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     See license terms at www.gsea-msigdb.org/gsea/license_terms_list. Please note that certain gene sets have special access terms.
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<MSIGDB BUILD_DATE="Jan 29, 2026" VERSION="2026.1.Hs" NAME="export">
    <GENESET STANDARD_NAME="GSE34205_HEALTHY_VS_RSV_INF_INFANT_PBMC_DN" SYSTEMATIC_NAME="M5137" HISTORICAL_NAMES="" PMID="22398282" AUTHORS="Ioannidis I,McNally B,Willette M,Peeples ME,Chaussabel D,Durbin JE,Ramilo O,Mejias A,Flaño E" GEOID="GSE34205" EXACT_SOURCE="GSE34205_2334_200_DN" GENESET_LISTING_URL="" EXTERNAL_DETAILS_URL="" CHIP="HUMAN_GENE_SYMBOL" CONTRIBUTOR="Jernej Godec" CONTRIBUTOR_ORG="Dana-Farber Cancer Institute" DESCRIPTION_BRIEF="Genes down-regulated in comparison of peripheral blood mononuclear cells (PBMC) from healthy donors versus PBMCs from infanct with acute RSV infection." DESCRIPTION_FULL="To study the transcriptional profile of patients with acute RSV or Influenza infection,children of median age 2.4 months (range 1.5-8.6) hospitalized with acute RSV and influenza virus infection were offered study enrollment after microbiologic confirmation of the diagnosis. Blood samples were collected from them within 42-72 hours of hospitalization. We excluded children with suspected or proven polymicrobial infections, with underlying chronic medical conditions (i.e congenital heart disease, renal insufficiency), with immunodeficiency, or those who received systemic steroids or other immunomodulatory therapies. The RSV cohort consisted of 51 patients with median age of 2 months (range 1.5-3.9) and the influenza cohort had 28 patients with median age of 5.5 months (range 1.4-21). Control samples were obtained from healthy children undergoing elective surgical procedures or at outpatient clinic visits. To exclude viral co-infections we performed nasopharyngeal viral cultures of all subjects. We recruited 10 control patients for the RSV cohort with median age of 6.7 months (range 5-10), and 12 control patients for the influenza cohort with median age of18.5 months (range 