STANDARD_NAME GSE30971_2H_VS_4H_LPS_STIM_MACROPHAGE_WBP7_KO_UP SYSTEMATIC_NAME M8703 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE30971_2H_VS_4H_LPS_STIM_MACROPHAGE_WBP7_KO_UP NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes up-regulated in bone marrow-derived macrophages with MLL4 [GeneID=9757] knockout: 2h LPS versus 4h LPS. DESCRIPTION_FULL Histone methyltransferases catalyze site-specific deposition of methyl groups, enabling recruitment of transcriptional regulators. In mammals, trimethylation of lysine 4 in histone H3, a modification localized at the transcription start sites of active genes, is catalyzed by six enzymes (SET1a and SET1b, MLL1–MLL4) whose specific functions are largely unknown. By using a genomic approach, we found that in macrophages, MLL4 (also known as Wbp7) was required for the expression of Pigp, an essential component of the GPI-GlcNAc transferase, the enzyme catalyzing the first step of glycosylphosphatidylinositol (GPI) anchor synthesis. Impaired Pigp expression in Wbp7-/- macrophages abolished GPI anchor-dependent loading of proteins on the cell membrane. Consistently, loss of GPI-anchored CD14, the coreceptor for lipopolysaccharide (LPS) and other bacterial molecules, markedly attenuated LPS-triggered intracellular signals and gene expression changes. These data link a histone-modifying enzyme to a biosynthetic pathway and indicate a specialized biological role for Wbp7 in macrophage function and antimicrobial response. PMID 22483804 GEOID GSE30971 AUTHORS Austenaa L,Barozzi I,Chronowska A,Termanini A,Ostuni R,Prosperini E,Stewart AF,Testa G,Natoli G CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE30971_2575_200_UP FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS ABCG1,ABLIM1,ADSS,AK8,AKAP7,AKAP8,ALDH2,AMZ1,ANGEL1,ANKH,APEX1,APLP2,ARGLU1,ATXN7L3B,B3GNT6,BCL2,BCL7C,BCORL1,BEND5,C10orf11,C10orf118,C16orf13,C19orf12,C1orf172,C20orf72,C3orf15,C7orf46,C9orf142,C9orf21,C9orf5,CABLES2,CAMK1D,CASKIN1,CCDC126,CCDC83,CCS,CCT6B,CD247,CD2AP,CDC14B,CDC25B,CDCP1,CLDN3,CLEC4E,COX10,CRHR2,CYP2S1,DBP,DDX4,DFNB31,DNTT,DOLPP1,DUSP8,EBF1,EBF4,EEF1B2,ENTPD5,EPSTI1,EXOG,FAIM3,FARSA,FBXO15,FBXO31