STANDARD_NAME	GSE31082_DN_VS_CD4_SP_THYMOCYTE_UP
SYSTEMATIC_NAME	M5057
COLLECTION	C7:IMMUNESIGDB
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE31082_DN_VS_CD4_SP_THYMOCYTE_UP
NAMESPACE	HUMAN_GENE_SYMBOL
DESCRIPTION_BRIEF	Genes up-regulated in comparison of CD4- [GeneID=920] CD8- thymocytes versus CD4+ [GeneID=920] CD8- thymocytes.
DESCRIPTION_FULL	Mouse thymocytes can be classified into four major subsets based on expression of CD4 and CD8 co-receptors. CD4-CD8- (double negative, DN) cells become CD4+CD8+ (double positive, DP) cells following productive T cell receptor (TCR) beta chain rearrangement. A small proportion of DP cells are selected through interaction of clonal TCRalpha/beta and MHC self peptide complex expressed on thymic stromal cells. DP cell expressing MHC class I-restricted TCR become CD4-CD8+ cells, which will finally differentiate into cytotoxic T cells, while MHC class II restricted selection generates CD4+CD8- helper lineage T cells. We used microarrays to identify genes important for thymocyte differentiation and lineage determination by profiling gene expression in different thymocyte subsets.
PMID	21873191
GEOID	GSE31082
AUTHORS	Egawa T,Littman DR
CONTRIBUTOR	Jernej Godec
CONTRIBUTOR_ORG	Dana-Farber Cancer Institute
EXACT_SOURCE	GSE31082_2168_200_UP
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	ACSL5,ADSS,AHCTF1,AIFM1,ALDH16A1,ANKRD13B,ANO6,ANUBL1,AP4E1,APITD1,ARL6IP6,ATP5G2,ATPAF2,AUH,BCAT1,BRPF3,C11orf31,C13orf27,C14orf135,C16orf48,C16orf80,C16orf88,C17orf85,C19orf10,C1orf151,C21orf59,C3orf37,C6orf130,C7orf26,C7orf30,C8orf55,C9orf78,CAMKV,CARHSP1,CBWD2,CCBL2,CCDC40,CCP110,CDCA7L,CDKN2AIPNL,CENPM,CEP128,CHCHD7,CKAP5,CLASP1,COX18,CPSF6,CRELD2,CSE1L,CSTF1,DAZAP1,DCUN1D5,DDX49,DEGS2,DHDDS,DHFR,DHRS13,DHX29,DIS3,DNAJC15,DNAJC2,DNTTIP2,DPY30,DRG2,EIF3A,EIF3K,EPB41L4A,ERCC6L,ERI1,ERI3,EXOSC9,FAM69B,FAM82A2,FAM98B,FBXO7,FEM1B,FGR,FUNDC1,GDI2,GINS1,GPD1L,GRWD1,GTF2E2,GTF2F2,GTF2H5,GTF3C4,HBS1L,HDAC1,HEATR3,HINT1,HMBS,HNRNPM,ILF2,IPMK,KIAA0146,KIAA1958,LIG3,LOC729852,LTV1,MEIR5,METTL11A,MGAT4B,MRPL22,MRPL45,MRPL51,MRPS9,MTHFD1,MTHFD1L,NAA20,NAA38,NDUFB4,NDUFS6,NEDD4,NKAP,NMD3,NT5M,NUP133,NUP93,PCBP1,PDCD5,PELP1,PFAS,PFDN6,PHB,PHB2,PHF10,PHF16,PHF5A,PMPCB,POLR2D,PPA1,PPAT,PRADC1,PSMA3,PSMA5,PSMA7,PSMC2,PSRC1,PTAR1,PTCD3,PTOV1,QDPR,RAB1A,RAD50,RBM19,RNF126,RNF168,RNF219,ROMO1,RPGR,RPGRIP1,RPL18A,RPL36A,RPS5,RPS6KA5,RWDD4,SCPEP1,SELM,SENP8,SF3A3,SF3B5,SIN3B,SLAMF6,SLC25A10,SLC25A3,SLC35E3,SLC7A1,SMC3,SNRPF,SNW1,SRSF7,SRSF9,STX12,SUB1,SUPV3L1,TARS2,TBL1XR1,TBP,TCF4,TFDP2,THAP11,THRA,TMEM11,TSG101,TTC27,TUBG1,TXNDC5,TXNL4A,UBE2A,UBE2L3,UCHL3,VARS,VRK1,WDR3,WDR70,WDR75,WDTC1,YPEL2,ZFP41,ZRANB3
GENE_SYMBOLS	ACSL5,ADSS2,AHCTF1,AIFM1,ALDH16A1,ANKRD13B,ANO6,ZFAND4,AP4E1,CENPS,ARL6IP6,ATP5MC2,ATPAF2,AUH,BCAT1,BRPF3,SELENOH,TEX30,PCNX4,ENKD1,CFAP20,KNOP1,NCBP3,MYDGF,MICOS10,CFAP298,HMCES,OARD1,INTS15,MALSU1,THEM6,C9orf78,CAMKV,CARHSP1,ZNG1B,KYAT3,CCDC40,CCP110,CDCA7L,CDKN2AIPNL,CENPM,CEP128,CHCHD7,CKAP5,CLASP1,COX18,CPSF6,CRELD2,CSE1L,CSTF1,DAZAP1,DCUN1D5,DDX49,DEGS2,DHDDS,DHFR,DHRS13,DHX29,DIS3,DNAJC15,DNAJC2,DNTTIP2,DPY30,DRG2,EIF3A,EIF3K,EPB41L4A,ERCC6L,ERI1,ERI3,EXOSC9,DIPK1B,RMDN3,FAM98B,FBXO7,FEM1B,FGR,FUNDC1,GDI2,GINS1,GPD1L,GRWD1,GTF2E2,GTF2F2,GTF2H5,GTF3C4,HBS1L,HDAC1,HEATR3,HINT1,HMBS,HNRNPM,ILF2,IPMK,SPIDR,KIAA1958,LIG3,UMAD1,LTV1,SFR1,NTMT1,MGAT4B,MRPL22,MRPL45,MRPL51,MRPS9,MTHFD1,MTHFD1L,NAA20,NAA38,NDUFB4,NDUFS6,NEDD4,NKAP,NMD3,NT5M,NUP133,NUP93,PCBP1,PDCD5,PELP1,PFAS,PFDN6,PHB1,PHB2,PHF10,JADE3,PHF5A,PMPCB,POLR2D,PPA1,PPAT,PRADC1,PSMA3,PSMA5,PSMA7,PSMC2,PSRC1,PTAR1,PTCD3,PTOV1,QDPR,RAB1A,RAD50,RBM19,RNF126,RNF168,OBI1,ROMO1,RPGR,RPGRIP1,RPL18A,RPL36A,RPS5,RPS6KA5,RWDD4,SCPEP1,SELENOM,SENP8,SF3A3,SF3B5,SIN3B,SLAMF6,SLC25A10,SLC25A3,SLC35E3,SLC7A1,SMC3,SNRPF,SNW1,SRSF7,SRSF9,STX12,SUB1,SUPV3L1,TARS2,TBL1XR1,TBP,TCF4,TFDP2,THAP11,THRA,TMEM11,TSG101,TTC27,TUBG1,TXNDC5,TXNL4A,UBE2A,UBE2L3,UCHL3,VARS1,VRK1,WDR3,WDR70,WDR75,WDTC1,YPEL2,ZFP41,ZRANB3
FOUNDER_NAMES