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<MSIGDB BUILD_DATE="Jan 29, 2026" VERSION="2026.1.Hs" NAME="export">
    <GENESET STANDARD_NAME="GSE2770_IL12_ACT_VS_ACT_CD4_TCELL_48H_DN" SYSTEMATIC_NAME="M6033" HISTORICAL_NAMES="" PMID="14607935" AUTHORS="Lund R,Aittokallio T,Nevalainen O,Lahesmaa R" GEOID="GSE2770" EXACT_SOURCE="GSE2770_2800_200_DN" GENESET_LISTING_URL="" EXTERNAL_DETAILS_URL="" CHIP="HUMAN_GENE_SYMBOL" CONTRIBUTOR="Jernej Godec" CONTRIBUTOR_ORG="Dana-Farber Cancer Institute" DESCRIPTION_BRIEF="Genes down-regulated in CD4 [GeneID=920] T cells activated by anti-CD3 and anti-CD28: IL-12 (48h) versus untreated (48h)." DESCRIPTION_FULL="Th1 and Th2 cells arise from a common precursor cell in response to triggering through the TCR and cytokine receptors for IL-12 or IL-4. This leads to activation of complex signaling pathways, which are not known in detail. Disturbances in the balance between type 1 and type 2 responses can lead to certain immune-mediated diseases. Thus, it is important to understand how Th1 and Th2 cells are generated. To clarify the mechanisms as to how IL-12 and IL-4 induce Th1 and Th2 differentiation and how TGF-beta can inhibit this process, we have used oligonucleotide arrays to examine the early polarization of Th1 and Th2 cells in the presence and absence of TGF-beta after 0, 2, 6 and 48 hours of polarization." TAGS="" MEMBERS="ADAMTS6,ADNP2,AIM1L,ANAPC11,AP1B1,ATP10D,BATF,BRAT1,BRD9,BRIP1,C10orf76,C12orf49,C16orf57,C16orf87,C17orf79,C17orf96,C18orf54,C1orf55,C20orf20,C20orf7,CAB39L,CASC5,CBX2,CBX7,CCT2,CD79A,CDCA3,CDK2,CEP250,CHCHD10,CLUAP1,CMTM3,COPG2,CORO1A,CROCC,CRTC2,CS,CTSH,DCAKD,DDX47,DFFA,DHX37,DIAPH2,DMXL2,DNAJC17,DTYMK,DUS2L,DYRK1A,EGR3,EHBP1L1,ESCO2,EZR,FAM134C,FAM160A1,FAM160A2,FASTKD3,FAU,FBXO10,FCHSD2,FLT3,FMR1,FRMD5,FUBP3,GALNT12,GGT7,GMEB1,GMNN,GRB2,HAUS2,HIC1,HNRNPA2B1,IGF2BP3,IL2RB,IPO5,IQCE,IRF5,ITPA,ITPR3,KCNS1,KCTD20,KDM1A,KIAA0101,KIF22,KLHL14,KLRAQ1,KPNA4,KRAS,KTN1,LITAF,LOC100506612,LRRC16B,LSM2,MAP2,MAPK11,MAX,MDC1,MED11,MGA,MIDN,MIF,MSL3,MTBP,MTMR3,MTPN,MUTYH,MYCBP2,MZT1,NAA50,NAAA,NACC1,NARG2,NCKIPSD,NEIL1,NFATC2IP,NPM1,NSUN5,NUF2,NUP54,OR4C3,ORMDL1,OSGIN2,PARP3,PCM1,PCTP,PDHX,PDIK1L,PDZD3,PHF2,PIF1,PKIB,PLCB3,PLEKHO2,POGK,POLR1B,POLR3B,PPIE,PPP3CB,PRDM16,PRMT5,PTEN,PVT1,QSER1,RABEP1,RANBP17,RAPGEF1,RBL1,RFX2,RFX7,RGS12,RGS19,RHEBL1,RIPK2,RNF41,RPGR,RPGRIP1,RPS6KA3,RQCD1,RRAS2,SAMD11,SEC22C,SETX,SGK223,SGSH,SIAH1,SLC25A37,SLC29A1,SLC4A8,SMARCC1,SNRPD1,SRBD1,SS18,ST13,STAG1,STIL,TAF4,TBC1D10C,TMEM216,TMX4,TOP2B,TPK1,TRIM59,TSN,TTC21B,TTC39B,TUBGCP6,TUSC3,TWISTNB,ULBP1,UNC119B,URB2,VHL,VPS33A,VSNL1,ZBTB43,ZCCHC2,ZMIZ1,ZNF395,ZNF48,ZNF507,ZNF579" MEMBERS_SYMBOLIZED="ADAMTS6,ADNP2,ANAPC11,AP1B1,ARMH3,ATP10D,BATF,BRAT1,BRD9,BRIP1,C16orf87,C18orf54,CAB39L,CARMIL3,CBX2,CBX7,CCT2,CD79A,CDCA3,CDK2,CEP250,CHCHD10,CLUAP1,CMTM3,CNOT9,COPG2,COPRS,CORO1A,CROCC,CRTC2,CRYBG2,CS,CTSH,DCAKD,DDX47,DFFA,DHX37,DIAPH2,DMXL2,DNAJC17,DTYMK,DUS2,DYRK1A,EGR3,EHBP1L1,EPOP,ESCO2,EZR,FASTKD3,FAU,FBXO10,FCHSD2,FHIP1A,FHIP1B,FLT3,FMR1,FRMD5,FUBP3,GALNT12,GGT7,GMEB1,GMNN,GRB2,HAUS2,HIC1,HNRNPA2B1,ICE2,IGF2BP3,IL2RB,IPO5,IQCE,IRF5,ITPA,ITPR3,KCNS1,KCTD20,KDM1A,KIF22,KLHL14,KNL1,KPNA4,KRAS,KTN1,LITAF,LSM2,MAP2,MAPK11,MAX,MDC1,MED11,MGA,MIDN,MIF,MRGBP,MSL3,MTBP,MTMR3,MTPN,MUTYH,MYCBP2,MZT1,NAA50,NAAA,NACC1,NCKIPSD,NDUFAF5,NEIL1,NFATC2IP,NHERF4,NPM1,NSUN5,NUF2,NUP54,OR4C3,ORMDL1,OSGIN2,PARP3,PCLAF,PCM1,PCTP,PDHX,PDIK1L,PHF2,PIF1,PKIB,PLCB3,PLEKHO2,POGK,POLR1B,POLR1F,POLR3B,PPIE,PPP1R21,PPP3CB,PRDM16,PRMT5,PTEN,PVT1,QSER1,RABEP1,RANBP17,RAPGEF1,RBL1,RETREG3,RFX2,RFX7,RGS12,RGS19,RHEBL1,RIPK2,RNF41,RPGR,RPGRIP1,RPS6KA3,RRAS2,SAMD11,SDE2,SEC22C,SETX,SGSH,SIAH1,SLC25A37,SLC29A1,SLC4A8,SMARCC1,SNRPD1,SPRING1,SRBD1,SS18,ST13,STAG1,STIL,TAF4,TBC1D10C,TMEM216,TMX4,TOP2B,TPK1,TRIM59,TSN,TTC21B,TTC39B,TUBGCP6,TUSC3,ULBP1,UNC119B,URB2,USB1,VHL,VPS33A,VSNL1,ZBTB43,ZCCHC2,ZMIZ1,ZNF395,ZNF48,ZNF507,ZNF579" MEMBERS_EZID="100170841,10039,1017,10193,10274,10287,10419,10450,10538,10576,10643,10691,10943,11151,11174,11190,112939,121268,123920,129285,136319,1431,148398,149420,1512,157570,158219,162,162427,162681,163033,163859,1676,1730,1841,1859,1960,197407,200186,2030,2197,221830,221927,222658,22800,22847,22850,23028,23059,23064,23077,23099,2322,23269,23288,23312,2332,23492,254102,256144,26267,2686,26958,27010,27085,27163,286827,2885,2889,3090,3181,3560,3663,3704,3710,374403,3787,3835,3840,3843,3845,388272,3895,400569,400916,4133,4149,4282,440145,4