STANDARD_NAME GSE2770_TGFB_AND_IL4_VS_IL4_TREATED_ACT_CD4_TCELL_48H_UP SYSTEMATIC_NAME M6112 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE2770_TGFB_AND_IL4_VS_IL4_TREATED_ACT_CD4_TCELL_48H_UP NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes up-regulated in CD4 [GeneID=920] T cells activated by anti-CD3 and anti-CD28: TGFB1 and IL4 [GeneID=7040;3565] (48h) versus IL4 [GeneID=3565] (48h). DESCRIPTION_FULL Th1 and Th2 cells arise from a common precursor cell in response to triggering through the TCR and cytokine receptors for IL-12 or IL-4. This leads to activation of complex signaling pathways, which are not known in detail. Disturbances in the balance between type 1 and type 2 responses can lead to certain immune-mediated diseases. Thus, it is important to understand how Th1 and Th2 cells are generated. To clarify the mechanisms as to how IL-12 and IL-4 induce Th1 and Th2 differentiation and how TGF-beta can inhibit this process, we have used oligonucleotide arrays to examine the early polarization of Th1 and Th2 cells in the presence and absence of TGF-beta after 0, 2, 6 and 48 hours of polarization. PMID 14607935 GEOID GSE2770 AUTHORS Lund R,Aittokallio T,Nevalainen O,Lahesmaa R CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE2770_2796_200_UP FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS ABCC1,ABHD4,ADAM17,ADAT3,AKR1B1,ALCAM,AMPD3,ANAPC7,ARCN1,ARFGAP3,ARHGAP31,ASB1,ASPH,ATL1,ATP6V0E1,BET1,BTBD7,BTG3,C19orf59,C1orf144,C3,CCDC132,CCL7,CCR5,CCRL2,CD22,CD2BP2,CD58,CD63,CD81,CD82,CDH7,CES1,CHST7,CLN5,COCH,CREG1,CRNKL1,CRYGS,CSRNP2,CTNS,CYBA,CYP51A1,DAB2,DCBLD1,DNAJA1,DNAJB6,DYNLL1,ELL2,EWSR1,EYA3,FAM129A,FAM71B,FLVCR2,FNIP2,FTH1,G3BP1,GLA,GSR,GSTO1,GTF2A1,HAS1,HDGFRP3,HHIPL2,HIP1,HIPK2,HMGCS1,HPD,HPS5,HSP90AB1,HSPA8,IER3,IGF2R,IL1A,IL1B,IL3RA,IPO9,IRAK2,ITGA5,ITPRIPL2,JAKMIP2,KCNN4,KDELR2,KIF1B,KLHL28,KLHL9,KMO,KPNB1,KYNU,LACTB,LAMTOR3,LGMN,LINS,LOC100132891,LOC100288617,LOC148413,LOC283050,LOC643714,LRP10,MAMLD1,MCOLN1,MED12,MED13,MFAP1,MFSD2A,MIR101-1,MMP19,MOBKL2C,MRPS6,MUT,MYO1B,NFE2L2,NFKB1,NPC1,NUP62,OBFC2A,OSGIN2,PDCD6IP,PDGFA,PDXK,PIK3R5,PIR,PJA1,PLA2G7,PLEKHB2,PNPLA8,POLR2A,PPP1R10,PRDM6,PSEN1,PSMA3,PSMD1,RAB13,RIT1,RNF145,RNF185,RPP14,RRAGC,RRAGD,SC4MOL,SC5DL,SDC4,SEC61B,SERINC1,SERPINB8,SERPINE2,SLC1A3,SLC26A2,SLC35F5,SLC41A2,SLC5A3,SNX9,SP4,SPINK1,SPRED2,SQRDL,SRP54,ST3GAL2,STAM2,STARD3NL,STIP1,STX3,TANK,TDP2,TGS1,TINF2,TM2D2,TMCO3,TMEM138,TMEM2,TMEM51,TPST1,TRAF3,TRIM28,TRIO,TSC22D1,TSG101,TTLL4,TUBB6,TXNRD1,UBE2A,UST,VCP,WDR1,WDR83,WSB2,YIPF6,ZC3H12C,ZFP3,ZFYVE1,ZNF100,ZNF140,ZNF189,ZNF200,ZNF207,ZNF230,ZNF232,ZNF434,ZNF701,ZNFX1 GENE_SYMBOLS ABCC1,ABHD4,ADAM17,ADAT3,AKR1B1,ALCAM,AMPD3,ANAPC7,ARCN1,ARFGAP3,ARHGAP31,ASB1,ASPH,ATL1,ATP6V0E1,BET1,BTBD7,BTG3,MCEMP1,SZRD1,C3,VPS50,CCL7,CCR5,CCRL2,CD22,CD2BP2,CD58,CD63,CD81,CD82,CDH7,CES1,CHST7,CLN5,COCH,CREG1,CRNKL1,CRYGS,CSRNP2,CTNS,CYBA,CYP51A1,DAB2,DCBLD1,DNAJA1,DNAJB6,DYNLL1,ELL2,EWSR1,EYA3,NIBAN1,GARIN3,FLVCR2,FNIP2,FTH1,G3BP1,GLA,GSR,GSTO1,GTF2A1,HAS1,,HHIPL2,HIP1,HIPK2,HMGCS1,HPD,HPS5,HSP90AB1,HSPA8,IER3,IGF2R,IL1A,IL1B,IL3RA,IPO9,IRAK2,ITGA5,ITPRIPL2,JAKMIP2,KCNN4,KDELR2,KIF1B,KLHL28,KLHL9,KMO,KPNB1,KYNU,LACTB,LAMTOR3,LGMN,LINS1,MSC-AS1,,MRPL20-AS1,ZMIZ1-AS1,CASC16,LRP10,MAMLD1,MCOLN1,MED12,MED13,MFAP1,MFSD2A,MIR101-1,MMP19,MOB3C,MRPS6,MMUT,MYO1B,NFE2L2,NFKB1,NPC1,NUP62,NABP1,OSGIN2,PDCD6IP,PDGFA,PDXK,PIK3R5,PIR,PJA1,PLA2G7,PLEKHB2,PNPLA8,POLR2A,PPP1R10,PRDM6,PSEN1,PSMA3,PSMD1,RAB13,RIT1,RNF145,RNF185,RPP14,RRAGC,RRAGD,MSMO1,SC5D,SDC4,SEC61B,SERINC1,SERPINB8,SERPINE2,SLC1A3,SLC26A2,SLC35F5,SLC41A2,SLC5A3,SNX9,SP4,SPINK1,SPRED2,SQOR,SRP54,ST3GAL2,STAM2,STARD3NL,STIP1,STX3,TANK,TDP2,TGS1,TINF2,TM2D2,TMCO3,TMEM138,CEMIP2,TMEM51,TPST1,TRAF3,TRIM28,TRIO,TSC22D1,TSG101,TTLL4,TUBB6,TXNRD1,UBE2A,UST,VCP,WDR1,WDR83,WSB2,YIPF6,ZC3H12C,ZFP3,ZFYVE1,ZNF100,ZNF140,ZNF189,ZNF200,ZNF207,ZNF230,ZNF232,ZSCAN32,ZNF701,ZNFX1 FOUNDER_NAMES