STANDARD_NAME	GSE2770_UNTREATED_VS_IL12_TREATED_ACT_CD4_TCELL_48H_DN
SYSTEMATIC_NAME	M6045
COLLECTION	C7:IMMUNESIGDB
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE2770_UNTREATED_VS_IL12_TREATED_ACT_CD4_TCELL_48H_DN
NAMESPACE	HUMAN_GENE_SYMBOL
DESCRIPTION_BRIEF	Genes down-regulated in CD4 [GeneID=920] T cells: untreated (0h) versus activated by anti-CD3 and anti-CD28 and then stimulated by IL-12 (48h).
DESCRIPTION_FULL	Th1 and Th2 cells arise from a common precursor cell in response to triggering through the TCR and cytokine receptors for IL-12 or IL-4. This leads to activation of complex signaling pathways, which are not known in detail. Disturbances in the balance between type 1 and type 2 responses can lead to certain immune-mediated diseases. Thus, it is important to understand how Th1 and Th2 cells are generated. To clarify the mechanisms as to how IL-12 and IL-4 induce Th1 and Th2 differentiation and how TGF-beta can inhibit this process, we have used oligonucleotide arrays to examine the early polarization of Th1 and Th2 cells in the presence and absence of TGF-beta after 0, 2, 6 and 48 hours of polarization.
PMID	14607935
GEOID	GSE2770
AUTHORS	Lund R,Aittokallio T,Nevalainen O,Lahesmaa R
CONTRIBUTOR	Jernej Godec
CONTRIBUTOR_ORG	Dana-Farber Cancer Institute
EXACT_SOURCE	GSE2770_2764_200_DN
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	ABCD3,ACBD3,ACVR1,ALDOB,ANXA1,ANXA5,AQR,ARCN1,ARL4C,ARMCX3,ASXL3,ATF3,AZIN1,BARHL2,BCL2L12,BRIX1,C10orf58,C12orf29,C14orf119,C1QC,C21orf59,C4orf32,C8orf38,C9orf100,C9orf23,CACHD1,CCAR1,CCDC117,CCDC141,CCNE2,CCNG1,CD164,CDK7,CDK8,CEP68,CEP95,CFH,CHML,CHURC1,CISD1,CNOT6,CRELD2,CRK,CRYM,CTAGE5,DDX18,DLD,DLK1,DNAJC2,DNAJC21,DNTTIP2,DRAM2,EBNA1BP2,EIF3E,EPDR1,EPS8,ESF1,EXOC1,EXOC3L1,EXTL3,FAM179B,FAM58A,FGB,GABRD,GKAP1,GLYR1,GPR153,GPR62,GRB2,GTF2E1,HABP4,HEATR2,HEBP1,HELZ,HHAT,HN1L,HNRPLL,HPS6,HSD17B4,HSDL2,HSP90AA1,HTRA1,IKZF2,IREB2,JAK2,KLHL7,LAS1L,LBH,LPPR2,MAF,MANF,MAP2K1,MATN4,MED13,MED21,MEMO1,METTL10,MLEC,MND1,MRPL18,MTERFD1,MTG1,NASP,NCAPG,NFKB1,NKRF,NLRP9,NOS2,NPR1,NTRK1,OMD,ORAOV1,ORC4,OSBP,PBK,PCGF6,PCM1,PDE4DIP,PDE6D,PGAM1,PHLPP1,PITPNA,PNO1,POLB,POM121L2,PPBP,PSMA2,PSMA3,PSPC1,PURB,PVRL2,PWP1,RAB1A,RAB39,RAD17,RBM18,RFWD2,RNASEH2B,RNF11,RNGTT,RPRD1B,RPS19BP1,SALL4,SBNO1,SCAF8,SCFD1,SDC4,SF3A3,SIRT1,SLAIN2,SLBP,SLC12A1,SLC15A4,SLC25A3,SLC35A3,SMARCAD1,SMEK2,SNX3,SNX5,SPATA2L,SPINK5,SRSF7,SSR2,STAC2,STRN,SYPL1,TAS1R1,TATDN3,TCEB1,TGDS,THUMPD3,TIMM23,TLCD1,TMEM64,TMEM70,TNPO3,TOP2A,TRIM5,TRNAU1AP,TSPAN14,UBA5,UBE2B,UBE2D3,UBE2L6,UCHL5,USF2,VOPP1,VPS53,WDR26,WDR62,WDR77,WRNIP1,YWHAE,ZBTB5,ZFX,ZMAT1,ZNF14,ZNF644,ZNF654,ZYX
GENE_SYMBOLS	ABCD3,ACBD3,ACVR1,ALDOB,ANXA1,ANXA5,AQR,ARCN1,ARL4C,ARMCX3,ASXL3,ATF3,AZIN1,BARHL2,BCL2L12,BRIX1,PRXL2A,RLIG1,C14orf119,C1QC,CFAP298,FAM241A,NDUFAF6,ARHGEF39,RPP25L,CACHD1,CCAR1,CCDC117,CCDC141,CCNE2,CCNG1,CD164,CDK7,CDK8,CEP68,CEP95,CFH,CHML,CHURC1,CISD1,CNOT6,CRELD2,CRK,CRYM,MIA2,DDX18,DLD,DLK1,DNAJC2,DNAJC21,DNTTIP2,DRAM2,EBNA1BP2,EIF3E,EPDR1,EPS8,ESF1,EXOC1,EXOC3L1,EXTL3,TOGARAM1,CCNQ,FGB,GABRD,GKAP1,GLYR1,GPR153,GPR62,GRB2,GTF2E1,HABP4,DNAAF5,HEBP1,HELZ,HHAT,JPT2,HNRNPLL,HPS6,HSD17B4,HSDL2,HSP90AA1,HTRA1,IKZF2,IREB2,JAK2,KLHL7,LAS1L,LBH,PLPPR2,MAF,MANF,MAP2K1,MATN4,MED13,MED21,MEMO1,EEF1AKMT2,MLEC,MND1,MRPL18,MTERF3,MTG1,NASP,NCAPG,NFKB1,NKRF,NLRP9,NOS2,NPR1,NTRK1,OMD,LTO1,ORC4,OSBP,PBK,PCGF6,PCM1,PDE4DIP,PDE6D,PGAM1,PHLPP1,PITPNA,PNO1,POLB,POM121L2,PPBP,PSMA2,PSMA3,PSPC1,PURB,NECTIN2,PWP1,RAB1A,RAB39A,RAD17,RBM18,COP1,RNASEH2B,RNF11,RNGTT,RPRD1B,RPS19BP1,SALL4,SBNO1,SCAF8,SCFD1,SDC4,SF3A3,SIRT1,SLAIN2,SLBP,SLC12A1,SLC15A4,SLC25A3,SLC35A3,SMARCAD1,PPP4R3B,SNX3,SNX5,SPATA2L,SPINK5,SRSF7,SSR2,STAC2,STRN,SYPL1,TAS1R1,TATDN3,ELOC,TGDS,THUMPD3,TIMM23,TLCD1,TMEM64,TMEM70,TNPO3,TOP2A,TRIM5,TRNAU1AP,TSPAN14,UBA5,UBE2B,UBE2D3,UBE2L6,UCHL5,USF2,VOPP1,VPS53,WDR26,WDR62,WDR77,WRNIP1,YWHAE,ZBTB5,ZFX,ZMAT1,ZNF14,ZNF644,ZNF654,ZYX
FOUNDER_NAMES