STANDARD_NAME	GSE27859_MACROPHAGE_VS_DC_DN
SYSTEMATIC_NAME	M8588
COLLECTION	C7:IMMUNESIGDB
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE27859_MACROPHAGE_VS_DC_DN
NAMESPACE	HUMAN_GENE_SYMBOL
DESCRIPTION_BRIEF	Genes down-regulated in macrophages versus dendritic cells.
DESCRIPTION_FULL	Dendritic cells (DCs) and macrophages (MPs) are important for immunological homeostasis in the colon. We found that F4/80hi CX3CR1hi (CD11b+CD103-) cells account for 80% of mouse colonic lamina propria (cLP) MHC-IIhi cells. Both CD11c+ and CD11c- cells within this population were identified as MPs based on multiple criteria, including a MP transcriptome revealed by microarray analysis. These MPs constitutively released high levels of IL-10 at least partially in response to the microbiota via an MyD88-independent mechanism. In contrast, cells expressing low to intermediate levels of F4/80 and CX3CR1 were identified as DCs, based on phenotypic and functional analysis and comprise three separate CD11chi cell populations: CD103+CX3CR1-CD11b- DCs, CD103+CX3CR1-CD11b+ DCs and CD103-CX3CR1intCD11b+ DCs. In non-inflammatory conditions, Ly6Chi monocytes differentiated primarily into CD11c+, but not CD11c- MPs. In contrast, during colitis, Ly6Chi monocytes massively invaded the colon and differentiated into pro-inflammatory CD103-CX3CR1intCD11b+ DCs, which produced high levels of IL-12, IL-23, iNOS and TNF. These findings demonstrate the dual capacity of Ly6Chi blood monocytes to differentiate into either regulatory MPs or inflammatory DCs in the colon, and that the balance of these immunologically antagonistic cell types is dictated by microenvironmental conditions.
PMID	22231304
GEOID	GSE27859
AUTHORS	Rivollier A,He J,Kole A,Valatas V,Kelsall BL
CONTRIBUTOR	Jernej Godec
CONTRIBUTOR_ORG	Dana-Farber Cancer Institute
EXACT_SOURCE	GSE27859_2495_200_DN
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	ABHD5,ACADVL,ACP5,ACSL1,ADAMTSL4,AGPAT2,AGPAT4,AICDA,ALDH8A1,ANKK1,ANKRD42,APH1B,APOC1,ARAP1,ARHGAP24,ATN1,AURKC,BSCL2,BSX,BTBD2,C10orf26,C6,C6orf47,C9orf106,CABLES1,CALML3,CBX7,CCDC38,CD68,CD9,CEBPB,CEP72,CHRM5,CHRNG,CLCNKB,CLIP4,CLN3,CNPY3,CPD,CPT1A,CRIPT,CTSD,CYGB,CYP27A1,CYTH1,DAG1,DCP1B,DET1,DHRS7C,DKFZP547L112,DMBX1,DND1,DSG4,EGLN2,EMID1,FAM189