STANDARD_NAME GSE2770_TGFB_AND_IL4_VS_IL4_TREATED_ACT_CD4_TCELL_2H_UP SYSTEMATIC_NAME M6079 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE2770_TGFB_AND_IL4_VS_IL4_TREATED_ACT_CD4_TCELL_2H_UP NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes up-regulated in CD4 [GeneID=920] T cells activated by anti-CD3 and anti-CD28: TGFB1 and IL4 [GeneID=7040;3565] (2h) versus IL4 [GeneID=3565] (2h). DESCRIPTION_FULL Th1 and Th2 cells arise from a common precursor cell in response to triggering through the TCR and cytokine receptors for IL-12 or IL-4. This leads to activation of complex signaling pathways, which are not known in detail. Disturbances in the balance between type 1 and type 2 responses can lead to certain immune-mediated diseases. Thus, it is important to understand how Th1 and Th2 cells are generated. To clarify the mechanisms as to how IL-12 and IL-4 induce Th1 and Th2 differentiation and how TGF-beta can inhibit this process, we have used oligonucleotide arrays to examine the early polarization of Th1 and Th2 cells in the presence and absence of TGF-beta after 0, 2, 6 and 48 hours of polarization. PMID 14607935 GEOID GSE2770 AUTHORS Lund R,Aittokallio T,Nevalainen O,Lahesmaa R CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE2770_2776_200_UP FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS ACAA2,AKAP12,ANKRD13D,ANXA8,AP3B1,APEX1,ARL4D,ARMC2,ART4,ASAP3,ATMIN,ATP1A3,BACE2,BCKDHA,BCO2,C12orf57,C14orf105,C19orf12,C1orf183,C20orf79,C2orf18,C2orf3,C4orf51,C6orf48,CABS1,CACNB4,CAPN5,CARD6,CBX2,CCDC28A,CCDC28B,CCKBR,CCNDBP1,CCR6,CD109,CD1D,CD7,CD79B,CDH3,CEL,CELSR3,CEP95,CHRNA9,CLUAP1,CPLX1,CPNE4,CREBBP,CRYGS,CRYZL1,DES,DOPEY2,DTX3,DYM,EBI3,EDN2,ELAVL4,ELF2,ELP3,EMID2,EPB41L1,EXTL1,FAM19A1,FAM71B,FAT1,FGD2,FHL1,FILIP1L,FMO5,FNDC7,FOXRED2,GAD1,GIT2,GLB1,GOLT1A,GPANK1,GRAP,GRIK5,GRIN3B,GRRP1,HAUS1,HEPACAM2,HIP1R,HLA-DMA,HNF4A,HPCAL4,HVCN1,ID4,IFT172,IFT74,IL4I1,KCNH1,KIAA0174,KREMEN1,KRTCAP3,LCLAT1,LIFR,LOC100505478,LOC144486,LOC644925,MAP1LC3B,MEIS3,METTL8,MPG,MS4A6A,MTA1,MYST1,NAGA,NENF,NKX3-1,NLRP5,NNMT,NPY2R,NRIP3,NUDT16,NUDT6,NUMA1,OGN,OSCP1,OTX1,PACS1,PCDHB15,PDC,PDCD2L,PGC,PKDREJ,PKN3,PLA2G4C,PLEKHN1,PPCDC,PRKACB,PRPF6,PRR5L,PRSS55,PTPLB,PTPN1,PTPN13,PTPN18,RABAC1,RCN1,REEP6,RENBP,RETSAT,RFTN1,RFX5,RNASE4,RNF130,RNF167,RTDR1,RXRA,S100A10,SCML4,SCN1B,SCNN1G,SEC14L2,SERPINC1,SIK3,SIRT5,SLC24A6,SLC25A45,SNRK,SPO11,SQRDL,SSH3,STARD3,STAT4,STX2,STXBP4,SULT6B1,SUN3,SYNJ2,SYT7,TACC2,TBC1D22A,THAP11,THAP2,TIFAB,TMEM138,TMEM146,TMEM234,TMEM63A,TNN,TPP1,TRIM10,TRPC7,TSPAN32,TTC21B,TXNRD2,TYK2,UNC119,VPS16,VTN,WDR66,WFIKKN2,XRCC6,YBEY,YPEL1,ZBED5,ZNF524,ZNF688,ZNF827 GENE_SYMBOLS ACAA2,AKAP12,ANKRD13D,ANXA8,AP3B1,APEX1,ARL4D,ARMC2,ART4,ASAP3,ATMIN,ATP1A3,BACE2,BCKDHA,BCO2,C12orf57,CCDC198,C19orf12,INKA2,SCP2D1,SLC35F6,GCFC2,C4orf51,SNHG32,CABS1,CACNB4,CAPN5,CARD6,CBX2,CCDC28A,CCDC28B,CCKBR,CCNDBP1,CCR6,CD109,CD1D,CD7,CD79B,CDH3,CEL,CELSR3,CEP95,CHRNA9,CLUAP1,CPLX1,CPNE4,CREBBP,CRYGS,CRYZL1,DES,DOP1B,DTX3,DYM,EBI3,EDN2,ELAVL4,ELF2,ELP3,COL26A1,EPB41L1,EXTL1,TAFA1,GARIN3,FAT1,FGD2,FHL1,FILIP1L,FMO5,FNDC7,FOXRED2,GAD1,GIT2,GLB1,GOLT1A,GPANK1,GRAP,GRIK5,GRIN3B,FAM110D,HAUS1,HEPACAM2,HIP1R,HLA-DMA,HNF4A,HPCAL4,HVCN1,ID4,IFT172,IFT74,IL4I1,KCNH1,IST1,KREMEN1,KRTCAP3,LCLAT1,LIFR,TEX48,CEP83-DT,,MAP1LC3B,MEIS3,METTL8,MPG,MS4A6A,MTA1,KAT8,NAGA,NENF,NKX3-1,NLRP5,NNMT,NPY2R,NRIP3,NUDT16,NUDT6,NUMA1,OGN,OSCP1,OTX1,PACS1,PCDHB15,PDC,PDCD2L,PGC,PKDREJ,PKN3,PLA2G4C,PLEKHN1,PPCDC,PRKACB,PRPF6,PRR5L,PRSS55,HACD2,PTPN1,PTPN13,PTPN18,RABAC1,RCN1,REEP6,RENBP,RETSAT,RFTN1,RFX5,RNASE4,RNF130,RNF167,RSPH14,RXRA,S100A10,SCML4,SCN1B,SCNN1G,SEC14L2,SERPINC1,SIK3,SIRT5,SLC8B1,SLC25A45,SNRK,SPO11,SQOR,SSH3,STARD3,STAT4,STX2,STXBP4,SULT6B1,SUN3,SYNJ2,SYT7,TACC2,TBC1D22A,THAP11,THAP2,TIFAB,TMEM138,CATSPERD,TMEM234,TMEM63A,TNN,TPP1,TRIM10,TRPC7,TSPAN32,TTC21B,TXNRD2,TYK2,UNC119,VPS16,VTN,CFAP251,WFIKKN2,XRCC6,YBEY,YPEL1,ZBED5,ZNF524,ZNF688,ZNF827 FOUNDER_NAMES