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<MSIGDB BUILD_DATE="Jan 29, 2026" VERSION="2026.1.Hs" NAME="export">
    <GENESET STANDARD_NAME="GSE31082_DN_VS_CD4_SP_THYMOCYTE_UP" SYSTEMATIC_NAME="M5057" HISTORICAL_NAMES="" PMID="21873191" AUTHORS="Egawa T,Littman DR" GEOID="GSE31082" EXACT_SOURCE="GSE31082_2168_200_UP" GENESET_LISTING_URL="" EXTERNAL_DETAILS_URL="" CHIP="HUMAN_GENE_SYMBOL" CONTRIBUTOR="Jernej Godec" CONTRIBUTOR_ORG="Dana-Farber Cancer Institute" DESCRIPTION_BRIEF="Genes up-regulated in comparison of CD4- [GeneID=920] CD8- thymocytes versus CD4+ [GeneID=920] CD8- thymocytes." DESCRIPTION_FULL="Mouse thymocytes can be classified into four major subsets based on expression of CD4 and CD8 co-receptors. CD4-CD8- (double negative, DN) cells become CD4+CD8+ (double positive, DP) cells following productive T cell receptor (TCR) beta chain rearrangement. A small proportion of DP cells are selected through interaction of clonal TCRalpha/beta and MHC self peptide complex expressed on thymic stromal cells. DP cell expressing MHC class I-restricted TCR become CD4-CD8+ cells, which will finally differentiate into cytotoxic T cells, while MHC class II restricted selection generates CD4+CD8- helper lineage T cells. We used microarrays to identify genes important for thymocyte differentiation and lineage determination by profiling gene expression in different thymocyte subsets." TAGS="" MEMBERS="ACSL5,ADSS,AHCTF1,AIFM1,ALDH16A1,ANKRD13B,ANO6,ANUBL1,AP4E1,APITD1,ARL6IP6,ATP5G2,ATPAF2,AUH,BCAT1,BRPF3,C11orf31,C13orf27,C14orf135,C16orf48,C16orf80,C16orf88,C17orf85,C19orf10,C1orf151,C21orf59,C3orf37,C6orf130,C7orf26,C7orf30,C8orf55,C9orf78,CAMKV,CARHSP1,CBWD2,CCBL2,CCDC40,CCP110,CDCA7L,CDKN2AIPNL,CENPM,CEP128,CHCHD7,CKAP5,CLASP1,COX18,CPSF6,CRELD2,CSE1L,CSTF1,DAZAP1,DCUN1D5,DDX49,DEGS2,DHDDS,DHFR,DHRS13,DHX29,DIS3,DNAJC15,DNAJC2,DNTTIP2,DPY30,DRG2,EIF3A,EIF3K,EPB41L4A,ERCC6L,ERI1,ERI3,EXOSC9,FAM69B,FAM82A2,FAM98B,FBXO7,FEM1B,FGR,FUNDC1,GDI2,GINS1,GPD1L,GRWD1,GTF2E2,GTF2F2,GTF2H5,GTF3C4,HBS1L,HDAC1,HEATR3,HINT1,HMBS,HNRNPM,ILF2,IPMK,KIAA0146,KIAA1958,LIG3,LOC729852,LTV1,MEIR5,METTL11A,MGAT4B,MRPL22,MRPL45,MRPL51,MRPS9,MTHFD1,MTHFD1L,NAA20,NAA38,NDUFB4,NDUFS6,NEDD4,NKAP,NMD3,NT5M,NUP133,NUP93,PCBP1,PDCD5,PELP1,PFAS,PFDN6,PHB,PHB2,PHF10,PHF16,