STANDARD_NAME GSE31082_DN_VS_CD4_SP_THYMOCYTE_DN SYSTEMATIC_NAME M5059 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE31082_DN_VS_CD4_SP_THYMOCYTE_DN NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes down-regulated in comparison of CD4- [GeneID=920] CD8- thymocytes versus CD4+ [GeneID=920] CD8- thymocytes. DESCRIPTION_FULL Mouse thymocytes can be classified into four major subsets based on expression of CD4 and CD8 co-receptors. CD4-CD8- (double negative, DN) cells become CD4+CD8+ (double positive, DP) cells following productive T cell receptor (TCR) beta chain rearrangement. A small proportion of DP cells are selected through interaction of clonal TCRalpha/beta and MHC self peptide complex expressed on thymic stromal cells. DP cell expressing MHC class I-restricted TCR become CD4-CD8+ cells, which will finally differentiate into cytotoxic T cells, while MHC class II restricted selection generates CD4+CD8- helper lineage T cells. We used microarrays to identify genes important for thymocyte differentiation and lineage determination by profiling gene expression in different thymocyte subsets. PMID 21873191 GEOID GSE31082 AUTHORS Egawa T,Littman DR CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE31082_2168_200_DN FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS ABCB9,ABTB2,ADCY6,AKT3,ANKRD37,ANXA6,ARAF,ARAP2,ARF5,ARHGEF6,ARID5B,ASB2,ATG9A,ATP1B1,ATP6V0E2,ATXN7L3,B4GALNT1,BACH2,BFAR,BIRC2,BNIP3L,C10orf26,C12orf57,C1orf130,C1orf86,C2orf68,C9orf103,C9orf72,CAMK1D,CCDC88C,CDIPT,CHD3,CHST10,CLCN4,CNPPD1,CORO1A,CREBBP,CRLF3,CYP2D6,CYTH1,DAAM1,DDX3Y,DIO3OS,DIP2B,DOCK4,DOLPP1,DUSP1,ENO3,ETV3,EVI5L,EXTL3,FAM117B,FAM49A,FBRS,FEZ2,FKBP1A,FOXJ2,FYCO1,GABRR2,GGT1,GMIP,GPR110,GSTA3,GTPBP2,HCST,HECTD2,HERC6,HSD11B1,IFNAR1,IRF1,IRF2BPL,JAK2,JARID2,JUP,KLHDC8B,KLHL18,KLHL4,LASP1,LASS5,LBH,LDB1,LOC401097,LRIG1,LYPLA2,LYSMD3,MADD,MAP3K14,MAP4K3,MAP4K5,MAPK7,MAPKAPK3,MARVELD1,MDP1,MFHAS1,MFSD8,MGST2,MKNK2,MLLT6,MMP16,MOBKL2A,MTERFD1,MTMR3,MUS81,MYD88,NCOA3,NEAT1,NFAT5,NR4A2,NUP210,OAS3,OXT,PARP3,PARP9,PEA15,PHF1,PIK3R3,PION,PRKD2,PTK2B,PTPN6,PTPRC,PVALB,RAB4B,RALGAPB,RAP2A,RAP2B,RAPH1,RARG,RASA2,RBL2,RBM5,REEP5,RELB,RERE,RFX3,RHOF,RNF114,RPE65,RPH3AL,RTN4RL1,RUNDC1,S100A13,S1PR4,SBK1,SDHAF1,SECISBP2L,SEPT9,SETD5,SETDB2,SF3B1,SIDT1,SIRT7,SLC17A9,SLC25A40,SLC26A6,SLC28A2,SLC37A3,SLC41A1,SLX4,SMARCA2,SP110,STAT2,STK24,STX16,SUV420H1,SYNJ1,TAP1,TBL1X,TBX6,TDGF1,TIMP2,TMEM106B,TMEM50A,TMEM64,TNFRSF1A,TNFSF8,TNIP1,TNIP2,TOB1,TRAF3,TRIM26,TRIOBP,TRIP11,TTC38,TXNDC16,UBE2J1,UBXN11,UCKL1,WDR26,XKRX,XPO6,YPEL5,ZCCHC11,ZHX2,ZMYM5,ZNF281,ZNF287,ZNF513,ZNF597,ZNF623 GENE_SYMBOLS ABCB9,ABTB2,ADCY6,AKT3,ANKRD37,ANXA6,ARAF,ARAP2,ARF5,ARHGEF6,ARID5B,ASB2,ATG9A,ATP1B1,ATP6V0E2,ATXN7L3,B4GALNT1,BACH2,BFAR,BIRC2,BNIP3L,WBP1L,C12orf57,NCMAP,FAAP20,C2orf68,IDNK,C9orf72,CAMK1D,CCDC88C,CDIPT,CHD3,CHST10,CLCN4,CNPPD1,CORO1A,CREBBP,CRLF3,CYP2D6,CYTH1,DAAM1,DDX3Y,DIO3OS,DIP2B,DOCK4,DOLPP1,DUSP1,ENO3,ETV3,EVI5L,EXTL3,FAM117B,CYRIA,FBRS,FEZ2,FKBP1A,FOXJ2,FYCO1,GABRR2,GGT1,GMIP,ADGRF1,GSTA3,GTPBP2,HCST,HECTD2,HERC6,HSD11B1,IFNAR1,IRF1,IRF2BPL,JAK2,JARID2,JUP,KLHDC8B,KLHL18,KLHL4,LASP1,CERS5,LBH,LDB1,C3orf80,LRIG1,LYPLA2,LYSMD3,MADD,MAP3K14,MAP4K3,MAP4K5,MAPK7,MAPKAPK3,MARVELD1,MDP1,MFHAS1,MFSD8,MGST2,MKNK2,MLLT6,MMP16,MOB3A,MTERF3,MTMR3,MUS81,MYD88,NCOA3,NEAT1,NFAT5,NR4A2,NUP210,OAS3,OXT,PARP3,PARP9,PEA15,PHF1,PIK3R3,GSAP,PRKD2,PTK2B,PTPN6,PTPRC,PVALB,RAB4B,RALGAPB,RAP2A,RAP2B,RAPH1,RARG,RASA2,RBL2,RBM5,REEP5,RELB,RERE,RFX3,RHOF,RNF114,RPE65,RPH3AL,RTN4RL1,RUNDC1,S100A13,S1PR4,SBK1,SDHAF1,SECISBP2L,SEPTIN9,SETD5,SETDB2,SF3B1,SIDT1,SIRT7,SLC17A9,SLC25A40,SLC26A6,SLC28A2,SLC37A3,SLC41A1,SLX4,SMARCA2,SP110,STAT2,STK24,STX16,KMT5B,SYNJ1,TAP1,TBL1X,TBX6,TDGF1,TIMP2,TMEM106B,TMEM50A,TMEM64,TNFRSF1A,TNFSF8,TNIP1,TNIP2,TOB1,TRAF3,TRIM26,TRIOBP,TRIP11,TTC38,TXNDC16,UBE2J1,UBXN11,UCKL1,WDR26,XKRX,XPO6,YPEL5,TUT4,ZHX2,ZMYM5,ZNF281,ZNF287,ZNF513,ZNF597,ZNF623 FOUNDER_NAMES