STANDARD_NAME GSE30971_2H_VS_4H_LPS_STIM_MACROPHAGE_WBP7_HET_DN SYSTEMATIC_NAME M8725 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE30971_2H_VS_4H_LPS_STIM_MACROPHAGE_WBP7_HET_DN NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes down-regulated in bone marrow-derived macrophages with heterozygous MLL4 [GeneID=9757] knockout: 2h LPS versus 4h LPS. DESCRIPTION_FULL Histone methyltransferases catalyze site-specific deposition of methyl groups, enabling recruitment of transcriptional regulators. In mammals, trimethylation of lysine 4 in histone H3, a modification localized at the transcription start sites of active genes, is catalyzed by six enzymes (SET1a and SET1b, MLL1–MLL4) whose specific functions are largely unknown. By using a genomic approach, we found that in macrophages, MLL4 (also known as Wbp7) was required for the expression of Pigp, an essential component of the GPI-GlcNAc transferase, the enzyme catalyzing the first step of glycosylphosphatidylinositol (GPI) anchor synthesis. Impaired Pigp expression in Wbp7-/- macrophages abolished GPI anchor-dependent loading of proteins on the cell membrane. Consistently, loss of GPI-anchored CD14, the coreceptor for lipopolysaccharide (LPS) and other bacterial molecules, markedly attenuated LPS-triggered intracellular signals and gene expression changes. These data link a histone-modifying enzyme to a biosynthetic pathway and indicate a specialized biological role for Wbp7 in macrophage function and antimicrobial response. PMID 22483804 GEOID GSE30971 AUTHORS Austenaa L,Barozzi I,Chronowska A,Termanini A,Ostuni R,Prosperini E,Stewart AF,Testa G,Natoli G CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE30971_2572_200_DN FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS AADACL2,ABTB2,ACOT12,ADCY10,AFAP1-AS1,AKIRIN2-AS1,ANKRD30BP2,ANKRD55,ARHGAP24,ATXN3L,BAALC,BCL2A1,BTNL8,C11orf40,C11orf45,C11orf96,C12orf54,C14orf105,C18orf21,C19orf10,C1orf100,C1orf87,C4orf17,C9orf96,CA10,CAPN5,CCL20,CDKN2A,CDKN2B,CEACAM3,CGRRF1,CHI3L2,CLGN,CNNM1,CSF2,CTHRC1,CTSL1P8,CXCL2,CYP7B1,DCAF4L2,DGKI,DNAJB9,DPH3P1,EFNB2,EIF2C2,ELL2,ELOVL7,EMP2,EPM2AIP1,ESRRG,FAM188A,FAM18B1,FAM40B,FBN1,FBXO39,FCGR1A,FERMT2,FGF13,FLT1,FSD1L,GADD45A,GADD45B,GDF11,GFPT2,GJC1,GNG2,GOLGA5,GPA33,GPR64,GRHL1,HCAR3,HIST1H2AL,HORMAD2,HOTTIP,