,PHF20,PHIP,PIGP,PIGX,PIK3R4,PLBD2,PORCN,POU2F2,PPM1E,PPP2CA,PRKCE,PRRC1,PRUNE2,PSMA8,PUM2,QSER1,RAB27A,RAB35,RABEP2,REPS1,RGL2,RMND5B,RNF115,RNF121,RNF216,RRAGC,RRP1B,RSRC2,RWDD3,SEC22A,SHISA5,SLC22A17,SLC38A9,SLFN13,SMCR8,SNRNP48,SNX14,SOCS6,SPAST,STX2,TATDN1,TBL2,TEF,TFB2M,TIAL1,TMED5,TMEM65,TMEM68,MYMK,TMF1,TMOD1,TNNT1,TOE1,TRIAP1,TRIM8,TRUB1,TSSC4,TTC27,TTC39B,TUBGCP6,TWF1,UBA5,UBLCP1,UBR1,USP19,WLS,XPNPEP3,XPO7,XYLB,YPEL2,YTHDF1,YTHDF2,ZBTB48,ZDHHC18,ZNF32,ZNF513,ZNF622,ZNF862,ZRSR2,ZSWIM3
FOUNDER_NAMES