B,FAM19A2,FAM71F1,FAM89A,FAM9B,FBXO46,FGF17,FRS3,FTH1,FTH1P5,GJD4,GNAS,GNRH2,GPC1,GRIN3B,HAPLN2,HCAR3,HCG8,HDHD3,HIST1H2AH,HMGB3P1,HMGN2P18,HMGN4,HSD17B14,HTR3E,ICAM2,IGSF9B,IL10RB,IL20RB,IMPA2,INF2,KCNA7,KCNC4,KCNJ5,KIAA1045,KIF1B,KLHDC7A,KLHDC8B,KLHL33,KLHL35,LCE3B,LDB3,LGALS3,LGI4,LOC100129831,LOC100131170,LOC399744,LRPAP1,LTA4H,LTB,LYSMD1,MADCAM1,MECP2,MFHAS1,MGST1,MIR191,MIR31,MLL4,MORC2-AS1,NIPSNAP3B,NKAPL,NPFFR2,NPHP4,NR1H3,NRF1,NRIP2,OR4D6,OR52K2,OR8I2,PARP15,PCDHB3,PCOLCE2,PDK4,PELI3,PKLR,PKNOX2,PLIN2,PLVAP,PON1,POU5F2,PPP1R15B,ProSAPiP1,PXDN,RAD51B,RAPGEFL1,RBM14,RBP1,RGL3,RNF149,RPP25,RPRML,RSPH3,RUNDC2C,SCARNA8,SCCPDH,SCN1A,SEPT3,SERINC2,SETD5,SGCE,SHANK3,SIK2,SIK3,SIRT2,SKP1,SLC12A6,SLC14A2,SLC24A6,SLC25A18,SLC27A1,SLC31A2,SLC39A11,SMARCD3,SNX27,STMN1,SVIL,TAF4,TANC2,TBC1D9,TMEM74,TMEM79,TNRC6C,TRH,TRIM25,TRMT112,TSPAN16,TSPAN3,TTLL8,UBE2R2,UBXN11,UNC5CL,USP49,UTS2R,VEGFB,WFDC3,WFDC5,WIZ,ZAR1L,ZBTB34,ZBTB47,ZDHHC8,ZDHHC8P1,ZFAND6,ZFYVE26,ZNF630
GENE_SYMBOLS	ABHD5,ACADVL,ACP5,ACSL1,ADAMTSL4,AGPAT2,AGPAT4,AICDA,ALDH8A1,ANKK1,ANKRD42,APH1B,APOC1,ARAP1,ARHGAP24,ATN1,AURKC,BSCL2,BSX,BTBD2,WBP1L,C6,C6orf47,,CABLES1,CALML3,CBX7,CCDC38,CD68,CD9,CEBPB,CEP72,CHRM5,CHRNG,CLCNKB,CLIP4,CLN3,CNPY3,CPD,CPT1A,CRIPT,CTSD,CYGB,CYP27A1,CYTH1,DAG1,DCP1B,DET1,DHRS7C,,DMBX1,DND1,DSG4,EGLN2,EMID1,ENTREP3,TAFA2,GARIN1B,FAM89A,FAM9B,FBXO46,FGF17,FRS3,FTH1,FTH1P5,GJD4,GNAS,GNRH2,GPC1,GRIN3B,HAPLN2,HCAR3,POLR1HASP,HDHD3,H2AC12,HMGB3P1,HMGN2P18,HMGN4,HSD17B14,HTR3E,ICAM2,IGSF9B,IL10RB,IL20RB,IMPA2,INF2,KCNA7,KCNC4,KCNJ5,PHF24,KIF1B,KLHDC7A,KLHDC8B,KLHL33,KLHL35,LCE3B,LDB3,LGALS3,LGI4,,,,LRPAP1,LTA4H,LTB,LYSMD1,MADCAM1,MECP2,MFHAS1,MGST1,MIR191,MIR31,KMT2D,MORC2-AS1,NIPSNAP3B,NKAPL,NPFFR2,NPHP4,NR1H3,NRF1,NRIP2,OR4D6,OR52K2,OR8I2,PARP15,PCDHB3,PCOLCE2,PDK4,PELI3,PKLR,PKNOX2,PLIN2,PLVAP,PON1,POU5F2,PPP1R15B,PXDN,LZTS3,RAD51B,RAPGEFL1,RBM14,RBP1,RGL3,RNF149,RPP25,RPRML,RSPH3,SNX29P2,SCARNA8,SCCPDH,SCN1A,SEPTIN3,SERINC2,SETD5,SGCE,SHANK3,SIK2,SIK3,SIRT2,SKP1,SLC12A6,SLC14A2,SLC8B1,SLC25A18,SLC27A1,SLC31A2,SLC39A11,SMARCD3,SNX27,STMN1,SVIL,TAF4,TANC2,TBC1D9,TMEM74,TMEM79,TNRC6C,TRH,TRIM25,TRMT112,TSPAN16,TSPAN3,TTLL8,UBE2R2,UBXN11,UNC5CL,USP49,UTS2R,VEGFB,WFDC3,WFDC5,WIZ,ZAR1L,ZBTB34,ZBTB47,ZDHHC8,ZDHHC8BP,ZFAND6,ZFYVE26,ZNF630
FOUNDER_NAMES