STANDARD_NAME	GSE34205_HEALTHY_VS_FLU_INF_INFANT_PBMC_UP
SYSTEMATIC_NAME	M5138
COLLECTION	C7:IMMUNESIGDB
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE34205_HEALTHY_VS_FLU_INF_INFANT_PBMC_UP
NAMESPACE	HUMAN_GENE_SYMBOL
DESCRIPTION_BRIEF	Genes up-regulated in comparison of peripheral blood mononuclear cells (PBMC) from healthy donors versus PBMCs from infanct with acute influenza infection.
DESCRIPTION_FULL	To study the transcriptional profile of patients with acute RSV or Influenza infection,children of median age 2.4 months (range 1.5-8.6) hospitalized with acute RSV and influenza virus infection were offered study enrollment after microbiologic confirmation of the diagnosis. Blood samples were collected from them within 42-72 hours of hospitalization. We excluded children with suspected or proven polymicrobial infections, with underlying chronic medical conditions (i.e congenital heart disease, renal insufficiency), with immunodeficiency, or those who received systemic steroids or other immunomodulatory therapies. The RSV cohort consisted of 51 patients with median age of 2 months (range 1.5-3.9) and the influenza cohort had 28 patients with median age of 5.5 months (range 1.4-21). Control samples were obtained from healthy children undergoing elective surgical procedures or at outpatient clinic visits. To exclude viral co-infections we performed nasopharyngeal viral cultures of all subjects. We recruited 10 control patients for the RSV cohort with median age of 6.7 months (range 5-10), and 12 control patients for the influenza cohort with median age of18.5 months (range 10.5-26).
PMID	22398282
GEOID	GSE34205
AUTHORS	Ioannidis I,McNally B,Willette M,Peeples ME,Chaussabel D,Durbin JE,Ramilo O,Mejias A,Flaño E
CONTRIBUTOR	Jernej Godec
CONTRIBUTOR_ORG	Dana-Farber Cancer Institute
EXACT_SOURCE	GSE34205_2335_200_UP
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	ABHD15,ACOX3,AKAP12,ALDH1A1,ANKH,ARHGAP17,ARHGAP9,ATL3,BAZ2A,BCL11A,BNC2,C11orf2,C12orf57,C17orf39,C17orf57,C19orf43,C22orf39,C5orf20,CBL,CBX7,CD1C,CD44,CIITA,CLDND2,CLEC4C,CLLU1,CMPK1,COMMD6,CR2,CRIP2,CYBASC3,CYBRD1,DALRD3,DCAF16,DFFA,DNAJB6,DNAL1,DPH5,DTWD1,DUS2L,EEF1B2,EEF1D,EEF1G,EEF2,EEF2K,EIF2C1,EIF2D,EIF3D,EIF3F,EIF3L,EMR3,ERBB2