STANDARD_NAME GSE26495_NAIVE_VS_PD1HIGH_CD8_TCELL_DN SYSTEMATIC_NAME M4656 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE26495_NAIVE_VS_PD1HIGH_CD8_TCELL_DN NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes down-regulated in comparison of naive CD8 T cells versus PD-1 high CD8 T cells. DESCRIPTION_FULL T cell dysfunction is an important feature of many chronic viral infections. In particular, it was shown that PD-1 regulates T cell dysfunction during chronic LCMV infection in mice and PD-1 high cells exhibit an intense exhausted gene signature. These findings were extended to human chronic infections such as HIV, HCV and HBV. However, it is not known if PD-1 high cells of healthy humans have the traits of exhausted cells. In this study, we provide a comprehensive description of phenotype, function and gene expression profiles of PD-1 high versus PD-1 low CD8 T cells in the peripheral blood of healthy human adults as following: 1) The percentage of naive and memory CD8 T cells varied widely in the peripheral blood cells of healthy humans and PD-1 was expressed by the memory CD8 T cells. 2) PD-1 high CD8 T cells in healthy humans did not significantly correlated with the PD-1 high exhausted gene signature of HIV specific human CD8 T cells or chronic LCMV specific CD8 T cells from mice. 3) PD-1 expression did not directly affect the ability of CD8 T cells to secrete cytokines in healthy adults. 4) PD-1 was expressed by the effector memory (TEM) compared to ‘terminally differentiated effector’ (TEMRA) CD8 T cells. 5) Finally, an interesting inverse relationship between CD45RA and PD-1 expression was observed. PMID 21383243 GEOID GSE26495 AUTHORS Duraiswamy J,Ibegbu CC,Masopust D,Miller JD,Araki K,Doho GH,Tata P,Gupta S,Zilliox MJ,Nakaya HI,Pulendran B,Haining WN,Freeman GJ,Ahmed R CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE26495_1502_200_DN FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS