STANDARD_NAME GSE30971_2H_VS_4H_LPS_STIM_MACROPHAGE_WBP7_KO_DN SYSTEMATIC_NAME M8694 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE30971_2H_VS_4H_LPS_STIM_MACROPHAGE_WBP7_KO_DN NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes down-regulated in bone marrow-derived macrophages with MLL4 [GeneID=9757] knockout: 2h LPS versus 4h LPS. DESCRIPTION_FULL Histone methyltransferases catalyze site-specific deposition of methyl groups, enabling recruitment of transcriptional regulators. In mammals, trimethylation of lysine 4 in histone H3, a modification localized at the transcription start sites of active genes, is catalyzed by six enzymes (SET1a and SET1b, MLL1–MLL4) whose specific functions are largely unknown. By using a genomic approach, we found that in macrophages, MLL4 (also known as Wbp7) was required for the expression of Pigp, an essential component of the GPI-GlcNAc transferase, the enzyme catalyzing the first step of glycosylphosphatidylinositol (GPI) anchor synthesis. Impaired Pigp expression in Wbp7-/- macrophages abolished GPI anchor-dependent loading of proteins on the cell membrane. Consistently, loss of GPI-anchored CD14, the coreceptor for lipopolysaccharide (LPS) and other bacterial molecules, markedly attenuated LPS-triggered intracellular signals and gene expression changes. These data link a histone-modifying enzyme to a biosynthetic pathway and indicate a specialized biological role for Wbp7 in macrophage function and antimicrobial response. PMID 22483804 GEOID GSE30971 AUTHORS Austenaa L,Barozzi I,Chronowska A,Termanini A,Ostuni R,Prosperini E,Stewart AF,Testa G,Natoli G CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE30971_2575_200_DN FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS ABTB2,ACCN2,ADAD1,ADCY10,ADD1,AKR1B1,ALDH2,ANKH,ANXA6,AP3M2,APEX1,ARHGEF26,ARL1,ARL4D,ARPP21,ASH1L,ATIC,ATP1B3,BCL11B,C12orf5,C14orf180,C16orf54,C18orf25,C1orf198,C1orf50,C1orf68,C1QBP,C2orf50,C2orf67,C5orf63,C6orf186,C8orf74,C9orf85,CARTPT,CAST,CCDC126,CCL19,CCNE1,CD247,CD70,CDC20B,CDC25B,CDC42SE2,CFLAR,CHADL,CLDN16,CLPB,CLYBL,CNN1,CTGF,CTNS,CXCL12,CYB5A,CYP27A1,CYP4B1,CYP4X1,DBC1,DCTN6,DHX38,DIO2,EEF1B2,EEF1D,ENOX1,ENTPD4,EXOC3L2,F8,FAM105