STANDARD_NAME GSE36095_WT_VS_HDAC9_KO_TREG_UP SYSTEMATIC_NAME M8934 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE36095_WT_VS_HDAC9_KO_TREG_UP NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes up-regulated in T reg: wildtype versus HDAC9 [GeneID=9734] knockout. DESCRIPTION_FULL Targeting histone/protein deacetylase (HDAC)-6, -9, or Sirtuin-1 (Sirt1) augments the suppressive functions of Foxp3+ T regulatory (Treg) cells, but it is unclear if this involves different mechanisms, such that combined inhibition would be beneficial. We compared the suppressive functions of Tregs from wild-type C57BL/6 mice or mice with global (HDAC6-/-, HDAC9-/-, dual HDAC6/9-/-) or conditional deletion (CD4-Cre or Foxp3-Cre and floxed Sirt1; GSE26425) alone, or after treatment with isoform-selective HDAC inhibitors (HDACi). We found the heat shock response was crucial in mediating the effects of HDAC6, but not Sirt1 inhibition. Furthermore, while HDAC6, HDAC9 and Sirt1 all deacetylate Foxp3, each has diverse effects on Foxp3 transcription, and loss of HDAC9 is associated with stabilization of Stat5 acetylation and its transcriptional activity. Targeting different HDAC can increase Treg function by multiple and additive mechanisms, indicating the therapeutic potential for combinations of HDACi in the management of autoimmunity and alloresponses post-transplant. PMID 22715468 GEOID GSE36095 AUTHORS Beier UH,Wang L,Han R,Akimova T,Liu Y,Hancock WW CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE36095_2870_200_UP FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS 1190002H23Rik,2510003E04Rik,4931406C07Rik,AAAS,ACAA2,ACSBG1,ADAMTS6,ADCY6,AKAP7,ALDOC,ALKBH6,ANXA4,APOE,ARHGEF3,ARMCX3,ASF1B,ASPM,BANF1,BCAT1,BLK,BLNK,BZW2,C330027C09Rik,CASP8,CD19,CD2,CD22,CD24A,CD36,CDC42SE2,CDKN1A,CENPI,CEP55,CERK,CHAF1B,CHST15,CISH,CLPTM1,CR2,CTNNA1,CTSH,CTSZ,CYBB,CYFIP1,D16ERTD472E,DDX19A,DGAT1,DNAJB13,DUSP6,ECT2,ELL2,ESCO2,ETFB,EYA2,F730047E07Rik,FAM105B,FAM114A2,FAM126A,FAM183B,FAM78B,FBXW8,FCER2A,FCRL1,FNDC8,GLUL,GM10759,GOT1,GPR172B,GSTO1,GSTT2,GTF2IRD2,GZF1,GZMB,H2-AA,H2-AB1,H2-EB1,H3F3B,HAUS4,HDAC1,HIF1A,HMGN3,HSPBAP1,IFI30,IGK,IMPA2,IPO5,IRF5,ITGB1BP3,JMJD1C,KCNQ5,KHDRBS3,KIF11,KIF20B,KIF23,LDHA,LIF,LPCAT3,LRRC57,MAP2K1,MASTL,MEF2C,MFF,MIR367,MMD,MPDU1,MPZL2,MR1,MS4A1,MTMR14,MXD4,MYO1E,NAPSA,NBAS,NEDD1,NFKB1,NFKBIA,NFKBIZ,NIT2,NUDT22,NUF2,OLFR1496,OLFR945,OPA1,PA2G4,PANX1,PDE1B,PDE7A,PFKL,PGAP2,PHLDA1,PIM1,PLA2G4F,PLCG2,PLCXD2,PLIN2,PLK1,PLK2,PLXDC2,PPARG,PPFIBP1,PPP2R3A,PRC1,PREB,PRKCSH,PROS1,RAB11FIP2,RAPGEF5,RAPH1,RASGRP3,RFWD3,RHOB,RNF41,RPIA,S100A6,SAMSN1,SCD1,SEMA7A,SERPINB6A,SERPINE2,SIRT4,SLC23A2,SLC27A2,SLC43A1,SLC43A3,SNX9,SPATA13,SPRR4,SQLE,STIL,SYPL,TBCB,TDP1,TGFA,TIA1,TMEM107,TMEM35,TMPRSS13,TNFAIP3,TNFAIP8,TOM1,TPD52,TRABD,TUBA1A,TXNIP,UBAC2,UHRF1BP1L,UNC93B1,USF1,USP10,USP18,USP54,VAV2,VIL1,VMN1R199,WDFY4,WEE1,XBP1,YEATS4,ZFP281,ZFP367 GENE_SYMBOLS ,,,AAAS,ACAA2,ACSBG1,ADAMTS6,ADCY6,AKAP7,ALDOC,ALKBH6,ANXA4,APOE,ARHGEF3,ARMCX3,ASF1B,ASPM,BANF1,BCAT1,BLK,BLNK,BZW2,,CASP8,CD19,CD2,CD22,CD24,CD36,CDC42SE2,CDKN1A,CENPI,CEP55,CERK,CHAF1B,CHST15,CISH,CLPTM1,CR2,CTNNA1,CTSH,CTSZ,CYBB,CYFIP1,,DDX19A,DGAT1,DNAJB13,DUSP6,ECT2,ELL2,ESCO2,ETFB,EYA2,,OTULIN,FAM114A2,HYCC1,FAM183BP,FAM78B,FBXW8,,FCRL1,FNDC8,GLUL,,GOT1,SLC52A1,GSTO1,GSTT2,GTF2IRD2,GZF1,GZMB,,,,H3-3B,HAUS4,HDAC1,HIF1A,HMGN3,HSPBAP1,IFI30,,IMPA2,IPO5,IRF5,NMRK2,JMJD1C,KCNQ5,KHDRBS3,KIF11,KIF20B,KIF23,LDHA,LIF,LPCAT3,LRRC57,MAP2K1,MASTL,MEF2C,MFF,MIR367,MMD,MPDU1,MPZL2,MR1,MS4A1,MTMR14,MXD4,MYO1E,NAPSA,NBAS,NEDD1,NFKB1,NFKBIA,NFKBIZ,NIT2,NUDT22,NUF2,,,OPA1,PA2G4,PANX1,PDE1B,PDE7A,PFKL,PGAP2,PHLDA1,PIM1,PLA2G4F,PLCG2,PLCXD2,PLIN2,PLK1,PLK2,PLXDC2,PPARG,PPFIBP1,PPP2R3A,PRC1,PREB,PRKCSH,PROS1,RAB11FIP2,RAPGEF5,RAPH1,RASGRP3,RFWD3,RHOB,RNF41,RPIA,S100A6,SAMSN1,SCD,SEMA7A,,SERPINE2,SIRT4,SLC23A2,SLC27A2,SLC43A1,SLC43A3,SNX9,SPATA13,SPRR4,SQLE,STIL,SYPL1,TBCB,TDP1,TGFA,TIA1,TMEM107,TMEM35A,TMPRSS13,TNFAIP3,TNFAIP8,TOM1,TPD52,TRABD,TUBA1A,TXNIP,UBAC2,BLTP3B,UNC93B1,USF1,USP10,USP18,USP54,VAV2,VIL1,,WDFY4,WEE1,XBP1,YEATS4,, FOUNDER_NAMES