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     See license terms at www.gsea-msigdb.org/gsea/license_terms_list. Please note that certain gene sets have special access terms.
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<MSIGDB BUILD_DATE="Jan 29, 2026" VERSION="2026.1.Hs" NAME="export">
    <GENESET STANDARD_NAME="GSE36476_YOUNG_VS_OLD_DONOR_MEMORY_CD4_TCELL_72H_TSST_ACT_UP" SYSTEMATIC_NAME="M5323" HISTORICAL_NAMES="" PMID="22434910" AUTHORS="Yu M,Li G,Lee WW,Yuan M,Cui D,Weyand CM,Goronzy JJ" GEOID="GSE36476" EXACT_SOURCE="GSE36476_1737_200_UP" GENESET_LISTING_URL="" EXTERNAL_DETAILS_URL="" CHIP="HUMAN_GENE_SYMBOL" CONTRIBUTOR="Jernej Godec" CONTRIBUTOR_ORG="Dana-Farber Cancer Institute" DESCRIPTION_BRIEF="Genes up-regulated in comparison of memory CD4 [GeneID=920] T cells from young donors treated with TSST at 72 h versus those from old donors treated with TSST at 72 h." DESCRIPTION_FULL="With increasing age, the ability of the immune system to protect against recurring infections or to control chronic infections erodes. The objective of the current study was to identify gene expression signatures in elderly CD4 T cell responses" TAGS="" MEMBERS="AARSD1,ABCB1,ADARB2,ADIPOQ,ARHGEF10L,ATP4A,BEAN1,C11orf1,C11orf67,C12orf49,C16orf88,C22orf24,C5orf13,CA8,CACNB2,CALB1,CBFA2T3,CCL2,CCZ1,CD8B,CD93,CEACAM3,CEBPD,CENPM,CES1,CHAF1A,CHRNA5,CHRNA6,COL3A1,COQ7,CPPED1,CR1,CTSC,CXCL2,DACH1,DCAF4,DGCR9,DNMT3B,DUS2L,ECHDC3,EFNB2,EIF2B5,ELOVL6,EMR2,EPB41,EPHA3,ESRRG,FAM124B,FANCC,FEZ1,FGL1,FICD,FOXF1,FOXN2,FSHR,GFPT2,GFRA1,GINS2,GLRA1,GNAI1,GP6,GPR12,GRIA1,GRM3,GRM4,GTF3A,HAS1,HAVCR1,HEATR2,HECW1,HMGB3P30,HMGN1,HMHB1,HN1,IBSP,IFI27,IL33,IL8,INCENP,INSL6,ITGA2,ITGB1BP2,ITGB8,ITIH2,KCNJ6,KCNV2,KHDRBS2,KIF20B,KIF2C,KIR2DL2,KRTAP1-3,LAMA1,LARS,LMAN2L,LOC157627,LRIG2,LRRC16A,LTBP1,MAGEA8,MAPK8,MATN1,MC4R,METTL10,MFAP3L,MICB,MMP1,MORC1,MSTN,MTMR11,MYBPC2,MYL3,MYO15A,MYO19,MYOM2,NANS,NCL,NCRNA00185,NDUFB8,NEFH,NOS2,NPHP4,NPTX2,NR1D2,NUDT1,OPRD1,OPTN,OTUD3,OVOL3,PBX2,PCBP3,PCDHB12,PCDHB13,PCP4,PDE11A,PDLIM4,PEX26,PKP3,PMP2,PODXL,PPAP2C,PPP1R2P9,PPP4R4,PRUNE2,PSPN,PTPRH,PTTG1,PXDN,RAB9BP1,RAD51L3,RAD54L,RBMY2FP,RBPJL,REEP4,REN,RSG1,S100