STANDARD_NAME	GSE2770_TGFB_AND_IL4_ACT_VS_ACT_CD4_TCELL_6H_UP
SYSTEMATIC_NAME	M6106
COLLECTION	C7:IMMUNESIGDB
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE2770_TGFB_AND_IL4_ACT_VS_ACT_CD4_TCELL_6H_UP
NAMESPACE	HUMAN_GENE_SYMBOL
DESCRIPTION_BRIEF	Genes up-regulated in CD4 [GeneID=920] T cells activated by anti-CD3 and anti-CD28: TGFB1 and IL4 [GeneID=7040;3565] (6h) versus untreated (6h).
DESCRIPTION_FULL	Th1 and Th2 cells arise from a common precursor cell in response to triggering through the TCR and cytokine receptors for IL-12 or IL-4. This leads to activation of complex signaling pathways, which are not known in detail. Disturbances in the balance between type 1 and type 2 responses can lead to certain immune-mediated diseases. Thus, it is important to understand how Th1 and Th2 cells are generated. To clarify the mechanisms as to how IL-12 and IL-4 induce Th1 and Th2 differentiation and how TGF-beta can inhibit this process, we have used oligonucleotide arrays to examine the early polarization of Th1 and Th2 cells in the presence and absence of TGF-beta after 0, 2, 6 and 48 hours of polarization.
PMID	14607935
GEOID	GSE2770
AUTHORS	Lund R,Aittokallio T,Nevalainen O,Lahesmaa R
CONTRIBUTOR	Jernej Godec
CONTRIBUTOR_ORG	Dana-Farber Cancer Institute
EXACT_SOURCE	GSE2770_2787_200_UP
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	ACE,ACP6,ACTB,ADRBK1,AFF1,AGXT2L2,AK3,AKIRIN2,ALKBH6,APBB1,ARHGEF3,ARID1A,ATP8B2,BBS2,BCL2A1,C19orf2,C20orf177,C3orf64,C4orf52,C6orf108,C8orf40,CBR3,CCNL1,CCR8,CD101,CDC42,CDK6,CHURC1,CIZ1,CMPK1,CMPK2,COMMD1,COMMD4,COX18,COX8A,CSDE1,CXCR6,CYP4V2,DAZAP2,DCAF15,DCPS,DDX17,DHFR,DHX35,DKFZP586I1420,DPP7,DPYSL2,DUS3L,DUSP1,DYNLL2,ECSIT,EIF4E3,ELOVL1,ERP27,ESD,EWSR1,EXOSC10,FAM162A,FAM171A1,FBXL8,FBXO4,FCGRT,FTSJD2,FURIN,GGT1,GGTLC2,GMEB2,GTF2I,H2AFY2,HAR1A,HAUS4,HDHD2,HEBP2,HECA,HNRNPA2B1,HNRNPU,HSD17B11,IGHD,IL12RB2,INO80E,INTS3,ITGAV,ITM2B,KIAA0748,KIAA1267,KLHL6,LASS5,LDB1,LMBR1L,LOC100128737,LOC100129250,LOC100134713,LOC100505483,LOC100505761,LOC152217,LOC285965,LOC541471,LRRC41,MDM2,MED10,MED24,MID2,MINK1,MKI67,MMP24,MPRIP,MT1H,MT1P2,MT2A,MYBL1,NBN,NCF2,NCRNA00246B,NDUFS2,NFU1,NSUN5P1,NT5DC1,NUP205,PANX1,PARVB,PBX3,PDE3B,PET117,PEX14,PGCP,PHC1,PLEKHB1,PLEKHM2,PLIN2,PPA2,PPBP,PPP1CA,PPP1R9B,PPP2R5A,PTP4A3,PTPLA,QARS,RABL3,RASSF2,RBCK1,REC8,REPIN1,RHOF,RILPL2,RIPK3,RLTPR,RNF44,RNPEPL1,ROBO3,ROD1,SAFB2,SCCPDH,SEMA3G,SENP7,SEPSECS,SHKBP1,SLC25A15,SLC35F2,SLC46A3,SMAD2,SMAP1,SMYD2,SNRNP35,SNX10,SPAG7,STAG1,STIM1,SUN2,TAOK2,TBCB,TLR10,TMEM116,TMEM143,TMF1,TNFAIP8,TNFRSF18,TNFRSF1A,TRABD,TRMT11,TTC32,TTC39B,TUBA1B,UBA5,UBE2D3,UBTF,ULK3,UPP1,UROD,USE1,USP7,VNN2,VPS28,WAS,WASF2,WDR6,WNK1,XRCC1,YWHAH,ZNF395,ZNF652
GENE_SYMBOLS	ACE,ACP6,ACTB,GRK2,AFF1,PHYKPL,AK3,AKIRIN2,ALKBH6,APBB1,ARHGEF3,ARID1A,ATP8B2,BBS2,BCL2A1,URI1,FAM217B,EOGT,SMIM20,DNPH1,SMIM19,CBR3,CCNL1,CCR8,CD101,CDC42,CDK6,CHURC1,CIZ1,CMPK1,CMPK2,COMMD1,COMMD4,COX18,COX8A,CSDE1,CXCR6,CYP4V2,DAZAP2,DCAF15,DCPS,DDX17,DHFR,DHX35,,DPP7,DPYSL2,DUS3L,DUSP1,DYNLL2,ECSIT,EIF4E3,ELOVL1,ERP27,ESD,EWSR1,EXOSC10,FAM162A,FAM171A1,FBXL8,FBXO4,FCGRT,CMTR1,FURIN,GGT1,GGTLC2,GMEB2,GTF2I,MACROH2A2,HAR1A,HAUS4,HDHD2,HEBP2,HECA,HNRNPA2B1,HNRNPU,HSD17B11,IGHD,IL12RB2,INO80E,INTS3,ITGAV,ITM2B,TESPA1,KANSL1,KLHL6,CERS5,LDB1,LMBR1L,,SMIM27,NDUFB2-AS1,PRKAG2-AS1,C10orf95-AS1,NCBP2AS2,EPHA1-AS1,MIR4435-2HG,LRRC41,MDM2,MED10,MED24,MID2,MINK1,MKI67,MMP24,MPRIP,MT1H,MT1HL1,MT2A,MYBL1,NBN,NCF2,FAM226B,NDUFS2,NFU1,NSUN5P1,NT5DC1,NUP205,PANX1,PARVB,PBX3,PDE3B,PET117,PEX14,CPQ,PHC1,PLEKHB1,PLEKHM2,PLIN2,PPA2,PPBP,PPP1CA,PPP1R9B,PPP2R5A,PTP4A3,HACD1,EPRS1,RABL3,RASSF2,RBCK1,REC8,REPIN1,RHOF,RILPL2,RIPK3,CARMIL2,RNF44,RNPEPL1,ROBO3,PTBP3,SAFB2,SCCPDH,SEMA3G,SENP7,SEPSECS,SHKBP1,SLC25A15,SLC35F2,SLC46A3,SMAD2,SMAP1,SMYD2,SNRNP35,SNX10,SPAG7,STAG1,STIM1,SUN2,TAOK2,TBCB,TLR10,TMEM116,TMEM143,TMF1,TNFAIP8,TNFRSF18,TNFRSF1A,TRABD,TRMT11,TTC32,TTC39B,TUBA1B,UBA5,UBE2D3,UBTF,ULK3,UPP1,UROD,USE1,USP7,VNN2,VPS28,WAS,WASF2,WDR6,WNK1,XRCC1,YWHAH,ZNF395,ZNF652
FOUNDER_NAMES