10.5-26)." TAGS="" MEMBERS="ABCC13,ACSL1,ADIPOR1,ADM,AGFG1,AHSP,ALAS2,AMELX,ANK1,ANXA3,ARF4,ARG1,ARL8A,ASGR2,BAMBI,BCL6,BLVRB,BNIP3L,BPGM,BPI,BST1,C12orf59,C16orf59,C19orf59,C5orf32,C8orf38,C9orf66,CA1,CALM3,CAMP,CCNE1,CCNL1,CD177,CD36,CDC34,CDC45,CDCA5,CDCA7,CDK1,CDKN3,CEACAM6,CEACAM8,CENPN,CTNNAL1,DCAF12,DEFA4,DNAJC6,DSC2,DYSF,E2F1,E2F2,E2F8,EIF1B,EPB42,ESPL1,EXOSC9,EXTL1,FAM100B,FAM104A,FAM53C,FBXO7,FCGR1B,FECH,FOXM1,GLRX5,GMPR,GNA15,GNG10,GPER,GPR84,GSG1,GSPT1,GYPA,GYPB,H1F0,HBBP1,HBD,HBM,HBQ1,HEMGN,HEPACAM2,HIST1H1C,HIST1H1D,HIST1H2AI,HIST1H2AJ,HLX,HMGN2,HP,HPSE,HTR4,IFI27,IFITM3,IL1RN,KIAA0101,KIF23,KLF1,KLHL15,KLHL2,KLK14,KRT1,LCN2,LDHA,LDLR,LGALS1,LIMK2,LRRC2,LTF,MAP1LC3B,MCM4,MELK,MKI67,MKRN1,MLF1IP,MMP8,MMP9,MOSC1,MPO,MPP1,MTHFD1L,MYADM,MYL4,NCF4,NKX3-2,NME1,NOP58,NRAS,NSUN3,OLFM4,ORM1,OSBP2,PCGF5,PGLYRP1,PIP5K1A,PLBD1,PPM1A,PPP4R2,PRTN3,PVRL2,RAB1A,RAD51,RANBP9,RAP1GAP,RBPMS,RETN,RHEB,RIOK3,RMND5A,RNASE2,RNASE3,RNF10,RPIA,S100A12,S100A8,S100A9,S100P,SAT1,SELENBP1,SERINC2,SLBP,SLC22A4,SLC4A1,SLC6A8,SLC9A8,SLMO2,SLPI,SMTN,SNCA,SPAG5,SPC25,STAG3,STMN1,STRADB,TAB3,TCN2,TFDP1,THBS3,THUMPD2,TK1,TMEM167A,TMEM184A,TMOD1,TNS1,TRAF3IP2-AS1,TRIB1,TRMT5,TTC36,TTK,TUBA1A,TUBA1B,TUBA1C,TUBB3,TYMS,UBE2B,UBE2C,UHRF1,UQCRFS1,VSTM1,XK,YOD1,ZNF326" MEMBERS_SYMBOLIZED="ABCC13,ACSL1,ADIPOR1,ADM,AGFG1,AHSP,ALAS2,AMELX,ANK1,ANXA3,ARF4,ARG1,ARL8A,ASGR2,BAMBI,BCL6,BLVRB,BNIP3L,BPGM,BPI,BST1,CA1,CALM3,CAMP,CCNE1,CCNL1,CD177,CD36,CDC34,CDC45,CDCA5,CDCA7,CDK1,CDKN3,CEACAM6,CEACAM8,CENPN,CENPU,CTNNAL1,CYSTM1,DCAF12,DEFA4,DNAJC6,DOCK8-AS1,DSC2,DYSF,E2F1,E2F2,E2F8,EIF1B,EPB42,ESPL1,EXOSC9,EXTL1,FAM53C,FBXO7,FCGR1BP,FECH,FOXM1,GLRX5,GMPR,GNA15,GNG10,GPER1,GPR84,GSG1,GSPT1,GYPA,GYPB,H1-0,H1-2,H1-3,H2AC13,H2AC14,HBBP1,HBD,HBM,HBQ1,HEMGN,HEPACAM2,HLX,HMGN2,HP,HPSE,HTR4,IFI27,IFITM3,IL1RN,KIF23,KLF1,KLHL15,KLHL2,KLK14,KRT1,LCN2,LDHA,LDLR,LGALS1,LIMK2,LRRC2,LTF,MAP1LC3B,MCEMP1,MCM4,MELK,MKI67,MKRN1,MMP8,MMP9,MPO,MPP1,MTARC1,MTHFD1L,MYADM,MYL4,NCF4,NDUFAF6,NECTIN2,NKX3-2,NME1,NOP58,NRAS,NSUN3,OLFM4,ORM1,OSBP2,PCGF5,PCLAF,PGLYRP1,PIP5K1A,PLBD1,PPM1A,PPP4R2,PRELID3B,PRTN3,RAB1A,RAD51,RANBP9,RAP1GAP,RBPMS,RETN,RHEB,RIOK3,RMND5A,RNASE2,RNASE3,RNF10,RPIA,S100A12,S100A8,S100A9,S100P,SAT1,SELENBP1,SERINC2,SLBP,SLC22A4,SLC4A1,SLC6A8,SLC9A8,SLPI,SMTN,SNCA,SPAG5,SPC25,STAG3,STMN1,STRADB,TAB3,TCN2,TEDC2,TFDP1,THBS3,THUMPD2,TK1,TMEM167A,TMEM184A,TMEM52B,TMOD1,TNS1,TRAF3IP2-AS1,TRIB1,TRMT5,TTC36,TTK,TUBA1A,TUBA1B,TUBA1C,TUBB3,TYMS,UBALD2,UBE2B,UBE2C,UHRF1,UQCRFS1,VCF1,VSTM1,XK,YOD1,ZNF326" MEMBERS_EZID="10048,10221,10289,1033,10376,10381,10410,10562,10615,10661,10734,10855,1088,11