A7,SCNN1B,SELE,SERPINB7,SH2D4A,SLC16A10,SLC16A8,SLC22A5,SLC27A5,SLC2A9,SLC5A5,SOX12,SPATA6,SRP19,STK16,STK24,TAF15,TAS2R3,TBC1D8B,TFF2,TM4SF4,TMEM159,TMOD2,TNFSF18,TNMD,TNPO1,TNPO3,TPM4,TRAM2,TRD@,TREML2,TRPV1,TSPYL5,TTC38,TUSC2,UGT2B17,VCAN,WNT3,XYLB,YY2,ZC3H4,ZDHHC7,ZNF157,ZNF480,ZNF532" MEMBERS_SYMBOLIZED="AAMDC,AARSD1,ABCB1,ADARB2,ADGRE2,ADIPOQ,ARHGEF10L,ATP4A,BEAN1,CA8,CACNB2,CALB1,CARMIL1,CBFA2T3,CCL2,CCZ1,CD8B,CD93,CEACAM3,CEBPD,CENPM,CES1,CFAP68,CHAF1A,CHRNA5,CHRNA6,COL3A1,COQ7,CPLANE2,CPPED1,CR1,CTSC,CXCL2,CXCL8,DACH1,DCAF4,DGCR5,DNAAF5,DNMT3B,DUS2,ECHDC3,EEF1AKMT2,EFNB2,EIF2B5,ELOVL6,EPB41,EPHA3,ESRRG,FAM124B,FANCC,FEZ1,FGL1,FICD,FOXF1,FOXN2,FSHR,GFPT2,GFRA1,GINS2,GLRA1,GNAI1,GP6,GPR12,GRIA1,GRM3,GRM4,GTF3A,HAS1,HAVCR1,HECW1,HMGB3P30,HMGN1,HMHB1,IBSP,IFI27,IL33,INCENP,INSL6,ITGA2,ITGB1BP2,ITGB8,ITIH2,JPT1,KCNJ6,KCNV2,KHDRBS2,KIF20B,KIF2C,KIR2DL2,KNOP1,KRTAP1-3,LAMA1,LARS1,LDAF1,LMAN2L,LRIG2,LTBP1,MAGEA8,MAPK8,MATN1,MC4R,MFAP3L,MICB,MIR124-1HG,MMP1,MORC1,MSTN,MTMR11,MYBPC2,MYL3,MYO15A,MYO19,MYOM2,NANS,NCL,NDUFB8,NEFH,NOS2,NPHP4,NPTX2,NR1D2,NREP,NUDT1,OPRD1,OPTN,OTUD3,OVOL3,PBX2,PCBP3,PCDHB12,PCDHB13,PCP4,PDE11A,PDLIM4,PEX26,PKP3,PLPP2,PMP2,PODXL,PPP1R2C,PPP4R4,PRUNE2,PSPN,PTPRH,PTTG1,PXDN,RAB9BP1,RAD51D,RAD54L,RBMY2FP,RBPJL,REEP4,REN,S100A7,SCNN1B,SELE,SERPINB7,SH2D4A,SLC16A10,SLC16A8,SLC22A5,SLC27A5,SLC2A9,SLC5A5,SOX12,SPATA6,SPRING1,SRP19,STK16,STK24,TAF15,TAS2R3,TBC1D8B,TFF2,TM4SF4,TMOD2,TNFSF18,TNMD,TNPO1,TNPO3,TPM4,TRAM2,TREML2,TRPV1,TSPYL5,TTC38,TTTY14,TUSC2,UGT2B17,VCAN,WNT3,XYLB,YWHAH-AS1,YY2,ZC3H4,ZDHHC7,ZNF157,ZNF480,ZNF532" MEMBERS_EZID="10036,10133,10229,105,1052,1066,1075,1084,10903,10998,11004,11153,11172,11187,11317,11334,1138,117247,1281,1378,1462,146227,147657,157627,158471,159162,1602,169522,1789,1948,202559,2035,203510,2042,2104,2176,2267,22918,2294,23072,23211,23252,23534,23539,2492,25775,26094,261734,26220,26548,2660,2674,26762,27136,2741,2770,2835,284217,2890,28971,2913,2914,2920,2971,29767,3036,30817,3150,3344,3381,3429,3576,3619,3673,3696,3698,3763,3803,3842,399818,400506,404281,4052,4107,4146,4160,4277,4312,4521,4606,4634,4691,4714,4744,4843,4885,495,4985,50831,5089,50940,51155,51168,51206,5121