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<MSIGDB BUILD_DATE="Jan 29, 2026" VERSION="2026.1.Hs" NAME="export">
    <GENESET STANDARD_NAME="GSE26351_WNT_VS_BMP_PATHWAY_STIM_HEMATOPOIETIC_PROGENITORS_DN" SYSTEMATIC_NAME="M8480" HISTORICAL_NAMES="" PMID="22036566" AUTHORS="Trompouki E,Bowman TV,Lawton LN,Fan ZP,Wu DC,DiBiase A,Martin CS,Cech JN,Sessa AK,Leblanc JL,Li P,Durand EM,Mosimann C,Heffner GC,Daley GQ,Paulson RF,Young RA,Zon LI" GEOID="GSE26351" EXACT_SOURCE="GSE26351_2247_200_DN" GENESET_LISTING_URL="" EXTERNAL_DETAILS_URL="" CHIP="HUMAN_GENE_SYMBOL" CONTRIBUTOR="Jernej Godec" CONTRIBUTOR_ORG="Dana-Farber Cancer Institute" DESCRIPTION_BRIEF="Genes down-regulated in CD34+ [GeneID=947] cells treated with GSK-3 Inhibitor IX (BIO) [PubChem=5287844] versus those stimulated by BMP4 [GeneID=652]." DESCRIPTION_FULL="Analysis of mobilized peripheral blood CD34+ cells from a healthy volunteer under erythroid differentiation conditions with and without stimulation to the BMP or Wnt signaling pathways. For erythroid differentiation, expanded CD34+ cells were placed in Stemspan SFEM medium supplemented with 2% pen/strep, 20ng/ml SCF, 1U/ml Epo, 5ng/ml IL3, 2uM dexamethasone, and 1uM beta-estradiol. Arrays were performed 2 hours after addition of cytokines. For signaling pathway stimulation, cells were exposed to 0.5uM BIO (a GSK3 inhibitor) for Wnt pathway activation, 25ng/ml rhBMP4 for BMP pathway activation, or vehicle control for 2 hours. Three biological replicates were performed per treatment group. We used microarrays to detail the global program of gene expression changes after Wnt or BMP pathway stimulation in human CD34+ hematopoietic progenitors under erythroid differentiation conditions." TAGS="" MEMBERS="AAGAB,ACCS,ACVR2A,AGPS,AKAP13,ALDH7A1,ALG14,ALKBH5,ANKRD50,ANKS3,ARMC7,ARVCF,ASPH,ATP6V1D,B4GALT6,BAZ1B,BCKDHB,C10orf118,C11orf30,C11orf67,C11orf74,C14orf119,C16orf52,C17orf101,C18orf55,C19orf12,C1orf27,C20orf24,C5orf28,C6orf145,C6orf203,C7orf23,CBX7,CDC42EP4,CDK10,CDK5R1,CLUAP1,CMYA5,COMMD9,CR1L,CST7,CTNND1,CXorf56,CYP2R1,DDIT4,DFNA5,DGAT1,DMAP1,DNAJC7,DOLK,DYNLT3,E4F1,EDEM3,EED,ELP2,ELP3,ENDOG,ENG,EXOC6B,FAM108C1,FAM3C,FAM40A,FARP1,FGF13,FUT11,FZD8,GAN,GAS2L1,GGNBP2,GHDC,GKAP1,GNA13,GSDMD,HGSNAT,HIVEP3,HK3,IKBKG,IL6ST,IRS2,ITGB3BP,ITPKB,KCTD18,KCTD3,KIAA0240,KIAA1279,KIF1B,KLHL24,LAP3,LMF1,LOC100009