STANDARD_NAME GSE2770_UNTREATED_VS_IL4_TREATED_ACT_CD4_TCELL_6H_DN SYSTEMATIC_NAME M6021 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE2770_UNTREATED_VS_IL4_TREATED_ACT_CD4_TCELL_6H_DN NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes down-regulated in CD4 [GeneID=920] T cells: untreated (0h) versus activated by anti-CD3 and anti-CD28 and then stimulated by IL4 [GeneID=3565] (6h). DESCRIPTION_FULL Th1 and Th2 cells arise from a common precursor cell in response to triggering through the TCR and cytokine receptors for IL-12 or IL-4. This leads to activation of complex signaling pathways, which are not known in detail. Disturbances in the balance between type 1 and type 2 responses can lead to certain immune-mediated diseases. Thus, it is important to understand how Th1 and Th2 cells are generated. To clarify the mechanisms as to how IL-12 and IL-4 induce Th1 and Th2 differentiation and how TGF-beta can inhibit this process, we have used oligonucleotide arrays to examine the early polarization of Th1 and Th2 cells in the presence and absence of TGF-beta after 0, 2, 6 and 48 hours of polarization. PMID 14607935 GEOID GSE2770 AUTHORS Lund R,Aittokallio T,Nevalainen O,Lahesmaa R CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE2770_2769_200_DN FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS ACP5,ACTR6,ADD3,AGER,AHCTF1,AKAP11,AKAP13,ANGPTL1,ANKRD11,ARHGAP33,ATXN10,ATXN7L1,B9D1,B9D2,BCAR3,BCL7A,BID,BNIP1,BTBD6,C11orf75,C14orf148,C16orf87,C17orf96,C18orf54,C19orf25,C1orf55,C3orf70,C4orf46,CA13,CBFB,CBX7,CD2,CDCA3,CDKN2D,CELSR1,CLIC1,CNST,CORO1B,CSK,CUX1,DDX26B,DENND1B,DNM1L,DSN1,DTNB,DTNBP1,DUS2L,ECT2,EID1,EIF3F,ESCO2,EXOC6,FAM168B,GAB3,GAPVD1,GCNT1,GMIP,GNA12,GNA13,GRB2,GYPC,HEATR6,HERC3,HIF1A,HIPK3,HLA-DOB,HLA-DRB1,HNRNPUL2,HSD17B7,IDH3B,IFIT2,IL4R,INVS,IPO5,IQCE,ITGAV,ITGB3,ITGB3BP,ITPA,ITPR1,JAK2,KIF11,KLHDC3,L3MBTL3,LIFR,LIMD1,LNX2,LOC148413,LONRF1,LSP1,LTK,MAD2L1,MAGOHB,MAP3K3,MAP4K2,MAP7,MAPK11,MBD4,MBP,MDM1,METTL10,METTL14,MFSD1,MID1IP1,MRPL3,MTBP,MZT1,N4BP3,NBEAL2,NCOA1,NCOA3,NEIL1,NEK2,NFATC2IP,NFATC3,NIPSNAP1,OAS1,ORMDL1,OSBPL9,OSGIN2,PAIP2,PANK2,PCM1,PCYT1B,PEA15,PEX7,PHF2,PHIP,PHKA1,PIF1,PLCG1,PLEKHO2,POLR1D,POLR3B,PPP1CA,PPP1R3F,PPP6R1,PTPN23,PXK,RABEP1,RAC2,RAP1GDS1,RDH12,REL,REV3L,RGS19,RHOF,RNF125,RNF41,ROPN1L,RPGR,RPS6KA3,RPS6KA5,SBF2,SCAI,SDCCAG8,SEC22C,SETD1A,SETD2,SF3B2,SH3KBP1,SLBP,SLC39A6,SLC9A5,SNRPD1,SNX30,SPEF1,SPI1,SPNS3,SPSB3,STAG2,SULF2,SULT1A1,SUMO3,TBCEL,TBL1XR1,TCOF1,TEN1,TFEB,THOC7,TK2,TMEFF1,TOP2B,TP53I11,TPD52,TUSC3,TXNDC16,UNC119,USP1,USP11,UVRAG,VASN,VPS33A,WIPF1,YWHAB,ZC3H14,ZC3H7B,ZNF346,ZNF367,ZNF746 GENE_SYMBOLS ACP5,ACTR6,ADD3,AGER,AHCTF1,AKAP11,AKAP13,ANGPTL1,ANKRD11,ARHGAP33,ATXN10,ATXN7L1,B9D1,B9D2,BCAR3,BCL7A,BID,BNIP1,BTBD6,SMCO4,NOXRED1,C16orf87,EPOP,C18orf54,C19orf25,SDE2,C3orf70,C4orf46,CA13,CBFB,CBX7,CD2,CDCA3,CDKN2D,CELSR1,CLIC1,CNST,CORO1B,CSK,CUX1,INTS6L,DENND1B,DNM1L,DSN1,DTNB,DTNBP1,DUS2,ECT2,EID1,EIF3F,ESCO2,EXOC6,FAM168B,GAB3,GAPVD1,GCNT1,GMIP,GNA12,GNA13,GRB2,GYPC,HEATR6,HERC3,HIF1A,HIPK3,HLA-DOB,HLA-DRB1,HNRNPUL2,HSD17B7,IDH3B,IFIT2,IL4R,INVS,IPO5,IQCE,ITGAV,ITGB3,ITGB3BP,ITPA,ITPR1,JAK2,KIF11,KLHDC3,L3MBTL3,LIFR,LIMD1,LNX2,MRPL20-AS1,LONRF1,LSP1,LTK,MAD2L1,MAGOHB,MAP3K3,MAP4K2,MAP7,MAPK11,MBD4,MBP,MDM1,EEF1AKMT2,METTL14,MFSD1,MID1IP1,MRPL3,MTBP,MZT1,N4BP3,NBEAL2,NCOA1,NCOA3,NEIL1,NEK2,NFATC2IP,NFATC3,NIPSNAP1,OAS1,ORMDL1,OSBPL9,OSGIN2,PAIP2,PANK2,PCM1,PCYT1B,PEA15,PEX7,PHF2,PHIP,PHKA1,PIF1,PLCG1,PLEKHO2,POLR1D,POLR3B,PPP1CA,PPP1R3F,PPP6R1,PTPN23,PXK,RABEP1,RAC2,RAP1GDS1,RDH12,REL,REV3L,RGS19,RHOF,RNF125,RNF41,ROPN1L,RPGR,RPS6KA3,RPS6KA5,SBF2,SCAI,SDCCAG8,SEC22C,SETD1A,SETD2,SF3B2,SH3KBP1,SLBP,SLC39A6,SLC9A5,SNRPD1,SNX30,SPEF1,SPI1,SPNS3,SPSB3,STAG2,SULF2,SULT1A1,SUMO3,TBCEL,TBL1XR1,TCOF1,TEN1,TFEB,THOC7,TK2,TMEFF1,TOP2B,TP53I11,TPD52,TUSC3,TXNDC16,UNC119,USP1,USP11,UVRAG,VASN,VPS33A,WIPF1,YWHAB,ZC3H14,ZC3H7B,ZNF346,ZNF367,ZNF746 FOUNDER_NAMES