A,FAM198B,FAM46C,FERMT2,FGB,FGF18,FMOD,FRMD4A,GDF9,GLCCI1,GLI1,GNA14,GPR101,GYG1,HADHB,HEATR7A,HEXB,HIF3A,HOOK1,HSD17B14,HSD17B2,ID3,IFI27L2,IFT80,IGDCC3,IGSF6,IKZF1,IL36RN,INO80,IRX1,ISLR,ITGB1,KBTBD13,KCNE1L,KIAA0040,KIAA1598,KLHL30,LAMTOR2,LARGE,LDLR,LIPH,LMAN1L,LOC100129269,LPCAT3,LRMP,LRRC47,LTA4H,MAGEB5,MC5R,MCL1,MEP1B,METTL20,METTL22,MOSPD3,MPG,MPI,MRC2,MRPL12,MRPS15,MTHFD1,MTTP,MUTYH,MYC,NARS2,NCKAP5,NCRNA00116,NEK7,NMNAT3,NOD1,NOL7,NOV,NRP1,NUP210,NXF3,NYNRIN,OC90,OPRD1,PDGFRB,PDHA1,PDZD4,PGPEP1L,PHLDA2,PPP1R14B,PRDM6,PRKAR2B,PRLR,PRSS41,PSMA6,PTGER4,RAB22A,RAB3C,RBFOX3,RBM15B,RHBDL1,RPL24,RPUSD1,RPUSD3,RSPH6A,RTN1,SCN1B,SDAD1,SEPP1,SEPT10,SF3A2,SLC12A6,SLC22A12,SLC22A5,SLC25A45,SLC26A1,SLC7A8,SLCO5A1,SLFN12,SNRPN,SPEG,SPTA1,SRD5A1,ST18,SUCNR1,TBC1D21,TBKBP1,THEMIS,THUMPD2,TMEM119,TOP2B,TRAIP,TUSC2,USP31,VPS26A,WDR82,XIRP1,XIST,ZFP36,ZNF518A,ZYG11A GENE_SYMBOLS ABTB2,ASIC1,ADAD1,ADCY10,ADD1,AKR1B1,ALDH2,ANKH,ANXA6,AP3M2,APEX1,ARHGEF26,ARL1,ARL4D,ARPP21,ASH1L,ATIC,ATP1B3,BCL11B,TIGAR,C14orf180,C16orf54,C18orf25,C1QBP,C1orf198,C1orf50,C1orf68,C2orf50,KANSL1L,C5orf63,METTL24,C8orf74,C9orf85,CARTPT,CAST,CCDC126,CCL19,CCNE1,CD247,CD70,CDC20B,CDC25B,CDC42SE2,CFLAR,CHADL,CLDN16,CLPB,CLYBL,CNN1,CCN2,CTNS,CXCL12,CYB5A,CYP27A1,CYP4B1,CYP4X1,BRINP1,DCTN6,DHX38,DIO2,EEF1B2,EEF1D,ENOX1,ENTPD4,EXOC3L2,F8,OTULINL,GASK1B,TENT5C,FERMT2,FGB,FGF18,FMOD,FRMD4A,GDF9,GLCCI1,GLI1,GNA14,GPR101,GYG1,HADHB,MROH1,HEXB,HIF3A,HOOK1,HSD17B14,HSD17B2,ID3,IFI27L2,IFT80,IGDCC3,IGSF6,IKZF1,IL36RN,INO80,IRX1,ISLR,ITGB1,KBTBD13,KCNE5,KIAA0040,SHTN1,KLHL30,LAMTOR2,LARGE1,LDLR,LIPH,LMAN1L,LINC01160,LPCAT3,IRAG2,LRRC47,LTA4H,MAGEB5,MC5R,MCL1,MEP1B,ETFBKMT,METTL22,MOSPD3,MPG,MPI,MRC2,MRPL12,MRPS15,MTHFD1,MTTP,MUTYH,MYC,NARS2,NCKAP5,MTLN,NEK7,NMNAT3,NOD1,NOL7,CCN3,NRP1,NUP210,NXF3,NYNRIN,OC90,OPRD1,PDGFRB,PDHA1,PDZD4,PGPEP1L,PHLDA2,PPP1R14B,PRDM6,PRKAR2B,PRLR,PRSS41,PSMA6,PTGER4,RAB22A,RAB3C,RBFOX3,RBM15B,RHBDL1,RPL24,RPUSD1,RPUSD3,RSPH6A,RTN1,SCN1B,SDAD1,SELENOP,SEPTIN10,SF3A2,SLC12A6,SLC22A12,SLC22A5,SLC25A45,SLC26A1,SLC7A8,SLCO5A1,SLFN12,SNRPN,SPEG,SPTA1,SRD5A1,ST18,SUCNR1,TBC1D21,TBKBP1,THEMIS,THUMPD2,TMEM119,TOP2B,TRAIP,TUSC2,USP31,VPS26A,WDR82,XIRP1,XIST,ZFP36,ZNF518A,ZYG11A FOUNDER_NAMES