595,4869,51053,5108,51202,51259,51312,51517,51529,5253,5331,53371,54877,54920,55057,55133,55142,55192,55257,5532,55352,55695,5570,55703,55893,5600,56255,57082,57096,57178,57205,5728,57565,57645,57647,57819,5820,58488,5933,5990,6002,6103,6197,63976,6448,6477,64864,64901,6491,65082,65980,6599,6632,6760,6767,6874,7155,7247,729830,734,7428,7430,7447,79072,79133,79591,79650,79661,79664,79695,79794,79809,79832,79849,79877,7991,80119,80218,80301,80329,8050,81617,83461,83540,83990,84067,84172,84733,84747,84901,84978,85378,8767,8897,8939,90007,90668,9117,9125,9135,94101,9498,9516,9656,9696,973,9768,9816,9873" MEMBERS_MAPPING="ADAMTS6,ADAMTS6,11174|ADNP2,ADNP2,22850|AIM1L,CRYBG2,55057|ANAPC11,ANAPC11,51529|AP1B1,AP1B1,162|ATP10D,ATP10D,57205|BATF,BATF,10538|BRAT1,BRAT1,221927|BRD9,BRD9,65980|BRIP1,BRIP1,83990|C10orf76,ARMH3,79591|C12orf49,SPRING1,79794|C16orf57,USB1,79650|C16orf87,C16orf87,388272|C17orf79,COPRS,55352|C17orf96,EPOP,100170841|C18orf54,C18orf54,162681|C1orf55,SDE2,163859|C20orf20,MRGBP,55257|C20orf7,NDUFAF5,79133|CAB39L,CAB39L,81617|CASC5,KNL1,57082|CBX2,CBX2,84733|CBX7,CBX7,23492|CCT2,CCT2,10576|CD79A,CD79A,973|CDCA3,CDCA3,83461|CDK2,CDK2,1017|CEP250,CEP250,11190|CHCHD10,CHCHD10,400916|CLUAP1,CLUAP1,23059|CMTM3,CMTM3,123920|COPG2,COPG2,26958|CORO1A,CORO1A,11151|CROCC,CROCC,9696|CRTC2,CRTC2,200186|CS,CS,1431|CTSH,CTSH,1512|DCAKD,DCAKD,79877|DDX47,DDX47,51202|DFFA,DFFA,1676|DHX37,DHX37,57647|DIAPH2,DIAPH2,1730|DMXL2,DMXL2,23312|DNAJC17,DNAJC17,55192|DTYMK,DTYMK,1841|DUS2L,DUS2,54920|DYRK1A,DYRK1A,1859|EGR3,EGR3,1960|EHBP1L1,EHBP1L1,254102|ESCO2,ESCO2,157570|EZR,EZR,7430|FAM134C,RETREG3,162427|FAM160A1,FHIP1A,729830|FAM160A2,FHIP1B,84067|FASTKD3,FASTKD3,79072|FAU,FAU,2197|FBXO10,FBXO10,26267|FCHSD2,FCHSD2,9873|FLT3,FLT3,2322|FMR1,FMR1,2332|FRMD5,FRMD5,84978|FUBP3,FUBP3,8939|GALNT12,GALNT12,79695|GGT7,GGT7,2686|GMEB1,GMEB1,10691|GMNN,GMNN,51053|GRB2,GRB2,2885|HAUS2,HAUS2,55142|HIC1,HIC1,3090|HNRNPA2B1,HNRNPA2B1,3181|IGF2BP3,IGF2BP3,10643|IL2RB,IL2RB,3560|IPO5,IPO5,3843|IQCE,IQCE,23288|IRF5,IRF5,3663|ITPA,ITPA,3704|ITPR3,ITPR3,3710|KCNS1,KCNS1,3787|KCTD20,KCTD20,222658|KDM1A,KDM1A,23028|KIAA0101,PCLAF,9768|KIF22,KIF22,3835|KLHL14,KLHL14,57565|KLRAQ1,PPP1R21,129285|KPNA4,KPNA4,3840|KRAS,KRAS,3845|KTN1,KTN1,3895|LITAF,LITAF,9516|LOC100506612,null,null|LRRC16B,CARMIL3,90668|LSM2,LSM2,57819|MAP2,MAP2,4133|MAPK11,MAPK11,5600|MAX,MAX,4149|MDC1,MDC1,9656|MED11,MED11,400569|MGA,MGA,23269|MIDN,MIDN,90007|MIF,MIF,4282|MSL3,MSL3,10943|MTBP,MTBP,27085|MTMR3,MTMR3,8897|MTPN,MTPN,136319|MUTYH,MUTYH,4595|MYCBP2,MYCBP2,23077|MZT1,MZT1,440145|NAA50,NAA50,80218|NAAA,NAAA,27163|NACC1,NACC1,112939|NARG2,ICE2,79664|NCKIPSD,NCKIPSD,51517|NEIL1,NEIL1,79661|NFATC2IP,NFATC2IP,84901|NPM1,NPM1,4869|NSUN5,NSUN5,55695|NUF2,NUF2,83540|NUP54,NUP54,53371|OR4C3,OR4C3,256144|ORMDL1,ORMDL1,94101|OSGIN2,OSGIN2,734|PARP3,PARP3,10039|PCM1,PCM1,5108|PCTP,PCTP,58488|PDHX,PDHX,8050|PDIK1L,PDIK1L,149420|PDZD3,NHERF4,79849|PHF2,PHF2,5253|PIF1,PIF1,80119|PKIB,PKIB,5570|PLCB3,PLCB3,5331|PLEKHO2,PLEKHO2,80301|POGK,POGK,57645|POLR1B,POLR1B,84172|POLR3B,POLR3B,55703|PPIE,PPIE,10450|PPP3CB,PPP3CB,5532|PRDM16,PRDM16,63976|PRMT5,PRMT5,10419|PTEN,PTEN,5728|PVT1,PVT1,5820|QSER1,QSER1,79832|RABEP1,RABEP1,9135|RANBP17,RANBP17,64901|RAPGEF1,RAPGEF1,2889|RBL1,RBL1,5933|RFX2,RFX2,5990|RFX7,RFX7,64864|RGS12,RGS12,6002|RGS19,RGS19,10287|RHEBL1,RHEBL1,121268|RIPK2,RIPK2,8767|RNF41,RNF41,10193|RPGR,RPGR,6103|RPGRIP1,RPGRIP1,57096|RPS6KA3,RPS6KA3,6197|RQCD1,CNOT9,9125|RRAS2,RRAS2,22800|SAMD11,SAMD11,148398|SEC22C,SEC22C,9117|SETX,SETX,23064|SGK223,null,null|SGSH,SGSH,6448|SIAH1,SIAH1,6477|SLC25A37,SLC25A37,51312|SLC29A1,SLC29A1,2030|SLC4A8,SLC4A8,9498|SMARCC1,SMARCC1,6599|SNRPD1,SNRPD1,6632|SRBD1,SRBD1,55133|SS18,SS18,6760|ST13,ST13,6767|STAG1,STAG1,10274|STIL,STIL,6491|TAF4,TAF4,6874|TBC1D10C,TBC1D10C,374403|TMEM216,TMEM216,51259|TMX4,TMX4,56255|TOP2B,TOP2B,7155|TPK1,TPK1,27010|TRIM59,TRIM59,286827|TSN,TSN,7247|TTC21B,TTC21B,79809|TTC39B,TTC39B,158219|TUBGCP6,TUBGCP6,85378|TUSC3,TUSC3,7991|TWISTNB,POLR1F,221830|ULBP1,ULBP1,80329|UNC119B,UNC119B,84747|URB2,URB2,9816|VHL,VHL,7428|VPS33A,VPS33A,65082|VSNL1,VSNL1,7447|ZBTB43,ZBTB43,23099|ZCCHC2,ZCCHC2,54877|ZMIZ1,ZMIZ1,57178|ZNF395,ZNF395,55893|ZNF48,ZNF48,197407|ZNF507,ZNF507,22847|ZNF579,ZNF579,163033" FILTERED_BY_SIMILARITY="" FOUNDER_NAMES="" REFINEMENT_DATASETS="" VALIDATION_DATASETS="" CATEGORY_CODE="C7" ORGANISM="Homo sapiens" SUB_CATEGORY_CODE="IMMUNESIGDB"/>
</MSIGDB>
