STANDARD_NAME GSE26495_PD1HIGH_VS_PD1LOW_CD8_TCELL_UP SYSTEMATIC_NAME M4660 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE26495_PD1HIGH_VS_PD1LOW_CD8_TCELL_UP NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes up-regulated in comparison of PD-1 high CD8 T cells versus PD-1 low CD8 T cells. DESCRIPTION_FULL T cell dysfunction is an important feature of many chronic viral infections. In particular, it was shown that PD-1 regulates T cell dysfunction during chronic LCMV infection in mice and PD-1 high cells exhibit an intense exhausted gene signature. These findings were extended to human chronic infections such as HIV, HCV and HBV. However, it is not known if PD-1 high cells of healthy humans have the traits of exhausted cells. In this study, we provide a comprehensive description of phenotype, function and gene expression profiles of PD-1 high versus PD-1 low CD8 T cells in the peripheral blood of healthy human adults as following: 1) The percentage of naive and memory CD8 T cells varied widely in the peripheral blood cells of healthy humans and PD-1 was expressed by the memory CD8 T cells. 2) PD-1 high CD8 T cells in healthy humans did not significantly correlated with the PD-1 high exhausted gene signature of HIV specific human CD8 T cells or chronic LCMV specific CD8 T cells from mice. 3) PD-1 expression did not directly affect the ability of CD8 T cells to secrete cytokines in healthy adults. 4) PD-1 was expressed by the effector memory (TEM) compared to ‘terminally differentiated effector’ (TEMRA) CD8 T cells. 5) Finally, an interesting inverse relationship between CD45RA and PD-1 expression was observed. PMID 21383243 GEOID GSE26495 AUTHORS Duraiswamy J,Ibegbu CC,Masopust D,Miller JD,Araki K,Doho GH,Tata P,Gupta S,Zilliox MJ,Nakaya HI,Pulendran B,Haining WN,Freeman GJ,Ahmed R CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE26495_1504_200_UP FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS ABCG2,ABTB2,ACOT9,ADAMTS17,ADCK3,ADPRHL1,AMIGO1,AMPD3,ANK2,ANKRD23,AOC3,ARHGAP35,ATP6V1G2,BBS1,BLVRA,BPHL,BRCA1,BTN2A1,C13orf38,C14orf64,C15orf40,C16orf54,C1orf167,C22orf15,C2orf61,C3orf64,C3orf79,C4orf31,C6orf147,CBFA2T2,CCDC62,CCDC64,CCL20,CCL23,CCR4,CD27,CD28,CECR3,CKAP2L,CNNM3,CYAT1,E2F3,EIF3L,EME2,ETS1,EVC2,FAM149A,FAM71F2,FANCD2,FLJ43944,FOXM1,FOXO1,FSD1,FYN,GALM,GAMT,GBP5,GDPD3,GLCCI1,GNAS-AS1,GPR172B,GPR183,GSR,GTPBP3,GZMK,HAUS5,HINT1,HLA-DOA,HNRPLL,ICOS,IL22,IL4,ING5,INMT,ITGA6,ITIH3,JMJD8,KANK2,KCNJ14,KCNQ1,KRT8,KRTAP2-4,LDLRAP1,LMBR1L,LOC100128239,LOC100129166,LOC100130691,LOC100287483,LOC100288418,LOC100288656,LOC100289612,LOC100505746,LOC100506127,LOC100507501,LOC283508,LOC283745,LOC643401,LPCAT2,LPCAT4,LRCH2,LRIG1,LRTOMT,MAN1C1,MBD1,MCF2L-AS1,MEGF6,METTL19,MIR155HG,MMACHC,MMEL1,MYH2,MYO1A,MYRIP,NAT9,NCK2,NCRNA00288,NELL2,NLRP13,NOC2L,NUP188,OLFM4,P2RX5,PBXIP1,PDCD1,PDCD4,PDIA5,PDZK1IP1,PHGDH,PIM2,PINX1,PLA2G2F,PLCG1,PLXND1,PNPLA5,POU2F3,PRDM6,PRG4,PTPN13,PTPRB,PTPRK,RANBP9,RFPL3,RNASET2,RNF214,RPL23AP32,RPS16,RTN4R,RXFP3,SCARB1,SEPT6,SF1,SGPP2,SH3GL1P2,SIRPG,SLAMF1,SLC23A2,SLC24A6,SLC43A3,SLC4A3,SPINK7,ST8SIA1,STK33,STON1,SUGT1P3,TAS2R1,TBC1D4,TCF7,TCL1A,THEMIS,TIMM44,TMC6,TMCC2,TMEM155,TMEM170A,TMEM22,TMEM63C,TMEM66,TNFRSF10B,TNFRSF14,TNFSF8,TRAIP,TRAT1,TRBC1,TTC9,UBA7,USP36,VCAM1,WRAP73,ZBTB8B,ZIK1,ZNF101,ZNF329,ZNF335,ZNF419,ZNF512B,ZNF583,ZNF587,ZNF839,ZNF862,ZP2 GENE_SYMBOLS ABCG2,ABTB2,ACOT9,ADAMTS17,COQ8A,ADPRHL1,AMIGO1,AMPD3,ANK2,ANKRD23,AOC3,ARHGAP35,ATP6V1G2,BBS1,BLVRA,BPHL,BRCA1,BTN2A1,CCDC169,LINC01550,C15orf40,C16orf54,C1orf167,C22orf15,STPG4,EOGT,LINC02877,NDNF,KHDC1,CBFA2T2,CCDC62,BICDL1,CCL20,CCL23,CCR4,CD27,CD28,CECR3,CKAP2L,CNNM3,,E2F3,EIF3L,EME2,ETS1,EVC2,FAM149A,GARIN1A,FANCD2,,FOXM1,FOXO1,FSD1,FYN,GALM,GAMT,GBP5,GDPD3,GLCCI1,GNAS-AS1,SLC52A1,GPR183,GSR,GTPBP3,GZMK,HAUS5,HINT1,HLA-DOA,HNRNPLL,ICOS,IL22,IL4,ING5,INMT,ITGA6,ITIH3,JMJD8,KANK2,KCNJ14,KCNQ1,KRT8,KRTAP2-4,LDLRAP1,LMBR1L,LINC02731,,ENSG00000213963,ELOCP28,,,,ITGB2-AS1,GVQW3,LINC01569,DGKH,,PURPL,LPCAT2,LPCAT4,LRCH2,LRIG1,LRTOMT,MAN1C1,MBD1,MCF2L-AS1,MEGF6,TRMT44,MIR155HG,MMACHC,MMEL1,MYH2,MYO1A,MYRIP,NAT9,NCK2,KIRREL3-AS3,NELL2,NLRP13,NOC2L,NUP188,OLFM4,P2RX5,PBXIP1,PDCD1,PDCD4,PDIA5,PDZK1IP1,PHGDH,PIM2,PINX1,PLA2G2F,PLCG1,PLXND1,PNPLA5,POU2F3,PRDM6,PRG4,PTPN13,PTPRB,PTPRK,RANBP9,RFPL3,RNASET2,RNF214,RPL23AP32,RPS16,RTN4R,RXFP3,SCARB1,SEPTIN6,SF1,SGPP2,SH3GL1P2,SIRPG,SLAMF1,SLC23A2,SLC8B1,SLC43A3,SLC4A3,SPINK7,ST8SIA1,STK33,STON1,SUGT1P3,TAS2R1,TBC1D4,TCF7,TCL1A,THEMIS,TIMM44,TMC6,TMCC2,,TMEM170A,SLC35G2,TMEM63C,SARAF,TNFRSF10B,TNFRSF14,TNFSF8,TRAIP,TRAT1,TRBC1,TTC9,UBA7,USP36,VCAM1,WRAP73,ZBTB8B,ZIK1,ZNF101,ZNF329,ZNF335,ZNF419,ZNF512B,ZNF583,ZNF587,ZNF839,ZNF862,ZP2 FOUNDER_NAMES