,51520,51622,51659,5243,5375,54039,54187,5420,54558,54885,54919,54920,55020,55160,55205,55313,55604,55625,55670,5599,56123,56124,5623,56606,57146,57718,57824,5794,5892,5972,6278,6338,6347,63898,6401,64102,64776,6528,6584,6666,6728,7032,7104,7171,728361,7367,7442,7473,767,7712,783,7837,79019,79071,793,79363,79746,79794,79843,79865,80179,80316,80346,80755,8148,81562,81850,83869,8428,8438,85453,8572,8576,8612,863,8710,8893,8973,8995,90865,9172,9232,926,9315,9366,9370,9585,9638,9697,9848,9860,9942,9945,9975" MEMBERS_MAPPING="AARSD1,AARSD1,80755|ABCB1,ABCB1,5243|ADARB2,ADARB2,105|ADIPOQ,ADIPOQ,9370|ARHGEF10L,ARHGEF10L,55160|ATP4A,ATP4A,495|BEAN1,BEAN1,146227|C11orf1,CFAP68,64776|C11orf67,AAMDC,28971|C12orf49,SPRING1,79794|C16orf88,KNOP1,400506|C22orf24,YWHAH-AS1,25775|C5orf13,NREP,9315|CA8,CA8,767|CACNB2,CACNB2,783|CALB1,CALB1,793|CBFA2T3,CBFA2T3,863|CCL2,CCL2,6347|CCZ1,CCZ1,51622|CD8B,CD8B,926|CD93,CD93,22918|CEACAM3,CEACAM3,1084|CEBPD,CEBPD,1052|CENPM,CENPM,79019|CES1,CES1,1066|CHAF1A,CHAF1A,10036|CHRNA5,CHRNA5,1138|CHRNA6,CHRNA6,8973|COL3A1,COL3A1,1281|COQ7,COQ7,10229|CPPED1,CPPED1,55313|CR1,CR1,1378|CTSC,CTSC,1075|CXCL2,CXCL2,2920|DACH1,DACH1,1602|DCAF4,DCAF4,26094|DGCR9,DGCR5,26220|DNMT3B,DNMT3B,1789|DUS2L,DUS2,54920|ECHDC3,ECHDC3,79746|EFNB2,EFNB2,1948|EIF2B5,EIF2B5,8893|ELOVL6,ELOVL6,79071|EMR2,ADGRE2,30817|EPB41,EPB41,2035|EPHA3,EPHA3,2042|ESRRG,ESRRG,2104|FAM124B,FAM124B,79843|FANCC,FANCC,2176|FEZ1,FEZ1,9638|FGL1,FGL1,2267|FICD,FICD,11153|FOXF1,FOXF1,2294|FOXN2,FOXN2,3344|FSHR,FSHR,2492|GFPT2,GFPT2,9945|GFRA1,GFRA1,2674|GINS2,GINS2,51659|GLRA1,GLRA1,2741|GNAI1,GNAI1,2770|GP6,GP6,51206|GPR12,GPR12,2835|GRIA1,GRIA1,2890|GRM3,GRM3,2913|GRM4,GRM4,2914|GTF3A,GTF3A,2971|HAS1,HAS1,3036|HAVCR1,HAVCR1,26762|HEATR2,DNAAF5,54919|HECW1,HECW1,23072|HMGB3P30,HMGB3P30,203510|HMGN1,HMGN1,3150|HMHB1,HMHB1,57824|HN1,JPT1,51155|IBSP,IBSP,3381|IFI27,IFI27,3429|IL33,IL33,90865|IL8,CXCL8,3576|INCENP,INCENP,3619|INSL6,INSL6,11172|ITGA2,ITGA2,3673|ITGB1BP2,ITGB1BP2,26548|ITGB8,ITGB8,3696|ITIH2,ITIH2,3698|KCNJ6,KCNJ6,3763|KCNV2,KCNV2,169522|KHDRBS2,KHDRBS2,202559|KIF20B,KIF20B,9585|KIF2C,KIF2C,11004|KIR2DL2,KIR2DL2,3803|KRTAP1-3,KRTAP1-3,81850|LAMA1,