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<MSIGDB BUILD_DATE="Jan 29, 2026" VERSION="2026.1.Hs" NAME="export">
    <GENESET STANDARD_NAME="GSE2770_TGFB_AND_IL4_ACT_VS_ACT_CD4_TCELL_6H_UP" SYSTEMATIC_NAME="M6106" HISTORICAL_NAMES="" PMID="14607935" AUTHORS="Lund R,Aittokallio T,Nevalainen O,Lahesmaa R" GEOID="GSE2770" EXACT_SOURCE="GSE2770_2787_200_UP" GENESET_LISTING_URL="" EXTERNAL_DETAILS_URL="" CHIP="HUMAN_GENE_SYMBOL" CONTRIBUTOR="Jernej Godec" CONTRIBUTOR_ORG="Dana-Farber Cancer Institute" DESCRIPTION_BRIEF="Genes up-regulated in CD4 [GeneID=920] T cells activated by anti-CD3 and anti-CD28: TGFB1 and IL4 [GeneID=7040;3565] (6h) versus untreated (6h)." DESCRIPTION_FULL="Th1 and Th2 cells arise from a common precursor cell in response to triggering through the TCR and cytokine receptors for IL-12 or IL-4. This leads to activation of complex signaling pathways, which are not known in detail. Disturbances in the balance between type 1 and type 2 responses can lead to certain immune-mediated diseases. Thus, it is important to understand how Th1 and Th2 cells are generated. To clarify the mechanisms as to how IL-12 and IL-4 induce Th1 and Th2 differentiation and how TGF-beta can inhibit this process, we have used oligonucleotide arrays to examine the early polarization of Th1 and Th2 cells in the presence and absence of TGF-beta after 0, 2, 6 and 48 hours of polarization." TAGS="" MEMBERS="ACE,ACP6,ACTB,ADRBK1,AFF1,AGXT2L2,AK3,AKIRIN2,ALKBH6,APBB1,ARHGEF3,ARID1A,ATP8B2,BBS2,BCL2A1,C19orf2,C20orf177,C3orf64,C4orf52,C6orf108,C8orf40,CBR3,CCNL1,CCR8,CD101,CDC42,CDK6,CHURC1,CIZ1,CMPK1,CMPK2,COMMD1,COMMD4,COX18,COX8A,CSDE1,CXCR6,CYP4V2,DAZAP2,DCAF15,DCPS,DDX17,DHFR,DHX35,DKFZP586I1420,DPP7,DPYSL2,DUS3L,DUSP1,DYNLL2,ECSIT,EIF4E3,ELOVL1,ERP27,ESD,EWSR1,EXOSC10,FAM162A,FAM171A1,FBXL8,FBXO4,FCGRT,FTSJD2,FURIN,GGT1,GGTLC2,GMEB2,GTF2I,H2AFY2,HAR1A,HAUS4,HDHD2,HEBP2,HECA,HNRNPA2B1,HNRNPU,HSD17B11,IGHD,IL12RB2,INO80E,INTS3,ITGAV,ITM2B,KIAA0748,KIAA1267,KLHL6,LASS5,LDB1,LMBR1L,LOC100128737,LOC100129250,LOC100134713,LOC100505483,LOC100505761,LOC152217,LOC285965,LOC541471,LRRC41,MDM2,MED10,MED24,MID2,MINK1,MKI67,MMP24,MPRIP,MT1H,MT1P2,MT2A,MYBL1,NBN,NCF2,NCRNA00246B,NDUFS2,NFU1,NSUN5P1,NT5DC1,NUP205,PANX1,PARVB,PBX3,PDE3B,PET117,PEX14,PGCP,PHC1,PLEKHB1,PLEKHM