PHF5A,PMPCB,POLR2D,PPA1,PPAT,PRADC1,PSMA3,PSMA5,PSMA7,PSMC2,PSRC1,PTAR1,PTCD3,PTOV1,QDPR,RAB1A,RAD50,RBM19,RNF126,RNF168,RNF219,ROMO1,RPGR,RPGRIP1,RPL18A,RPL36A,RPS5,RPS6KA5,RWDD4,SCPEP1,SELM,SENP8,SF3A3,SF3B5,SIN3B,SLAMF6,SLC25A10,SLC25A3,SLC35E3,SLC7A1,SMC3,SNRPF,SNW1,SRSF7,SRSF9,STX12,SUB1,SUPV3L1,TARS2,TBL1XR1,TBP,TCF4,TFDP2,THAP11,THRA,TMEM11,TSG101,TTC27,TUBG1,TXNDC5,TXNL4A,UBE2A,UBE2L3,UCHL3,VARS,VRK1,WDR3,WDR70,WDR75,WDTC1,YPEL2,ZFP41,ZRANB3" MEMBERS_SYMBOLIZED="ACSL5,ADSS2,AHCTF1,AIFM1,ALDH16A1,ANKRD13B,ANO6,AP4E1,ARL6IP6,ATP5MC2,ATPAF2,AUH,BCAT1,BRPF3,C9orf78,CAMKV,CARHSP1,CCDC40,CCP110,CDCA7L,CDKN2AIPNL,CENPM,CENPS,CEP128,CFAP20,CFAP298,CHCHD7,CKAP5,CLASP1,COX18,CPSF6,CRELD2,CSE1L,CSTF1,DAZAP1,DCUN1D5,DDX49,DEGS2,DHDDS,DHFR,DHRS13,DHX29,DIPK1B,DIS3,DNAJC15,DNAJC2,DNTTIP2,DPY30,DRG2,EIF3A,EIF3K,ENKD1,EPB41L4A,ERCC6L,ERI1,ERI3,EXOSC9,FAM98B,FBXO7,FEM1B,FGR,FUNDC1,GDI2,GINS1,GPD1L,GRWD1,GTF2E2,GTF2F2,GTF2H5,GTF3C4,HBS1L,HDAC1,HEATR3,HINT1,HMBS,HMCES,HNRNPM,ILF2,INTS15,IPMK,JADE3,KIAA1958,KNOP1,KYAT3,LIG3,LTV1,MALSU1,MGAT4B,MICOS10,MRPL22,MRPL45,MRPL51,MRPS9,MTHFD1,MTHFD1L,MYDGF,NAA20,NAA38,NCBP3,NDUFB4,NDUFS6,NEDD4,NKAP,NMD3,NT5M,NTMT1,NUP133,NUP93,OARD1,OBI1,PCBP1,PCNX4,PDCD5,PELP1,PFAS,PFDN6,PHB1,PHB2,PHF10,PHF5A,PMPCB,POLR2D,PPA1,PPAT,PRADC1,PSMA3,PSMA5,PSMA7,PSMC2,PSRC1,PTAR1,PTCD3,PTOV1,QDPR,RAB1A,RAD50,RBM19,RMDN3,RNF126,RNF168,ROMO1,RPGR,RPGRIP1,RPL18A,RPL36A,RPS5,RPS6KA5,RWDD4,SCPEP1,SELENOH,SELENOM,SENP8,SF3A3,SF3B5,SFR1,SIN3B,SLAMF6,SLC25A10,SLC25A3,SLC35E3,SLC7A1,SMC3,SNRPF,SNW1,SPIDR,SRSF7,SRSF9,STX12,SUB1,SUPV3L1,TARS2,TBL1XR1,TBP,TCF4,TEX30,TFDP2,THAP11,THEM6,THRA,TMEM11,TSG101,TTC27,TUBG1,TXNDC5,TXNL4A,UBE2A,UBE2L3,UCHL3,UMAD1,VARS1,VRK1,WDR3,WDR70,WDR75,WDTC1,YPEL2,ZFAND4,ZFP41,ZNG1B,ZRANB3" MEMBERS_EZID="10111,10116,10471,10767,10885,10907,10923,10946,11052,11282,11331,114836,115416,119392,123099,123228,124930,126133,138311,139341,140606,140823,1434,145508,1468,147015,1477,150472,151188,158405,159,165918,1719,1819,196527,201965,221443,2268,22894,22938,23038,23171,23309,23332,23431,23514,23589,23673,253430,25793,25902,25909,26528,2665,27000,27043,27154,27335,280636,283742,285521,286128,28989,29093,29103,29105,2961,2963,3065,30836,3094,3145,3608,375743,378708,388403,3980,400506,404672,440574,4522,4670,4710,4726,4734,5093