676,LRRC33,LTF,LUC7L2,LUZP1,MADD,MAEA,MAP2K3,MAP3K4,MAP3K5,MAPRE2,MARCH5,MBTD1,MCART6,MEIR5,MESDC2,METTL23,MMP9,MMS19,MON1B,MTF1,MYO1E,NAT8L,NKRF,NMD3,PCM1,PCMT1,PCMTD1,PCP4,PDZD8,PER3,PHF20,PHIP,PIGP,PIGX,PIK3R4,PLBD2,PORCN,POU2F2,PPM1E,PPP2CA,PRKCE,PRRC1,PRUNE2,PSMA8,PUM2,QSER1,RAB27A,RAB35,RABEP2,REPS1,RGL2,RMND5B,RNF115,RNF121,RNF216,RRAGC,RRP1B,RSRC2,RWDD3,SEC22A,SHISA5,SLC22A17,SLC38A9,SLFN13,SMCR8,SNRNP48,SNX14,SOCS6,SPAST,STX2,TATDN1,TBL2,TEF,TFB2M,TIAL1,TMED5,TMEM65,TMEM68,TMEM8C,TMF1,TMOD1,TNNT1,TOE1,TRIAP1,TRIM8,TRUB1,TSSC4,TTC27,TTC39B,TUBGCP6,TWF1,UBA5,UBLCP1,UBR1,USP19,WLS,XPNPEP3,XPO7,XYLB,YPEL2,YTHDF1,YTHDF2,ZBTB48,ZDHHC18,ZNF32,ZNF513,ZNF622,ZNF862,ZRSR2,ZSWIM3" MEMBERS_SYMBOLIZED="AAGAB,AAMDC,ABHD17C,ACCS,ACVR2A,AGPS,AKAP13,ALDH7A1,ALG14,ALKBH5,ANKRD50,ANKS3,ARMC7,ARVCF,ASPH,ATP6V1D,B4GALT6,BAZ1B,BCKDHB,BICRAL,C14orf119,C19orf12,CBX7,CCDC186,CDC42EP4,CDK10,CDK5R1,CLUAP1,CMYA5,COMMD9,CR1L,CST7,CTNND1,CYP2R1,DDIT4,DGAT1,DMAP1,DNAJC7,DOLK,DYNLT3,E4F1,EDEM3,EED,ELP2,ELP3,EMSY,ENDOG,ENG,EXOC6B,FAM3C,FARP1,FGF13,FUT11,FZD8,GAN,GAS2L1,GGNBP2,GHDC,GKAP1,GNA13,GSDMD,GSDME,HGSNAT,HIVEP3,HK3,IFTAP,IKBKG,IL6ST,IRS2,ITGB3BP,ITPKB,KCTD18,KCTD3,KIF1B,KIFBP,KLHL24,LAP3,LMF1,LTF,LUC7L2,LUZP1,MADD,MAEA,MAP2K3,MAP3K4,MAP3K5,MAPRE2,MARCHF5,MBTD1,MESD,METTL23,MMP9,MMS19,MON1B,MOSMO,MTF1,MTRES1,MYMK,MYO1E,NAT8L,NKRF,NMD3,NRROS,ODR4,OGFOD3,PCM1,PCMT1,PCMTD1,PCP4,PDZD8,PER3,PHF20,PHIP,PIGP,PIGX,PIK3R4,PLBD2,PORCN,POU2F2,PPM1E,PPP2CA,PRKCE,PRRC1,PRUNE2,PSMA8,PUM2,PXDC1,QSER1,RAB27A,RAB35,RAB5IF,RABEP2,REPS1,RGL2,RMND5B,RNF115,RNF121,RNF216,RRAGC,RRP1B,RSRC2,RWDD3,SEC22A,SFR1,SHISA5,SLC22A17,SLC25A53,SLC38A9,SLFN13,SMCR8,SNRNP48,SNX14,SOCS6,SPAST,STEEP1,STRIP1,STX2,TATDN1,TBL2,TEF,TFB2M,TIAL1,TIMM21,TMED5,TMEM243,TMEM267,TMEM65,TMEM68,TMF1,TMOD1,TNNT1,TOE1,TRIAP1,TRIM8,TRUB1,TSSC4,TTC27,TTC39B,TUBGCP6,TWF1,UBA5,UBLCP1,UBR1,USP19,WLS,XPNPEP3,XPO7,XYLB,YPEL2,YTHDF1,YTHDF2,ZBTB11-AS1,ZBTB48,ZDHHC18,ZNF32,ZNF513,ZNF622,ZNF862,ZRSR2,ZSWIM3" MEMBERS_EZID="100009676,10078,10160,10296,10447,10634,10672,10869,10982,11021,11214,114034,115294,118987,119392,119710,120227,124401,124512,130535,130557,133619,134510,137695,1379,138050,140775,140831,142940,143471,146857,1500,153129,154007,157378,158219,158471,1687,170384,1877,196463,197131,199857,2021,2022,202333,2054,221749,2258,22843,22845,22879,23039,23059,23076,23095,23184,23233,23369,