STANDARD_NAME GSE2770_IL12_AND_TGFB_ACT_VS_ACT_CD4_TCELL_6H_UP SYSTEMATIC_NAME M6067 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE2770_IL12_AND_TGFB_ACT_VS_ACT_CD4_TCELL_6H_UP NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes up-regulated in CD4 [GeneID=920] T cells activated by anti-CD3 and anti-CD28: TGFB1 [GeneID=7040] and IL-12 (6h) versus untreated (6h). DESCRIPTION_FULL Th1 and Th2 cells arise from a common precursor cell in response to triggering through the TCR and cytokine receptors for IL-12 or IL-4. This leads to activation of complex signaling pathways, which are not known in detail. Disturbances in the balance between type 1 and type 2 responses can lead to certain immune-mediated diseases. Thus, it is important to understand how Th1 and Th2 cells are generated. To clarify the mechanisms as to how IL-12 and IL-4 induce Th1 and Th2 differentiation and how TGF-beta can inhibit this process, we have used oligonucleotide arrays to examine the early polarization of Th1 and Th2 cells in the presence and absence of TGF-beta after 0, 2, 6 and 48 hours of polarization. PMID 14607935 GEOID GSE2770 AUTHORS Lund R,Aittokallio T,Nevalainen O,Lahesmaa R CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE2770_2792_200_UP FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS ABCD4,ABHD4,ACP6,ADAM30,ADAMTS20,ALAD,AMPD3,AMT,ANO10,AOAH,APBA2,ATP8A2,ATRNL1,AVIL,BBS4,BBS9,BSCL2,BTF3P12,BTN3A2,BTN3A3,C14orf132,C16orf45,C2orf44,C2orf68,C3orf37,C5orf54,C6orf48,CACNA2D2,CAPN2,CASC5,CAV1,CCDC28B,CD44,CDH12,CDKN1B,CECR1,CHRDL1,CLCA4,COG4,COL6A3,CSNK2A2,CTDSP2,CUX2,CXCR2,CXCR4,CYP2R1,CYTH4,DCAF8,DDB2,DEPTOR,DFNB31,DHRS1,DHRS3,DPEP2,DTNB,DYNC2H1,EGOT,EPHB6,EPHX2,EVL,FAHD2A,FAM102A,FGD6,FLJ10038,FLNB,FOXO3,GALNT11,GALNT12,GALNT3,GLS2,GLT25D2,GNB5,GNG7,GRAMD1C,GRM6,HIST3H2A,HLA-F-AS1,HTR1F,ID3,IFNA8,IFT140,IL11RA,IL16,INPP5D,INSL5,ITGB7,ITM2C,KCNE4,KCTD7,KDELR3,KIAA0182,KIAA1324,KLKB1,KRT86,LBH,LDLRAP1,LEP,LEPROTL1,LETMD1,LIME1,LPCAT4,LRP5L,LY9,MAN1C1,MAP3K6,MCTP1,MEGF8,METTL7A,MLC1,MMRN1,MOSC2,MXD3,NACAD,NBEA,NDE1,NDRG3,NLRP1,NMT2,OPHN1,OXA1L,PBXIP1,PCNXL2,PDLIM1,PECR,PEX11A,PHC1,PIK3IP1,PLCB2,PLCG2,PLXDC1,POMT1,PPOX,PRCP,PRM2,PRMT8,PRRC2B,PTPRS,PYHIN1,QSER1,RAB38,RAMP1,RASSF2,RCAN3,RGS10,RIN3,RNASEL,RNASET2,RPL11,RPS17P5,RPS20,SALL2,SCAPER,SEPP1,SEPT9,SFRP4,SFXN3,SIDT2,SIGIRR,SIRPG,SIRT4,SLC16A5,SLC1A4,SLC24A1,SLC35E2B,SMYD3,SOX12,SPOCK2,SPON2,SPTBN1,TARP,TBC1D8,TCEAL1,TCF7,TCTN2,TMEM14A,TMSB4Y,TNFAIP3,TPP1,TRAC,TRAF3IP3,TRAM2,TRDV2,TSC22D3,TSPYL4,UBASH3A,UST,VASH1,WNT16,ZBTB40,ZFP30,ZFP36L2,ZFYVE26,ZMYM3,ZNF334,ZNF343,ZNF506,ZNF589,ZNF671,ZNF695,ZNF862 GENE_SYMBOLS ABCD4,ABHD4,ACP6,ADAM30,ADAMTS20,ALAD,AMPD3,AMT,ANO10,AOAH,APBA2,ATP8A2,ATRNL1,AVIL,BBS4,BBS9,BSCL2,BTF3P12,BTN3A2,BTN3A3,C14orf132,BMERB1,WDCP,C2orf68,HMCES,FAM200C,SNHG32,CACNA2D2,CAPN2,KNL1,CAV1,CCDC28B,CD44,CDH12,CDKN1B,ADA2,CHRDL1,CLCA4,COG4,COL6A3,CSNK2A2,CTDSP2,CUX2,CXCR2,CXCR4,CYP2R1,CYTH4,DCAF8,DDB2,DEPTOR,WHRN,DHRS1,DHRS3,DPEP2,DTNB,DYNC2H1,EGOT,EPHB6,EPHX2,EVL,FAHD2A,EEIG1,FGD6,GABPB1-IT1,FLNB,FOXO3,GALNT11,GALNT12,GALNT3,GLS2,COLGALT2,GNB5,GNG7,GRAMD1C,GRM6,H2AC25,HLA-F-AS1,HTR1F,ID3,IFNA8,IFT140,IL11RA,IL16,INPP5D,INSL5,ITGB7,ITM2C,KCNE4,KCTD7,KDELR3,GSE1,ELAPOR1,KLKB1,KRT86,LBH,LDLRAP1,LEP,LEPROTL1,LETMD1,LIME1,LPCAT4,LRP5L,LY9,MAN1C1,MAP3K6,MCTP1,MEGF8,METTL7A,MLC1,MMRN1,MTARC2,MXD3,NACAD,NBEA,NDE1,NDRG3,NLRP1,NMT2,OPHN1,OXA1L,PBXIP1,PCNX2,PDLIM1,PECR,PEX11A,PHC1,PIK3IP1,PLCB2,PLCG2,PLXDC1,POMT1,PPOX,PRCP,PRM2,PRMT8,PRRC2B,PTPRS,PYHIN1,QSER1,RAB38,RAMP1,RASSF2,RCAN3,RGS10,RIN3,RNASEL,RNASET2,RPL11,RPS17P5,RPS20,SALL2,SCAPER,SELENOP,SEPTIN9,SFRP4,SFXN3,SIDT2,SIGIRR,SIRPG,SIRT4,SLC16A5,SLC1A4,SLC24A1,SLC35E2B,SMYD3,SOX12,SPOCK2,SPON2,SPTBN1,TARP,TBC1D8,TCEAL1,TCF7,TCTN2,TMEM14A,TMSB4Y,TNFAIP3,TPP1,TRAC,TRAF3IP3,TRAM2,TRDV2,TSC22D3,TSPYL4,UBASH3A,UST,VASH1,WNT16,ZBTB40,ZFP30,ZFP36L2,ZFYVE26,ZMYM3,ZNF334,ZNF343,ZNF506,ZNF589,ZNF671,ZNF695,ZNF862 FOUNDER_NAMES