STANDARD_NAME GSE33513_TCF7_KO_VS_HET_EARLY_THYMIC_PROGENITOR_DN SYSTEMATIC_NAME M5107 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE33513_TCF7_KO_VS_HET_EARLY_THYMIC_PROGENITOR_DN NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes down-regulated in comparison of TCF7 [GeneID=6932] deficient early thymic progenitors versus the TCF7 [GeneID=6932] sufficient ones. DESCRIPTION_FULL Although transcriptional programs associated with T-cell specification and commitment have been described, the functional hierarchy and the roles of key regulators in structuring/ orchestrating these programs remain unclear. Activation of Notch signaling in uncommitted precursors by the thymic stroma initiates the T-cell differentiation program. One regulator first induced in these precursors is the DNA binding protein Tcf-1, a T-cell specific mediator of Wnt signaling. Yet the specific contribution of Tcf-1 to early T-cell development and the signals inducing it in these cells remain unclear. Here we assign functional significance to Tcf-1 as a gatekeeper of T-cell fate. We show that Tcf-1 is directly activated by Notch signals. Tcf-1 is required at the earliest phase of Tcell determination for progression beyond the early thymic progenitor (ETP) stage. The global expression profile of Tcf-1 deficient progenitors indicates that basic processes of DNA metabolism are downregulated in its absence and the blocked T-cell progenitors become abortive and die by apoptosis. Our data thus add an important functional relationship to the roadmap of T-cell development. We used microarrays to detail the global programme of gene expression of mouse ETP thymocyte after Ikaros inactivation with dominant negative of Ik at different stage. PMID 22109558 GEOID GSE33513 AUTHORS Germar K,Dose M,Konstantinou T,Zhang J,Wang H,Lobry C,Arnett KL,Blacklow SC,Aifantis I,Aster JC,Gounari F CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE33513_2166_200_DN FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS ABHD14A,ACAD8,ACVR2B,ADD3,AGPAT2,ALCAM,ANAPC5,AP1G2,APAF1,AQP7,AR,ATP11C,ATP13A2,ATP5S,ATXN10,BAZ1B,BCR,BCS1L,BRD9,BRDT,C11orf46,C13orf31,C18orf10,C2CD3,C5orf28,C6orf115,C7orf46,CACNA1D,CASD1,CCL25,CCR9,CD276,CD300LD,CD93,CDK16,CFL2,CGGBP1,CHDH,CHL1,COASY,CORO1A,CPSF6,CRYL1,CSE1L,DEDD,DLG4,DNA2,DNTT,DOCK7,DSE,E2F2,ECHDC1,ECI2,EFCAB11,EIF1B,EIF2A,ELTD1,ENO3,EPB41L4B,ESR1,EXOC7,EXOSC3,FAM105A,FAM192A,FAM53C,FAM84A,FLT3,FRMD5,GALNTL1,GAS2L3,GIMAP1,GIMAP6,GIPC1,GLIS2,GLOD4,GPR137B,GPR87,GPRC5B,GRWD1,H2AFY,HELB,HIF1A,HOOK1,HOXD9,HS1BP3,HSD17B6,ICA1,IFT80,IKBKB,IL12A,INPP5F,INTS3,INTS9,IQSEC1,JUP,KIF7,KLHDC10,KLHL35,KLKB1,KRTAP2-4,LDHAL6B,LRRC33,LRRCC1,LSM4,MAD1L1,MAST2,MBTD1,MELK,METTL21A,MGA,MKL1,MRPL34,MRPS34,MUDENG,MYL10,NCAPD2,NDUFA6,NET1,NFYA,NPC1,NR4A2,PABPN1,PAOX,PAQR3,PHF2,PHOX2B,PHPT1,PIGM,PIGN,PLEK,PNRC1,POLG2,POLR2D,POLR2G,PPIH,PPM1F,PSMD3,PTBP1,PYCR2,RERE,RGL1,RHOG,RNF157,RNF220,ROM1,RPL14,RPL26,RPS18,RPS26,SASS6,SCAP,SEC23A,SEPT15,SF3B4,SGOL1,SIRT3,SKIV2L,SLC15A1,SLC16A4,SLC25A27,SLC2A1,SLC30A4,SLC3A1,SLC5A3,SMG1,SMPD1,SNN,SNRPD2,SNX9,SPATA1,SPRED3,SSH1,STX19,SUB1,SUPT3H,SYNC,TCF7L2,TES,TFAP4,TMEM108,TMX3,TPM2,TRIM32,TSN,TSPAN2,TSPAN6,TYW1,UHRF1BP1,USP54,VAPB,VSIG10,WDR85,YEATS2,YPEL3,ZC4H2,ZCCHC3,ZDHHC15,ZNF362,ZNF619,ZNRD1 GENE_SYMBOLS ABHD14A,ACAD8,ACVR2B,ADD3,AGPAT2,ALCAM,ANAPC5,AP1G2,APAF1,AQP7,AR,ATP11C,ATP13A2,DMAC2L,ATXN10,BAZ1B,BCR,BCS1L,BRD9,BRDT,ARL14EP,LACC1,TPGS2,C2CD3,TMEM267,ABRACL,FAM221A,CACNA1D,CASD1,CCL25,CCR9,CD276,CD300LD,CD93,CDK16,CFL2,CGGBP1,CHDH,CHL1,COASY,CORO1A,CPSF6,CRYL1,CSE1L,DEDD,DLG4,DNA2,DNTT,DOCK7,DSE,E2F2,ECHDC1,ECI2,EFCAB11,EIF1B,EIF2A,ADGRL4,ENO3,EPB41L4B,ESR1,EXOC7,EXOSC3,OTULINL,PSME3IP1,FAM53C,LRATD1,FLT3,FRMD5,GALNT16,GAS2L3,GIMAP1,GIMAP6,GIPC1,GLIS2,GLOD4,GPR137B,GPR87,GPRC5B,GRWD1,MACROH2A1,HELB,HIF1A,HOOK1,HOXD9,HS1BP3,HSD17B6,ICA1,IFT80,IKBKB,IL12A,INPP5F,INTS3,INTS9,IQSEC1,JUP,KIF7,KLHDC10,KLHL35,KLKB1,KRTAP2-4,LDHAL6B,NRROS,LRRCC1,LSM4,MAD1L1,MAST2,MBTD1,MELK,METTL21A,MGA,MRTFA,MRPL34,MRPS34,AP5M1,MYL10,NCAPD2,NDUFA6,NET1,NFYA,NPC1,NR4A2,PABPN1,PAOX,PAQR3,PHF2,PHOX2B,PHPT1,PIGM,PIGN,PLEK,PNRC1,POLG2,POLR2D,POLR2G,PPIH,PPM1F,PSMD3,PTBP1,PYCR2,RERE,RGL1,RHOG,RNF157,RNF220,ROM1,RPL14,RPL26,RPS18,RPS26,SASS6,SCAP,SEC23A,,SF3B4,SGO1,SIRT3,SKIC2,SLC15A1,SLC16A4,SLC25A27,SLC2A1,SLC30A4,SLC3A1,SLC5A3,SMG1,SMPD1,SNN,SNRPD2,SNX9,SPATA1,SPRED3,SSH1,STX19,SUB1,SUPT3H,SYNC,TCF7L2,TES,TFAP4,TMEM108,TMX3,TPM2,TRIM32,TSN,TSPAN2,TSPAN6,TYW1,BLTP3A,USP54,VAPB,VSIG10,DPH7,YEATS2,YPEL3,ZC4H2,ZCCHC3,ZDHHC15,ZNF362,ZNF619,POLR1H FOUNDER_NAMES