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     See license terms at www.gsea-msigdb.org/gsea/license_terms_list. Please note that certain gene sets have special access terms.
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<MSIGDB BUILD_DATE="Jan 29, 2026" VERSION="2026.1.Hs" NAME="export">
    <GENESET STANDARD_NAME="GSE2770_UNTREATED_VS_IL12_TREATED_ACT_CD4_TCELL_48H_DN" SYSTEMATIC_NAME="M6045" HISTORICAL_NAMES="" PMID="14607935" AUTHORS="Lund R,Aittokallio T,Nevalainen O,Lahesmaa R" GEOID="GSE2770" EXACT_SOURCE="GSE2770_2764_200_DN" GENESET_LISTING_URL="" EXTERNAL_DETAILS_URL="" CHIP="HUMAN_GENE_SYMBOL" CONTRIBUTOR="Jernej Godec" CONTRIBUTOR_ORG="Dana-Farber Cancer Institute" DESCRIPTION_BRIEF="Genes down-regulated in CD4 [GeneID=920] T cells: untreated (0h) versus activated by anti-CD3 and anti-CD28 and then stimulated by IL-12 (48h)." DESCRIPTION_FULL="Th1 and Th2 cells arise from a common precursor cell in response to triggering through the TCR and cytokine receptors for IL-12 or IL-4. This leads to activation of complex signaling pathways, which are not known in detail. Disturbances in the balance between type 1 and type 2 responses can lead to certain immune-mediated diseases. Thus, it is important to understand how Th1 and Th2 cells are generated. To clarify the mechanisms as to how IL-12 and IL-4 induce Th1 and Th2 differentiation and how TGF-beta can inhibit this process, we have used oligonucleotide arrays to examine the early polarization of Th1 and Th2 cells in the presence and absence of TGF-beta after 0, 2, 6 and 48 hours of polarization." TAGS="" MEMBERS="ABCD3,ACBD3,ACVR1,ALDOB,ANXA1,ANXA5,AQR,ARCN1,ARL4C,ARMCX3,ASXL3,ATF3,AZIN1,BARHL2,BCL2L12,BRIX1,C10orf58,C12orf29,C14orf119,C1QC,C21orf59,C4orf32,C8orf38,C9orf100,C9orf23,CACHD1,CCAR1,CCDC117,CCDC141,CCNE2,CCNG1,CD164,CDK7,CDK8,CEP68,CEP95,CFH,CHML,CHURC1,CISD1,CNOT6,CRELD2,CRK,CRYM,CTAGE5,DDX18,DLD,DLK1,DNAJC2,DNAJC21,DNTTIP2,DRAM2,EBNA1BP2,EIF3E,EPDR1,EPS8,ESF1,EXOC1,EXOC3L1,EXTL3,FAM179B,FAM58A,FGB,GABRD,GKAP1,GLYR1,GPR153,GPR62,GRB2,GTF2E1,HABP4,HEATR2,HEBP1,HELZ,HHAT,HN1L,HNRPLL,HPS6,HSD17B4,HSDL2,HSP90AA1,HTRA1,IKZF2,IREB2,JAK2,KLHL7,LAS1L,LBH,LPPR2,MAF,MANF,MAP2K1,MATN4,MED13,MED21,MEMO1,METTL10,MLEC,MND1,MRPL18,MTERFD1,MTG1,NASP,NCAPG,NFKB1