23421,23492,23506,23580,25950,26128,26608,26984,27246,28971,29090,29099,30849,3101,3104,339983,3572,3707,375387,388403,389827,401612,4057,421,4216,4217,4318,444,4520,4643,501,50999,51056,51068,5108,5110,51133,5121,51227,51230,51246,51250,51310,51382,51441,51499,51631,54476,5452,54541,54708,54799,54800,54890,54915,54953,54965,55017,55023,55088,55140,5515,55250,55298,55622,5581,55922,55929,55969,5606,56946,57182,57231,5756,58489,5863,5873,59269,594,63929,63932,64121,64210,64216,643641,64417,64777,64788,64840,65117,6683,6990,7008,7073,7110,7111,7138,7266,730094,7580,7798,79161,79637,79701,79719,79792,79832,79874,79876,79893,79971,80267,80318,8139,81603,8233,8325,83636,83940,84243,84514,84680,85021,8517,8530,85369,85378,8540,8558,8567,8660,8694,8726,8851,8863,9031,90441,92,9306,9331,9942" MEMBERS_MAPPING="AAGAB,AAGAB,79719|ACCS,ACCS,84680|ACVR2A,ACVR2A,92|AGPS,AGPS,8540|AKAP13,AKAP13,11214|ALDH7A1,ALDH7A1,501|ALG14,ALG14,199857|ALKBH5,ALKBH5,54890|ANKRD50,ANKRD50,57182|ANKS3,ANKS3,124401|ARMC7,ARMC7,79637|ARVCF,ARVCF,421|ASPH,ASPH,444|ATP6V1D,ATP6V1D,51382|B4GALT6,B4GALT6,9331|BAZ1B,BAZ1B,9031|BCKDHB,BCKDHB,594|C10orf118,CCDC186,55088|C11orf30,EMSY,56946|C11orf67,AAMDC,28971|C11orf74,IFTAP,119710|C14orf119,C14orf119,55017|C16orf52,MOSMO,730094|C17orf101,OGFOD3,79701|C18orf55,TIMM21,29090|C19orf12,C19orf12,83636|C1orf27,ODR4,54953|C20orf24,RAB5IF,55969|C5orf28,TMEM267,64417|C6orf145,PXDC1,221749|C6orf203,MTRES1,51250|C7orf23,TMEM243,79161|CBX7,CBX7,23492|CDC42EP4,CDC42EP4,23580|CDK10,CDK10,8558|CDK5R1,CDK5R1,8851|CLUAP1,CLUAP1,23059|CMYA5,CMYA5,202333|COMMD9,COMMD9,29099|CR1L,CR1L,1379|CST7,CST7,8530|CTNND1,CTNND1,1500|CXorf56,STEEP1,63932|CYP2R1,CYP2R1,120227|DDIT4,DDIT4,54541|DFNA5,GSDME,1687|DGAT1,DGAT1,8694|DMAP1,DMAP1,55929|DNAJC7,DNAJC7,7266|DOLK,DOLK,22845|DYNLT3,DYNLT3,6990|E4F1,E4F1,1877|EDEM3,EDEM3,80267|EED,EED,8726|ELP2,ELP2,55250|ELP3,ELP3,55140|ENDOG,ENDOG,2021|ENG,ENG,2022|EXOC6B,EXOC6B,23233|FAM108C1,ABHD17C,58489|FAM3C,FAM3C,10447|FAM40A,STRIP1,85369|FARP1,FARP1,10160|FGF13,FGF13,2258|FUT11,FUT11,170384|FZD8,FZD8,8325|GAN,GAN,8139|GAS2L1,GAS2L1,10634|GGNBP2,GGNBP2,79893|GHDC,GHDC,84514|GKAP1,GKAP1,80318|GNA13,GNA13,10672|GSDMD,GSDMD,79792|HGSNAT,HGSNAT,138050|HIVEP3,HIVEP3,59269|HK3,HK3,3101|IKBKG,IKBKG,8517|IL6ST,IL6ST,3572|IRS2,IRS2,8660|ITGB3BP,ITGB3BP,23421|ITPKB,ITPKB,3707|KCTD18,KCTD18,130535|KCTD