<?xml version="1.0" encoding="UTF-8" standalone="yes"?>

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     See license terms at www.gsea-msigdb.org/gsea/license_terms_list. Please note that certain gene sets have special access terms.
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<MSIGDB BUILD_DATE="Jan 29, 2026" VERSION="2026.1.Hs" NAME="export">
    <GENESET STANDARD_NAME="GSE32901_TH1_VS_TH17_ENRICHED_CD4_TCELL_DN" SYSTEMATIC_NAME="M8920" HISTORICAL_NAMES="" PMID="22715389" AUTHORS="Zhang W,Ferguson J,Ng SM,Hui K,Goh G,Lin A,Esplugues E,Flavell RA,Abraham C,Zhao H,Cho JH" GEOID="GSE32901" EXACT_SOURCE="GSE32901_3355_200_DN" GENESET_LISTING_URL="" EXTERNAL_DETAILS_URL="" CHIP="HUMAN_GENE_SYMBOL" CONTRIBUTOR="Jernej Godec" CONTRIBUTOR_ORG="Dana-Farber Cancer Institute" DESCRIPTION_BRIEF="Genes down-regulated in CD4 [GeneID=920] T cells: Th1 versus Th17 enriched." DESCRIPTION_FULL="In this study, we examined differential gene expression in naïve human CD4+ T cells, as well as in effector Th1, Th17-negative and Th17-enriched CD4- T cell subsets. We observed a marked enrichment for increased gene expression in effector CD4+ T cells compared to naive CD4+ among immune-mediated disease oci genes. Within effector T cells, expression of disease-associated genes was increased in Th17-enriched compared to Th17-negative cells. We used microarray to examine the gene expresssion profile and level of human naïve, Th1 and effector T cell subsets." TAGS="" MEMBERS="0610031J06Rik,1700020D05Rik,1700062I23Rik,1700086D15Rik,1810030J14Rik,2310011J03Rik,2310033P09Rik,2310040G07Rik,2510003E04Rik,4930528F23Rik,5430401F13Rik,6330416G13Rik,9030224M15Rik,ACOT1,AGGF1,AHSA1,AKR1B8,AMFR,ANAPC16,ANKFN1,ANKRD53,ANXA4,AOC2,ARL5C,ASB13,ATP6V0E,AY512915,BC027231,BSCL2,CAMK2N1,CAML,CCDC69,CD300LD,CD302,CD82,CDK5RAP3,CDX1,CHKA,CLDN16,CNGA1,CNPY2,CRADD,CRIP1,CRLS1,CRYL1,DERL1,DNAJA3,DNAJC18,DOHH,DPPA4,EIF2B4,EIF3C,EML3,ETV2,EXOSC2,FAM118B,FAM119A,FAM96B,GGTA1,GKN2,GM10862,GM11285,GM12538,GM12595,GM4833,GM5080,GM9717,GM9931,GM9990,GNB5,GOLT1B,GPR155,GRB2,GSTP1,GTF2H3,H2-AB1,H2-KE2,HDAC1,HMGCS1,HSD17B7,HSPBAP1,IER5,IL21,INHBC,IPO5,KCTD20,L2HGDH,LANCL3,LCORL,LIPI,LRRC56,LRRC63,LY9,MCCC2,MCRS