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<MSIGDB BUILD_DATE="Jan 29, 2026" VERSION="2026.1.Hs" NAME="export">
    <GENESET STANDARD_NAME="GSE27434_WT_VS_DNMT1_KO_TREG_UP" SYSTEMATIC_NAME="M9620" HISTORICAL_NAMES="" PMID="23444399" AUTHORS="Wang L,Liu Y,Beier UH,Han R,Bhatti TR,Akimova T,Hancock WW" GEOID="GSE27434" EXACT_SOURCE="GSE27434_3798_200_UP" GENESET_LISTING_URL="" EXTERNAL_DETAILS_URL="" CHIP="HUMAN_GENE_SYMBOL" CONTRIBUTOR="Jernej Godec" CONTRIBUTOR_ORG="Dana-Farber Cancer Institute" DESCRIPTION_BRIEF="Genes up-regulated in T reg: wildtype versus DNMT1 [GeneID=1786] knockout." DESCRIPTION_FULL="We investigated the role of DNMT1 in immune homeostasis by generating mice lacking DNMT1 in Foxp3+ T-regulatory (Treg) cells. These mice showed decreased peripheral Foxp3+ Tregs, complete loss of Foxp3+ Treg suppressive functions in vitro and in vivo, and died from autoimmunity by 3-4 weeks unless they received perinatal transfer of wild-type Tregs that prolonged their survival. Methylation of CpG-sites in the TSDR region of Foxp3 was unaffected by DNMT1 deletion, but microarray revealed more &gt;500 proinflammatory and other genes were upregulated in DNMT1-/- Tregs. CD4-Cre-mediated DNMT1 deletion showed inability of conventional T cells to convert to Foxp3+ Treg under appropriate polarizing conditions. Hence, DNMT1 is absolutely necessary for maintenance of the gene program required for normal Treg development and function." TAGS="" MEMBERS="ABCC5,ACVRL1,ADAM28,AES,AKAP1,ALDOAP2,AMMECR1L,ANAPC11,ANKZF1,APOA1BP,ARL10,ATP5L,ATP6V0A2,ATP6V0E1,B3GALT4,BAK1,BCAT2,BMP10,C11orf31,C11orf73,C17orf48,C17orf62,C19orf6,C1orf63,C1QB,C22orf32,C7orf43,C9orf23,CAPNS1,CASP9,CD99,CDC37,CDCA7L,CDK4,CDT1,CEP89,CHORDC1,CIAO1,CLN6,CLTA,COL13A1,COL4A4,COTL1,CRISP2,CSK,CSNK1G2,CTSA,CTSE,CTSG,CTSW,DAD1,DAP,DCTN3,DDX27,DDX39B,DFFA,DLGAP5,DYNLL1,ECH1,EFNA1,EIF3K,ENO1,ERP29,ESRRA,ETHE1,EYA4,FAF1,FAM100B,FASTK,FES,FGF12,FKBP8,FLCN,FLT1,FRAT1,GLI1,GNAS,GOLGA3,GRN,GTF3C1,GUK1,HFE,HMHA1,HRAS,HSF1,IBSP,ING4,INTS3,ISYNA1,JMJD8,JOSD2,KCNJ9,KCNK1,KLRAQ1,KRT6A,LMAN2,LMF1,LOC152217,LRP10,LSMD1,LYPLA2,MAN2B1,MBD3,MBD4,MFNG,MFSD5,MKNK2,MRPL44,MRPS12,MXD4,NBR1,NDUFS3,NME6,NR2C2AP,NUBP1,OGDH,PAFAH1B3,PAM,PCK2,