STANDARD_NAME GSE30962_ACUTE_VS_CHRONIC_LCMV_SECONDARY_INF_CD8_TCELL_DN SYSTEMATIC_NAME M5052 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE30962_ACUTE_VS_CHRONIC_LCMV_SECONDARY_INF_CD8_TCELL_DN NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes down-regulated in comparison of splenic secondary CD8 effector T cells at day 8 post-acute infection versus splenic secondary CD8 effector T cells at day 8 post-chronic infection. DESCRIPTION_FULL Understanding the response of memory CD8 T cells to persistent antigen re-stimulation and the role of CD4 T cell help is critical to the design of successful vaccines for chronic diseases. However, studies comparing the protective abilities and qualities of memory and naïve cells have been mostly performed in acute infections, and little is known about their roles during chronic infections. Herein, we show that memory cells dominate over naïve cells and are protective when present in large enough numbers to quickly reduce infection. In contrast, when infection is not rapidly reduced, memory cells are quickly lost, unlike naïve cells. This loss of memory cells is due to (i) an early block in cell proliferation, (ii) selective regulation by the inhibitory receptor 2B4, and (iii) increased reliance on CD4 T cell help. These findings have important implications towards the design of T cell vaccines against chronic infections and tumors. PMID 21856186 GEOID GSE30962 AUTHORS West EE,Youngblood B,Tan WG,Jin HT,Araki K,Alexe G,Konieczny BT,Calpe S,Freeman GJ,Terhorst C,Haining WN,Ahmed R CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE30962_1573_200_DN FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS ACOXL,AIFM1,AKR1B15,AMIGO1,ARHGAP11A,BARD1,BCAP29,BCL2A1,BIRC5,BRCA1,BTBD19,BTF3L4,C12orf75,C2orf56,C4orf27,C6orf168,C9orf152,CASC5,CASP3,CCDC28B,CD109,CD160,CD244,CD81,CDC14A,CDKN3,CENPE,CENPH,CEP128,CEP19,CEP57,CHST2,CKAP2L,CLPB,CLSPN,CORO2A,COX5A,CPT1A,CYTH3,DDX1,DHFR,DNAJB13,DSCC1,DTL,DUSP6,DUT,DYNLL2,E2F1,EFHA2,EGR1,EGR2,EHD4,EPCAM,EPDR1,ESCO2,EZH2,FAM20A,FAM3C,FARP1,FGFR1OP,FILIP1,FRMD4B,GAR1,GBP6,GCNT1,GCSH,GFI1,GINS1,GLIPR1,GLRX,GNPTAB,GPD2,GPR56,GPR65,HELLS,HHEX,HMBS,HMGB3,HOOK1,HRH4,HSD17B12,ICA1,IFI27L2,IFI30,IFNGR1,IFT80,IL1R2,IL21,INO80C,INPP4B,IPCEF1,IQGAP3,IRF8,ISG20,ITIH5,JDP2,KALRN,KDELC2,KIAA0141,KIAA1524,KIF20B,KIF22,LAG3,LAMP2,LDHA,LITAF,LOC144486,LPGAT1,LSM2,LSM6,MCM10,MCM8,MED7,MIPEP,NAMPT,NAPSA,NASP,NCF1,NDFIP2,NDRG1,NMRAL1,NPNT,NR4A2,NUP93,OXSR1,PAQR4,PBK,PCGF5,PDCD1,PERP,PFKFB1,PHACTR2,PIP4K2A,PITPNM2,PLK4,PLXND1,PMVK,PPA1,PPIL1,PRC1,PSMB7,PTGER2,PTPN12,RAD51,RAD51AP1,RCN1,RGS16,RNF128,RRM1,RRM2,RSAD2,RTP4,RUVBL1,SC5DL,SEC63,SEMA4C,SEMA7A,SERPINB9,SERPINE2,SHCBP1,SKAP2,SMARCA5,SMC2,SMCHD1,SMYD2,SNRNP35,SNX9,SPATS2,SPC25,SPRED1,SRFBP1,SRGAP3,ST14,STARD4,STMN1,STT3B,SYNPO,TACC2,TACC3,TEX9,TFRC,THOC4,TIPIN,TK1,TMBIM1,TMCC3,TMEM20,TMEM38B,TNFRSF9,TOP2A,TPX2,TSR1,TWSG1,TYMS,UBASH3B,XCL1,XPNPEP1,ZAP70,ZNF367,ZWILCH GENE_SYMBOLS ACOXL,AIFM1,AKR1B15,AMIGO1,ARHGAP11A,BARD1,BCAP29,BCL2A1,BIRC5,BRCA1,BTBD19,BTF3L4,C12orf75,NDUFAF7,HPF1,FAXC,C9orf152,KNL1,CASP3,CCDC28B,CD109,CD160,CD244,CD81,CDC14A,CDKN3,CENPE,CENPH,CEP128,CEP19,CEP57,CHST2,CKAP2L,CLPB,CLSPN,CORO2A,COX5A,CPT1A,CYTH3,DDX1,DHFR,DNAJB13,DSCC1,DTL,DUSP6,DUT,DYNLL2,E2F1,MICU3,EGR1,EGR2,EHD4,EPCAM,EPDR1,ESCO2,EZH2,FAM20A,FAM3C,FARP1,CEP43,FILIP1,FRMD4B,GAR1,GBP6,GCNT1,GCSH,GFI1,GINS1,GLIPR1,GLRX,GNPTAB,GPD2,ADGRG1,GPR65,HELLS,HHEX,HMBS,HMGB3,HOOK1,HRH4,HSD17B12,ICA1,IFI27L2,IFI30,IFNGR1,IFT80,IL1R2,IL21,INO80C,INPP4B,IPCEF1,IQGAP3,IRF8,ISG20,ITIH5,JDP2,KALRN,POGLUT3,DELE1,CIP2A,KIF20B,KIF22,LAG3,LAMP2,LDHA,LITAF,CEP83-DT,LPGAT1,LSM2,LSM6,MCM10,MCM8,MED7,MIPEP,NAMPT,NAPSA,NASP,NCF1,NDFIP2,NDRG1,NMRAL1,NPNT,NR4A2,NUP93,OXSR1,PAQR4,PBK,PCGF5,PDCD1,PERP,PFKFB1,PHACTR2,PIP4K2A,PITPNM2,PLK4,PLXND1,PMVK,PPA1,PPIL1,PRC1,PSMB7,PTGER2,PTPN12,RAD51,RAD51AP1,RCN1,RGS16,RNF128,RRM1,RRM2,RSAD2,RTP4,RUVBL1,SC5D,SEC63,SEMA4C,SEMA7A,SERPINB9,SERPINE2,SHCBP1,SKAP2,SMARCA5,SMC2,SMCHD1,SMYD2,SNRNP35,SNX9,SPATS2,SPC25,SPRED1,SRFBP1,SRGAP3,ST14,STARD4,STMN1,STT3B,SYNPO,TACC2,TACC3,TEX9,TFRC,ALYREF,TIPIN,TK1,TMBIM1,TMCC3,SLC35G1,TMEM38B,TNFRSF9,TOP2A,TPX2,TSR1,TWSG1,TYMS,UBASH3B,XCL1,XPNPEP1,ZAP70,ZNF367,ZWILCH FOUNDER_NAMES