HS2ST1,HSD3B1,IFNA16,IGHV3OR16-13,IL23A,IL36G,ILDR2,KANK1,KAZN,KCNAB1,KCNK2,KIAA1324,KIF9,KRT23,KRTAP4-2,LAMA2,LCOR,LDHAL6A,LIX1,LOC100129858,LOC100288413,LOC100289049,LOC100289210,LOC100506229,LOC144776,LOC203274,LOC285401,LOC285423,LOC285857,LOC286087,LOC339535,LOC400620,LOC400940,LOC401022,LOC401324,LOC404266,LOC642891,LOC645188,LOC647323,LONRF2,LRP11,MAP3K4,MARCH3,MCC,MED14,MEIR5,MGAT2,MIR155HG,MS4A5,MSH4,MST4,MTPN,MYO5B,MYOT,NCR1,NCRNA00318,NDP,NEDD4,NEK11,NEURL1B,NEUROD6,NFAT5,NKX3-1,NME5,NUDT21,NYNRIN,OAZ3,OLFM3,OR10A5,OR8D1,OSTCL,OTX2,PCA3,PDE4B,PDGFRA,PLAC8,PLAT,PLEKHA6,PNPLA8,POU2F3,PPP1R3A,PRH1,PRKAA2,PRRC1,PRRC2C,PTGS2,RALGAPA1,RBM17,RBM7,RGN,RPGRIP1,SAP30BP,SERPINB7,SH2D4B,SH3GL1P2,SH3GLB1,SIGLEC15,SIGLEC6,SLAMF1,SLC14A2,SLC25A45,SMOC2,SOCS3,STAT3,STEAP1,SYPL2,TACR3,TEX15,TLE1,TM4SF1,TMEM90A,TNFRSF21,TP53BP2,TRAF3IP2,TTC29,TXLNB,UGT2B15,XBP1,ZAK,ZBTB10,ZBTB38,ZIM3,ZKSCAN5,ZNF214,ZNF705G,ZXDA GENE_SYMBOLS AADACL2,ABTB2,ACOT12,ADCY10,AFAP1-AS1,,ANKRD30BP2,ANKRD55,ARHGAP24,ATXN3L,BAALC,BCL2A1,BTNL8,C11orf40,KCNJ5-AS1,C11orf96,C12orf54,CCDC198,C18orf21,MYDGF,C1orf100,C1orf87,C4orf17,STKLD1,CA10,CAPN5,CCL20,CDKN2A,CDKN2B,CEACAM3,CGRRF1,CHI3L2,CLGN,CNNM1,CSF2,CTHRC1,CTSLP8,CXCL2,CYP7B1,DCAF4L2,DGKI,DNAJB9,DPH3P1,EFNB2,AGO2,ELL2,ELOVL7,EMP2,EPM2AIP1,ESRRG,MINDY3,TVP23B,STRIP2,FBN1,FBXO39,FCGR1A,FERMT2,FGF13,FLT1,FSD1L,GADD45A,GADD45B,GDF11,GFPT2,GJC1,GNG2,GOLGA5,GPA33,ADGRG2,GRHL1,HCAR3,H2AC16,HORMAD2,HOTTIP,HS2ST1,HSD3B1,IFNA16,IGHV3OR16-13,IL23A,IL36G,ILDR2,KANK1,KAZN,KCNAB1,KCNK2,ELAPOR1,KIF9,KRT23,KRTAP4-2,LAMA2,LCOR,LDHAL6A,LIX1,SCOC-AS1,ERVMER34-1,,,LINC01093,LINC00410,,LINC00698,IQCM,LINC02537,,LINC01139,LINC02092,,HAGLR,,HOXB-AS3,CHL1-AS2,ENSG00000223438,LINC02026,LONRF2,LRP11,MAP3K4,MARCHF3,MCC,MED14,SFR1,MGAT2,MIR155HG,MS4A5,MSH4,STK26,MTPN,MYO5B,MYOT,NCR1,ZNF295-AS1,NDP,NEDD4,NEK11,NEURL1B,NEUROD6,NFAT5,NKX3-1,NME5,NUDT21,NYNRIN,OAZ3,OLFM3,OR10A5,OR8D1,OSTCP1,OTX2,PCA3,PDE4B,PDGFRA,PLAC8,PLAT,PLEKHA6,PNPLA8,POU2F3,PPP1R3A,PRH1,PRKAA2,PRRC1,PRRC2C,PTGS2,RALGAPA1,RBM17,RBM7,RGN,RPGRIP1,SAP30BP,SERPINB7,SH2D4B,SH3GL1P2,SH3GLB1,SIGLEC15,SIGLEC6,SLAMF1,SLC14A2,SLC25A45,SMOC2,SOCS3,STAT3,STEAP1,SYPL2,TACR3,TEX15,TLE1,TM4SF1,SYNDIG1L,TNFRSF21,TP53BP2,TRAF3IP2,TTC29,TXLNB,UGT2B15,XBP1,MAP3K20,ZBTB10,ZBTB38,ZIM3,ZKSCAN5,ZNF214,ZNF705G,ZXDA FOUNDER_NAMES