PDZK1,PKIG,PLEKHO1,PNKP,PPFIA4,PPIB,PRKACA,PRKCD,PRKCSH,PROM1,PRPF31,PSMB6,PSMD3,PTCD2,PTOV1,RAB4A,RAD1,RAD50,RBCK1,RBL1,RBM42,RCVRN,RDBP,REEP5,RERE,RGL2,RING1,RNF26,RPL19,RPL28,RPL34,RPS23,RPS5,RPS6KB2,SAMM50,SAP30,SART3,SCEL,SCNM1,SDC3,SDHC,SEC24C,SEC61A1,SEC61B,SEMA4A,SESN1,SH2D1B,SHE,SLC2A4,SLC35A1,SLC38A10,SLC39A3,SLC50A1,SLC6A13,SNRPB,SPSB2,SRP9,STX18,SYNJ2BP,SYT17,TCAP,TFIP11,TM7SF2,TMEM179B,TMEM70,TPI1,TXNIP,TYMP,UBE4B,UQCRC1,USP29,USP5,VIPR2,XRCC1,XRN1,YIF1A,YIPF3,ZFYVE19,ZNF276,ZNF574,ZNF808" MEMBERS_SYMBOLIZED="ABCC5,ACVRL1,ADAM28,ADPRM,AKAP1,ALDOAP2,AMMECR1L,ANAPC11,ANKZF1,ARHGAP45,ARL10,ATP5MG,ATP6V0A2,ATP6V0E1,B3GALT4,BAK1,BCAT2,BMP10,C1QB,CAPNS1,CASP9,CD99,CDC37,CDCA7L,CDK4,CDT1,CEP89,CHORDC1,CIAO1,CLN6,CLTA,COL13A1,COL4A4,COTL1,CRISP2,CSK,CSNK1G2,CTSA,CTSE,CTSG,CTSW,CYBC1,DAD1,DAP,DCTN3,DDX27,DDX39B,DFFA,DLGAP5,DYNLL1,ECH1,EFNA1,EIF3K,ENO1,ERP29,ESRRA,ETHE1,EYA4,FAF1,FASTK,FES,FGF12,FKBP8,FLCN,FLT1,FRAT1,GLI1,GNAS,GOLGA3,GRN,GTF3C1,GUK1,HFE,HIKESHI,HRAS,HSF1,IBSP,ING4,INTS3,ISYNA1,JMJD8,JOSD2,KCNJ9,KCNK1,KRT6A,LMAN2,LMF1,LRP10,LYPLA2,MAN2B1,MBD3,MBD4,MFNG,MFSD5,MKNK2,MRPL44,MRPS12,MXD4,NAA38,NAXE,NBR1,NCBP2AS2,NDUFS3,NELFE,NME6,NR2C2AP,NUBP1,OGDH,PAFAH1B3,PAM,PCK2,PDZK1,PKIG,PLEKHO1,PNKP,PPFIA4,PPIB,PPP1R21,PRKACA,PRKCD,PRKCSH,PROM1,PRPF31,PSMB6,PSMD3,PTCD2,PTOV1,RAB4A,RAD1,RAD50,RBCK1,RBL1,RBM42,RCVRN,REEP5,RERE,RGL2,RING1,RNF26,RPL19,RPL28,RPL34,RPP25L,RPS23,RPS5,RPS6KB2,RSRP1,SAMM50,SAP30,SART3,SCEL,SCNM1,SDC3,SDHC,SEC24C,SEC61A1,SEC61B,SELENOH,SEMA4A,SESN1,SH2D1B,SHE,SLC2A4,SLC35A1,SLC38A10,SLC39A3,SLC50A1,SLC6A13,SMDT1,SNRPB,SPSB2,SRP9,STX18,SYNJ2BP,SYT17,TCAP,TFIP11,TLE5,TM7SF2,TMEM179B,TMEM259,TMEM70,TPI1,TRAPPC14,TXNIP,TYMP,UBALD2,UBE4B,UQCRC1,USP29,USP5,VIPR2,XRCC1,XRN1,YIF1A,YIPF3,ZFYVE19,ZNF276,ZNF574,ZNF808" MEMBERS_EZID="10023,10057,10111,1019,10201,10277,10559,10608,10616,10628,10632,10863,10897,10922,10952,10960,10961,11124,11140,11142,11258,11284,11313,117157,1211,124565,126119,126382,126669,128240,1286,129285,1305,138716,1445,1455,1510,1511,1521,152217,1603,1611,166,1676,1890,1891,1942,201163,2023,2070,2101,2242,2257,228,2321,23406,23474,23526,23545,23770,24144,25813,25844,26020,26121,26973,27244,27302,27335,2735,2778,2802,280636,283991,285598,2872,2