IP,ERGIC3,ESYT1,EZH1,FBL,FBXL17,FCER1A,FCRL3,FCRLA,FLJ35934,FLJ39639,GALNT10,GDI2,GLTSCR2,GNB2L1,GPR44,GSPT2,HADHA,HIF1AN,HLA-DOA,HLA-DOB,HLA-DPB1,HLA-DQB1,HSPA1L,IL16,INTS3,ITFG2,KCTD7,KDM4B,KDM4C,KIAA0182,KIAA1147,KIAA1377,KLRB1,LARGE,LBH,LILRA4,LOC100289086,LOC100289420,LOC200772,LOC285286,LOC285972,LOC340947,LRP8,LTB,LZTFL1,MAPK1,MAST3,MLL5,MMGT1,MOBKL2B,MRC1,MUM1,NACA,NAP1L1,NELL2,NONO,NRCAM,ODF2,ORAI3,PABPC4,PAK2,PBXIP1,PID1,PKN2,POLR2L,PPP1R3E,PRKRIR,PTDSS1,PTOV1,QARS,RAB14,RABEP2,RFTN1,RPL10,RPL13,RPL15,RPL18,RPL19,RPL21,RPL27,RPL31,RPL32,RPL35,RPL38,RPL4,RPL5,RPL7,RPL7A,RPL8,RPLP1,RPLP2,RPS10,RPS12,RPS14,RPS18,RPS23,RPS3,RPS3A,RPS5,RTN1,SCRN1,SDCCAG3,SEMA4B,SGSM3,SH3BP4,SIRT4,SLC25A6,SLC27A5,SNAI2,SNHG10,SPIB,ST13,ST6GALNAC3,STMN3,SUDS3,SYPL1,TBC1D9,TBL1XR1,THEM4,TMED10,TMED4,TOP1MT,TPT1,TRIM27,TRIT1,TSPAN13,TTC31,TUFM,UBA52,UBE4B,ULK4,UXT,VPS36,WDR11,YPEL1,YY1,ZBTB40,ZCCHC7,ZMAT3,ZMYND11,ZNF264,ZNF415,ZNF575,ZNF577,ZNF641,ZNF665,ZNF785,ZNF91
GENE_SYMBOLS	ABHD15,ACOX3,AKAP12,ALDH1A1,ANKH,ARHGAP17,ARHGAP9,ATL3,BAZ2A,BCL11A,BNC2,VPS51,C12orf57,GID4,EFCAB13,TRIR,C22orf39,DCANP1,CBL,CBX7,CD1C,CD44,CIITA,CLDND2,CLEC4C,CLLU1,CMPK1,COMMD6,CR2,CRIP2,CYB561A3,CYBRD1,DALRD3,DCAF16,DFFA,DNAJB6,DNAL1,DPH5,DTWD1,DUS2,EEF1B2,EEF1D,EEF1G,EEF2,EEF2K,AGO1,EIF2D,EIF3D,EIF3F,EIF3L,ADGRE3,ERBIN,ERGIC3,ESYT1,EZH1,FBL,FBXL17,FCER1A,FCRL3,FCRLA,LINC02076,LINC00921,GALNT10,GDI2,NOP53,RACK1,PTGDR2,GSPT2,HADHA,HIF1AN,HLA-DOA,HLA-DOB,HLA-DPB1,HLA-DQB1,HSPA1L,IL16,INTS3,ITFG2,KCTD7,KDM4B,KDM4C,GSE1,DENND11,CEP126,KLRB1,LARGE1,LBH,LILRA4,,,UICLM,LINC00877,LINC00996,EIF3LP3,LRP8,LTB,LZTFL1,MAPK1,MAST3,KMT2E,MMGT1,MOB3B,MRC1,IRF4,NACA,NAP1L1,NELL2,NONO,NRCAM,ODF2,ORAI3,PABPC4,PAK2,PBXIP1,PID1,PKN2,POLR2L,PPP1R3E,THAP12,PTDSS1,PTOV1,EPRS1,RAB14,RABEP2,RFTN1,RPL10,RPL13,RPL15,RPL18,RPL19,RPL21,RPL27,RPL31,RPL32,RPL35,RPL38,RPL4,RPL5,RPL7,RPL7A,RPL8,RPLP1,RPLP2,RPS10,RPS12,RPS14,RPS18,RPS23,RPS3,RPS3A,RPS5,RTN1,SCRN1,ENTR1,SEMA4B,SGSM3,SH3BP4,SIRT4,SLC25A6,SLC27A5,SNAI2,SNHG10,SPIB,ST13,ST6GALNAC3,STMN3,SUDS3,SYPL1,TBC1D9,TBL1XR1,THEM4,TMED10,TMED4,TOP1MT,TPT1,TRIM27,TRIT1,TSPAN13,TTC31,TUFM,UBA52,UBE4B,ULK4,UXT,VPS36,WDR11,YPEL1,YY1,ZBTB40,ZCCHC7,ZMAT3,ZMYND11,ZNF264,ZNF415,ZNF575,ZNF577,ZNF641,ZNF665,ZNF785,ZNF91
FOUNDER_NAMES