,FGB,FSCN3,FXYD1,GABRG1,GAS2L1,GEMIN6,GIMAP4,GLI1,GNG3,GPR179,GPR63,GPX6,GRAMD4,GRM1,HEXB,HMG20A,HMHA1,HNRNPAB,HOOK1,HOXC10,IFI27L2,IFT80,IGFLR1,IL16,IL17RA,INCA1,ITGA4,ITGA6,ITPR3,KAT2B,KBTBD13,KCNJ3,KIAA0040,KIAA0182,KIAA0319,KIDINS220,KLC3,KLF3,KLHDC8A,LAMA1,LIMK2,LLGL2,LOC100288797,LOC55908,LSP1,LTC4S,LUC7L3,MADCAM1,MAP4K2,MBTPS1,MPI,MPP4,MPZL2,MRC2,MSX1,MUC5B,NCKAP5,NEUROD2,NHSL2,NOV,NPAS3,NRP1,NUDT14,NUP50,OR51B6,OSBPL6,OTOF,PAFAH2,PATL2,PDK2,PELI1,PGPEP1L,PIK3R5,PIM1,PIM2,POP5,PPP1R3A,PRELP,PRG4,PRKD3,PRSS37,PTPN4,PTPRA,PTPRCAP,PVALB,RABEPK,RAMP2,RCN1,REPIN1,RFC1,RPL3,RRAS2,RYR2,SBF2,SELP,SFXN3,SH3BP2,SKAP1,SLC12A6,SLC22A5,SLC25A33,SLC2A3,SLC4A7,SLC7A7,SNRNP70,SPIRE1,SPTBN1,ST6GALNAC4,STC1,SUN2,SYNGR1,SYT8,TCF7,TCF7L1,TMC4,TMEM231,TMEM35,TMEM86B,TRAIP,TRHR,TRMT12,TSPAN32,TTC13,TUBE1,UPF3A,USP28,USP31,UTS2R,WDR26,WDR38,WDR6,WNK4,ZC3H4,ZFP36,ZFR2,ZNF25,ZNF329 GENE_SYMBOLS ABCG1,ABLIM1,ADSS2,AK8,AKAP7,AKAP8,ALDH2,AMZ1,ANGEL1,ANKH,APEX1,APLP2,ARGLU1,ATXN7L3B,B3GNT6,BCL2,BCL7C,BCORL1,BEND5,LRMDA,CCDC186,METTL26,C19orf12,KDF1,MGME1,CFAP91,FAM221A,PAXX,PRXL2C,TMEM245,CABLES2,CAMK1D,CASKIN1,CCDC126,CCDC83,CCS,CCT6B,CD247,CD2AP,CDC14B,CDC25B,CDCP1,CLDN3,CLEC4E,COX10,CRHR2,CYP2S1,DBP,DDX4,WHRN,DNTT,DOLPP1,DUSP8,EBF1,EBF4,EEF1B2,ENTPD5,EPSTI1,EXOG,FCMR,FARSA,FBXO15,FBXO31,FGB,FSCN3,FXYD1,GABRG1,GAS2L1,GEMIN6,GIMAP4,GLI1,GNG3,GPR179,GPR63,GPX6,GRAMD4,GRM1,HEXB,HMG20A,ARHGAP45,HNRNPAB,HOOK1,HOXC10,IFI27L2,IFT80,IGFLR1,IL16,IL17RA,INCA1,ITGA4,ITGA6,ITPR3,KAT2B,KBTBD13,KCNJ3,KIAA0040,GSE1,KIAA0319,KIDINS220,KLC3,KLF3,KLHDC8A,LAMA1,LIMK2,LLGL2,TMEM239,ANGPTL8,LSP1,LTC4S,LUC7L3,MADCAM1,MAP4K2,MBTPS1,MPI,MPP4,MPZL2,MRC2,MSX1,MUC5B,NCKAP5,NEUROD2,NHSL2,CCN3,NPAS3,NRP1,NUDT14,NUP50,OR51B6,OSBPL6,OTOF,PAFAH2,PATL2,PDK2,PELI1,PGPEP1L,PIK3R5,PIM1,PIM2,POP5,PPP1R3A,PRELP,PRG4,PRKD3,PRSS37,PTPN4,PTPRA,PTPRCAP,PVALB,RABEPK,RAMP2,RCN1,REPIN1,RFC1,RPL3,RRAS2,RYR2,SBF2,SELP,SFXN3,SH3BP2,SKAP1,SLC12A6,SLC22A5,SLC25A33,SLC2A3,SLC4A7,SLC7A7,SNRNP70,SPIRE1,SPTBN1,ST6GALNAC4,STC1,SUN2,SYNGR1,SYT8,TCF7,TCF7L1,TMC4,TMEM231,TMEM35A,TMEM86B,TRAIP,TRHR,TRMT12,TSPAN32,TTC13,TUBE1,UPF3A,USP28,USP31,UTS2R,WDR26,WDR38,WDR6,WNK4,ZC3H4,ZFP36,ZFR2,ZNF25,ZNF329 FOUNDER_NAMES