STANDARD_NAME	GSE36009_UNSTIM_VS_LPS_STIM_NLRP10_KO_DC_DN
SYSTEMATIC_NAME	M8768
COLLECTION	C7:IMMUNESIGDB
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE36009_UNSTIM_VS_LPS_STIM_NLRP10_KO_DC_DN
NAMESPACE	HUMAN_GENE_SYMBOL
DESCRIPTION_BRIEF	Genes down-regulated in dendritic cells with knockout of NLRP10 [GeneID=338322]: control versus LPS.
DESCRIPTION_FULL	Nlrp10-deficient mice have a profound defect in helper T cell-driven immune responses. T cell priming is impaired due to a defect in the emigration of a dendritic cells from inflamed tissue and antigen transport to draining lymph nodes. DC chemotaxis to CCR7-dependent and independent ligands is intact in the absence of Nlrp10. Therefore to identify novel molecules potentially involved in Nlrp10-dependent DC function we used an unbiased gene array approach on Nlrp10-deficient BMDCs treated with or without LPS.
PMID	22538615
GEOID	GSE36009
AUTHORS	Eisenbarth SC,Williams A,Colegio OR,Meng H,Strowig T,Rongvaux A,Henao-Mejia J,Thaiss CA,Joly S,Gonzalez DG,Xu L,Zenewicz LA,Haberman AM,Elinav E,Kleinstein SH,Sutterwala FS,Flavell RA
CONTRIBUTOR	Jernej Godec
CONTRIBUTOR_ORG	Dana-Farber Cancer Institute
EXACT_SOURCE	GSE36009_2674_200_DN
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	ABHD11,ACACA,ACBD3,ADI1,ADRA2C,AGA,AIM1,AK2,AKIP1,AKR7A2,ANKRD11,ANKRD23,ARFRP1,ARID2,ATF4,ATP11C,ATP5G2,ATP6AP1,BARHL2,BAZ1A,BCAT2,BCL2A1,BCLAF1,BDH1,C12orf49,C1orf122,C22orf28,C22orf36,C6orf72,CCDC164,CCDC91,CCND1,CCNT2,CCT8L2,CD2AP,CD44,CDK6,CDKL3,CHEK1,CHURC1,CLDN19,CLEC10A,CLK4,CNIH,CNOT8,COBRA1,CPNE1,CSRP2BP,CXorf21,CXXC1,DDX46,DNAJA1,DNASE1,EARS2,EID2,EIF4A2,ERCC3,ERN1,ETNK1,EXOSC1,EYA2,FAM160A2,FAM69A,FASTKD1,FGF7,FHOD3,FMR1,FOLR2,FOXK1,FXYD7,FYB,GNB2L1,GPATCH4,GPN1,GPN3,GPRC5C,GRWD1,H2AFY,HIPK1,HIST2H2BF,HSPA9,IARS,IFIT3,IL31RA,KCNQ1OT1,KCTD3,KIAA0368,KIF3A,KLK8,LAPTM5,LHCGR,LHFPL3,LIMS3L,LMO1,LOC100506562,LRIG1,LYAR,MAK16,MAMDC4,MATN4,MESDC2,METTL7A,MRPL12,MRPL19,MRPL28,MRPL47,MRPS34,MSMB,MTHFD2,MUT,MVK,NARFL,NDOR1,NDUFAF4,NECAP1,NEMF,NEURL4,NFE2L2,NOB1,NOL11,NOP10,NOP56,NUFIP1,NUP37,PANX3,PCNT,PES1,PEX5,PFDN5,PIP5K1A,PLEKHF1,PLEKHJ1,PML,POLR1C,PPP2R5A,PPP3CC,PRF1,PRKD3,PSMA7,PSMC2,PTK2,PTPN11,PTRH1,RAB3IL1,RANBP1,RARS,RBM5,RCL1,RECK,REV3L,RFC1,RINL,RPA1,RPAIN,RPRD1B,RPS19,RPS6KB1,RPS6KB2,RPS8,RRS1,RUNX3,SASH1,SESTD1,SGK223,SH2B1,SIT1,SKAP1,SKP1,SLC16A1,SLFN12,SMEK2,SMPD4,SMPD5,SMR3A,SPPL2B,SRPX2,SS18L2,STK17B,SUCLG1,SYNJ1,TBL1X,TEX9,TFAP2B,TGM3,TRAPPC8,TTC14,TTL,TUBA1B,UBN2,UNC119B,USE1,USP31,VPS37B,WDR46,WDR89,YME1L1,ZBTB43,ZFAND5,ZNF410,ZNF777
GENE_SYMBOLS	ABHD11,ACACA,ACBD3,ADI1,ADRA2C,AGA,CRYBG1,AK2,AKIP1,AKR7A2,ANKRD11,ANKRD23,ARFRP1,ARID2,ATF4,ATP11C,ATP5MC2,ATP6AP1,BARHL2,BAZ1A,BCAT2,BCL2A1,BCLAF1,BDH1,SPRING1,C1orf122,RTCB,LRRC75B,GINM1,DRC1,CCDC91,CCND1,CCNT2,CCT8L2,CD2AP,CD44,CDK6,CDKL3,CHEK1,CHURC1,CLDN19,CLEC10A,CLK4,CNIH1,CNOT8,NELFB,CPNE1,KAT14,CXXC1,TASL,DDX46,DNAJA1,DNASE1,EARS2,EID2,EIF4A2,ERCC3,ERN1,ETNK1,EXOSC1,EYA2,FHIP1B,DIPK1A,FASTKD1,FGF7,FHOD3,FMR1,FOLR2,FOXK1,FXYD7,FYB1,RACK1,GPATCH4,GPN1,GPN3,GPRC5C,GRWD1,MACROH2A1,HIPK1,H2BC18,HSPA9,IARS1,IFIT3,IL31RA,KCNQ1OT1,KCTD3,ECPAS,KIF3A,KLK8,LAPTM5,LHCGR,LHFPL3,LIMS4,LMO1,,LRIG1,LYAR,MAK16,MAMDC4,MATN4,MESD,TMT1A,MRPL12,MRPL19,MRPL28,MRPL47,MRPS34,MSMB,MTHFD2,MMUT,MVK,CIAO3,NDOR1,NDUFAF4,NECAP1,NEMF,NEURL4,NFE2L2,NOB1,NOL11,NOP10,NOP56,NUFIP1,NUP37,PANX3,PCNT,PES1,PEX5,PFDN5,PIP5K1A,PLEKHF1,PLEKHJ1,PML,POLR1C,PPP2R5A,PPP3CC,PRF1,PRKD3,PSMA7,PSMC2,PTK2,PTPN11,PTRH1,RAB3IL1,RANBP1,RARS1,RBM5,RCL1,RECK,REV3L,RFC1,RINL,RPA1,RPAIN,RPRD1B,RPS19,RPS6KB1,RPS6KB2,RPS8,RRS1,RUNX3,SASH1,SESTD1,,SH2B1,SIT1,SKAP1,SKP1,SLC16A1,SLFN12,PPP4R3B,SMPD4,SMPD5,SMR3A,SPPL2B,SRPX2,SS18L2,STK17B,SUCLG1,SYNJ1,TBL1X,TEX9,TFAP2B,TGM3,TRAPPC8,TTC14,TTL,TUBA1B,UBN2,UNC119B,USE1,USP31,VPS37B,WDR46,WDR89,YME1L1,ZBTB43,ZFAND5,ZNF410,ZNF777
FOUNDER_NAMES