,NKRF,NLRP9,NOS2,NPR1,NTRK1,OMD,ORAOV1,ORC4,OSBP,PBK,PCGF6,PCM1,PDE4DIP,PDE6D,PGAM1,PHLPP1,PITPNA,PNO1,POLB,POM121L2,PPBP,PSMA2,PSMA3,PSPC1,PURB,PVRL2,PWP1,RAB1A,RAB39,RAD17,RBM18,RFWD2,RNASEH2B,RNF11,RNGTT,RPRD1B,RPS19BP1,SALL4,SBNO1,SCAF8,SCFD1,SDC4,SF3A3,SIRT1,SLAIN2,SLBP,SLC12A1,SLC15A4,SLC25A3,SLC35A3,SMARCAD1,SMEK2,SNX3,SNX5,SPATA2L,SPINK5,SRSF7,SSR2,STAC2,STRN,SYPL1,TAS1R1,TATDN3,TCEB1,TGDS,THUMPD3,TIMM23,TLCD1,TMEM64,TMEM70,TNPO3,TOP2A,TRIM5,TRNAU1AP,TSPAN14,UBA5,UBE2B,UBE2D3,UBE2L6,UCHL5,USF2,VOPP1,VPS53,WDR26,WDR62,WDR77,WRNIP1,YWHAE,ZBTB5,ZFX,ZMAT1,ZNF14,ZNF644,ZNF654,ZYX" MEMBERS_SYMBOLIZED="ABCD3,ACBD3,ACVR1,ALDOB,ANXA1,ANXA5,AQR,ARCN1,ARHGEF39,ARL4C,ARMCX3,ASXL3,ATF3,AZIN1,BARHL2,BCL2L12,BRIX1,C14orf119,C1QC,CACHD1,CCAR1,CCDC117,CCDC141,CCNE2,CCNG1,CCNQ,CD164,CDK7,CDK8,CEP68,CEP95,CFAP298,CFH,CHML,CHURC1,CISD1,CNOT6,COP1,CRELD2,CRK,CRYM,DDX18,DLD,DLK1,DNAAF5,DNAJC2,DNAJC21,DNTTIP2,DRAM2,EBNA1BP2,EEF1AKMT2,EIF3E,ELOC,EPDR1,EPS8,ESF1,EXOC1,EXOC3L1,EXTL3,FAM241A,FGB,GABRD,GKAP1,GLYR1,GPR153,GPR62,GRB2,GTF2E1,HABP4,HEBP1,HELZ,HHAT,HNRNPLL,HPS6,HSD17B4,HSDL2,HSP90AA1,HTRA1,IKZF2,IREB2,JAK2,JPT2,KLHL7,LAS1L,LBH,LTO1,MAF,MANF,MAP2K1,MATN4,MED13,MED21,MEMO1,MIA2,MLEC,MND1,MRPL18,MTERF3,MTG1,NASP,NCAPG,NDUFAF6,NECTIN2,NFKB1,NKRF,NLRP9,NOS2,NPR1,NTRK1,OMD,ORC4,OSBP,PBK,PCGF6,PCM1,PDE4DIP,PDE6D,PGAM1,PHLPP1,PITPNA,PLPPR2,PNO1,POLB,POM121L2,PPBP,PPP4R3B,PRXL2A,PSMA2,PSMA3,PSPC1,PURB,PWP1,RAB1A,RAB39A,RAD17,RBM18,RLIG1,RNASEH2B,RNF11,RNGTT,RPP25L,RPRD1B,RPS19BP1,SALL4,SBNO1,SCAF8,SCFD1,SDC4,SF3A3,SIRT1,SLAIN2,SLBP,SLC12A1,SLC15A4,SLC25A3,SLC35A3,SMARCAD1,SNX3,SNX5,SPATA2L,SPINK5,SRSF7,SSR2,STAC2,STRN,SYPL1,TAS1R1,TATDN3,TGDS,THUMPD3,TIMM23,TLCD1,TMEM64,TMEM70,TNPO3,TOGARAM1,TOP2A,TRIM5,TRNAU1AP,TSPAN14,UBA5,UBE2B,UBE2D3,UBE2L6,UCHL5,USF2,VOPP1,VPS53,WDR26,WDR62,WDR77,WRNIP1,YWHAE,ZBTB5,ZFX,ZMAT1,ZNF14,ZNF644,ZNF654,ZYX" MEMBERS_EZID="100287932,10123,1022,1024,10946,10969,11005,11137,1122,116238,118442,121260,124044,128338,128387,132720,134218,137682,138716,1398,1428,150275,169200,1738,2059,2137,220064,2244,22807,22828,229,22927,23116,23177,23239,23256,23411,23443,23483,23534,2563,25917,26994,27000,27131,283849,284403,285025,2885,29074,2960,301,3075,308,30836,3295,3320,338321,342667,343472,3646,3658,3717,372,387509,399818,4094,4253