030,11065,11275,113130,120939,127829,133,137682,143941,150000,151987,153339,157983,1669,1824,1869,1870,199675,202915,2038,212,2134,2180,2210,2235,22934,2305,23315,23608,23762,253012,257397,25793,25805,25853,25902,265,2766,2769,2790,283991,284415,284695,2852,286,29128,2935,2993,2994,3005,3006,3007,3042,3044,3045,3049,306,3142,3151,3240,3267,3360,3429,347735,3557,378,383,3848,3925,3934,3939,3949,3956,3985,4057,4173,4288,4317,4318,433,4353,4354,43847,4635,4680,4689,4830,4893,5004,51012,51094,51218,51307,51327,51602,53831,5393,5494,55363,55432,55437,55839,5657,56729,57018,57126,57405,57570,579,5819,5861,5888,5909,6009,6036,6037,604,6279,6280,6283,6286,6303,63899,643749,645,64757,64795,6521,6525,6535,6583,6590,6622,665,669,671,683,6948,7027,7059,7083,7111,7145,7272,7298,7320,7386,7504,759,7846,7884,79442,79682,79733,79887,80178,80311,80745,808,81631,820,8291,8318,8329,8331,83445,83879,8394,84333,84418,84790,84923,8727,8780,898,8991,8993,91663,948,9493,9700,9768,9829,983,9833,9921,997" MEMBERS_MAPPING="ABCC13,ABCC13,150000|ACSL1,ACSL1,2180|ADIPOR1,ADIPOR1,51094|ADM,ADM,133|AGFG1,AGFG1,3267|AHSP,AHSP,51327|ALAS2,ALAS2,212|AMELX,AMELX,265|ANK1,ANK1,286|ANXA3,ANXA3,306|ARF4,ARF4,378|ARG1,ARG1,383|ARL8A,ARL8A,127829|ASGR2,ASGR2,433|BAMBI,BAMBI,25805|BCL6,BCL6,604|BLVRB,BLVRB,645|BNIP3L,BNIP3L,665|BPGM,BPGM,669|BPI,BPI,671|BST1,BST1,683|C12orf59,TMEM52B,120939|C16orf59,TEDC2,80178|C19orf59,MCEMP1,199675|C5orf32,CYSTM1,84418|C8orf38,NDUFAF6,137682|C9orf66,DOCK8-AS1,157983|CA1,CA1,759|CALM3,CALM3,808|CAMP,CAMP,820|CCNE1,CCNE1,898|CCNL1,CCNL1,57018|CD177,CD177,57126|CD36,CD36,948|CDC34,CDC34,997|CDC45,CDC45,8318|CDCA5,CDCA5,113130|CDCA7,CDCA7,83879|CDK1,CDK1,983|CDKN3,CDKN3,1033|CEACAM6,CEACAM6,4680|CEACAM8,CEACAM8,1088|CENPN,CENPN,55839|CTNNAL1,CTNNAL1,8727|DCAF12,DCAF12,25853|DEFA4,DEFA4,1669|DNAJC6,DNAJC6,9829|DSC2,DSC2,1824|DYSF,DYSF,8291|E2F1,E2F1,1869|E2F2,E2F2,1870|E2F8,E2F8,79733|EIF1B,EIF1B,10289|EPB42,EPB42,2038|ESPL1,ESPL1,9700|EXOSC9,EXOSC9,5393|EXTL1,EXTL1,2134|FAM100B,UBALD2,283991|FAM104A,VCF1,84923|FAM53C,FAM53C,51307|FBXO7,FBXO7,25793|FCGR1B,FCGR1BP,2210|FECH,FECH,2235|FOXM1,FOXM1,2305|GLRX5,GLRX5,51218|GMPR,GMPR,2766|GNA15,GNA15,2769|GNG10,GNG10,2790|GPER,GPER1,2852|GPR84,GPR84,53831|GSG1,GSG1,83445|GSPT1,GSPT1,2935|GYPA,GYPA,2993|GYPB,GYPB,2994|H1F0,H1-0,3005|HBBP1,HBBP1,3044|HBD,HBD,3045|HBM,HBM,3042|HBQ1