,51068,51126,51258,51337,517,51703,51759,5198,5245,5250,53635,5393,5433,54505,54555,5464,5471,54821,549,55027,55036,55037,55100,55177,55274,55421,55508,55536,55622,55658,55746,56005,56267,56683,5684,5686,5688,56941,56953,5701,57096,57215,586,5860,5861,59342,6103,6142,6173,6193,64097,6432,64430,64965,6541,6636,6832,6908,6925,7029,7067,7251,7283,729852,7319,7332,7347,7407,7443,79012,79019,79033,79034,79145,79174,79576,79596,79718,79947,80222,81567,83443,83743,84080,84083,84128,84259,84279,84311,84316,84661,84722,84844,84946,8661,8683,8834,90459,9126,9131,91368,9141,91647,9252,93081,9329,93550,9512,9688,9738,9767,9793,9837,9904" MEMBERS_MAPPING="ACSL5,ACSL5,51703|ADSS,ADSS2,159|AHCTF1,AHCTF1,25909|AIFM1,AIFM1,9131|ALDH16A1,ALDH16A1,126133|ANKRD13B,ANKRD13B,124930|ANO6,ANO6,196527|ANUBL1,ZFAND4,93550|AP4E1,AP4E1,23431|APITD1,CENPS,378708|ARL6IP6,ARL6IP6,151188|ATP5G2,ATP5MC2,517|ATPAF2,ATPAF2,91647|AUH,AUH,549|BCAT1,BCAT1,586|BRPF3,BRPF3,27154|C11orf31,SELENOH,280636|C13orf27,TEX30,93081|C14orf135,PCNX4,64430|C16orf48,ENKD1,84080|C16orf80,CFAP20,29105|C16orf88,KNOP1,400506|C17orf85,NCBP3,55421|C19orf10,MYDGF,56005|C1orf151,MICOS10,440574|C21orf59,CFAP298,56683|C3orf37,HMCES,56941|C6orf130,OARD1,221443|C7orf26,INTS15,79034|C7orf30,MALSU1,115416|C8orf55,THEM6,51337|C9orf78,C9orf78,51759|CAMKV,CAMKV,79012|CARHSP1,CARHSP1,23589|CBWD2,ZNG1B,150472|CCBL2,KYAT3,56267|CCDC40,CCDC40,55036|CCP110,CCP110,9738|CDCA7L,CDCA7L,55536|CDKN2AIPNL,CDKN2AIPNL,91368|CENPM,CENPM,79019|CEP128,CEP128,145508|CHCHD7,CHCHD7,79145|CKAP5,CKAP5,9793|CLASP1,CLASP1,23332|COX18,COX18,285521|CPSF6,CPSF6,11052|CRELD2,CRELD2,79174|CSE1L,CSE1L,1434|CSTF1,CSTF1,1477|DAZAP1,DAZAP1,26528|DCUN1D5,DCUN1D5,84259|DDX49,DDX49,54555|DEGS2,DEGS2,123099|DHDDS,DHDDS,79947|DHFR,DHFR,1719|DHRS13,DHRS13,147015|DHX29,DHX29,54505|DIS3,DIS3,22894|DNAJC15,DNAJC15,29103|DNAJC2,DNAJC2,27000|DNTTIP2,DNTTIP2,30836|DPY30,DPY30,84661|DRG2,DRG2,1819|EIF3A,EIF3A,8661|EIF3K,EIF3K,27335|EPB41L4A,EPB41L4A,64097|ERCC6L,ERCC6L,54821|ERI1,ERI1,90459|ERI3,ERI3,79033|EXOSC9,EXOSC9,5393|FAM69B,DIPK1B,138311|FAM82A2,RMDN3,55177|FAM98B,FAM98B,283742|FBXO7,FBXO7,25793|FEM1B,FEM1B,10116|FGR,FGR,2268|FUNDC1,FUNDC1,139341|GDI2,GDI2,2665|GINS1,GINS1,9837|GPD1L,GPD1L,23171|GRWD1,GRWD1,83743|GTF2E2,GTF2E2,2961|GTF2F2,GTF2F2,2963