STANDARD_NAME GSE30971_CTRL_VS_LPS_STIM_MACROPHAGE_WBP7_HET_4H_UP SYSTEMATIC_NAME M8705 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE30971_CTRL_VS_LPS_STIM_MACROPHAGE_WBP7_HET_4H_UP NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes up-regulated in bone marrow-derived macrophages with heterozygous MLL4 [GeneID=9757] knockout: control versus treated with LPS for 4h. DESCRIPTION_FULL Histone methyltransferases catalyze site-specific deposition of methyl groups, enabling recruitment of transcriptional regulators. In mammals, trimethylation of lysine 4 in histone H3, a modification localized at the transcription start sites of active genes, is catalyzed by six enzymes (SET1a and SET1b, MLL1–MLL4) whose specific functions are largely unknown. By using a genomic approach, we found that in macrophages, MLL4 (also known as Wbp7) was required for the expression of Pigp, an essential component of the GPI-GlcNAc transferase, the enzyme catalyzing the first step of glycosylphosphatidylinositol (GPI) anchor synthesis. Impaired Pigp expression in Wbp7-/- macrophages abolished GPI anchor-dependent loading of proteins on the cell membrane. Consistently, loss of GPI-anchored CD14, the coreceptor for lipopolysaccharide (LPS) and other bacterial molecules, markedly attenuated LPS-triggered intracellular signals and gene expression changes. These data link a histone-modifying enzyme to a biosynthetic pathway and indicate a specialized biological role for Wbp7 in macrophage function and antimicrobial response. PMID 22483804 GEOID GSE30971 AUTHORS Austenaa L,Barozzi I,Chronowska A,Termanini A,Ostuni R,Prosperini E,Stewart AF,Testa G,Natoli G CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE30971_2571_200_UP FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS ACTG1,ADCK3,ADH1C,ADORA2A,AEBP2,AGPAT4,AKAP12,ALDH3A2,AP1S2,AP3B1,ARL6IP6,ARNT,ATP1B4,ATP6V1C2,BET1L,BMP1,C14orf43,C19orf63,C5orf63,C9orf40,CALHM2,CBFB,CBY1,CCDC51,CCDC97,CEL,CHAC2,CHD2,CHST11,CNBP,CNDP2,CNFN,CPM,CREB3L2,CSRNP2,CTLA4,CUL2,DCP1B,DGAT2,DGCR2,DNAAF2,DNAJB2,DNAJC12,DOCK3,DUSP5,EIF4EBP2,EMD,ENAM,EPRS,EPS8L1,ERGIC1,ERLIN2,EYA3,FAM118B,FAM46A,FAM84A,FANCB,FOS,FOSL2,