3,KCTD3,51133|KIAA0240,BICRAL,23506|KIAA1279,KIFBP,26128|KIF1B,KIF1B,23095|KLHL24,KLHL24,54800|LAP3,LAP3,51056|LMF1,LMF1,64788|LOC100009676,ZBTB11-AS1,100009676|LRRC33,NRROS,375387|LTF,LTF,4057|LUC7L2,LUC7L2,51631|LUZP1,LUZP1,7798|MADD,MADD,8567|MAEA,MAEA,10296|MAP2K3,MAP2K3,5606|MAP3K4,MAP3K4,4216|MAP3K5,MAP3K5,4217|MAPRE2,MAPRE2,10982|MARCH5,MARCHF5,54708|MBTD1,MBTD1,54799|MCART6,SLC25A53,401612|MEIR5,SFR1,119392|MESDC2,MESD,23184|METTL23,METTL23,124512|MMP9,MMP9,4318|MMS19,MMS19,64210|MON1B,MON1B,22879|MTF1,MTF1,4520|MYO1E,MYO1E,4643|NAT8L,NAT8L,339983|NKRF,NKRF,55922|NMD3,NMD3,51068|PCM1,PCM1,5108|PCMT1,PCMT1,5110|PCMTD1,PCMTD1,115294|PCP4,PCP4,5121|PDZD8,PDZD8,118987|PER3,PER3,8863|PHF20,PHF20,51230|PHIP,PHIP,55023|PIGP,PIGP,51227|PIGX,PIGX,54965|PIK3R4,PIK3R4,30849|PLBD2,PLBD2,196463|PORCN,PORCN,64840|POU2F2,POU2F2,5452|PPM1E,PPM1E,22843|PPP2CA,PPP2CA,5515|PRKCE,PRKCE,5581|PRRC1,PRRC1,133619|PRUNE2,PRUNE2,158471|PSMA8,PSMA8,143471|PUM2,PUM2,23369|QSER1,QSER1,79832|RAB27A,RAB27A,5873|RAB35,RAB35,11021|RABEP2,RABEP2,79874|REPS1,REPS1,85021|RGL2,RGL2,5863|RMND5B,RMND5B,64777|RNF115,RNF115,27246|RNF121,RNF121,55298|RNF216,RNF216,54476|RRAGC,RRAGC,64121|RRP1B,RRP1B,23076|RSRC2,RSRC2,65117|RWDD3,RWDD3,25950|SEC22A,SEC22A,26984|SHISA5,SHISA5,51246|SLC22A17,SLC22A17,51310|SLC38A9,SLC38A9,153129|SLFN13,SLFN13,146857|SMCR8,SMCR8,140775|SNRNP48,SNRNP48,154007|SNX14,SNX14,57231|SOCS6,SOCS6,9306|SPAST,SPAST,6683|STX2,STX2,2054|TATDN1,TATDN1,83940|TBL2,TBL2,26608|TEF,TEF,7008|TFB2M,TFB2M,64216|TIAL1,TIAL1,7073|TMED5,TMED5,50999|TMEM65,TMEM65,157378|TMEM68,TMEM68,137695|TMEM8C,MYMK,389827|TMF1,TMF1,7110|TMOD1,TMOD1,7111|TNNT1,TNNT1,7138|TOE1,TOE1,114034|TRIAP1,TRIAP1,51499|TRIM8,TRIM8,81603|TRUB1,TRUB1,142940|TSSC4,TSSC4,10078|TTC27,TTC27,55622|TTC39B,TTC39B,158219|TUBGCP6,TUBGCP6,85378|TWF1,TWF1,5756|UBA5,UBA5,79876|UBLCP1,UBLCP1,134510|UBR1,UBR1,197131|USP19,USP19,10869|WLS,WLS,79971|XPNPEP3,XPNPEP3,63929|XPO7,XPO7,23039|XYLB,XYLB,9942|YPEL2,YPEL2,388403|YTHDF1,YTHDF1,54915|YTHDF2,YTHDF2,51441|ZBTB48,ZBTB48,3104|ZDHHC18,ZDHHC18,84243|ZNF32,ZNF32,7580|ZNF513,ZNF513,130557|ZNF622,ZNF622,90441|ZNF862,ZNF862,643641|ZRSR2,ZRSR2,8233|ZSWIM3,ZSWIM3,140831" FILTERED_BY_SIMILARITY="" FOUNDER_NAMES="" REFINEMENT_DATASETS="" VALIDATION_DATASETS="" CATEGORY_CODE="C7" ORGANISM="Homo sapiens" SUB_CATEGORY_CODE="IMMUNESIGDB"/>
</MSIGDB>