1,MDH2,MEPE,MIF4GD,MIR1-2,MIR367,MIR491,MIR532,MIR709,MMP20,MMP9,MOSC2,MRPL49,MRPL50,MTRR,NDUFA12,NDUFS8,NF2,NPC2,OAT,OLFR1216,OLFR1217,OLFR134,OLFR1387,OLFR1496,OLFR536,OLFR624,OLFR666,OLFR726,OLFR829,OLFR887,OLFR996,ORM1,OSGEP,OSGIN2,P2RY13,PABPC4L,PACRGL,PACSIN2,PANK4,PCYT2,PEF1,PES1,PFKL,PHB2,PHLDA1,PHPT1,PHYHD1,PINK1,PPP5C,PRAMEL7,PRMT1,PRPF38A,PSMA5,PSMD4,PSMD9,PSMG4,PTPMT1,PTPN18,PYGB,RELN,RFXAP,RHOB,RILP,RNASE12,RNF41,RPL13,RWDD1,SART3,SDCCAG3,SDR16C5,SEPHS2,SFMBT1,SFXN2,SIRT4,SIVA1,SLC15A1,SLC25A45,SLC37A2,SLC39A7,SMR3A,SNORD96A,SYTL2,TACR2,TAS2R124,TATDN2,TBRG1,TIMM17A,TMEM107,TMEM186,TMEM223,TNFAIP8,TOMM40L,TOMM5,TRADD,TRAF7,TTC9,TXNDC5,VMN1R6,VMN2R93,VPS16,WDR17,WDR24,YARS,ZFP444,ZFP580" MEMBERS_SYMBOLIZED="ACOT1,AGGF1,AHSA1,AMFR,ANAPC16,ANKFN1,ANKRD53,ANXA4,AOC2,ARL5C,ASB13,ATP6V0E1,BSCL2,CAMK2N1,CAMLG,CCDC69,CD300LD,CD302,CD82,CDK5RAP3,CDX1,CHKA,CIAO2B,CLDN16,CNGA1,CNPY2,CRADD,CRIP1,CRLS1,CRYL1,DERL1,DNAJA3,DNAJC18,DOHH,DPPA4,EIF2B4,EIF3C,EML3,ENTR1,ETV2,EXOSC2,FAM118B,GGTA1,GKN2,GNB5,GOLT1B,GPR155,GRB2,GSTP1,GTF2H3,HDAC1,HMGCS1,HSD17B7,HSPBAP1,IER5,IL21,INHBC,IPO5,KCTD20,L2HGDH,LANCL3,LCORL,LIPI,LRRC56,LRRC63,LY9,MCCC2,MCRS1,MDH2,MEPE,METTL21A,MIF4GD,MIR1-2,MIR367,MIR491,MIR532,MMP20,MMP9,MRPL49,MRPL50,MTARC2,MTRR,NDUFA12,NDUFS8,NEPRO,NF2,NPC2,OAT,ORM1,OSGEP,OSGIN2,P2RY13,PABPC4L,PACRGL,PACSIN2,PANK4,PCYT2,PEF1,PES1,PFDN6,PFKL,PHB2,PHLDA1,PHPT1,PHYHD1,PINK1,PPP5C,PRMT1,PRPF38A,PSMA5,PSMD4,PSMD9,PSMG4,PTPMT1,PTPN18,PYGB,RELN,RFXAP,RHOB,RILP,RNASE12,RNF41,RPL13,RWDD1,SART3,SDR16C5,SEPHS2,SFMBT1,SFXN2,SIRT4,SIVA1,SLC15A1,SLC25A45,SLC37A2,SLC39A7,SMR3A,SNORD96A,SYTL2,TACR2,TATDN2,TBRG1,TIMM17A,TMEM107,TMEM186,TMEM223,TNFAIP8,TOMM40L,TOMM5,TRADD,TRAF7,TTC9,TXNDC5,VPS16,WDR17,WDR24,YARS1" MEMBERS_EZID="100131439,10193,10330,1044,10440,10445,10471,10572,10577,10598,10681,10686,10807,1119,11252,11331,114971,115399,116966,118980,119504,1259,132430,133015,1396,149998,151194,151556,162282,195814,200504,202052,2116,219855,220416,222658,22822,22928,23404,23409,23481,23508,254251,254295,256364,25816,25871,25880,26112,26469,26580,267,2681,26952,283130,2885,29085,2950,2967,3065,307,314,3157,3276,347404,3626,3732,3843,388,389362,390790,401505,4063,406905,4191,4318,442912