|GTF2H5,GTF2H5,404672|GTF3C4,GTF3C4,9329|HBS1L,HBS1L,10767|HDAC1,HDAC1,3065|HEATR3,HEATR3,55027|HINT1,HINT1,3094|HMBS,HMBS,3145|HNRNPM,HNRNPM,4670|ILF2,ILF2,3608|IPMK,IPMK,253430|KIAA0146,SPIDR,23514|KIAA1958,KIAA1958,158405|LIG3,LIG3,3980|LOC729852,UMAD1,729852|LTV1,LTV1,84946|MEIR5,SFR1,119392|METTL11A,NTMT1,28989|MGAT4B,MGAT4B,11282|MRPL22,MRPL22,29093|MRPL45,MRPL45,84311|MRPL51,MRPL51,51258|MRPS9,MRPS9,64965|MTHFD1,MTHFD1,4522|MTHFD1L,MTHFD1L,25902|NAA20,NAA20,51126|NAA38,NAA38,84316|NDUFB4,NDUFB4,4710|NDUFS6,NDUFS6,4726|NEDD4,NEDD4,4734|NKAP,NKAP,79576|NMD3,NMD3,51068|NT5M,NT5M,56953|NUP133,NUP133,55746|NUP93,NUP93,9688|PCBP1,PCBP1,5093|PDCD5,PDCD5,9141|PELP1,PELP1,27043|PFAS,PFAS,5198|PFDN6,PFDN6,10471|PHB,PHB1,5245|PHB2,PHB2,11331|PHF10,PHF10,55274|PHF16,JADE3,9767|PHF5A,PHF5A,84844|PMPCB,PMPCB,9512|POLR2D,POLR2D,5433|PPA1,PPA1,5464|PPAT,PPAT,5471|PRADC1,PRADC1,84279|PSMA3,PSMA3,5684|PSMA5,PSMA5,5686|PSMA7,PSMA7,5688|PSMC2,PSMC2,5701|PSRC1,PSRC1,84722|PTAR1,PTAR1,375743|PTCD3,PTCD3,55037|PTOV1,PTOV1,53635|QDPR,QDPR,5860|RAB1A,RAB1A,5861|RAD50,RAD50,10111|RBM19,RBM19,9904|RNF126,RNF126,55658|RNF168,RNF168,165918|RNF219,OBI1,79596|ROMO1,ROMO1,140823|RPGR,RPGR,6103|RPGRIP1,RPGRIP1,57096|RPL18A,RPL18A,6142|RPL36A,RPL36A,6173|RPS5,RPS5,6193|RPS6KA5,RPS6KA5,9252|RWDD4,RWDD4,201965|SCPEP1,SCPEP1,59342|SELM,SELENOM,140606|SENP8,SENP8,123228|SF3A3,SF3A3,10946|SF3B5,SF3B5,83443|SIN3B,SIN3B,23309|SLAMF6,SLAMF6,114836|SLC25A10,SLC25A10,1468|SLC25A3,SLC25A3,5250|SLC35E3,SLC35E3,55508|SLC7A1,SLC7A1,6541|SMC3,SMC3,9126|SNRPF,SNRPF,6636|SNW1,SNW1,22938|SRSF7,SRSF7,6432|SRSF9,SRSF9,8683|STX12,STX12,23673|SUB1,SUB1,10923|SUPV3L1,SUPV3L1,6832|TARS2,TARS2,80222|TBL1XR1,TBL1XR1,79718|TBP,TBP,6908|TCF4,TCF4,6925|TFDP2,TFDP2,7029|THAP11,THAP11,57215|THRA,THRA,7067|TMEM11,TMEM11,8834|TSG101,TSG101,7251|TTC27,TTC27,55622|TUBG1,TUBG1,7283|TXNDC5,TXNDC5,81567|TXNL4A,TXNL4A,10907|UBE2A,UBE2A,7319|UBE2L3,UBE2L3,7332|UCHL3,UCHL3,7347|VARS,VARS1,7407|VRK1,VRK1,7443|WDR3,WDR3,10885|WDR70,WDR70,55100|WDR75,WDR75,84128|WDTC1,WDTC1,23038|YPEL2,YPEL2,388403|ZFP41,ZFP41,286128|ZRANB3,ZRANB3,84083" FILTERED_BY_SIMILARITY="" FOUNDER_NAMES="" REFINEMENT_DATASETS="" VALIDATION_DATASETS="" CATEGORY_CODE="C7" ORGANISM="Mus musculus" SUB_CATEGORY_CODE="IMMUNESIGDB"/>
</MSIGDB>
