STANDARD_NAME GSE2770_IL12_ACT_VS_ACT_CD4_TCELL_48H_DN SYSTEMATIC_NAME M6033 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE2770_IL12_ACT_VS_ACT_CD4_TCELL_48H_DN NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes down-regulated in CD4 [GeneID=920] T cells activated by anti-CD3 and anti-CD28: IL-12 (48h) versus untreated (48h). DESCRIPTION_FULL Th1 and Th2 cells arise from a common precursor cell in response to triggering through the TCR and cytokine receptors for IL-12 or IL-4. This leads to activation of complex signaling pathways, which are not known in detail. Disturbances in the balance between type 1 and type 2 responses can lead to certain immune-mediated diseases. Thus, it is important to understand how Th1 and Th2 cells are generated. To clarify the mechanisms as to how IL-12 and IL-4 induce Th1 and Th2 differentiation and how TGF-beta can inhibit this process, we have used oligonucleotide arrays to examine the early polarization of Th1 and Th2 cells in the presence and absence of TGF-beta after 0, 2, 6 and 48 hours of polarization. PMID 14607935 GEOID GSE2770 AUTHORS Lund R,Aittokallio T,Nevalainen O,Lahesmaa R CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE2770_2800_200_DN FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS ADAMTS6,ADNP2,AIM1L,ANAPC11,AP1B1,ATP10D,BATF,BRAT1,BRD9,BRIP1,C10orf76,C12orf49,C16orf57,C16orf87,C17orf79,C17orf96,C18orf54,C1orf55,C20orf20,C20orf7,CAB39L,CASC5,CBX2,CBX7,CCT2,CD79A,CDCA3,CDK2,CEP250,CHCHD10,CLUAP1,CMTM3,COPG2,CORO1A,CROCC,CRTC2,CS,CTSH,DCAKD,DDX47,DFFA,DHX37,DIAPH2,DMXL2,DNAJC17,DTYMK,DUS2L,DYRK1A,EGR3,EHBP1L1,ESCO2,EZR,FAM134C,FAM160A1,FAM160A2,FASTKD3,FAU,FBXO10,FCHSD2,FLT3,FMR1,FRMD5,FUBP3,GALNT12,GGT7,GMEB1,GMNN,GRB2,HAUS2,HIC1,HNRNPA2B1,IGF2BP3,IL2RB,IPO5,IQCE,IRF5,ITPA,ITPR3,KCNS1,KCTD20,KDM1A,KIAA0101,KIF22,KLHL14,KLRAQ1,KPNA4,KRAS,KTN1,LITAF,LOC100506612,LRRC16B,LSM2,MAP2,MAPK11,MAX,MDC1,MED11,MGA,MIDN,MIF,MSL3,MTBP,MTMR3,MTPN,MUTYH,MYCBP2,MZT1,NAA50,NAAA,NACC1,NARG2,NCKIPSD,NEIL1,NFATC2IP,NPM1,NSUN5,NUF2,NUP54,OR4C3,ORMDL1,OSGIN2,PARP3,PCM1,PCTP,PDHX,PDIK1L,PDZD3,PHF2,PIF1,PKIB,PLCB3,PLEKHO2,POGK,POLR1B,POLR3B,PPIE,PPP3CB,PRDM16,PRMT5,PTEN,PVT1,QSER1,RABEP1,RANBP17,RAPGEF1,RBL1,RFX2,RFX7,RGS12,RGS19,RHEBL1,RIPK2,RNF41,RPGR,RPGRIP1,RPS6KA3,RQCD1,RRAS2,SAMD11,SEC22C,SETX,SGK223,SGSH,SIAH1,SLC25A37,SLC29A1,SLC4A8,SMARCC1,SNRPD1,SRBD1,SS18,ST13,STAG1,STIL,TAF4,TBC1D10C,TMEM216,TMX4,TOP2B,TPK1,TRIM59,TSN,TTC21B,TTC39B,TUBGCP6,TUSC3,TWISTNB,ULBP1,UNC119B,URB2,VHL,VPS33A,VSNL1,ZBTB43,ZCCHC2,ZMIZ1,ZNF395,ZNF48,ZNF507,ZNF579 GENE_SYMBOLS ADAMTS6,ADNP2,CRYBG2,ANAPC11,AP1B1,ATP10D,BATF,BRAT1,BRD9,BRIP1,ARMH3,SPRING1,USB1,C16orf87,COPRS,EPOP,C18orf54,SDE2,MRGBP,NDUFAF5,CAB39L,KNL1,CBX2,CBX7,CCT2,CD79A,CDCA3,CDK2,CEP250,CHCHD10,CLUAP1,CMTM3,COPG2,CORO1A,CROCC,CRTC2,CS,CTSH,DCAKD,DDX47,DFFA,DHX37,DIAPH2,DMXL2,DNAJC17,DTYMK,DUS2,DYRK1A,EGR3,EHBP1L1,ESCO2,EZR,RETREG3,FHIP1A,FHIP1B,FASTKD3,FAU,FBXO10,FCHSD2,FLT3,FMR1,FRMD5,FUBP3,GALNT12,GGT7,GMEB1,GMNN,GRB2,HAUS2,HIC1,HNRNPA2B1,IGF2BP3,IL2RB,IPO5,IQCE,IRF5,ITPA,ITPR3,KCNS1,KCTD20,KDM1A,PCLAF,KIF22,KLHL14,PPP1R21,KPNA4,KRAS,KTN1,LITAF,,CARMIL3,LSM2,MAP2,MAPK11,MAX,MDC1,MED11,MGA,MIDN,MIF,MSL3,MTBP,MTMR3,MTPN,MUTYH,MYCBP2,MZT1,NAA50,NAAA,NACC1,ICE2,NCKIPSD,NEIL1,NFATC2IP,NPM1,NSUN5,NUF2,NUP54,OR4C3,ORMDL1,OSGIN2,PARP3,PCM1,PCTP,PDHX,PDIK1L,NHERF4,PHF2,PIF1,PKIB,PLCB3,PLEKHO2,POGK,POLR1B,POLR3B,PPIE,PPP3CB,PRDM16,PRMT5,PTEN,PVT1,QSER1,RABEP1,RANBP17,RAPGEF1,RBL1,RFX2,RFX7,RGS12,RGS19,RHEBL1,RIPK2,RNF41,RPGR,RPGRIP1,RPS6KA3,CNOT9,RRAS2,SAMD11,SEC22C,SETX,,SGSH,SIAH1,SLC25A37,SLC29A1,SLC4A8,SMARCC1,SNRPD1,SRBD1,SS18,ST13,STAG1,STIL,TAF4,TBC1D10C,TMEM216,TMX4,TOP2B,TPK1,TRIM59,TSN,TTC21B,TTC39B,TUBGCP6,TUSC3,POLR1F,ULBP1,UNC119B,URB2,VHL,VPS33A,VSNL1,ZBTB43,ZCCHC2,ZMIZ1,ZNF395,ZNF48,ZNF507,ZNF579 FOUNDER_NAMES