STANDARD_NAME	GSE27434_WT_VS_DNMT1_KO_TREG_UP
SYSTEMATIC_NAME	M9620
COLLECTION	C7:IMMUNESIGDB
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE27434_WT_VS_DNMT1_KO_TREG_UP
NAMESPACE	HUMAN_GENE_SYMBOL
DESCRIPTION_BRIEF	Genes up-regulated in T reg: wildtype versus DNMT1 [GeneID=1786] knockout.
DESCRIPTION_FULL	We investigated the role of DNMT1 in immune homeostasis by generating mice lacking DNMT1 in Foxp3+ T-regulatory (Treg) cells. These mice showed decreased peripheral Foxp3+ Tregs, complete loss of Foxp3+ Treg suppressive functions in vitro and in vivo, and died from autoimmunity by 3-4 weeks unless they received perinatal transfer of wild-type Tregs that prolonged their survival. Methylation of CpG-sites in the TSDR region of Foxp3 was unaffected by DNMT1 deletion, but microarray revealed more >500 proinflammatory and other genes were upregulated in DNMT1-/- Tregs. CD4-Cre-mediated DNMT1 deletion showed inability of conventional T cells to convert to Foxp3+ Treg under appropriate polarizing conditions. Hence, DNMT1 is absolutely necessary for maintenance of the gene program required for normal Treg development and function.
PMID	23444399
GEOID	GSE27434
AUTHORS	Wang L,Liu Y,Beier UH,Han R,Bhatti TR,Akimova T,Hancock WW
CONTRIBUTOR	Jernej Godec
CONTRIBUTOR_ORG	Dana-Farber Cancer Institute
EXACT_SOURCE	GSE27434_3798_200_UP
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	ABCC5,ACVRL1,ADAM28,AES,AKAP1,ALDOAP2,AMMECR1L,ANAPC11,ANKZF1,APOA1BP,ARL10,ATP5L,ATP6V0A2,ATP6V0E1,B3GALT4,BAK1,BCAT2,BMP10,C11orf31,C11orf73,C17orf48,C17orf62,C19orf6,C1orf63,C1QB,C22orf32,C7orf43,C9orf23,CAPNS1,CASP9,CD99,CDC37,CDCA7L,CDK4,CDT1,CEP89,CHORDC1,CIAO1,CLN6,CLTA,COL13A1,COL4A4,COTL1,CRISP2,CSK,CSNK1G2,CTSA,CTSE,CTSG,CTSW,DAD1,DAP,DCTN3,DDX27,DDX39B,DFFA,DLGAP5,DYNLL1,ECH1,EFNA1,EIF3K,ENO1,ERP29,ESRRA,ETHE1,EYA4,FAF1,FAM100B,FASTK,FES,FGF12,FKBP8,FLCN,FLT1,FRAT1,GLI1,GNAS,GOLGA3,GRN,GTF3C1,GUK1,HFE,HMHA1,HRAS,HSF1,IBSP,ING4,INTS3,ISYNA1,JMJD8,JOSD2,KCNJ9,KCNK1,KLRAQ1,KRT6A,LMAN2,LMF1,LOC152217,LRP10,LSMD1,LYPLA2,MAN2B1,MBD3,MBD4,MFNG,MFSD5,MKNK2,MRPL44,MRPS12,MXD4,NBR1,NDUFS3,NME6,NR2C2AP,NUBP1,OGDH,PAFAH1B3,PAM,PCK2,PDZK1,PKIG,PLEKHO1,PNKP,PPFIA4,PPIB,PRKACA,PRKCD,PRKCSH,PROM1,PRPF31,PSMB6,PSMD3,PTCD2,PTOV1,RAB4A,RAD1,RAD50,RBCK1,RBL1,RBM42,RCVRN,RDBP,REEP5,RERE,RGL2,RING1,RNF26,RPL19,RPL28,RPL34,RPS23,RPS5,RPS6KB2,SAMM50,SAP30,SART3,SCEL,SCNM1,SDC3,SDHC,SEC24C,SEC61A1,SEC61B,SEMA4A,SESN1,SH2D1B,SHE,SLC2A4,SLC35A1,SLC38A10,SLC39A3,SLC50A1,SLC6A13,SNRPB,SPSB2,SRP9,STX18,SYNJ2BP,SYT17,TCAP,TFIP11,TM7SF2,TMEM179B,TMEM70,TPI1,TXNIP,TYMP,UBE4B,UQCRC1,USP29,USP5,VIPR2,XRCC1,XRN1,YIF1A,YIPF3,ZFYVE19,ZNF276,ZNF574,ZNF808
GENE_SYMBOLS	ABCC5,ACVRL1,ADAM28,TLE5,AKAP1,ALDOAP2,AMMECR1L,ANAPC11,ANKZF1,NAXE,ARL10,ATP5MG,ATP6V0A2,ATP6V0E1,B3GALT4,BAK1,BCAT2,BMP10,SELENOH,HIKESHI,ADPRM,CYBC1,TMEM259,C1QB,RSRP1,SMDT1,TRAPPC14,RPP25L,CAPNS1,CASP9,CD99,CDC37,CDCA7L,CDK4,CDT1,CEP89,CHORDC1,CIAO1,CLN6,CLTA,COL13A1,COL4A4,COTL1,CRISP2,CSK,CSNK1G2,CTSA,CTSE,CTSG,CTSW,DAD1,DAP,DCTN3,DDX27,DDX39B,DFFA,DLGAP5,DYNLL1,ECH1,EFNA1,EIF3K,ENO1,ERP29,ESRRA,ETHE1,EYA4,FAF1,UBALD2,FASTK,FES,FGF12,FKBP8,FLCN,FLT1,FRAT1,GLI1,GNAS,GOLGA3,GRN,GTF3C1,GUK1,HFE,ARHGAP45,HRAS,HSF1,IBSP,ING4,INTS3,ISYNA1,JMJD8,JOSD2,KCNJ9,KCNK1,PPP1R21,KRT6A,LMAN2,LMF1,NCBP2AS2,LRP10,NAA38,LYPLA2,MAN2B1,MBD3,MBD4,MFNG,MFSD5,MKNK2,MRPL44,MRPS12,MXD4,NBR1,NDUFS3,NME6,NR2C2AP,NUBP1,OGDH,PAFAH1B3,PAM,PCK2,PDZK1,PKIG,PLEKHO1,PNKP,PPFIA4,PPIB,PRKACA,PRKCD,PRKCSH,PROM1,PRPF31,PSMB6,PSMD3,PTCD2,PTOV1,RAB4A,RAD1,RAD50,RBCK1,RBL1,RBM42,RCVRN,NELFE,REEP5,RERE,RGL2,RING1,RNF26,RPL19,RPL28,RPL34,RPS23,RPS5,RPS6KB2,SAMM50,SAP30,SART3,SCEL,SCNM1,SDC3,SDHC,SEC24C,SEC61A1,SEC61B,SEMA4A,SESN1,SH2D1B,SHE,SLC2A4,SLC35A1,SLC38A10,SLC39A3,SLC50A1,SLC6A13,SNRPB,SPSB2,SRP9,STX18,SYNJ2BP,SYT17,TCAP,TFIP11,TM7SF2,TMEM179B,TMEM70,TPI1,TXNIP,TYMP,UBE4B,UQCRC1,USP29,USP5,VIPR2,XRCC1,XRN1,YIF1A,YIPF3,ZFYVE19,ZNF276,ZNF574,ZNF808
FOUNDER_NAMES