ABCA2,ACOT9,ACTN4,ADAM8,ADRB2,AHNAK,ANXA2,ANXA2P2,APOBEC3G,ARF6,ARHGAP25,ARHGAP35,ATP2B4,ATXN1,AUTS2,B4GALT5,BCL2L1,BHLHE40,BLVRA,BZRAP1,C12orf75,C20orf3,C3orf64,CALHM2,CAPN2,CASP1,CAST,CCL5,CCR5,CD58,CD99,CHST11,CLEC2B,CMC1,CNNM3,CPEB2,CST7,CTSC,DERL1,DLG3,DNAJC1,DOK2,DPY19L1,EFHD2,EIF2C4,ELP3,EOMES,EPS15,ERN1,FAM129A,FAM179A,FAS,FCRL3,FGFBP2,FYCO1,FYN,GAB3,GALM,GALNT3,GBP5,GCLM,GFI1,GLCCI1,GLT25D2,GPR114,GPR137B,GPR56,GPR68,GSR,GYG1,GZMA,GZMH,GZMK,HERPUD2,HOPX,HSPB11,IL10RA,IL15,ITCH,ITGAL,JAKMIP1,JAKMIP2,JAZF1,KAT2B,KATNAL1,KIAA0368,KIAA1841,KLF6,KLRD1,KLRG1,LAG3,LOC100507564,LOC144571,LOC285812,LOC339988,LPCAT1,LPP,MAF,MAN1A1,MAP3K5,MAP3K8,MCOLN2,MCTP2,MDFIC,MIAT,MICAL2,MIR155HG,MRPL10,MXRA7,MYBL1,NCRNA00152,NDRG1,NEDD9,NKG7,NPC1,NUDT19,OPTN,OSBPL3,PAM,PDGFD,PHLDB2,PIF1,PIK3R3,PLA2G16,PLCG2,PLCXD2,PLEKHO2,PPP2R2B,PPP4R1,PRF1,PRR5L,PTGDR,PTP4A2,PTPLAD2,PTPN22,PTPRJ,PYHIN1,RAB27A,RAB7L1,RAP1GAP2,RASGEF1A,RGS3,RHBDF2,RHOU,RUNX3,S100A4,SAP30,SEMA4C,SERPINI1,SESN2,SFXN3,SH2B3,SH3BP2,SH3BP5,SLAMF6,SLAMF7,SLC15A4,SLC16A6,SLC27A3,SLC2A1,SLCO3A1,SLFN11,SMAD3,SMAD7,SNTB2,SP140,SPATS2L,SRGAP2,SRXN1,STARD3NL,STOM,SYNE2,SYT11,SYTL3,TARP,TBK1,TBX21,TCIRG1,TGFBR3,TIGIT,TLR3,TMED9,TNFRSF1B,TOB2,TOX,TP53INP1,TPM4,TTC38,TTYH2,USP28,UTRN,VANGL1,WIPI1,WSB2,WWP2,YPEL1,YWHAQ,ZBTB38,ZDHHC14,ZEB2 GENE_SYMBOLS ABCA2,ACOT9,ACTN4,ADAM8,ADRB2,AHNAK,ANXA2,ANXA2P2,APOBEC3G,ARF6,ARHGAP25,ARHGAP35,ATP2B4,ATXN1,AUTS2,B4GALT5,BCL2L1,BHLHE40,BLVRA,TSPOAP1,C12orf75,APMAP,EOGT,CALHM2,CAPN2,CASP1,CAST,CCL5,CCR5,CD58,CD99,CHST11,CLEC2B,CMC1,CNNM3,CPEB2,CST7,CTSC,DERL1,DLG3,DNAJC1,DOK2,DPY19L1,EFHD2,AGO4,ELP3,EOMES,EPS15,ERN1,NIBAN1,TOGARAM2,FAS,FCRL3,FGFBP2,FYCO1,FYN,GAB3,GALM,GALNT3,GBP5,GCLM,GFI1,GLCCI1,COLGALT2,ADGRG5,GPR137B,ADGRG1,GPR68,GSR,GYG1,GZMA,GZMH,GZMK,HERPUD2,HOPX,IFT25,IL10RA,IL15,ITCH,ITGAL,JAKMIP1,JAKMIP2,JAZF1,KAT2B,KATNAL1,ECPAS,SANBR,KLF6,KLRD1,KLRG1,LAG3,MAGOH-DT,A2M-AS1,GFOD1,LINC02481,LPCAT1,LPP,MAF,MAN1A1,MAP3K5,MAP3K8,MCOLN2,MCTP2,MDFIC,MIAT,MICAL2,MIR155HG,MRPL10,MXRA7,MYBL1,CYTOR,NDRG1,NEDD9,NKG7,NPC1,NUDT19,OPTN,OSBPL3,PAM,PDGFD,PHLDB2,PIF1,PIK3R3,PLAAT3,PLCG2,PLCXD2,PLEKHO2,PPP2R2B,PPP4R1,PRF1,PRR5L,PTGDR,PTP4A2,HACD4,PTPN22,PTPRJ,PYHIN1,RAB27A,RAB29,RAP1GAP2,RASGEF1A,RGS3,RHBDF2,RHOU,RUNX3,S100A4,SAP30,SEMA4C,SERPINI1,SESN2,SFXN3,SH2B3,SH3BP2,SH3BP5,SLAMF6,SLAMF7,SLC15A4,SLC16A6,SLC27A3,SLC2A1,SLCO3A1,SLFN11,SMAD3,SMAD7,SNTB2,SP140,SPATS2L,SRGAP2,SRXN1,STARD3NL,STOM,SYNE2,SYT11,SYTL3,TARP,TBK1,TBX21,TCIRG1,TGFBR3,TIGIT,TLR3,TMED9,TNFRSF1B,TOB2,TOX,TP53INP1,TPM4,TTC38,TTYH2,USP28,UTRN,VANGL1,WIPI1,WSB2,WWP2,YPEL1,YWHAQ,ZBTB38,ZDHHC14,ZEB2 FOUNDER_NAMES