STANDARD_NAME	GSE360_L_DONOVANI_VS_B_MALAYI_HIGH_DOSE_DC_DN
SYSTEMATIC_NAME	M5201
COLLECTION	C7:IMMUNESIGDB
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE360_L_DONOVANI_VS_B_MALAYI_HIGH_DOSE_DC_DN
NAMESPACE	HUMAN_GENE_SYMBOL
DESCRIPTION_BRIEF	Genes down-regulated in comparison of dendritic cells (DC) exposed to L. donovani versus DCs exposed to 50 worm/well B. malayi.
DESCRIPTION_FULL	Monocyte-derived dendritic cells (DC) and macrophages (MΦ) generated in vitro from the same individual blood donors were exposed to five different pathogens, and gene expression profiles were assessed by microarray analysis. Responses to Mycobacterium tuberculosis and to phylogenetically distinct protozoan (Leishmania major, L. donovani, Toxoplasma gondii) and helminth (Brugia malayi) parasites were examined, each of which produces chronic infections in humans yet vary considerably in the nature of the immune responses they trigger.
PMID	12663451
GEOID	GSE360
AUTHORS	Chaussabel D,Semnani RT,McDowell MA,Sacks D,Sher A,Nutman TB
CONTRIBUTOR	Jernej Godec
CONTRIBUTOR_ORG	Dana-Farber Cancer Institute
EXACT_SOURCE	GSE360_1022_200_DN
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	AASDHPPT,ACP5,ACTR2,ADORA3,AES,ALDH1A1,ALDH3A2,ALDH5A1,ALG8,AMHR2,AMPD2,ANKS1A,AP1S2,AP2A2,APOC1,APRT,ARF6,ARHGAP4,ARSA,ASAP2,ASF1A,ATP2B1,B3GNT1,BLCAP,BLMH,BLOC1S1,BTG2,BUB1B,C12orf29,C19orf2,C3orf63,CBX7,CCBL1,CCT6A,CD14,CD1B,CD1D,CD1E,CDC6,CDH2,CGGBP1,CLEC2B,CMAHP,CNOT3,COIL,CPNE3,CPVL,CREB3L2,CTAGE5,DAB2,DCAF8,DDX28,DGCR2,DLEC1,DNAJC16,DNASE2,DPYD,DRAP1,EEF1B2,EIF2B5,EIF4EBP1,ERCC1,ERP29,F2,FAM98A,FARSA,FASTK,FCAR,FGL2,FLI1,FYN,GART,GNPAT,GNRH2,GOLGA8A,GPX3,GRHPR,GSTP1,HCFC1,HELZ,HEXA,HLA-DRB4,HLA-E,HPCAL1,IDH3G,IFNA16,INPP5D,IQSEC2,KAT2A,KDELR2,KDELR3,KLF4,KPNA5,LAIR2,LPL,LY96,MAP3K5,MDFIC,MED12,MEF2A,MEGF9,MNDA,MRC2,MRS2,MSH3,MUC6,MYCBP2,NASP,NCAPD2,NDUFS6,NDUFV1,NME4,NUP210,P2RY11,P2RY14,PCNA,PDE3B,PECAM1,PFKP,PGRMC2,PHF8,PKI55,POU2F1,PPP6R1,PREPL,PRKY,PRPF40A,PSMD3,PSMD8,PTDSS1,RAB5C,RABGGTB,RBMX,RCBTB2,RNF187,RNF6,RNF8,ROR2,RPL22,RPS10,RPS14,RPS4Y1,RPS6KA1,RXRA,SEC14L1,SEPP1,SEPT9,SGCG,SGMS1,SHC1,SLC25A12,SLC35A3,SLC38A10,SLC7A8,SLCO2B1,SMC3,SMPD1,SNX2,SPICE1,SPINK4,SPN,SREK1,ST14,ST3GAL5,STX5,SVIL,SYNE1,SYT17,TACC1,TBC1D2B,TDRD3,TET3,TKT,TMEM131,TMEM59,TMX4,TRAF3IP1,TRAPPC8,TREX1,TSC2,TUFM,TXNIP,TXNL1,UBA7,UBAC1,UBXN1,USF2,USP15,UTP14C,VAV1,VEZF1,VGLL4,VSIG4,WDFY3,WIPI2,XYLT1,ZBTB1,ZC3H15,ZMIZ1,ZZZ3
GENE_SYMBOLS	AASDHPPT,ACP5,ACTR2,ADORA3,TLE5,ALDH1A1,ALDH3A2,ALDH5A1,ALG8,AMHR2,AMPD2,ANKS1A,AP1S2,AP2A2,APOC1,APRT,ARF6,ARHGAP4,ARSA,ASAP2,ASF1A,ATP2B1,B3GNT2,BLCAP,BLMH,BLOC1S1,BTG2,BUB1B,RLIG1,URI1,TASOR,CBX7,KYAT1,CCT6A,CD14,CD1B,CD1D,CD1E,CDC6,CDH2,CGGBP1,CLEC2B,CMAHP,CNOT3,COIL,CPNE3,CPVL,CREB3L2,MIA2,DAB2,DCAF8,DDX28,DGCR2,DLEC1,DNAJC16,DNASE2,DPYD,DRAP1,EEF1B2,EIF2B5,EIF4EBP1,ERCC1,ERP29,F2,FAM98A,FARSA,FASTK,FCAR,FGL2,FLI1,FYN,GART,GNPAT,GNRH2,GOLGA8A,GPX3,GRHPR,GSTP1,HCFC1,HELZ,HEXA,HLA-DRB4,HLA-E,HPCAL1,IDH3G,IFNA16,INPP5D,IQSEC2,KAT2A,KDELR2,KDELR3,KLF4,KPNA5,LAIR2,LPL,LY96,MAP3K5,MDFIC,MED12,MEF2A,MEGF9,MNDA,MRC2,MRS2,MSH3,MUC6,MYCBP2,NASP,NCAPD2,NDUFS6,NDUFV1,NME4,NUP210,P2RY11,P2RY14,PCNA,PDE3B,PECAM1,PFKP,PGRMC2,PHF8,,POU2F1,PPP6R1,PREPL,PRKY,PRPF40A,PSMD3,PSMD8,PTDSS1,RAB5C,RABGGTB,RBMX,RCBTB2,RNF187,RNF6,RNF8,ROR2,RPL22,RPS10,RPS14,RPS4Y1,RPS6KA1,RXRA,SEC14L1,SELENOP,SEPTIN9,SGCG,SGMS1,SHC1,SLC25A12,SLC35A3,SLC38A10,SLC7A8,SLCO2B1,SMC3,SMPD1,SNX2,SPICE1,SPINK4,SPN,SREK1,ST14,ST3GAL5,STX5,SVIL,SYNE1,SYT17,TACC1,TBC1D2B,TDRD3,TET3,TKT,TMEM131,TMEM59,TMX4,TRAF3IP1,TRAPPC8,TREX1,TSC2,TUFM,TXNIP,TXNL1,UBA7,UBAC1,UBXN1,USF2,USP15,UTP14C,VAV1,VEZF1,VGLL4,VSIG4,WDFY3,WIPI2,XYLT1,ZBTB1,ZC3H15,ZMIZ1,ZZZ3
FOUNDER_NAMES