2,PLIN2,PPA2,PPBP,PPP1CA,PPP1R9B,PPP2R5A,PTP4A3,PTPLA,QARS,RABL3,RASSF2,RBCK1,REC8,REPIN1,RHOF,RILPL2,RIPK3,RLTPR,RNF44,RNPEPL1,ROBO3,ROD1,SAFB2,SCCPDH,SEMA3G,SENP7,SEPSECS,SHKBP1,SLC25A15,SLC35F2,SLC46A3,SMAD2,SMAP1,SMYD2,SNRNP35,SNX10,SPAG7,STAG1,STIM1,SUN2,TAOK2,TBCB,TLR10,TMEM116,TMEM143,TMF1,TNFAIP8,TNFRSF18,TNFRSF1A,TRABD,TRMT11,TTC32,TTC39B,TUBA1B,UBA5,UBE2D3,UBTF,ULK3,UPP1,UROD,USE1,USP7,VNN2,VPS28,WAS,WASF2,WDR6,WNK1,XRCC1,YWHAH,ZNF395,ZNF652" MEMBERS_SYMBOLIZED="ACE,ACP6,ACTB,AFF1,AK3,AKIRIN2,ALKBH6,APBB1,ARHGEF3,ARID1A,ATP8B2,BBS2,BCL2A1,C10orf95-AS1,CARMIL2,CBR3,CCNL1,CCR8,CD101,CDC42,CDK6,CERS5,CHURC1,CIZ1,CMPK1,CMPK2,CMTR1,COMMD1,COMMD4,COX18,COX8A,CPQ,CSDE1,CXCR6,CYP4V2,DAZAP2,DCAF15,DCPS,DDX17,DHFR,DHX35,DNPH1,DPP7,DPYSL2,DUS3L,DUSP1,DYNLL2,ECSIT,EIF4E3,ELOVL1,EOGT,EPHA1-AS1,EPRS1,ERP27,ESD,EWSR1,EXOSC10,FAM162A,FAM171A1,FAM217B,FAM226B,FBXL8,FBXO4,FCGRT,FURIN,GGT1,GGTLC2,GMEB2,GRK2,GTF2I,HACD1,HAR1A,HAUS4,HDHD2,HEBP2,HECA,HNRNPA2B1,HNRNPU,HSD17B11,IGHD,IL12RB2,INO80E,INTS3,ITGAV,ITM2B,KANSL1,KLHL6,LDB1,LMBR1L,LRRC41,MACROH2A2,MDM2,MED10,MED24,MID2,MINK1,MIR4435-2HG,MKI67,MMP24,MPRIP,MT1H,MT1HL1,MT2A,MYBL1,NBN,NCBP2AS2,NCF2,NDUFB2-AS1,NDUFS2,NFU1,NSUN5P1,NT5DC1,NUP205,PANX1,PARVB,PBX3,PDE3B,PET117,PEX14,PHC1,PHYKPL,PLEKHB1,PLEKHM2,PLIN2,PPA2,PPBP,PPP1CA,PPP1R9B,PPP2R5A,PRKAG2-AS1,PTBP3,PTP4A3,RABL3,RASSF2,RBCK1,REC8,REPIN1,RHOF,RILPL2,RIPK3,RNF44,RNPEPL1,ROBO3,SAFB2,SCCPDH,SEMA3G,SENP7,SEPSECS,SHKBP1,SLC25A15,SLC35F2,SLC46A3,SMAD2,SMAP1,SMIM19,SMIM20,SMIM27,SMYD2,SNRNP35,SNX10,SPAG7,STAG1,STIM1,SUN2,TAOK2,TBCB,TESPA1,TLR10,TMEM116,TMEM143,TMF1,TNFAIP8,TNFRSF18,TNFRSF1A,TRABD,TRMT11,TTC32,TTC39B,TUBA1B,UBA5,UBE2D3,UBTF,ULK3,UPP1,URI1,UROD,USE1,USP7,VNN2,VPS28,WAS,WASF2,WDR6,WNK1,XRCC1,YWHAH,ZNF395,ZNF652" MEMBERS_EZID="100129250,100134713,100303755,100505483,100505761,10163,10166,1021,10274,10376,10404,10489,10521,10591,10616,10663,10893,11035,11043,11066,11156,11180,114926,1155,121506,123,1237,129607,130502,1351,140735,146206,150684,152217,155400,156,158219,1636,1719,1808,1843,1911,196383,2058,2098,2130,221061,221294,2217,22834,22838,23070,23164,23165,23207,23593,24145,25777,25792,25816,25989,26205,26272,26355,2678,27068,27247,283537,283899,284058,285203,285282,285440,285521,285965,28960,2969,29780,29803,29887,29952,317649,3181,3192,322,