STANDARD_NAME GSE36826_NORMAL_VS_STAPH_AUREUS_INF_IL1R_KO_SKIN_DN SYSTEMATIC_NAME M9532 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE36826_NORMAL_VS_STAPH_AUREUS_INF_IL1R_KO_SKIN_DN NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes down-regulated in skin with IL1R1 [GeneID=3554] knockout: uninfected versus S. aureus infection. DESCRIPTION_FULL Neutrophil abscess formation is critical in innate immunity against many pathogens. Here, the mechanism of neutrophil abscess formation was investigated using a mouse model of Staphylococcus aureus cutaneous infection. Gene expression analysis of S. aureus-infected skin revealed that induction of neutrophil recruitment genes was largely dependent upon IL-1beta/IL-1R activation. Unexpectedly, using IL 1beta reporter mice, neutrophils were identified as the primary source of IL-1beta at the site of infection. Furthermore, IL-1beta-producing neutrophils were necessary and sufficient for abscess formation and bacterial clearance. S. aureus-induced IL 1beta production by neutrophils required TLR2, NOD2, FPRs and the ASC/NLRP3 inflammasome. Taken together, IL-1beta and neutrophil abscess formation during an infection are functionally, spatially and temporally linked as a consequence of direct IL-1beta production by neutrophils. PMID 23209417 GEOID GSE36826 AUTHORS Cho JS,Guo Y,Ramos RI,Hebroni F,Plaisier SB,Xuan C,Granick JL,Matsushima H,Takashima A,Iwakura Y,Cheung AL,Cheng G,Lee DJ,Simon SI,Miller LS CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE36826_2304_200_DN FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS ABCD3,ACSL5,ADAM10,ADK,ADSS,AHNAK,AKAP17A,ALDOA,ALOX5AP,AMPD2,ANP32A,ANXA2,AP1S2,ARF5,ARL4C,ATP6V0B,ATP6V0D1,ATRN,BICD2,BRD3,C14orf118,C14orf139,C16orf53,C20orf11,C20orf30,CALM2,CALR,CARD8,CBX5,CCL22,CD37,CD58,CEP85,CERK,CHP,CLDND1,COPZ1,COTL1,CPPED1,CSF1R,CST7,CXCR4,CYP27A1,CYTIP,DIAPH1,DNMBP,DYM,EGR2,EIF2C1,EIF3L,EMP1,EREG,FAM105A,FAM108A1,FAU,FBXW7,FLNA,FOS,FPR1,GABARAP,GALC,GIGYF2,GLT8D1,GMCL1,GMIP,GNB1,GPR35,GPR77,HCCS,HERPUD1,HLA-DPB1,HLA-DQB1,HMGN2,HNRNPA3,HSD17B10,HSP90B1,HTT,IFFO1,IFNGR1,ILF3,INTS8,IRAK1,ITGAE,KCTD7,KIAA0232,KRT10,LBR,LCP1,LOC729580,LOR,LPXN,LRP8,LRRC8D,MAP3K3,MAP3K4,MAP4K3,METTL9,MPP1,MYCL1,NAB1,NACA,NONO,NPL,OSBPL11,PACSIN2,PAPSS1,PCGF3,PCMT1,PDE4A,PDLIM7,PEA15,PICALM,PION,PITPNA,PLCB2,POLR2L,POR,PPP1R14B,PPP3CA,PROSC,PTGS1,PTPN22,PXN,PYCARD,RASA1,RCBTB2,REV3L,RHOB,RNASE4,RNASE6,RNF41,RNFT1,RNH1,RPL27,RPL41,RPL7,RPL8,RPS23,RPS3,RPS4Y1,RPS9,RTN3,RUFY2,RXRA,S100A12,S100P,SATB1,SEC63,SELT,SERF2,SERP1,SETD3,SFXN3,SH2B3,SH3BGRL3,SH3GL1,SLC11A1,SLC16A6,SLC38A2,SLC3A2,SLC4A7,SMC4,SORL1,SPG21,SSR2,STK38L,SYK,TACC3,TALDO1,TCIRG1,TDP1,TFEB,TGFBI,TGIF1,THBS1,TLR5,TM6SF1,TM9SF1,TMEM66,TPST2,TRMT5,TRPS1,TTLL4,TULP4,U2AF1,UNC119B,USP34,USP4,VAMP4,VAV1,VPS13D,WDR26,XPOT,ZCCHC14,ZFAND5,ZFC3H1,ZFP36L2,ZMIZ1,ZMYM1,ZNF706 GENE_SYMBOLS ABCD3,ACSL5,ADAM10,ADK,ADSS2,AHNAK,AKAP17A,ALDOA,ALOX5AP,AMPD2,ANP32A,ANXA2,AP1S2,ARF5,ARL4C,ATP6V0B,ATP6V0D1,ATRN,BICD2,BRD3,GPATCH2L,SYNE3,PAGR1,GID8,TMEM230,CALM2,CALR,CARD8,CBX5,CCL22,CD37,CD58,CEP85,CERK,CHP1,CLDND1,COPZ1,COTL1,CPPED1,CSF1R,CST7,CXCR4,CYP27A1,CYTIP,DIAPH1,DNMBP,DYM,EGR2,AGO1,EIF3L,EMP1,EREG,OTULINL,ABHD17A,FAU,FBXW7,FLNA,FOS,FPR1,GABARAP,GALC,GIGYF2,GLT8D1,GMCL1,GMIP,GNB1,GPR35,C5AR2,HCCS,HERPUD1,HLA-DPB1,HLA-DQB1,HMGN2,HNRNPA3,HSD17B10,HSP90B1,HTT,IFFO1,IFNGR1,ILF3,INTS8,IRAK1,ITGAE,KCTD7,KIAA0232,KRT10,LBR,LCP1,,LORICRIN,LPXN,LRP8,LRRC8D,MAP3K3,MAP3K4,MAP4K3,METTL9,MPP1,MYCL,NAB1,NACA,NONO,NPL,OSBPL11,PACSIN2,PAPSS1,PCGF3,PCMT1,PDE4A,PDLIM7,PEA15,PICALM,GSAP,PITPNA,PLCB2,POLR2L,POR,PPP1R14B,PPP3CA,PLPBP,PTGS1,PTPN22,PXN,PYCARD,RASA1,RCBTB2,REV3L,RHOB,RNASE4,RNASE6,RNF41,RNFT1,RNH1,RPL27,RPL41,RPL7,RPL8,RPS23,RPS3,RPS4Y1,RPS9,RTN3,RUFY2,RXRA,S100A12,S100P,SATB1,SEC63,SELENOT,SERF2,SERP1,SETD3,SFXN3,SH2B3,SH3BGRL3,SH3GL1,SLC11A1,SLC16A6,SLC38A2,SLC3A2,SLC4A7,SMC4,SORL1,SPG21,SSR2,STK38L,SYK,TACC3,TALDO1,TCIRG1,TDP1,TFEB,TGFBI,TGIF1,THBS1,TLR5,TM6SF1,TM9SF1,SARAF,TPST2,TRMT5,TRPS1,TTLL4,TULP4,U2AF1,UNC119B,USP34,USP4,VAMP4,VAV1,VPS13D,WDR26,XPOT,ZCCHC14,ZFAND5,ZFC3H1,ZFP36L2,ZMIZ1,ZMYM1,ZNF706 FOUNDER_NAMES