,4552,4728,4771,493901,4942,5004,51026,51084,51278,51389,51460,51478,51647,5211,53829,54534,54675,54843,54996,55109,55211,55229,553115,5536,55450,55644,55967,5649,5686,56955,5710,5715,57409,574444,5833,5834,59067,5994,6137,619571,64087,641371,64601,65018,6564,6865,693124,734,740,79064,79139,7922,79607,79663,79754,79944,79998,80279,81567,819,83475,83547,84134,84219,84231,84314,84897,84950,8565,8663,8717,8738,8890,8992,9093,9313,9733,9797,9936" MEMBERS_MAPPING="0610031J06Rik,null,null|1700020D05Rik,null,null|1700062I23Rik,null,null|1700086D15Rik,null,null|1810030J14Rik,null,null|2310011J03Rik,null,null|2310033P09Rik,null,null|2310040G07Rik,null,null|2510003E04Rik,null,null|4930528F23Rik,null,null|5430401F13Rik,null,null|6330416G13Rik,null,null|9030224M15Rik,null,null|ACOT1,ACOT1,641371|AGGF1,AGGF1,55109|AHSA1,AHSA1,10598|AKR1B8,null,null|AMFR,AMFR,267|ANAPC16,ANAPC16,119504|ANKFN1,ANKFN1,162282|ANKRD53,ANKRD53,79998|ANXA4,ANXA4,307|AOC2,AOC2,314|ARL5C,ARL5C,390790|ASB13,ASB13,79754|ATP6V0E,ATP6V0E1,8992|AY512915,null,null|BC027231,NEPRO,25871|BSCL2,BSCL2,26580|CAMK2N1,CAMK2N1,55450|CAML,CAMLG,819|CCDC69,CCDC69,26112|CD300LD,CD300LD,100131439|CD302,CD302,9936|CD82,CD82,3732|CDK5RAP3,CDK5RAP3,80279|CDX1,CDX1,1044|CHKA,CHKA,1119|CLDN16,CLDN16,10686|CNGA1,CNGA1,1259|CNPY2,CNPY2,10330|CRADD,CRADD,8738|CRIP1,CRIP1,1396|CRLS1,CRLS1,54675|CRYL1,CRYL1,51084|DERL1,DERL1,79139|DNAJA3,DNAJA3,9093|DNAJC18,DNAJC18,202052|DOHH,DOHH,83475|DPPA4,DPPA4,55211|EIF2B4,EIF2B4,8890|EIF3C,EIF3C,8663|EML3,EML3,256364|ETV2,ETV2,2116|EXOSC2,EXOSC2,23404|FAM118B,FAM118B,79607|FAM119A,METTL21A,151194|FAM96B,CIAO2B,51647|GGTA1,GGTA1,2681|GKN2,GKN2,200504|GM10862,null,null|GM11285,null,null|GM12538,null,null|GM12595,null,null|GM4833,null,null|GM5080,null,null|GM9717,null,null|GM9931,null,null|GM9990,null,null|GNB5,GNB5,10681|GOLT1B,GOLT1B,51026|GPR155,GPR155,151556|GRB2,GRB2,2885|GSTP1,GSTP1,2950|GTF2H3,GTF2H3,2967|H2-AB1,null,null|H2-KE2,PFDN6,10471|HDAC1,HDAC1,3065|HMGCS1,HMGCS1,3157|HSD17B7,HSD17B7,51478|HSPBAP1,HSPBAP1,79663|IER5,IER5,51278|IL21,IL21,59067|INHBC,INHBC,3626|IPO5,IPO5,3843|KCTD20,KCTD20,222658|L2HGDH,L2HGDH,79944|LANCL3,LANCL3,347404|LCORL,LCORL,254251|LIPI,LIPI,149998|LRRC56,LRRC56