3495,3595,3685,389203,4087,4193,4288,4299,4496,4502,4603,4683,4688,4720,5045,50488,50650,50808,5090,51091,51097,51160,51170,51205,51295,5140,51696,51727,5195,5394,541471,54509,5473,54733,54930,54939,5499,55122,5525,55260,55336,55506,55716,55850,55893,56920,56931,56950,57018,57140,57198,57337,583,58473,597,60,60487,60625,60682,63939,64221,645745,64834,65123,65125,653687,6786,7110,7132,7323,7343,7378,7389,7454,7515,7533,768096,7812,7874,79876,80305,81793,8289,84064,84246,84687,84964,85007,8725,874,8784,8861,8875,89857,89894,90379,91012,91227,91612,9200,92799,9344,9398,9445,9552,9667,9770,9802,9840,9862,998,9985,9991" MEMBERS_MAPPING="ACE,ACE,1636|ACP6,ACP6,51205|ACTB,ACTB,60|ADRBK1,GRK2,156|AFF1,AFF1,4299|AGXT2L2,PHYKPL,85007|AK3,AK3,50808|AKIRIN2,AKIRIN2,55122|ALKBH6,ALKBH6,84964|APBB1,APBB1,322|ARHGEF3,ARHGEF3,50650|ARID1A,ARID1A,8289|ATP8B2,ATP8B2,57198|BBS2,BBS2,583|BCL2A1,BCL2A1,597|C19orf2,URI1,8725|C20orf177,FAM217B,63939|C3orf64,EOGT,285203|C4orf52,SMIM20,389203|C6orf108,DNPH1,10591|C8orf40,SMIM19,114926|CBR3,CBR3,874|CCNL1,CCNL1,57018|CCR8,CCR8,1237|CD101,CD101,9398|CDC42,CDC42,998|CDK6,CDK6,1021|CHURC1,CHURC1,91612|CIZ1,CIZ1,25792|CMPK1,CMPK1,51727|CMPK2,CMPK2,129607|COMMD1,COMMD1,150684|COMMD4,COMMD4,54939|COX18,COX18,285521|COX8A,COX8A,1351|CSDE1,CSDE1,7812|CXCR6,CXCR6,10663|CYP4V2,CYP4V2,285440|DAZAP2,DAZAP2,9802|DCAF15,DCAF15,90379|DCPS,DCPS,28960|DDX17,DDX17,10521|DHFR,DHFR,1719|DHX35,DHX35,60625|DKFZP586I1420,null,null|DPP7,DPP7,29952|DPYSL2,DPYSL2,1808|DUS3L,DUS3L,56931|DUSP1,DUSP1,1843|DYNLL2,DYNLL2,140735|ECSIT,ECSIT,51295|EIF4E3,EIF4E3,317649|ELOVL1,ELOVL1,64834|ERP27,ERP27,121506|ESD,ESD,2098|EWSR1,EWSR1,2130|EXOSC10,EXOSC10,5394|FAM162A,FAM162A,26355|FAM171A1,FAM171A1,221061|FBXL8,FBXL8,55336|FBXO4,FBXO4,26272|FCGRT,FCGRT,2217|FTSJD2,CMTR1,23070|FURIN,FURIN,5045|GGT1,GGT1,2678|GGTLC2,GGTLC2,91227|GMEB2,GMEB2,26205|GTF2I,GTF2I,2969|H2AFY2,MACROH2A2,55506|HAR1A,HAR1A,768096|HAUS4,HAUS4,54930|HDHD2,HDHD2,84064|HEBP2,HEBP2,23593|HECA,HECA,51696|HNRNPA2B1,HNRNPA2B1,3181|HNRNPU,HNRNPU,3192|HSD17B11,HSD17B11,51170|IGHD,IGHD,3495|IL12RB2,IL12RB2,3595|INO80E,INO80E,283899|INTS3,INTS3,65123|ITGAV,ITGAV,3685|ITM2B,ITM2B,9445|KIAA0748,TESPA1,9840|KIAA1267,KANSL1,284058|KLHL6,KLHL6,89857|LASS5,CERS5,91012|LDB1,LDB1,8861|LMBR1L,LMBR1L,55716|LOC100