FTH1,FUCA1,GABRB3,GABRQ,GADD45A,GADD45B,GAS2L3,GCK,GCNT1,GDI2,GIMAP1,GPBP1,GRAMD3,H2AFB2,H2AFZ,HIF1A,HIRA,HOXA13,HSPA2,HSPA8,ID2,IFRD1,IL10,IL13RA2,IL6ST,INTS5,IRAK1BP1,ISY1,ITGAV,ITK,JUNB,KAZN,KCTD12,KIAA1033,KIF20B,KLF7,KLHL2,LAG3,LDHAL6B,LIN54,LONRF1,LRP4,LRRC8D,MDN1,MECOM,MELK,MIA3,MIDN,MSRB3,MTCH1,MXI1,MYL12B,MYL6,NAGA,NCOA6,NEFM,NEIL1,NELF,NFIL3,NFKBIE,NR2F6,NR4A2,NRD1,OXNAD1,PFAS,PHLPP1,PIGB,PIP4K2A,PLAGL1,PLEKHG3,PLXNC1,PPP1R14A,PRDX6,PRKAB1,PRKCB,PRPF8,PSPH,RAB3IP,RALGAPB,RASA2,RELL1,REXO4,RGS1,RHBG,RLBP1,RNF138,RPA3,RPAP3,RRAD,RUNX2,SCYL1,SDF4,SEC23IP,SEC61A1,SELS,SEMA4B,SERP1,SH3BP5,SH3D19,SH3RF1,SIPA1L1,SIX1,SLC16A6,SLC1A3,SLC5A3,SNX18,SNX9,SORCS3,SPATA6,SPN,SPRED2,SS18,SSH2,STK33,STX11,TBC1D30,TFE3,TM6SF1,TMEM159,TMEM214,TNFAIP3,TNFRSF18,TNFRSF21,TRAF1,TRAM1,TRAPPC2,TRNT1,TSG101,TTC28,TXNDC5,UNK,VAMP4,VPS37B,WBP5,WNT9A,WRAP73,ZDHHC24,ZEB1,ZNF23,ZNF616,ZNF708 GENE_SYMBOLS ACTG1,COQ8A,ADH1C,ADORA2A,AEBP2,AGPAT4,AKAP12,ALDH3A2,AP1S2,AP3B1,ARL6IP6,ARNT,ATP1B4,ATP6V1C2,BET1L,BMP1,MIDEAS,EMC10,C5orf63,C9orf40,CALHM2,CBFB,CBY1,CCDC51,CCDC97,CEL,CHAC2,CHD2,CHST11,CNBP,CNDP2,CNFN,CPM,CREB3L2,CSRNP2,CTLA4,CUL2,DCP1B,DGAT2,DGCR2,DNAAF2,DNAJB2,DNAJC12,DOCK3,DUSP5,EIF4EBP2,EMD,ENAM,EPRS1,EPS8L1,ERGIC1,ERLIN2,EYA3,FAM118B,TENT5A,LRATD1,FANCB,FOS,FOSL2,FTH1,FUCA1,GABRB3,GABRQ,GADD45A,GADD45B,GAS2L3,GCK,GCNT1,GDI2,GIMAP1,GPBP1,GRAMD2B,H2AB2,H2AZ1,HIF1A,HIRA,HOXA13,HSPA2,HSPA8,ID2,IFRD1,IL10,IL13RA2,IL6ST,INTS5,IRAK1BP1,ISY1,ITGAV,ITK,JUNB,KAZN,KCTD12,WASHC4,KIF20B,KLF7,KLHL2,LAG3,LDHAL6B,LIN54,LONRF1,LRP4,LRRC8D,MDN1,MECOM,MELK,MIA3,MIDN,MSRB3,MTCH1,MXI1,MYL12B,MYL6,NAGA,NCOA6,NEFM,NEIL1,NSMF,NFIL3,NFKBIE,NR2F6,NR4A2,NRDC,OXNAD1,PFAS,PHLPP1,PIGB,PIP4K2A,PLAGL1,PLEKHG3,PLXNC1,PPP1R14A,PRDX6,PRKAB1,PRKCB,PRPF8,PSPH,RAB3IP,RALGAPB,RASA2,RELL1,REXO4,RGS1,RHBG,RLBP1,RNF138,RPA3,RPAP3,RRAD,RUNX2,SCYL1,SDF4,SEC23IP,SEC61A1,SELENOS,SEMA4B,SERP1,SH3BP5,SH3D19,SH3RF1,SIPA1L1,SIX1,SLC16A6,SLC1A3,SLC5A3,SNX18,SNX9,SORCS3,SPATA6,SPN,SPRED2,SS18,SSH2,STK33,STX11,TBC1D30,TFE3,TM6SF1,LDAF1,TMEM214,TNFAIP3,TNFRSF18,TNFRSF21,TRAF1,TRAM1,TRAPPC2,TRNT1,TSG101,TTC28,TXNDC5,UNK,VAMP4,VPS37B,TCEAL9,WNT9A,WRAP73,ZDHHC24,ZEB1,ZNF23,ZNF616,ZNF708 FOUNDER_NAMES