STANDARD_NAME GSE35543_IN_VITRO_ITREG_VS_CONVERTED_EX_ITREG_UP SYSTEMATIC_NAME M9437 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE35543_IN_VITRO_ITREG_VS_CONVERTED_EX_ITREG_UP NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes up-regulated in comparison between in vitro derived induced T reg (iTreg) and converted ex iTreg. DESCRIPTION_FULL Induced Treg (iTreg) cells are essential for tolerance and can be used therapeutically, yet their stability in vivo and mechanisms of suppression are unresolved. Here, we used a treatment model of colitis to examine the role of autologous IL-10 in iTreg cell function. Mice treated with IL-10+/+ iTreg cells in combination with IL-10–/– natural Treg (nTreg) cells survived and gained weight, even though iTreg cells were numerically disadvantaged and comprised just ~20% of all Treg cells in treated mice. Notably, ~85% of the transferred iTreg cells lost Foxp3 expression (ex-iTreg) but retained a portion of the iTreg transcriptome which failed to limit their pathogenic potential. The TCR repertoires of iTreg and ex-iTreg cells exhibited almost no overlap, which indicates that the two populations are clonally unrelated and maintained by different selective pressures. These data demonstrate a potent and critical role for iTreg cell produced IL-10 that can supplant the IL-10 produced by nTreg cells and compensate for the inherent instability of the iTreg population. PMID 23125413 GEOID GSE35543 AUTHORS Schmitt EG,Haribhai D,Williams JB,Aggarwal P,Jia S,Charbonnier LM,Yan K,Lorier R,Turner A,Ziegelbauer J,Georgiev P,Simpson P,Salzman NH,Hessner MJ,Broeckel U,Chatila TA,Williams CB CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE35543_3051_200_UP FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS ABCA7,ADCY4,AMOTL1,ARHGAP11A,ASPM,BABAM1,BIRC5,BRCA1,C11orf31,C11orf51,C11orf82,C14orf45,C1orf123,C1orf172,C1orf96,C22orf13,C3orf31,C4orf27,C8orf46,CAPNS1,CAPS2,CASK,CASKIN2,CCDC12,CCNB2,CDC25B,CDCA3,CDCA8,CDK1,CENPF,CENPH,CENPL,CENPM,CENPN,CENPP,CENPQ,CENPV,CEP128,CEP89,CHAF1B,CHTF18,CIT,CKAP2L,CKS1B,CNP,CORO1A,COX18,CRIP1,CXCR7,CYP20A1,DBF4,DBNDD2,DCAF15,DCXR,DDB2,DEK,E2F1,E2F2,E2F8,ECI2,ESPL1,FABP2,FBXO5,FCGRT,FKBP2,FOXM1,FRMPD1,FXN,GAS2L3,GINS2,GLE1,GLIS2,GPN1,GRK6,GSG2,HAUS4,HAUS6,HDAC6,HEATR1,HHAT,HIRIP3,HJURP,HNRNPA2B1,HOXD9,HPX,IFT27,IMPDH2,IQGAP3,KCNE3,KCNV2,KIAA1967,KIF22,KIF23,KIF24,KIF4A,KRTAP13-1,KRTAP3-3,L1CAM,LBR,LGALS3BP,LPXN,LSM6,MAD2L1,MASTL,MAZ,MCM5,MCM7,METRN,MFSD10,MIS18BP1,MKI67,MKX,MRPL47,MRPS10,MRPS11,NCAPD2,NCAPG2,NDUFS8,NEK2,NRM,NRP1,NSMCE1,NTAN1,NUBP1,NUP210,NUSAP1,OR52N4,PACS2,PARP12,PCNT,PDCL2,PDZD9,PHF19,PIH1D1,PKMYT1,PLAU,PMF1,POC1A,POLA1,POLE,POLE4,PPIH,PPP2R4,PRIM2,PRM2,PRPS1,PRR11,PSMC3,PSRC1,PTPN13,PTTG1,RACGAP1,RBBP8,RBM3,RFC4,RFC5,RNASEH2B,RNF26,RRAD,RTEL1,SCN4B,SEMA3D,SFPQ,SGOL2,SKA1,SKA3,SLBP,SLC10A2,SLC14A1,SLC30A4,SLC7A2,SMC4,SNCG,SPAG5,SRSF7,ST18,STIL,STMN1,SUCLG2,SUGP2,SUV39H1,TACC3,TAF1B,TC2N,TCIRG1,TEX9,TH1L,TLL2,TOPBP1,TRAIP,TSSK2,TUBA8,UBE2C,UBE2S,UCHL3,VRK1,WDR62,YTHDF2,ZBTB8B,ZDHHC2 GENE_SYMBOLS ABCA7,ADCY4,AMOTL1,ARHGAP11A,ASPM,BABAM1,BIRC5,BRCA1,SELENOH,ANAPC15,DDIAS,BBOF1,CZIB,KDF1,CCSAP,GUCD1,TAMM41,HPF1,VXN,CAPNS1,CAPS2,CASK,CASKIN2,CCDC12,CCNB2,CDC25B,CDCA3,CDCA8,CDK1,CENPF,CENPH,CENPL,CENPM,CENPN,CENPP,CENPQ,CENPV,CEP128,CEP89,CHAF1B,CHTF18,CIT,CKAP2L,CKS1B,CNP,CORO1A,COX18,CRIP1,ACKR3,CYP20A1,DBF4,DBNDD2,DCAF15,DCXR,DDB2,DEK,E2F1,E2F2,E2F8,ECI2,ESPL1,FABP2,FBXO5,FCGRT,FKBP2,FOXM1,FRMPD1,FXN,GAS2L3,GINS2,GLE1,GLIS2,GPN1,GRK6,HASPIN,HAUS4,HAUS6,HDAC6,HEATR1,HHAT,HIRIP3,HJURP,HNRNPA2B1,HOXD9,HPX,IFT27,IMPDH2,IQGAP3,KCNE3,KCNV2,CCAR2,KIF22,KIF23,KIF24,KIF4A,KRTAP13-1,KRTAP3-3,L1CAM,LBR,LGALS3BP,LPXN,LSM6,MAD2L1,MASTL,MAZ,MCM5,MCM7,METRN,MFSD10,MIS18BP1,MKI67,MKX,MRPL47,MRPS10,MRPS11,NCAPD2,NCAPG2,NDUFS8,NEK2,NRM,NRP1,NSMCE1,NTAN1,NUBP1,NUP210,NUSAP1,OR52N4,PACS2,PARP12,PCNT,PDCL2,PDZD9,PHF19,PIH1D1,PKMYT1,PLAU,PMF1,POC1A,POLA1,POLE,POLE4,PPIH,PTPA,PRIM2,PRM2,PRPS1,PRR11,PSMC3,PSRC1,PTPN13,PTTG1,RACGAP1,RBBP8,RBM3,RFC4,RFC5,RNASEH2B,RNF26,RRAD,RTEL1,SCN4B,SEMA3D,SFPQ,SGO2,SKA1,SKA3,SLBP,SLC10A2,SLC14A1,SLC30A4,SLC7A2,SMC4,SNCG,SPAG5,SRSF7,ST18,STIL,STMN1,SUCLG2,SUGP2,SUV39H1,TACC3,TAF1B,TC2N,TCIRG1,TEX9,NELFCD,TLL2,TOPBP1,TRAIP,TSSK2,TUBA8,UBE2C,UBE2S,UCHL3,VRK1,WDR62,YTHDF2,ZBTB8B,ZDHHC2 FOUNDER_NAMES