STANDARD_NAME GSE32986_GMCSF_VS_GMCSF_AND_CURDLAN_HIGHDOSE_STIM_DC_UP SYSTEMATIC_NAME M8630 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE32986_GMCSF_VS_GMCSF_AND_CURDLAN_HIGHDOSE_STIM_DC_UP NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes up-regulated in bone marrow-derived dendritic cells CSF2 [GeneID=1437] versus CSF2 [GeneID=1437] and high dose of 1,3-beta-D-oligoglucan [PubChem=11375554]. DESCRIPTION_FULL A simultaneous engagement of different pathogen recognition receptors provides a tailor made adaptive immunity for an efficient defence against distinct pathogens. For example, cross talk of TLR and c-type lectin signalling effectively shapes distinct gene expression patterns by integrating the signals at the level of NF-κB. Here, we extend this principle to a strong synergism between the Dectin-1 agonist, curdlan, and an inflammatory growth factor, GM-CSF. Both together act in synergy in inducing a strong inflammatory signature which converts immature DCs to potent effector DCs. A variety of cytokines (IL-1β, IL-6, TNF-α, IL-2 and IL-12p70), costimulatory molecules (CD80, CD86, CD40 and CD70), chemokines (CxCl1, CxCl2, CxCl3, CCl12, CCl17) as well as receptors and molecules involved in fugal recognition and immunity such as Mincle, Dectin-1, Dectin-2 and Pentraxin 3 are strongly up-regulated in DC treated simultaneously with curdlan and GM-CSF. The synergistic effect of both stimuli resulted in strong IKBα phosphorylation, in its rapid degradation and in enhanced nuclear translocation of all NF-κB subunits. We further identified MAPK ERK, as one possible integration site of both signals, since its phosphorylation was clearly augmented when curdlan was co-applied with GM-CSF. Our data demonstrate that the immunomodulatory activity of curdlan requires an additional signal provided by GM-CSF to successfully initiate a robust β-glucan specific cytokine and chemokine response. The integration of both signals clearly prime and tailor a more effective innate and adaptive response against invading microbes and fungi. PMID 22250091 GEOID GSE32986 AUTHORS Min L,Isa SA,Fam WN,Sze SK,Beretta O,Mortellaro A,Ruedl C CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE32986_3112_200_UP FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS ABCC3,ABCG1,ABHD12,ADAM18,AMACR,ANGPTL4,ANXA3,APH1B,APPL2,AQP7,ARHGAP19,ARHGAP24,ARPC1B,ARRDC3,ASB4,ATP6V0D1,ATP6V1B2,BBS5,BLVRA,C15orf17,C17orf103,C19orf28,C19orf38,C20orf30,C22orf40,C2orf18,C6orf192,C6orf62,CAMLG,CD200R1,CD300C,CD48,CD93,CDS2,CEBPA,CERK,CLMP,CNKSR3,CNRIP1,COL4A3BP,COMT,CPEB3,CPT1A,CRYL1,CTC1,CTSA,CTSK,DBP,DDX27,DENND2A,DNA2,DPP7,EHD4,ENC1,FAM110B,FAM110C,FAM63B,FAM89B,FBXO32,FBXO8,FGF13,FGF3,FTSJ2,G3BP2,GAB2,GADD45G,GAK,GALNT4,GAS6,GAS8,GATM,GLB1,GMNN,GPR155,GPT2,GUSB,GYG1,HEBP1,HEY1,HIPK2,HK2,HMX1,IGF1,IL11RA,IL1RL2,KIAA0513,KIAA0930,KIAA1609,KIF3A,KRTAP13-2,LAMP1,LEPROTL1,LOC344595,LONRF3,LPAR6,LRP4,LTB4R2,MAFB,MAPK9,MBTPS2,MDFIC,MERTK,METTL21A,MFSD11,MKL2,MLKL,MMAA,MOCOS,MTO1,MXD4,MXI1,MYLIP,MYO1E,NCRNA00116,NPC2,NQO2,NR1D2,NRBF2,OSBPL11,PDE7B,PDSS1,PDXK,PGD,PGRMC1,PHYH,PI4K2A,PLA2G15,POLR2G,PPP1R12C,PPP1R3B,PREPL,PRMT10,PRRC1,PSEN2,PTPLAD2,PTPN20B,PTPN21,QDPR,RAB11FIP5,RAB3IL1,RAP2A,RASA1,RCAN3,RCOR3,REPS2,RGAG4,RGS2,RHOB,RMND1,RNF144B,RRAGC,RRAGD,S1PR1,SDC3,SENP8,SLC10A7,SLC16A6,SLC26A11,SLC36A4,SLC3A2,SLC40A1,SNX24,SOCS6,SORD,SPRY2,ST6GAL1,STXBP5,SYNGR1,TATDN3,TBC1D2,TBC1D24,TCEAL8,TEC,TESK2,THBD,TIMP2,TM6SF1,TMEM41B,TMEM50A,TMEM86A,TMEM87B,TP53INP1,TPST1,TRIM14,TRIM44,TROVE2,TSC22D3,TSTD1,TTC39A,UBE2T,UGDH,VPS41,VWF,WDR7,WHSC1L1,WWC2,YPEL2,ZBTB16,ZNF438,ZNF839 GENE_SYMBOLS ABCC3,ABCG1,ABHD12,ADAM18,AMACR,ANGPTL4,ANXA3,APH1B,APPL2,AQP7,ARHGAP19,ARHGAP24,ARPC1B,ARRDC3,ASB4,ATP6V0D1,ATP6V1B2,BBS5,BLVRA,FAM219B,NATD1,MFSD12,C19orf38,TMEM230,CDPF1,SLC35F6,SLC18B1,C6orf62,CAMLG,CD200R1,CD300C,CD48,CD93,CDS2,CEBPA,CERK,CLMP,CNKSR3,CNRIP1,CERT1,COMT,CPEB3,CPT1A,CRYL1,CTC1,CTSA,CTSK,DBP,DDX27,DENND2A,DNA2,DPP7,EHD4,ENC1,FAM110B,FAM110C,MINDY2,FAM89B,FBXO32,FBXO8,FGF13,FGF3,MRM2,G3BP2,GAB2,GADD45G,GAK,GALNT4,GAS6,GAS8,GATM,GLB1,GMNN,GPR155,GPT2,GUSB,GYG1,HEBP1,HEY1,HIPK2,HK2,HMX1,IGF1,IL11RA,IL1RL2,KIAA0513,KIAA0930,MEAK7,KIF3A,KRTAP13-2,LAMP1,LEPROTL1,DUBR,LONRF3,LPAR6,LRP4,LTB4R2,MAFB,MAPK9,MBTPS2,MDFIC,MERTK,METTL21A,MFSD11,MRTFB,MLKL,MMAA,MOCOS,MTO1,MXD4,MXI1,MYLIP,MYO1E,MTLN,NPC2,NQO2,NR1D2,NRBF2,OSBPL11,PDE7B,PDSS1,PDXK,PGD,PGRMC1,PHYH,PI4K2A,PLA2G15,POLR2G,PPP1R12C,PPP1R3B,PREPL,PRMT9,PRRC1,PSEN2,HACD4,PTPN20,PTPN21,QDPR,RAB11FIP5,RAB3IL1,RAP2A,RASA1,RCAN3,RCOR3,REPS2,RTL5,RGS2,RHOB,RMND1,RNF144B,RRAGC,RRAGD,S1PR1,SDC3,SENP8,SLC10A7,SLC16A6,SLC26A11,SLC36A4,SLC3A2,SLC40A1,SNX24,SOCS6,SORD,SPRY2,ST6GAL1,STXBP5,SYNGR1,TATDN3,TBC1D2,TBC1D24,TCEAL8,TEC,TESK2,THBD,TIMP2,TM6SF1,TMEM41B,TMEM50A,TMEM86A,TMEM87B,TP53INP1,TPST1,TRIM14,TRIM44,RO60,TSC22D3,TSTD1,TTC39A,UBE2T,UGDH,VPS41,VWF,WDR7,NSD3,WWC2,YPEL2,ZBTB16,ZNF438,ZNF839 FOUNDER_NAMES