896,2975,2987,29927,29985,3077,3265,3297,3381,339123,374395,3765,3775,3853,388558,4077,4125,4242,4267,4682,4722,473,4967,5050,5066,5106,51147,51177,51477,51501,51529,5174,51760,53407,53615,53635,54464,5476,5479,54968,54982,55139,55262,55333,55536,5566,55661,5580,5589,55974,5694,56985,57035,5709,57663,578,5810,5863,5867,587,5933,5957,6015,6143,6158,6164,6183,6193,6199,6228,6391,64218,64763,64788,65080,65123,6517,6540,6628,6726,7108,713,7167,7180,7384,7434,7515,79005,7905,79102,79171,7919,7936,79415,79810,8078,81620,8165,826,83607,842,84316,84727,84902,84936,8497,84975,8557,8655,8705,8796,8819,8842,8930,8992,91304,91689,92822,9391,94,9632,9672,9733,9787" MEMBERS_MAPPING="ABCC5,ABCC5,10057|ACVRL1,ACVRL1,94|ADAM28,ADAM28,10863|AES,TLE5,166|AKAP1,AKAP1,8165|ALDOAP2,ALDOAP2,228|AMMECR1L,AMMECR1L,83607|ANAPC11,ANAPC11,51529|ANKZF1,ANKZF1,55139|APOA1BP,NAXE,128240|ARL10,ARL10,285598|ATP5L,ATP5MG,10632|ATP6V0A2,ATP6V0A2,23545|ATP6V0E1,ATP6V0E1,8992|B3GALT4,B3GALT4,8705|BAK1,BAK1,578|BCAT2,BCAT2,587|BMP10,BMP10,27302|C11orf31,SELENOH,280636|C11orf73,HIKESHI,51501|C17orf48,ADPRM,56985|C17orf62,CYBC1,79415|C19orf6,TMEM259,91304|C1QB,C1QB,713|C1orf63,RSRP1,57035|C22orf32,SMDT1,91689|C7orf43,TRAPPC14,55262|C9orf23,RPP25L,138716|CAPNS1,CAPNS1,826|CASP9,CASP9,842|CD99,CD99,4267|CDC37,CDC37,11140|CDCA7L,CDCA7L,55536|CDK4,CDK4,1019|CDT1,CDT1,81620|CEP89,CEP89,84902|CHORDC1,CHORDC1,26973|CIAO1,CIAO1,9391|CLN6,CLN6,54982|CLTA,CLTA,1211|COL13A1,COL13A1,1305|COL4A4,COL4A4,1286|COTL1,COTL1,23406|CRISP2,CRISP2,7180|CSK,CSK,1445|CSNK1G2,CSNK1G2,1455|CTSA,CTSA,5476|CTSE,CTSE,1510|CTSG,CTSG,1511|CTSW,CTSW,1521|DAD1,DAD1,1603|DAP,DAP,1611|DCTN3,DCTN3,11258|DDX27,DDX27,55661|DDX39B,DDX39B,7919|DFFA,DFFA,1676|DLGAP5,DLGAP5,9787|DYNLL1,DYNLL1,8655|ECH1,ECH1,1891|EFNA1,EFNA1,1942|EIF3K,EIF3K,27335|ENO1,ENO1,2023|ERP29,ERP29,10961|ESRRA,ESRRA,2101|ETHE1,ETHE1,23474|EYA4,EYA4,2070|FAF1,FAF1,11124|FAM100B,UBALD2,283991|FASTK,FASTK,10922|FES,FES,2242|FGF12,FGF12,2257|FKBP8,FKBP8,23770|FLCN,FLCN,201163|FLT1,FLT1,2321|FRAT1,FRAT1,10023|GLI1,GLI1,2735|GNAS,GNAS,2778|GOLGA3,GOLGA3,2802|GRN,GRN,2896|GTF3C1,GTF3C1,2975|GUK1,GUK1,2987|HFE,HFE,3077|HMHA1,ARHGAP45,23526|HRAS,HRAS,3265|HSF1,HSF1,3297|IBSP,IBSP,3381|ING4,ING4,51