STANDARD_NAME GSE2770_TGFB_AND_IL4_VS_TGFB_AND_IL12_TREATED_ACT_CD4_TCELL_48H_UP SYSTEMATIC_NAME M6109 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE2770_TGFB_AND_IL4_VS_TGFB_AND_IL12_TREATED_ACT_CD4_TCELL_48H_UP NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes up-regulated in CD4 [GeneID=920] T cells activated by anti-CD3 and anti-CD28: TGFB1 and IL4 [GeneID=7040;3565] (48h) versus TGFB1 [GeneID-7040] and IL-12 (48h). DESCRIPTION_FULL Th1 and Th2 cells arise from a common precursor cell in response to triggering through the TCR and cytokine receptors for IL-12 or IL-4. This leads to activation of complex signaling pathways, which are not known in detail. Disturbances in the balance between type 1 and type 2 responses can lead to certain immune-mediated diseases. Thus, it is important to understand how Th1 and Th2 cells are generated. To clarify the mechanisms as to how IL-12 and IL-4 induce Th1 and Th2 differentiation and how TGF-beta can inhibit this process, we have used oligonucleotide arrays to examine the early polarization of Th1 and Th2 cells in the presence and absence of TGF-beta after 0, 2, 6 and 48 hours of polarization. PMID 14607935 GEOID GSE2770 AUTHORS Lund R,Aittokallio T,Nevalainen O,Lahesmaa R CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE2770_2795_200_UP FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS ACAD8,ACSF2,AGPAT1,AGPAT6,AIM1L,AKAP17A,ALDOC,AP2M1,ARMC10,ASCC1,ATF6,ATOX1,ATRIP,BAD,BIVM,BLCAP,BOD1L,BTBD11,C12orf10,C14orf126,C14orf135,C14orf45,C16orf13,C17orf90,C2orf43,C2orf74,C6orf163,C9orf6,CASC3,CCDC41,CCDC77,CCDC90B,CCDC96,CCNB1IP1,CCT3,CEP19,CLTCL1,COPS7B,COQ10A,COQ9,COX16,CPSF1,CSTB,DCAF10,DCLRE1A,DCTN4,DLG1,DNAJC13,EIF2S3,ERC1,FAHD2A,FANCF,FANCI,FBF1,FBXW12,FLJ36031,FOXJ3,FPGS,FRS2,FTL,FXYD7,GABBR1,GALE,GINS4,GKAP1,GMCL1,GPAM,GPR108,GPR155,GPR180,GTPBP2,HCFC1R1,HIST1H2AC,IARS2,IFNGR1,KCTD13,KCTD17,KIAA0408,KIAA1919,KLHL9,KRI1,LAMTOR1,LOC100127983,LOC100131564,LOC100132832,LOC285178,LOC286071,LRWD1,LSM10,LZTFL1,MAD2L2,MALAT1,MANBAL,MCM3AP,MED25,MEF2A,METTL21B,MEX3D,MGA,MRS2,MYH3,MYL6B,NAT9,NCAPD2,NCRNA00287,NDFIP2,NFS1,NTHL1,NUDCD3,NUDT9,OSTM1,PCBD2,PDE6D,PDZK1P1,PET112,PFDN6,PGD,PHKB,PIGQ,PILRB,PIP5K1C,PL-5283,POLR1A,PPM1F,PRDX3,PRKAG2,PRKCB,PRPF3,PRPF40B,PRPF6,PSMC3,PTER,PUF60,PUS3,R3HCC1,RAB5B,RAB7A,RAD52,RBM34,RCN3,RELL2,RFC4,RFX2,RPAP1,RPL13P5,RPL36,RUSC1,SCFD2,SELRC1,SEPT4,SFT2D3,SHPRH,SLC22A5,SLC25A23,SLC2A6,SLC45A1,SLC48A1,SMCR8,SMG5,SNAP29,SNAPC1,SNAPIN,SNHG11,SNORA21,SPG11,SSBP3,STRADB,TAF10,TBC1D13,TBC1D8,TECR,THAP9,THOC1,TIMM9,TMEM134,TMEM177,TMEM52,TNFRSF19,TP73-AS1,TTBK2,TTC14,TUBG2,TULP4,UBE2V2,UCN,VPS25,VPS29,WDR61,WDR89,XRCC1,YTHDF2,ZC3H10,ZFAND1,ZFP90,ZKSCAN5,ZNF277,ZNF280B,ZNF540,ZNF559,ZNF605 GENE_SYMBOLS ACAD8,ACSF2,AGPAT1,GPAT4,CRYBG2,AKAP17A,ALDOC,AP2M1,ARMC10,ASCC1,ATF6,ATOX1,ATRIP,BAD,BIVM,BLCAP,BOD1L1,ABTB3,MYG1,DTD2,PCNX4,BBOF1,METTL26,OXLD1,LDAH,C2orf74,C6orf163,ABITRAM,CASC3,CEP83,CCDC77,CCDC90B,CCDC96,CCNB1IP1,CCT3,CEP19,CLTCL1,COPS7B,COQ10A,COQ9,COX16,CPSF1,CSTB,DCAF10,DCLRE1A,DCTN4,DLG1,DNAJC13,EIF2S3,ERC1,FAHD2A,FANCF,FANCI,FBF1,FBXW12,CCDC71L,FOXJ3,FPGS,FRS2,FTL,FXYD7,GABBR1,GALE,GINS4,GKAP1,GMCL1,GPAM,GPR108,GPR155,GPR180,GTPBP2,HCFC1R1,H2AC6,IARS2,IFNGR1,KCTD13,KCTD17,KIAA0408,MFSD4B,KLHL9,KRI1,LAMTOR1,C8orf88,CCDC18-AS1,PMS2P9,,,LRWD1,LSM10,LZTFL1,MAD2L2,MALAT1,MANBAL,MCM3AP,MED25,MEF2A,EEF1AKMT3,MEX3D,MGA,MRS2,MYH3,MYL6B,NAT9,NCAPD2,MIR600HG,NDFIP2,NFS1,NTHL1,NUDCD3,NUDT9,OSTM1,PCBD2,PDE6D,PDZK1P1,GATB,PFDN6,PGD,PHKB,PIGQ,PILRB,PIP5K1C,STMP1,POLR1A,PPM1F,PRDX3,PRKAG2,PRKCB,PRPF3,PRPF40B,PRPF6,PSMC3,PTER,PUF60,PUS3,R3HCC1,RAB5B,RAB7A,RAD52,RBM34,RCN3,RELL2,RFC4,RFX2,RPAP1,RPL13P5,RPL36,RUSC1,SCFD2,COA7,SEPTIN4,SFT2D3,SHPRH,SLC22A5,SLC25A23,SLC2A6,SLC45A1,SLC48A1,SMCR8,SMG5,SNAP29,SNAPC1,SNAPIN,SNHG11,SNORA21,SPG11,SSBP3,STRADB,TAF10,TBC1D13,TBC1D8,TECR,THAP9,THOC1,TIMM9,TMEM134,TMEM177,TMEM52,TNFRSF19,TP73-AS1,TTBK2,TTC14,TUBG2,TULP4,UBE2V2,UCN,VPS25,VPS29,SKIC8,WDR89,XRCC1,YTHDF2,ZC3H10,ZFAND1,ZFP90,ZKSCAN5,ZNF277,ZNF280B,ZNF540,ZNF559,ZNF605 FOUNDER_NAMES