,467,4678,4790,4843,4881,4914,4958,5000,5007,50865,51001,51072,5108,51377,5147,51566,51575,51582,5223,5250,5306,5423,5473,54734,54749,54919,54952,54968,55017,55206,55269,55275,55279,55299,55733,55749,55763,55847,55872,55922,55975,5604,5654,56683,5683,5684,56897,56902,56916,57167,57223,57472,57606,57685,5814,5819,5825,58490,5861,5884,6385,64151,6432,64326,64746,64748,6557,6746,6801,6856,6921,714,7153,7320,7323,7392,7531,7543,7561,7791,7873,7884,79084,79174,79621,79803,79876,80232,80318,80816,80835,81552,81606,81619,81887,83596,84057,84108,84146,84263,84293,84460,84656,84904,85363,8724,8732,8763,8785,8788,8886,90,900,90799,90861,91298,9134,91582,91612,92002,92170,92400,9246,92906,94026,9412,9659,9716,9761,9925,9931,9969" MEMBERS_MAPPING="ABCD3,ABCD3,5825|ACBD3,ACBD3,64746|ACVR1,ACVR1,90|ALDOB,ALDOB,229|ANXA1,ANXA1,301|ANXA5,ANXA5,308|AQR,AQR,9716|ARCN1,ARCN1,372|ARL4C,ARL4C,10123|ARMCX3,ARMCX3,51566|ASXL3,ASXL3,80816|ATF3,ATF3,467|AZIN1,AZIN1,51582|BARHL2,BARHL2,343472|BCL2L12,BCL2L12,83596|BRIX1,BRIX1,55299|C10orf58,PRXL2A,84293|C12orf29,RLIG1,91298|C14orf119,C14orf119,55017|C1QC,C1QC,714|C21orf59,CFAP298,56683|C4orf32,FAM241A,132720|C8orf38,NDUFAF6,137682|C9orf100,ARHGEF39,84904|C9orf23,RPP25L,138716|CACHD1,CACHD1,57685|CCAR1,CCAR1,55749|CCDC117,CCDC117,150275|CCDC141,CCDC141,285025|CCNE2,CCNE2,9134|CCNG1,CCNG1,900|CD164,CD164,8763|CDK7,CDK7,1022|CDK8,CDK8,1024|CEP68,CEP68,23177|CEP95,CEP95,90799|CFH,CFH,3075|CHML,CHML,1122|CHURC1,CHURC1,91612|CISD1,CISD1,55847|CNOT6,CNOT6,57472|CRELD2,CRELD2,79174|CRK,CRK,1398|CRYM,CRYM,1428|CTAGE5,MIA2,4253|DDX18,DDX18,8886|DLD,DLD,1738|DLK1,DLK1,8788|DNAJC2,DNAJC2,27000|DNAJC21,DNAJC21,134218|DNTTIP2,DNTTIP2,30836|DRAM2,DRAM2,128338|EBNA1BP2,EBNA1BP2,10969|EIF3E,EIF3E,3646|EPDR1,EPDR1,54749|EPS8,EPS8,2059|ESF1,ESF1,51575|EXOC1,EXOC1,55763|EXOC3L1,EXOC3L1,283849|EXTL3,EXTL3,2137|FAM179B,TOGARAM1,23116|FAM58A,CCNQ,92002|FGB,FGB,2244|GABRD,GABRD,2563|GKAP1,GKAP1,80318|GLYR1,GLYR1,84656|GPR153,GPR153,387509|GPR62,GPR62,118442|GRB2,GRB2,2885|GTF2E1,GTF2E1,2960|HABP4,HABP4,22927|HEATR2,DNAAF5,54919|HEBP1,HEBP1,50865|HELZ,HELZ,9931|HHAT,HHAT,55733|HN1L,JPT2,90861|HNRPLL,HNRNPLL,92906|HPS6,HPS6,79803|HSD17B4,HSD17B4,3295|HSDL2,HSDL2,84263|HSP90AA1,HSP90AA1,3320|HTRA1,HTRA1,5654|IKZF2,IKZF2,22807|IREB2,IREB2,3658|JAK2,JAK2,3717|KLHL7,KLHL7,55975|LAS1L,LAS1L,81887|LBH,LBH,81606|LPPR2,PLPPR2,64748|MAF,MAF,4094|MANF,MANF,7873|MAP2K1,MAP2K1,5604|MATN4,MATN4,8785|MED13,MED13,9969|MED21,MED21,9412|MEMO1,MEMO1,51072|METTL10,EEF1AKMT2,399818|MLEC,MLEC,9761|MND1,MND1,84057|MRPL18,MRPL18,29074|MTERFD1,MTERF3,51001|MTG1,MTG1,92170|NASP,NASP,4678|NCAPG,NCAPG,64151|NFKB1,NFKB1,4790|NKRF,NKRF,55922|NLRP9,NLRP9,338321|NOS2,NOS2,4843|NPR1,NPR1,4881|NTRK1,NTRK1,4914|OMD,OMD,4958|ORAOV1,LTO1,220064|ORC4,ORC4,5000|OSBP,OSBP,5007|PBK,PBK,55872|PCGF6,PCGF6,84108|PCM1,PCM1,5108|PDE4DIP,PDE4DIP,9659|PDE6D,PDE6D,5147|PGAM1,PGAM1,5223|PHLPP1,PHLPP1,23239|PITPNA,PITPNA,5306|PNO1,PNO1,56902|POLB,POLB,5423|POM121L2,POM121L2,94026|PPBP,PPBP,5473|PSMA2,PSMA2,5683|PSMA3,PSMA3,5684|PSPC1,PSPC1,55269|PURB,PURB,5814|PVRL2,NECTIN2,5819|PWP1,PWP1,11137|RAB1A,RAB1A,5861|RAB39,RAB39A,54734|RAD17,RAD17,5884|RBM18,RBM18,92400|RFWD2,COP1,64326|RNASEH2B,RNASEH2B,79621|RNF11,RNF11,26994|RNGTT,RNGTT,8732|RPRD1B,RPRD1B,58490|RPS19BP1,RPS19BP1,91582|SALL4,SALL4,57167|SBNO1,SBNO1,55206|SCAF8,SCAF8,22828|SCFD1,SCFD1,23256|SDC4,SDC4,6385|SF3A3,SF3A3,10946|SIRT1,SIRT1,23411|SLAIN2,SLAIN2,57606|SLBP,SLBP,7884|SLC12A1,SLC12A1,6557|SLC15A4,SLC15A4,121260|SLC25A3,SLC25A3,5250|SLC35A3,SLC35A3,23443|SMARCAD1,SMARCAD1,56916|SMEK2,PPP4R3B,57223|SNX3,SNX3,8724|SNX5,SNX5,27131|SPATA2L,SPATA2L,124044|SPINK5,SPINK5,11005|SRSF7,SRSF7,6432|SSR2,SSR2,6746|STAC2,STAC2,342667|STRN,STRN,6801|SYPL1,SYPL1,6856|TAS1R1,TAS1R1,80835|TATDN3,TATDN3,128387|TCEB1,ELOC,6921|TGDS,TGDS,23483|THUMPD3,THUMPD3,25917|TIMM23,TIMM23,100287932|TLCD1,TLCD1,116238|TMEM64,TMEM64,169200|TMEM70,TMEM70,54968|TNPO3,TNPO3,23534|TOP2A,TOP2A,7153|TRIM5,TRIM5,85363|TRNAU1AP,TRNAU1AP,54952|TSPAN14,TSPAN14,81619|UBA5,UBA5,79876|UBE2B,UBE2B,7320|UBE2D3,UBE2D3,7323|UBE2L6,UBE2L6,9246|UCHL5,UCHL5,51377|USF2,USF2,7392|VOPP1,VOPP1,81552|VPS53,VPS53,55275|WDR26,WDR26,80232|WDR62,WDR62,284403|WDR77,WDR77,79084|WRNIP1,WRNIP1,56897|YWHAE,YWHAE,7531|ZBTB5,ZBTB5,9925|ZFX,ZFX,7543|ZMAT1,ZMAT1,84460|ZNF14,ZNF14,7561|ZNF644,ZNF644,84146|ZNF654,ZNF654,55279|ZYX,ZYX,7791" FILTERED_BY_SIMILARITY="" FOUNDER_NAMES="" REFINEMENT_DATASETS="" VALIDATION_DATASETS="" CATEGORY_CODE="C7" ORGANISM="Homo sapiens" SUB_CATEGORY_CODE="IMMUNESIGDB"/>
</MSIGDB>