147|INTS3,INTS3,65123|ISYNA1,ISYNA1,51477|JMJD8,JMJD8,339123|JOSD2,JOSD2,126119|KCNJ9,KCNJ9,3765|KCNK1,KCNK1,3775|KLRAQ1,PPP1R21,129285|KRT6A,KRT6A,3853|LMAN2,LMAN2,10960|LMF1,LMF1,64788|LOC152217,NCBP2AS2,152217|LRP10,LRP10,26020|LSMD1,NAA38,84316|LYPLA2,LYPLA2,11313|MAN2B1,MAN2B1,4125|MBD3,MBD3,53615|MBD4,MBD4,8930|MFNG,MFNG,4242|MFSD5,MFSD5,84975|MKNK2,MKNK2,2872|MRPL44,MRPL44,65080|MRPS12,MRPS12,6183|MXD4,MXD4,10608|NBR1,NBR1,4077|NDUFS3,NDUFS3,4722|NME6,NME6,10201|NR2C2AP,NR2C2AP,126382|NUBP1,NUBP1,4682|OGDH,OGDH,4967|PAFAH1B3,PAFAH1B3,5050|PAM,PAM,5066|PCK2,PCK2,5106|PDZK1,PDZK1,5174|PKIG,PKIG,11142|PLEKHO1,PLEKHO1,51177|PNKP,PNKP,11284|PPFIA4,PPFIA4,8497|PPIB,PPIB,5479|PRKACA,PRKACA,5566|PRKCD,PRKCD,5580|PRKCSH,PRKCSH,5589|PROM1,PROM1,8842|PRPF31,PRPF31,26121|PSMB6,PSMB6,5694|PSMD3,PSMD3,5709|PTCD2,PTCD2,79810|PTOV1,PTOV1,53635|RAB4A,RAB4A,5867|RAD1,RAD1,5810|RAD50,RAD50,10111|RBCK1,RBCK1,10616|RBL1,RBL1,5933|RBM42,RBM42,79171|RCVRN,RCVRN,5957|RDBP,NELFE,7936|REEP5,REEP5,7905|RERE,RERE,473|RGL2,RGL2,5863|RING1,RING1,6015|RNF26,RNF26,79102|RPL19,RPL19,6143|RPL28,RPL28,6158|RPL34,RPL34,6164|RPS23,RPS23,6228|RPS5,RPS5,6193|RPS6KB2,RPS6KB2,6199|SAMM50,SAMM50,25813|SAP30,SAP30,8819|SART3,SART3,9733|SCEL,SCEL,8796|SCNM1,SCNM1,79005|SDC3,SDC3,9672|SDHC,SDHC,6391|SEC24C,SEC24C,9632|SEC61A1,SEC61A1,29927|SEC61B,SEC61B,10952|SEMA4A,SEMA4A,64218|SESN1,SESN1,27244|SH2D1B,SH2D1B,117157|SHE,SHE,126669|SLC2A4,SLC2A4,6517|SLC35A1,SLC35A1,10559|SLC38A10,SLC38A10,124565|SLC39A3,SLC39A3,29985|SLC50A1,SLC50A1,55974|SLC6A13,SLC6A13,6540|SNRPB,SNRPB,6628|SPSB2,SPSB2,84727|SRP9,SRP9,6726|STX18,STX18,53407|SYNJ2BP,SYNJ2BP,55333|SYT17,SYT17,51760|TCAP,TCAP,8557|TFIP11,TFIP11,24144|TM7SF2,TM7SF2,7108|TMEM179B,TMEM179B,374395|TMEM70,TMEM70,54968|TPI1,TPI1,7167|TXNIP,TXNIP,10628|TYMP,TYMP,1890|UBE4B,UBE4B,10277|UQCRC1,UQCRC1,7384|USP29,USP29,57663|USP5,USP5,8078|VIPR2,VIPR2,7434|XRCC1,XRCC1,7515|XRN1,XRN1,54464|YIF1A,YIF1A,10897|YIPF3,YIPF3,25844|ZFYVE19,ZFYVE19,84936|ZNF276,ZNF276,92822|ZNF574,ZNF574,64763|ZNF808,ZNF808,388558" FILTERED_BY_SIMILARITY="" FOUNDER_NAMES="" REFINEMENT_DATASETS="" VALIDATION_DATASETS="" CATEGORY_CODE="C7" ORGANISM="Mus musculus" SUB_CATEGORY_CODE="IMMUNESIGDB"/>
</MSIGDB>