128737,null,null|LOC100129250,SMIM27,100129250|LOC100134713,NDUFB2-AS1,100134713|LOC100505483,PRKAG2-AS1,100505483|LOC100505761,C10orf95-AS1,100505761|LOC152217,NCBP2AS2,152217|LOC285965,EPHA1-AS1,285965|LOC541471,MIR4435-2HG,541471|LRRC41,LRRC41,10489|MDM2,MDM2,4193|MED10,MED10,84246|MED24,MED24,9862|MID2,MID2,11043|MINK1,MINK1,50488|MKI67,MKI67,4288|MMP24,MMP24,10893|MPRIP,MPRIP,23164|MT1H,MT1H,4496|MT1P2,MT1HL1,645745|MT2A,MT2A,4502|MYBL1,MYBL1,4603|NBN,NBN,4683|NCF2,NCF2,4688|NCRNA00246B,FAM226B,653687|NDUFS2,NDUFS2,4720|NFU1,NFU1,27247|NSUN5P1,NSUN5P1,155400|NT5DC1,NT5DC1,221294|NUP205,NUP205,23165|PANX1,PANX1,24145|PARVB,PARVB,29780|PBX3,PBX3,5090|PDE3B,PDE3B,5140|PET117,PET117,100303755|PEX14,PEX14,5195|PGCP,CPQ,10404|PHC1,PHC1,1911|PLEKHB1,PLEKHB1,58473|PLEKHM2,PLEKHM2,23207|PLIN2,PLIN2,123|PPA2,PPA2,27068|PPBP,PPBP,5473|PPP1CA,PPP1CA,5499|PPP1R9B,PPP1R9B,84687|PPP2R5A,PPP2R5A,5525|PTP4A3,PTP4A3,11156|PTPLA,HACD1,9200|QARS,EPRS1,2058|RABL3,RABL3,285282|RASSF2,RASSF2,9770|RBCK1,RBCK1,10616|REC8,REC8,9985|REPIN1,REPIN1,29803|RHOF,RHOF,54509|RILPL2,RILPL2,196383|RIPK3,RIPK3,11035|RLTPR,CARMIL2,146206|RNF44,RNF44,22838|RNPEPL1,RNPEPL1,57140|ROBO3,ROBO3,64221|ROD1,PTBP3,9991|SAFB2,SAFB2,9667|SCCPDH,SCCPDH,51097|SEMA3G,SEMA3G,56920|SENP7,SENP7,57337|SEPSECS,SEPSECS,51091|SHKBP1,SHKBP1,92799|SLC25A15,SLC25A15,10166|SLC35F2,SLC35F2,54733|SLC46A3,SLC46A3,283537|SMAD2,SMAD2,4087|SMAP1,SMAP1,60682|SMYD2,SMYD2,56950|SNRNP35,SNRNP35,11066|SNX10,SNX10,29887|SPAG7,SPAG7,9552|STAG1,STAG1,10274|STIM1,STIM1,6786|SUN2,SUN2,25777|TAOK2,TAOK2,9344|TBCB,TBCB,1155|TLR10,TLR10,81793|TMEM116,TMEM116,89894|TMEM143,TMEM143,55260|TMF1,TMF1,7110|TNFAIP8,TNFAIP8,25816|TNFRSF18,TNFRSF18,8784|TNFRSF1A,TNFRSF1A,7132|TRABD,TRABD,80305|TRMT11,TRMT11,60487|TTC32,TTC32,130502|TTC39B,TTC39B,158219|TUBA1B,TUBA1B,10376|UBA5,UBA5,79876|UBE2D3,UBE2D3,7323|UBTF,UBTF,7343|ULK3,ULK3,25989|UPP1,UPP1,7378|UROD,UROD,7389|USE1,USE1,55850|USP7,USP7,7874|VNN2,VNN2,8875|VPS28,VPS28,51160|WAS,WAS,7454|WASF2,WASF2,10163|WDR6,WDR6,11180|WNK1,WNK1,65125|XRCC1,XRCC1,7515|YWHAH,YWHAH,7533|ZNF395,ZNF395,55893|ZNF652,ZNF652,22834" FILTERED_BY_SIMILARITY="" FOUNDER_NAMES="" REFINEMENT_DATASETS="" VALIDATION_DATASETS="" CATEGORY_CODE="C7" ORGANISM="Homo sapiens" SUB_CATEGORY_CODE="IMMUNESIGDB"/>
</MSIGDB>
