STANDARD_NAME GSE3337_CTRL_VS_4H_IFNG_IN_CD8POS_DC_DN SYSTEMATIC_NAME M5099 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE3337_CTRL_VS_4H_IFNG_IN_CD8POS_DC_DN NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes down-regulated in comparison of untreated CD8+ dendritic cells (DC) at 4 h versus those treated with IFNG [GeneID=3458] at 4 h. DESCRIPTION_FULL Although much is known on the transcriptional profiles of dendritic cells (DCs) during maturation, the molecular switches critical for the acquisition of a tolerogenic program by DCs are still obscure. In the present study, we explored the gene expression pattern of CD8+ DCs purified from the mouse spleen and treated with interferon (IFN)-gamma. The cytokine, indeed, potentiates the tolerogenic potential of this DC subset via induction of the immunosuppressive tryptophan catabolism mediated by indoleamine 2,3-dioxygenase (IDO). By comparing the expression of the IFN-gamma-modulated genes in IDO+ versus IDO- murine DCs, we found a consistent and selective association of the IDO-competent phenotype with the down-modulation of the Tyrobp gene, encoding the adapter molecule DAP12. IFN-gamma-mediated down-modulation of this gene involved IFN consensus sequence binding protein (ICSBP), a transcription factor also known as IRF-8. While silencing of Tyrobp conferred IDO functional competence on IDO- DCs, silencing of Icsbp1 in IDO+ cells completely abolished IDO expression and function. In parallel, silencing of TYROBP conferred IDO competence on human IDO- DCs while silencing of IRF8 impaired IDO expression and activity in human IDO+ DCs. Therefore, the same small set of molecular switches controls IDO competence in murine and human DCs. PMID 16339401 GEOID GSE3337 AUTHORS Orabona C,Puccetti P,Vacca C,Bicciato S,Luchini A,Fallarino F,Bianchi R,Velardi E,Perruccio K,Velardi A,Bronte V,Fioretti MC,Grohmann U CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE3337_1053_200_DN FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS ABCC1,ABR,ACADL,ADAR,AHRR,ALB,ANXA2,AP1S1,APLP1,ARF3,ARFGEF1,ARHGAP5,ARHGEF2,ATP5A1,ATP5O,BZW2,C9orf103,CA5A,CAMK2D,CAND1,CAP1,CASP4,CCDC88A,CCL1,CCNE2,CD2BP2,CD36,CD40,CD44,CD8B,CDC73,CDK4,CEBPG,CHIA,CHPT1,CLK2,CNN3,CPNE3,CSF1,CSNK1D,CTSC,CX3CR1,CXCL10,DAXX,DCPS,DR1,EIF1AY,ELAVL2,ENPP1,ENTPD1,ESD,FAM109A,FAM82A2,FAU,FBL,FGL2,FLI1,FLNB,GABRD,GADD45G,GBP2,GBP4,GBP7,GGPS1,GIMAP1,GIMAP4,GLIPR2,GNB4,GPD2,GPN2,GPR125,GPR132,GRAMD3,GSPT1,GTPBP2,GZMB,HERC2,HIST1H2BD,HNRNPAB,HOPX,HSD3B7,ICOS,IER3,IFI35,IFIT1B,IFIT2,IFIT3,IKBKB,IL13RA2,IL18,IL18RAP,IMP4,IRF1,JUN,KDR,KHDC1L,KLF4,KRT84,KSR1,LANCL2,LAT,LIMA1,LMAN2,LMNB1,LTBP2,LXN,LYPLA1,MDM1,MED28,MPEG1,MRPL54,MTMR1,MXD1,MYC,NAMPT,NBN,NCK2,NDRG1,NDUFA6,NMBR,NOC4L,NONO,NOP10,NOTCH4,NXF1,PABPC1,PAPOLA,PCGF5,PDIA6,PFKP,PKIB,PLG,PML,PNPO,PON1,POU6F1,PPAT,PPP3CB,PRDM1,PREP,PRKCH,PRRX1,PSMB10,PSMB8,PSMB9,RAB7A,RBL1,RBMXL1,RNF14,RORA,RPL3,SCAF11,SERPINA10,SERPINB1,SLA,SLFN12L,SMAGP,SNAPC3,SNRPD3,SOCS1,SP4,ST3GAL6,ST6GALNAC6,STAM2,STAT1,STAT3,STOML2,STX2,STX3,SWAP70,TAP1,TCF19,TENC1,TG,TIMM8A,TLR7,TNF,TNFAIP2,TNFAIP3,TNNC2,TOR3A,TPSB2,TPST1,TRAF3IP2,TRIM21,TUBB,TXK,TXNDC17,UBA7,UBD,UGGT1,UPP1,USP18,USP22,VPS54,WARS,XCL1,YKT6,ZFP106,ZNFX1 GENE_SYMBOLS ABCC1,ABR,ACADL,ADAR,AHRR,ALB,ANXA2,AP1S1,APLP1,ARF3,ARFGEF1,ARHGAP5,ARHGEF2,ATP5F1A,ATP5PO,BZW2,IDNK,CA5A,CAMK2D,CAND1,CAP1,CASP4,CCDC88A,CCL1,CCNE2,CD2BP2,CD36,CD40,CD44,CD8B,CDC73,CDK4,CEBPG,CHIA,CHPT1,CLK2,CNN3,CPNE3,CSF1,CSNK1D,CTSC,CX3CR1,CXCL10,DAXX,DCPS,DR1,EIF1AY,ELAVL2,ENPP1,ENTPD1,ESD,PHETA1,RMDN3,FAU,FBL,FGL2,FLI1,FLNB,GABRD,GADD45G,GBP2,GBP4,GBP7,GGPS1,GIMAP1,GIMAP4,GLIPR2,GNB4,GPD2,GPN2,ADGRA3,GPR132,GRAMD2B,GSPT1,GTPBP2,GZMB,HERC2,H2BC5,HNRNPAB,HOPX,HSD3B7,ICOS,IER3,IFI35,IFIT1B,IFIT2,IFIT3,IKBKB,IL13RA2,IL18,IL18RAP,IMP4,IRF1,JUN,KDR,KHDC1L,KLF4,KRT84,KSR1,LANCL2,LAT,LIMA1,LMAN2,LMNB1,LTBP2,LXN,LYPLA1,MDM1,MED28,MPEG1,MRPL54,MTMR1,MXD1,MYC,NAMPT,NBN,NCK2,NDRG1,NDUFA6,NMBR,NOC4L,NONO,NOP10,NOTCH4,NXF1,PABPC1,PAPOLA,PCGF5,PDIA6,PFKP,PKIB,PLG,PML,PNPO,PON1,POU6F1,PPAT,PPP3CB,PRDM1,PREP,PRKCH,PRRX1,PSMB10,PSMB8,PSMB9,RAB7A,RBL1,RBMXL1,RNF14,RORA,RPL3,SCAF11,SERPINA10,SERPINB1,SLA,SLFN12L,SMAGP,SNAPC3,SNRPD3,SOCS1,SP4,ST3GAL6,ST6GALNAC6,STAM2,STAT1,STAT3,STOML2,STX2,STX3,SWAP70,TAP1,TCF19,TNS2,TG,TIMM8A,TLR7,TNF,TNFAIP2,TNFAIP3,TNNC2,TOR3A,TPSB2,TPST1,TRAF3IP2,TRIM21,TUBB,TXK,TXNDC17,UBA7,UBD,UGGT1,UPP1,USP18,USP22,VPS54,WARS1,XCL1,YKT6,ZNF106,ZNFX1 FOUNDER_NAMES