,HBQ1,3049|HEMGN,HEMGN,55363|HEPACAM2,HEPACAM2,253012|HIST1H1C,H1-2,3006|HIST1H1D,H1-3,3007|HIST1H2AI,H2AC13,8329|HIST1H2AJ,H2AC14,8331|HLX,HLX,3142|HMGN2,HMGN2,3151|HP,HP,3240|HPSE,HPSE,10855|HTR4,HTR4,3360|IFI27,IFI27,3429|IFITM3,IFITM3,10410|IL1RN,IL1RN,3557|KIAA0101,PCLAF,9768|KIF23,KIF23,9493|KLF1,KLF1,10661|KLHL15,KLHL15,80311|KLHL2,KLHL2,11275|KLK14,KLK14,43847|KRT1,KRT1,3848|LCN2,LCN2,3934|LDHA,LDHA,3939|LDLR,LDLR,3949|LGALS1,LGALS1,3956|LIMK2,LIMK2,3985|LRRC2,LRRC2,79442|LTF,LTF,4057|MAP1LC3B,MAP1LC3B,81631|MCM4,MCM4,4173|MELK,MELK,9833|MKI67,MKI67,4288|MKRN1,MKRN1,23608|MLF1IP,CENPU,79682|MMP8,MMP8,4317|MMP9,MMP9,4318|MOSC1,MTARC1,64757|MPO,MPO,4353|MPP1,MPP1,4354|MTHFD1L,MTHFD1L,25902|MYADM,MYADM,91663|MYL4,MYL4,4635|NCF4,NCF4,4689|NKX3-2,NKX3-2,579|NME1,NME1,4830|NOP58,NOP58,51602|NRAS,NRAS,4893|NSUN3,NSUN3,63899|OLFM4,OLFM4,10562|ORM1,ORM1,5004|OSBP2,OSBP2,23762|PCGF5,PCGF5,84333|PGLYRP1,PGLYRP1,8993|PIP5K1A,PIP5K1A,8394|PLBD1,PLBD1,79887|PPM1A,PPM1A,5494|PPP4R2,PPP4R2,151987|PRTN3,PRTN3,5657|PVRL2,NECTIN2,5819|RAB1A,RAB1A,5861|RAD51,RAD51,5888|RANBP9,RANBP9,10048|RAP1GAP,RAP1GAP,5909|RBPMS,RBPMS,11030|RETN,RETN,56729|RHEB,RHEB,6009|RIOK3,RIOK3,8780|RMND5A,RMND5A,64795|RNASE2,RNASE2,6036|RNASE3,RNASE3,6037|RNF10,RNF10,9921|RPIA,RPIA,22934|S100A12,S100A12,6283|S100A8,S100A8,6279|S100A9,S100A9,6280|S100P,S100P,6286|SAT1,SAT1,6303|SELENBP1,SELENBP1,8991|SERINC2,SERINC2,347735|SLBP,SLBP,7884|SLC22A4,SLC22A4,6583|SLC4A1,SLC4A1,6521|SLC6A8,SLC6A8,6535|SLC9A8,SLC9A8,23315|SLMO2,PRELID3B,51012|SLPI,SLPI,6590|SMTN,SMTN,6525|SNCA,SNCA,6622|SPAG5,SPAG5,10615|SPC25,SPC25,57405|STAG3,STAG3,10734|STMN1,STMN1,3925|STRADB,STRADB,55437|TAB3,TAB3,257397|TCN2,TCN2,6948|TFDP1,TFDP1,7027|THBS3,THBS3,7059|THUMPD2,THUMPD2,80745|TK1,TK1,7083|TMEM167A,TMEM167A,153339|TMEM184A,TMEM184A,202915|TMOD1,TMOD1,7111|TNS1,TNS1,7145|TRAF3IP2-AS1,TRAF3IP2-AS1,643749|TRIB1,TRIB1,10221|TRMT5,TRMT5,57570|TTC36,TTC36,143941|TTK,TTK,7272|TUBA1A,TUBA1A,7846|TUBA1B,TUBA1B,10376|TUBA1C,TUBA1C,84790|TUBB3,TUBB3,10381|TYMS,TYMS,7298|UBE2B,UBE2B,7320|UBE2C,UBE2C,11065|UHRF1,UHRF1,29128|UQCRFS1,UQCRFS1,7386|VSTM1,VSTM1,284415|XK,XK,7504|YOD1,YOD1,55432|ZNF326,ZNF326,284695" FILTERED_BY_SIMILARITY="" FOUNDER_NAMES="" REFINEMENT_DATASETS="" VALIDATION_DATASETS="" CATEGORY_CODE="C7" ORGANISM="Homo sapiens" SUB_CATEGORY_CODE="IMMUNESIGDB"/>
</MSIGDB>