LAMA1,284217|LARS,LARS1,51520|LMAN2L,LMAN2L,81562|LOC157627,MIR124-1HG,157627|LRIG2,LRIG2,9860|LRRC16A,CARMIL1,55604|LTBP1,LTBP1,4052|MAGEA8,MAGEA8,4107|MAPK8,MAPK8,5599|MATN1,MATN1,4146|MC4R,MC4R,4160|METTL10,EEF1AKMT2,399818|MFAP3L,MFAP3L,9848|MICB,MICB,4277|MMP1,MMP1,4312|MORC1,MORC1,27136|MSTN,MSTN,2660|MTMR11,MTMR11,10903|MYBPC2,MYBPC2,4606|MYL3,MYL3,4634|MYO15A,MYO15A,51168|MYO19,MYO19,80179|MYOM2,MYOM2,9172|NANS,NANS,54187|NCL,NCL,4691|NCRNA00185,TTTY14,83869|NDUFB8,NDUFB8,4714|NEFH,NEFH,4744|NOS2,NOS2,4843|NPHP4,NPHP4,261734|NPTX2,NPTX2,4885|NR1D2,NR1D2,9975|NUDT1,NUDT1,4521|OPRD1,OPRD1,4985|OPTN,OPTN,10133|OTUD3,OTUD3,23252|OVOL3,OVOL3,728361|PBX2,PBX2,5089|PCBP3,PCBP3,54039|PCDHB12,PCDHB12,56124|PCDHB13,PCDHB13,56123|PCP4,PCP4,5121|PDE11A,PDE11A,50940|PDLIM4,PDLIM4,8572|PEX26,PEX26,55670|PKP3,PKP3,11187|PMP2,PMP2,5375|PODXL,PODXL,5420|PPAP2C,PLPP2,8612|PPP1R2P9,PPP1R2C,80316|PPP4R4,PPP4R4,57718|PRUNE2,PRUNE2,158471|PSPN,PSPN,5623|PTPRH,PTPRH,5794|PTTG1,PTTG1,9232|PXDN,PXDN,7837|RAB9BP1,RAB9BP1,9366|RAD51L3,RAD51D,5892|RAD54L,RAD54L,8438|RBMY2FP,RBMY2FP,159162|RBPJL,RBPJL,11317|REEP4,REEP4,80346|REN,REN,5972|RSG1,CPLANE2,79363|S100A7,S100A7,6278|SCNN1B,SCNN1B,6338|SELE,SELE,6401|SERPINB7,SERPINB7,8710|SH2D4A,SH2D4A,63898|SLC16A10,SLC16A10,117247|SLC16A8,SLC16A8,23539|SLC22A5,SLC22A5,6584|SLC27A5,SLC27A5,10998|SLC2A9,SLC2A9,56606|SLC5A5,SLC5A5,6528|SOX12,SOX12,6666|SPATA6,SPATA6,54558|SRP19,SRP19,6728|STK16,STK16,8576|STK24,STK24,8428|TAF15,TAF15,8148|TAS2R3,TAS2R3,50831|TBC1D8B,TBC1D8B,54885|TFF2,TFF2,7032|TM4SF4,TM4SF4,7104|TMEM159,LDAF1,57146|TMOD2,TMOD2,29767|TNFSF18,TNFSF18,8995|TNMD,TNMD,64102|TNPO1,TNPO1,3842|TNPO3,TNPO3,23534|TPM4,TPM4,7171|TRAM2,TRAM2,9697|TRD@,null,null|TREML2,TREML2,79865|TRPV1,TRPV1,7442|TSPYL5,TSPYL5,85453|TTC38,TTC38,55020|TUSC2,TUSC2,11334|UGT2B17,UGT2B17,7367|VCAN,VCAN,1462|WNT3,WNT3,7473|XYLB,XYLB,9942|YY2,YY2,404281|ZC3H4,ZC3H4,23211|ZDHHC7,ZDHHC7,55625|ZNF157,ZNF157,7712|ZNF480,ZNF480,147657|ZNF532,ZNF532,55205" FILTERED_BY_SIMILARITY="" FOUNDER_NAMES="" REFINEMENT_DATASETS="" VALIDATION_DATASETS="" CATEGORY_CODE="C7" ORGANISM="Homo sapiens" SUB_CATEGORY_CODE="IMMUNESIGDB"/>
</MSIGDB>