,115399|LRRC63,LRRC63,220416|LY9,LY9,4063|MCCC2,MCCC2,64087|MCRS1,MCRS1,10445|MDH2,MDH2,4191|MEPE,MEPE,56955|MIF4GD,MIF4GD,57409|MIR1-2,MIR1-2,406905|MIR367,MIR367,442912|MIR491,MIR491,574444|MIR532,MIR532,693124|MIR709,null,null|MMP20,MMP20,9313|MMP9,MMP9,4318|MOSC2,MTARC2,54996|MRPL49,MRPL49,740|MRPL50,MRPL50,54534|MTRR,MTRR,4552|NDUFA12,NDUFA12,55967|NDUFS8,NDUFS8,4728|NF2,NF2,4771|NPC2,NPC2,10577|OAT,OAT,4942|OLFR1216,null,null|OLFR1217,null,null|OLFR134,null,null|OLFR1387,null,null|OLFR1496,null,null|OLFR536,null,null|OLFR624,null,null|OLFR666,null,null|OLFR726,null,null|OLFR829,null,null|OLFR887,null,null|OLFR996,null,null|ORM1,ORM1,5004|OSGEP,OSGEP,55644|OSGIN2,OSGIN2,734|P2RY13,P2RY13,53829|PABPC4L,PABPC4L,132430|PACRGL,PACRGL,133015|PACSIN2,PACSIN2,11252|PANK4,PANK4,55229|PCYT2,PCYT2,5833|PEF1,PEF1,553115|PES1,PES1,23481|PFKL,PFKL,5211|PHB2,PHB2,11331|PHLDA1,PHLDA1,22822|PHPT1,PHPT1,29085|PHYHD1,PHYHD1,254295|PINK1,PINK1,65018|PPP5C,PPP5C,5536|PRAMEL7,null,null|PRMT1,PRMT1,3276|PRPF38A,PRPF38A,84950|PSMA5,PSMA5,5686|PSMD4,PSMD4,5710|PSMD9,PSMD9,5715|PSMG4,PSMG4,389362|PTPMT1,PTPMT1,114971|PTPN18,PTPN18,26469|PYGB,PYGB,5834|RELN,RELN,5649|RFXAP,RFXAP,5994|RHOB,RHOB,388|RILP,RILP,83547|RNASE12,RNASE12,493901|RNF41,RNF41,10193|RPL13,RPL13,6137|RWDD1,RWDD1,51389|SART3,SART3,9733|SDCCAG3,ENTR1,10807|SDR16C5,SDR16C5,195814|SEPHS2,SEPHS2,22928|SFMBT1,SFMBT1,51460|SFXN2,SFXN2,118980|SIRT4,SIRT4,23409|SIVA1,SIVA1,10572|SLC15A1,SLC15A1,6564|SLC25A45,SLC25A45,283130|SLC37A2,SLC37A2,219855|SLC39A7,SLC39A7,7922|SMR3A,SMR3A,26952|SNORD96A,SNORD96A,619571|SYTL2,SYTL2,54843|TACR2,TACR2,6865|TAS2R124,null,null|TATDN2,TATDN2,9797|TBRG1,TBRG1,84897|TIMM17A,TIMM17A,10440|TMEM107,TMEM107,84314|TMEM186,TMEM186,25880|TMEM223,TMEM223,79064|TNFAIP8,TNFAIP8,25816|TOMM40L,TOMM40L,84134|TOMM5,TOMM5,401505|TRADD,TRADD,8717|TRAF7,TRAF7,84231|TTC9,TTC9,23508|TXNDC5,TXNDC5,81567|VMN1R6,null,null|VMN2R93,null,null|VPS16,VPS16,64601|WDR17,WDR17,116966|WDR24,WDR24,84219|YARS,YARS1,8565|ZFP444,null,null|ZFP580,null,null" FILTERED_BY_SIMILARITY="" FOUNDER_NAMES="" REFINEMENT_DATASETS="" VALIDATION_DATASETS="" CATEGORY_CODE="C7" ORGANISM="Homo sapiens" SUB_CATEGORY_CODE="IMMUNESIGDB"/>
</MSIGDB>
